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Key Research Projects in Breast Cancer
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Mechanism-based discovery of Selective Estrogen Receptor Modulators (SERMs) and Selective Estrogen Receptor Downregulators (SERDs) (i.e., elacestrant and lasofoxifene)
Definition of the relative importance of cancer cell intrinsic and cancer cell extrinsic ER activity on the pathobiology of cancer and on tumor responses to ER modulators
Identification and exploitation of targetable vulnerabilities in endocrine therapy resistant cancer cells (i.e., LYPD and AGR2)
Impact of obesity and dyslipidemia on breast cancer pathobiology
Estrogen receptor related receptor (ERR) as a therapeutic target in breast cancer
Key Research Projects in Prostate Cancer
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Exploitation of the concept of functional allostery to identify novel classes of AR-directed therapeutics as treatments for metastatic prostate canccer
Retinoid receptors as therapeutic targets in prostate cancer
HOXB13, an AR coregulator, as a therapeutic target in CRPC
