Research

Classical genetic approaches, such as gene overexpression and conditional mutations, have been instrumental in elucidating cellular pathways and protein function. However, they often lack temporal precision and can produce systemic effects. To overcome these limitations, researchers increasingly employ chemical probes that enable precise spatial, temporal, and mechanistic control in biochemical, cellular, and animal models. Advances in synthetic organic chemistry and high-throughput screening have accelerated probe discovery, yielding powerful tools to interrogate disease pathways and identify therapeutic targets. Because chemical probes closely mimic the behavior of therapeutic agents, they offer strong translational relevance. As a result, they have become indispensable for both fundamental biology and early-stage drug discovery.

Inspired by the transformative impact of chemical probes in biology and the power of interdisciplinary collaboration, the Hong group focuses on developing innovative chemical tools and strategies to expand pharmacological modulation of biological processes.