Haase Lab

Systems Biology of Biological Clocks

SD2: a DARPA project focusing on synergistic discovery and design

Steve Haase was recently featured in a video describing our work in the Syngerstic Discovery and Design (SD2) DARPA Program. This large collaboration focused on bringing experts together to study complex problems while creating a framework for scientific collaboration. This allowed for a 10-fold increase in the speed of an experimental cycle, while simultaneously increasing the complexity and accuracy.

“The SD2 program was designed in order to pursue these scientific endeavors much faster, must more accurately than we have in the past, by creating this interplay of technology and human capital.” – Dr. Jennifer Roberts

 

Congrats to Steve on the Dean’s Leadership Award!

Steve Haase received the 2021 Dean’s Leadership Award for his work as part of Duke’s COVID-19 response team!

Steve is an essential member of the team that shaped Duke’s COVID-19 response and, in particular, organized and monitored our surveillance testing program, which at its peak included a dozen self-administered test sites serving undergraduate and graduate students, faculty and staff.

Before vaccines were available, the use of surveillance testing and rapid turnaround of test results was credited with keeping infections low.

The data produced at those sites – routed through Steve and his colleagues for analysis and modeling – was invaluable in guiding university decisions throughout the pandemic.

As an example, in June 2021 they elected to continue surveillance testing of students and the university community despite a significant decline in cases. At the time, Duke was the only university to do so, but with the arrival of Delta in September last year, many others followed suit – and quickly.

https://trinity.duke.edu/faculty/award-winners

 

Welcome Huarui Zhou!

Welcome to our newest graduate student from the Program in Cell and Molecular Biology!

Visualizing Tool Developed by Robert Moseley and Sophia Campione Published in JoVE

Robert Moseley and Sophia Campione recently developed a browser-based tool that allows for interactive visualization and generation of network models. The Inherent Dynamics Visualizer (IDV) connects to the network inference tool developed with our collaborators the Inherent Dynamics Pipeline (IDP). The IDV allows for informed decision-making on parameter choices made throughout the IDP. Together, the tools allow for streamlined inference of gene-regulatory networks.

See the papers for the IDV and the IDP. Watch the video for the IDV here:

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

 

Duke Chronicle names Biological Clocks with Steve Haase and Anna Christina Nelson an ‘interesting class to take’ for Fall 2022

The class taught this fall by Steve alongside Anna Christina Nelson was mentioned in the Duke Chronicle article ‘Seven Interesting Classes to Take in Fall 2022’!

“This course will examine the many rhythmic behaviors exhibited by organisms and cells, from sleep and wake cycles to flower openings to cell division and malaria infections. Classwork will center around the genetic and molecular networks that comprise clocks regulating cell division and circadian rhythms, as well as the quantitative aspects of clock networks through a data analysis and dynamical systems model perspective.” Alison Korn, Duke Chronicle

Full article here.

Congratulations to newly minted Dr. Lauren Smith!

Congratulations to our graduate student Lauren Smith for successfully defending her thesis on March 29, 2022!

 

 

 

Duke Today: The Modeling Data Behind Duke’s Covid Response Plan

“The questions I wanted answered were ‘How do I deliver a great course while keeping people safe?’ and ‘How do I optimize the student experience while keeping people safe?’”
— Steve Haase

Full article at Duke Today. Video with Sally Kornbluth, Steve Haase, and Greg Wray:

Media Briefing: COVID Testing Keeps A Campus Safe

Steve Haase participated in a media briefing regarding the ongoing COVID testing on campus.

Haase and Takahashi Groups find evidence for intrinsic clocks in malaria parasites.

Duke Today, HHMI, The Scientist, and Science News all reported on recent work from our lab as well as from the Takahashi lab indicating that the malaria parasite has an intrinsic clock!

“The idea is, if we can learn these mechanisms then we have targets potentially for new antimalarial treatments.” – Steve Haase, from The Scientist

“If we can figure out if and how the malaria parasite synchronizes the ticking of its clock with that of its host (..) we might be able to disrupt those signals and help the human immune system better fight these invaders.” – Steve Haase, from Duke Today

See our publications page for links to the publication or see the publication here.

Welcome Sophie Campione!

Our newest graduate student from the Developmental and Stem Cell Biology Program.

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