March 4, 2016

Current Projects

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  • Identification of properties of tumor proagating cells that can be therapeutically targeted in mouse and human sarcomas
  • Use of genetically modified mice to determine how novel members in the hedgehog-signaling cascade regulate bone development, growth, cartilaginous neoplasia and the development of osteoarthritis
  • Study of interactions between hematopoietic and mesenchymal cells, and the role of novel proteins involved in this interaction in bone and cartilage development, repair, and the rejuvenation of fracture healing
  • Discovery of novel therapies for desmoid tumor, a mesenchymal tumor also called aggressive fibromatosis, using cell culture and genetically modified mice