Publications

  1. Siska, Peter J.; Beckermann, Kathryn E.; Mason, Frank M.; Andrejeva, Gabriela; Greenplate, Allison R.; Sendor, Adam B.; Chiang, Yun-Chen J.; Corona, Armando L.; Gemta, Lelisa F.; Vincent, Benjamin G.; Wang, Richard C.; Kim, Bumki; Hong, Jiyong; Chen, Chiu-lan.; Bullock, Timothy N.; Irish, JM.; Rathmell, W. Kimryn; Rathmell, Jeffrey C. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. Journal of Clinical Investigation Insight, 2017, 2, e93411. PMID: 28614802
  2. Lanier, Megan L.; Park, Hyeri; Mukherjee, Paramita; Timmerman, Jacob C.; Ribeiro, Anthony A.; Widenhoefer, Ross A.; Hong, Jiyong. Formal synthesis of (+)-laurencin by gold(I)-catalyzed intramolecular dehydrative alkoxylation. Chemistry – A European Journal, 2017, 23, 7180–7184. PMID: 28393406
  3. Kim, Bumki; Ratnayake, Ranjala; Lee, Hyunji; Shi, Guqin; Zeller, Sabrina; Li, Chenglong; Luesch, Hendrik; Hong, Jiyong. Synthesis and biological evaluation of largazole zinc-binding group analogs. Bioorganic & Medicinal Chemistry, 2017, 25, 3077–3086. PMID: 28416100
  4. Lee, Kiyoun; Lanier, Megan, L.; Kwak, Jae-Hwan; Kim, Hyoungsu; Hong, Jiyong. Advances in the synthesis of glycosidic macrolides: Clavosolides A–D and cyanolide A. Natural Product Reports, 2016, 33, 1393–1424. PMID: 27714078
  5. Siska, Peter J.; Kim, Bumki; Ji, Xiangming; Massion, Pierre P.; Wu, Jianli; Chi, Jen-Tsan; Hong, Jiyong; Rathmell, Jeffrey C. Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. Journal of Immunological Methods, 2016, 438, 51–58. PMID: 27594594
  6. Geer, M. Ariel; Kwon, Do-Yeon; Weitzel, Douglas H.; Lee, Chen-Ting; Stephenson, Tesia N.; Chi, Jen-Tsan; Mook, Robert A.; Dewhirst, Mark W.; Hong, Jiyong; Fitzgerald, Michael C. Discovery of manassantin A protein targets using large-scale protein folding and stability measurements. Journal of Proteome Research, 2016, 15, 2688–2696. PMID: 27322910
  7. Chung, Ben C.; Mashalidis, Ellene H.; Tanino, Tetsuya; Kim, Mijung; Matsuda, Akira; Hong, Jiyong; Ichikawa, Satoshi; Lee, Seok-Yong. Structural insights into inhibition of Lipid I production in bacterial cell wall synthesis. Nature 2016, 533, 557–560. PMID: 27088606
  8. Kwon, Do-Yeon; Lee, Hye Eun; Weitzel, Douglas; Park, Kyunghye; Lee, Sun Hee; Lee, Chen-Ting; Stephenson, Tesia; Park, Hyeri; Fitzgerald, Michael C.; Chi, Jen-Tsan; Mook, Robert; Dewhirst, Mark; Lee, You Mie; Hong, Jiyong. Synthesis and biological evaluation of manassantin analogues for HIF-1α inhibition. Journal of Medicinal Chemistry 2015, 58, 7659–7671. PMID: 26394152, PMCID: PMC4765894
  9. Lim, Wonchung; Park, Joonwoo; Lee, Yong Hee; Hong, Jiyong*; Lee, Youngjoo.* Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist. Biochemical Biophysical Research Communications 2015, 461, 507–512. PMID: 25896764 (*co-corresponding author)
