This conversation was led by James DeGregori, Courtenay C. And Lucy Patten Davis Endowed Chair in Lung Cancer Research at the University of Colorado Anschutz Medical Campus. In the last five years, multiple studies have demonstrated that apparently healthy tissues in humans are patchworks of clones bearing somatic mutations, and the sizes and frequencies of these clones increases dramatically in old age. Often, there is clear evidence for positive selection for variants, which are frequently in genes frequently mutated in cancers, and yet the vast (VAST!) majority of these mutation-bearing clones will never develop into a cancer. We discussed the implications of these findings for different evolutionary theories of aging and cancer.
- Martincorena et al. 2018, “Somatic mutant clones colonize the human esophagus with age“
- Kakiuchi et al. 2020, “Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis“