Select Publications

Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma

This work highlights the importance of cancer cell intrinsic actions of estrogen receptor modulators in their therapeutic efficacy.

27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology

This study demonstrates that 27-hydroxycholesterol is a/the biochemical link between hypercholesterolemia/dyslipidemia and increased breast cancer risk and poor response to endocrine therapies. It resulted in several significant clinical trials to evaluate the impact of modulating 27-hydroxycholesterol on endocrine therapy in breast cancer.

The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer

Determined the mechanisms by which ERRα impacts breast cancer pathobiology and validated this receptor as a therapeutic target in cance

The homeodomain protein HOXB13 regulates the cellular response to androgens

Identified and characterized a coregulator mutation which results in familial prostate cancer.

Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands

A discovery platform that exploits differential coregulator/NR interaction profiles to drive new drug discovery.

Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium

Defined the molecular mechanisms underlying the non-genomic actions of estrogens.

Peptide antagonists of the human estrogen receptor

Demonstrated that receptor conformation and differential presentation of protein-protein interaction surfaces are the primary determinants of ER pharmacology and demonstrated the utility of disrupting protein-protein interaction surfaces as a therapeutic approach.

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens

Study challenged the classical models of ER antagonist action and first to propose “functional allostery”.

Identification of a negative regulatory function for steroid receptors

Genetic evidence that cellular factors distal to the receptor influence nuclear receptor pharmacology.