- Identification of properties of tumor proagating cells that can be therapeutically targeted in mouse and human sarcomas
- Use of genetically modified mice to determine how novel members in the hedgehog-signaling cascade regulate bone development, growth, cartilaginous neoplasia and the development of osteoarthritis
- Study of interactions between hematopoietic and mesenchymal cells, and the role of novel proteins involved in this interaction in bone and cartilage development, repair, and the rejuvenation of fracture healing
- Discovery of novel therapies for desmoid tumor, a mesenchymal tumor also called aggressive fibromatosis, using cell culture and genetically modified mice