  10. Baker, Joseph B.; Kim, Hyoungsu; Hong, Jiyong. Total synthesis of clavosolide A via tandem allylic oxidation/oxa-conjugate addition reaction. Tetrahedron Letters 2015, 56, 3120–3122. PMID: 26236051 (Symposium-in-print in memory of Harry Wasserman)
  11. Kim, Bumki; Hong, Jiyong. An overview of naturally occurring histone deacetylase inhibitors. Current Topics in Medicinal Chemistry 2014, 14, 2759–2782. PMID: 25487010
  12. Kim, Bumki; Park, Heekwang; Salvador, Lilibeth A.; Serrano, Patrick E.; Kwan, Jason C.; Zeller, Sabrina L.; Chen, Qi-Yin; Ryu, Soyoung; Liu, Yanxia; Byeon, Seongrim; Luesch, Hendrik; Hong, Jiyong. Evaluation of class I HDAC isoform selectivity of largazole analogues. Bioorganic Medicinal Chemistry Letters 2014, 24, 3728–3731. PMID: 25070421, PMCID: PMC4135083
  13. Salvador, Lilibeth A.; Park, Heekwang; Al-Awadhi, Fatma H.; Liu, Yanxia; Kim, Bumki; Zeller, Sabrina L.; Chen, Qi-Yin; Hong, Jiyong; Luesch, Hendrik. Modulation of activity profiles for largazole-based HDAC inhibitors through alteration of prodrug properties. ACS Medicinal Chemistry Letters 2014, 5, 905–910. PMID: 25147612
  14. Johnson, Zachary L.; Lee, Jun-Ho; Lee, Kiyoun; Lee, Minhee; Kwon, Do-Yeon; Hong, Jiyong; Lee, Seok-Yong. Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife 2014, 3, e03604/1-e03604/19. PMID: 25082345
  15. Hong, Jiyong. Natural product synthesis at the interface of chemistry and biology. Chemistry – A European Journal 2014, 20, 10204–10212. PMID: 25043880
  16. Lanier, Megan L.; Kasper, Amanda C.; Kim, Hyoungsu; Hong, Jiyong. Synthesis of α,α’-trans-oxepanes through an organocatalytic oxa-conjugate addition reaction. Organic Letters 2014, 16, 2406–2409. PMCID: PMC4018174
  17. Lin, Regina; Kim, Hyoungsu; Hong, Jiyong*; Li, Qi-Jing.* Biological evaluation of subglutinol A as a novel immunosuppressive agent for inflammation. ACS Medicinal Chemistry Letters 2014, 5, 485–490. PMID: 24900866 (*co-corresponding author)
  18. Yu, Mingming; Salvador, Lilibeth A.; Sy, Sherwin K. B.; Tang, Yufei; Singh, Ravi; Chen, Qi-Yin; Liu, Yanxia; Hong, Jiyong; Derendorf, Hartmut; Luesch, Hendrik. Largazole pharmacokinetics in rats by LC-MS/MS. Marine Drugs 2014, 12, 1623–1640. PMID: 24658499
  19. Strickland, Erin C.; Geer, M. Ariel; Hong, Jiyong; Fitzgerald, Michael C. False positive rate of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform. Journal of the American Society for Mass Spectrometry 2014, 25, 132–140.
  20. Chung, Ben C.; Zhao, Jinshi; Gillespie, Robert A.; Kwon, Do-Yeon; Guan, Ziqiang; Hong, Jiyong; Zhou, Pei; Lee, Seok-Yong. Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis. Science 2013, 341, 1012–1016. PMID: 23990562
