Systems Biology of Biological Clocks

Category: Papers

Coupling between the malaria intrinsic developmental cycle and the host circadian rhythm

New article in PNAS from Francis Motta and our group showing that the parasite’s intraerythrocytic cycle and the human host circadian cycle are coupled during malaria infection.

We provide direct evidence that the parasite’s intrinsic developmental cycle is aligned to the host’s circadian rhythm during malaria infection. This alignment suggests an evolutionary adaptation that creates synchrony between parasites during the blood phase and a method for evading host defenses or optimizing utilization of host resources that are controlled by the host circadian clock. This work opens the door for chronotherapeutic strategies for treating malaria infections.

See the PNAS paper.

New Tool for Alignment of Synchronized Time-Series Data Published in JOVE

Sophia Campione recently published an article in JOVE that allows for the alignment of synchronized time-series data using our previously developed CLOCCS model. This tool helps overcome a major challenge in analyzing synchronized time-series experiment, which is that the experiments can differ in the length of recovery from synchrony and the period. This means that measurements from different experiments cannot easily be analyzed together or compared. This tool allows for phase-specific and biologically relevant comparisons between experiments.

See the papers for the Alignment Tool and for the CLOCCS model.

Visualizing Tool Developed by Robert Moseley and Sophia Campione Published in JoVE

Robert Moseley and Sophia Campione recently developed a browser-based tool that allows for interactive visualization and generation of network models. The Inherent Dynamics Visualizer (IDV) connects to the network inference tool developed with our collaborators the Inherent Dynamics Pipeline (IDP). The IDV allows for informed decision-making on parameter choices made throughout the IDP. Together, the tools allow for streamlined inference of gene-regulatory networks.

See the papers for the IDV and the IDP. Watch the video for the IDV here:

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline


Haase and Takahashi Groups find evidence for intrinsic clocks in malaria parasites.

Duke Today, HHMI, The Scientist, and Science News all reported on recent work from our lab as well as from the Takahashi lab indicating that the malaria parasite has an intrinsic clock!

“The idea is, if we can learn these mechanisms then we have targets potentially for new antimalarial treatments.” – Steve Haase, from The Scientist

“If we can figure out if and how the malaria parasite synchronizes the ticking of its clock with that of its host (..) we might be able to disrupt those signals and help the human immune system better fight these invaders.” – Steve Haase, from Duke Today

See our publications page for links to the publication or see the publication here.

New Research Published

Haase Lab questions conclusions of Cross Lab detailed in Rahi et al. Cell, 2016. See publication here:

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