  21. Law, Mary E.; Corsino, Patrick E.; Jahn, Stephan C.; Davis, Bradley J.; Chen, Sixue; Patel, Bhavitaben; Pham, Kien; Lu, Jianrong; Sheppard, Barbara, J.; Norgaard, Peter; Hong, Jiyong; Higgins, Paul; Kim, Jae-Sung; Luesch, Hendrik; Law, Brian K. Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms. Oncogene 2013, 32, 1316–1329. PMID: 22543582, PMCID: PMC3773700
  22. Kaoud, Tamer S.; Park, Heekwang; Mitra, Shreya; Yan, Chunli; Tseng, Chun-Chia; Shi, Y.; Jose, Jiney; Taliaferro, Juliana M.; Lee, Kiyoun; Ren, Pengyu; Hong, Jiyong; Dalby, Kevin N. Manipulating JNK signaling with (–)-zuonin A. ACS Chemical Biology 2012, 7, 1873–1883. PMID: 22916726
  23. Kaoud, Tamer S.; Yan, Chunli; Mitra, Shreya; Tseng, Chun-Chia; Jose, Jiney; Taliaferro, Juliana M.; Tuohetahuntila, Maidina; Devkota, Ashwini; Sammons, Rachel; Park, Jihyun; Park, Heekwang.; Shi, Yue; Hong, Jiyong; Ren, Pengyu; Dalby, Kevin N. From in silico discovery to intra-cellular activity: Targeting JNK-protein interactions with small molecules. ACS Medicinal Chemistry Letters 2012, 3, 721–725. PMID: 23002419
  24. Lee, Kiyoun; Kim, Hyoungsu; Hong, Jiyong. N-Heterocyclic carbene-catalyzed oxidative macrolactonization: Total synthesis of (+)-dactylolide. Angewandte Chemie International Edition 2012, 51, 5735–5738. PMID: 22539442
  25. Hong, Jiyong*; Luesch, Hendrik.* Largazole: From discovery to broad-spectrum therapy. Natural Product Reports 2012, 29, 449–456. PMID: 22334030 (*co-corresponding author)
  26. Lee, Kiyoun; Kim, Hyoungsu; Hong, Jiyong. Stereoselective synthesis of tetrahydropyrans via tandem and organocatalytic oxa-Michael reactions: Synthesis of the tetrahydropyran cores of ent-(+)-sorangicin A. European Journal of Organic Chemistry 2012, 1025–1032.
  27. Lee, Won-Gil; Kim, Woo-Seok; Park, Sung-Gyoo; Kim, Hyoungsu; Hong, Jiyong; Ko, Hyojin; Kim, Yong-Chul. Immunosuppressive effects of subglutinol derivatives. ChemMedChem 2012, 7, 218–222. PMID: 22114006
  28. Byeon, Seong Rim; Park. Heekwang; Kim, Hyoungsu; Hong, Jiyong. Stereoselective synthesis of 2,6-trans-tetrahydropyran via primary diamine-catalyzed oxa-conjugate addition reaction of a,b-unsaturated ketone: Total synthesis of psymberin. Organic Letters 2011, 13, 5816–5819. PMID: 21988493
  29. Park, Heekwang; Kim, Hyoungsu; Hong, Jiyong. A Formal synthesis of SCH 351448. Organic Letters 2011, 13, 3742–3745. PMID: 21692467
  30. Lee, Kiyoun; Kim, Hyoungsu; Hong, Jiyong. A Stereoselective formal synthesis of leucascandrolide A. Organic Letters 2011, 13, 2722–2725. PMID: 21528873
  31. Hong, Jiyong. Role of natural product diversity in chemical biology. Current Opinion in Chemical Biology 2011, 15, 350–354. PMID: 21489856, PMCID: PMC3110584
  32. Kim, Hyoungsu; Byeon, Seong Rim; Leed, Marina G. D.; Hong, Jiyong. Intramolecular Michael reactions of aliphatic aldehyde enolates generated by imidazolium carbenes. Tetrahedron Letters 2011, 52, 2468–2470.
  33. Harrington, James M.; Park, Heekwang; Ying, Yongcheng; Hong, Jiyong; Crumbliss, Alvin L. Characterization of iron(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: Implications for the iron transport mechanism in mycobacteria. Metallomics 2011, 3, 464–471. PMID: 21442123
  34. Ying, Yongcheng; Kim, Hyoungsu; Hong, Jiyong. Stereoselective synthesis of 2,6-cis– and 2,6-trans-piperidines through organocatalytic aza-Michael reactions: A facile Synthesis of (+)-myrtine and (–)-epimyrtine. Organic Letters 201113, 796–799. PMID: 21250755
  35. Lee, Su-Ui; Kwak, Han Bok; Pi, Sung-Hee; You, Hyung-Keun; Byeon, Seong Rim; Ying, Yongcheng; Luesch, Hendrik; Hong, Jiyong*; Kim, Seong Hwan.* In vitro and in vivo osteogenic activity of largazole. ACS Medicinal Chemistry Letters 2011, 2, 248–251. PMID: 21666868 (*co-corresponding author)
  36. Liu, Yanxia; Salvador, Lilibeth A.; Byeon, Seongrim; Ying, Yongcheng; Kwan, Jason C.; Law, Brian K.; Hong, Jiyong; Luesch, Hendrik. Anti-colon cancer activity of largazole, a marine-derived tunable histone deaceylase inhibitor. Journal of Pharmacology and Experimental Therapeutics 2010, 335, 351–361. PMID: 20739454
  37. Kim, Hyoungsu; Hong, Jiyong. Total synthesis of cyanolide A and confirmation of its absolute stereochemistry. Organic Letters. 2010, 12, 2880–2883. PMID: 20491466
  38. Kim, Hyoungsu; Baker, Joseph B.; Park, Yongho; Park, Hyung-Bae; DeArmond, Patrick D.; Kim, Seong Hwan; Fitzgerald, Michael C.; Lee, Dong-Sup.; Hong, Jiyong. Total synthesis, assignment of the absolute stereochemistry, and structure–activity relationship studies of subglutinols A and B. Chemistry – An Asian Journal 2010, 5, 1902–1910. PMID: 20564278
  39. Lee, Kiyoun; Kim, Hyoungsu; Hong, Jiyong. A facile and efficient synthesis of 4-hydroxy-2,6-cis-tetrahydropyrans via tandem cross-metathesis/thermal SN2´ reaction: Protecting-group-free synthesis of (±)-diospongin A. Organic Letters 2009, 11, 5202–5205. PMID: 19824665
  40. Kim, Hyoungsu; Park, Yongho; Hong, Jiyong. Stereoselective synthesis of 2,6-cis-tetrahydropyrans through a tandem allylic oxidation/oxa-Michael reaction promoted by the gem-disubstituent effect: Synthesis of (+)-neopeltolide macrolactone. Angewandte Chemie International Edition 2009, 48, 7577–7581. PMID: 19739173
  41. Yuan, Langtian; Seo, Jin-Soo; Kang, Nam Sook; Keinan, Shahar; Steele, Sarah. E.; Michelotti, George A.; Wetsel, William C.; Beratan, David N.; Gong, Young-Dae; Lee, Tong H.; Hong, Jiyong. Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-z inhibitors and potential therapeutics for psychostimulant abuse. Molecular BioSystems 2009, 5, 927–930. PMID: 19668856 (Emerging investigators issue)
  42. Kasper, Amanda C.; Moon, Eui Jung; Hu, Xiangqian; Park, Yongho; Wooten, Ceshea M.; Kim, Hyoungsu; Yang, Weitao; Dewhirst, Mark W.; Hong, Jiyong. Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. Bioorganic and Medicinal Chemistry Letters 2009, 19, 3783–3786.PMID: 19423348, PMCID: PMC2709708 (Symposium-in-print honoring C. F. Barbas, 2009 Tetrahedron Young Investigator Award)
  43. Kasper, Amanda C.; Baker, Joseph B.; Kim, Hyoungsu; Hong, Jiyong. The end game of chemical genetics: Target identification. Future Medicinal Chemistry 2009, 1, 727–736. PMID: 21426035
  44. Kim, Hyoungsu; Baker, Joseph B.; Lee, Su-Ui; Park, Yongho; Bolduc, Kyle L.; Park, Hyung-Bae; Dickens, Marina G.; Lee, Dong-Sup; Kim, Yong-Chul; Kim, Seong Hwan; Hong, Jiyong. Stereoselective synthesis and osteogenic activity of subglutinols A and B. Journal of the American Chemical Society 2009, 131, 3192–3194. PMID: 19216570
  45. Kim, Hyoungsu; Kasper, Amanda C.; Wooten, Ceshea M.; Park, Yongho; Moon, Eui Jung; Dewhirst, Mark W.; Hong, Jiyong. Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: Stereoselective synthesis of manassantins A and B. Organic Letters 2009, 11, 89–92. PMID: 19111058, PMCID: PMC2656112
  46. Ying, Yongcheng; Liu, Y.; Byeon, Seong Rim; Kim, Hyoungsu; Luesch, Hendrik; Hong, Jiyong. Synthesis and activity of largazole analogues with linker and macrocycle modification. Organic Letters 2008, 10, 4021–4024. PMID: 18707106
  47. Ying, Yongcheng; Taori, Kanchan; Kim, Hyoungsu; Hong, Jiyong*; Luesch, Hendrik.* Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. Journal of the American Chemical Society 2008, 130, 8455–8459. PMID: 18507379 (*co-corresponding author)
  48. Lee, Hyunjoo; Kim, Kwan Woo; Park, Janghyun; Kim, Hyoungsu; Kim, Sanghee; Kim, Deukjoon; Hu, Xiangqian; Yang, Weitao; Hong, Jiyong. A general strategy for construction of both 2,6-cis– and 2,6-trans-disubstituted tetrahydropyrans: Substrate-controlled asymmetric total synthesis of (+)-scanlonenyne. Angewandte Chemie International Edition 2008, 47, 4200–4203. PMID: 18435525
  49. Ying, Yongcheng; Hong, Jiyong. Synthesis of brasilibactin A and confirmation of absolute configuration of of b-hydroxy acid fragment. Tetrahedron Letters 2007, 48, 8104–8107.
  50. Kim, Hyoungsu; Wooten, Ceshea M.; Park, Yongho; Hong, Jiyong. Stereoselective synthesis of tetrahydrofuran lignans via BF3·OEt2-promoted reductive deoxygenation/epimerization of cyclic hemiketal: Synthesis of (–)-odoratisol C, (–)-futokadsurin A, (–)-veraguensin, (+)-fragransin A2, (+)-galbelgin, and (+)-talaumidin. Organic Letters 2007, 9, 3965–3968. PMID: 17764190
  51. Lee, Jongkook; Hong, Jiyong; Nam, Tae-Gyu; Peters, Eric C.; Orth, Anthony P.; Geierstanger, Bernhard H.; Goldfinger, Lawrence E.; Ginsberg, Mark H.; Cho, Charles Y.; Schultz, Peter G. A small molecule inhibitor of a4 integrin-dependent cell migration. Bioorganic and Medicinal Chemistry 2009, 17, 977–980. PMID: 18329275
  52. Lee, Jongkook; Wu, Xu; di Magliano, Marina P.; Peters, Eric C.; Wang, Yan; Hong, Jiyong; Hebrok, Metthias; Ding, Sheng; Cho, Charles Y.; Schultz, Peter G. A small molecule antagonist of the hedgehog signaling pathway. ChemBioChem 2007, 8, 1916–1919. PMID: 17886323
  53. Hong, Jiyong; Lee, Jongkook; Min, Kyung Hoon; Walker, John R.; Peters, Eric C.; Gray, Nathanael S.; Cho, Charles Y.; Schultz, Peter G. Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation. ACS Chemical Biology 2007, 2, 171–175. PMID: 17348628
  54. Collins, Cynthia*; Hong, Jiyong*; Sapinoso, Lisa; Zhou, Yingyao; Liu, Zheng; Micklash, Kenneth; Schultz, Peter G.; Hampton, Garret M. A genetic siRNA screen for modulators of tumor cell motility identifies MAP4K4 as a pro-migratory kinase. Proceedings of the National Academy of Sciences of the United States of America 2006, 103, 3775–3780. PMID: 16537454 (*equal contribution)
  55. Lee, Jongkook; Hong, Jiyong. First synthesis and structural elucidation of (–)-presphaerene. Journal of Organic Chemistry 2004, 69, 6433–6440. PMID: 15357605
  56. Boger, Dale L.; Hong, Jiyong. Asymmetric total synthesis of ent-(–)-roseophilin: Assignment of absolute configuration. Journal of the American Chemical Society 2001, 123, 8515–8519.
  57. Boger, Dale L.; Hong, Jiyong; Hikota, Masataka; Ishida, Michio. Total synthesis of phomazarin. Journal of the American Chemical Society 1999, 121, 2471–2477.
  58. Boger, Dale L.; Hong, Jiyong. Total synthesis of nothapodytine B and (–)-mappicine. Journal of the American Chemical Society 1998, 120, 1218–1222.
  59. Kim, Deukjoon; Choi, Won Jun; Hong, Jiyong; Park, Il Yeong; Kim, Yang Bae. An asymmetric synthesis of (+)-isonitramine by ‘triple allylic strain-controlled’ intramolecular SN2´ alkylation. Tetrahedron Letters 1996, 37, 1433–1434.