Publications

  1. Dome, P. A.; Cochrane, C. S.; Switzer, H. J.; Lee, H.; Jeong, P.; Hong, J.*; Zhou, P.* From obscurity to opportunity: LpxH emerges as a promising antibiotic target in the battle against Gram-negative pathogens, ACS Infectious Diseases 2025. DOI: 10.1021/acsinfecdis.5c00625.
  2. Wang, E. C.; Jeong, P.; Han, C.; Oh, Y.; Zhao, Y.; Hong, J.* Asymmetric synthesis of the TRPV1 modulator AMG8562 via lipase-catalyzed kinetic resolution, ACS Omega 2025. DOI: 10.1021/acsomega.5c08033.
  3. Zhao, Y.; Wang, E. C.; Park, J.; Shin, I.; Kim, H.; Hong, J.* Asymmetric total synthesis of daucane-type sesquiterpenoids (+)-ferutinin and (+)-kuhistanicaol G. Organic Letters 2025. DOI: 10.1021/acs.orglett.5c03283.
  4. Lee H, Jang H, Myung H, Rivera A, Averette AF, Heitman J, Park J, Kim D, Kim H, Hong J* Asymmetric total synthesis of 4,9,10-trihydroxyguaia-11(13)en-12,6-olide and discovery of its anticancer activity against atypical teratoid rhabdoid tumor. ACS Central Science 2025. DOI: 10.1021/acscentsci.5c00332.
  5. Dome PA, Jeong P, Nam G, Jang H, Rivera A, Averette AF, Park E, Liao TC, Ciofani M, Wu J, Chi JA, Venters RA, Park HJ, Steinbach WJ, Juvvadi PR, Heitman J*, Hong J*. Structure-guided design, synthesis, and characterization of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi. Proceedings of the National Academy of Science of the United States of America, 2025, 122, e2419883121 (bioRxiv [Preprint], doi: 10.1101/2024.09.27.615491). (*co-corresponding authors)
  6. Wright NJ, Matsuoka Y, Park H, He W, Webster CG, Furutani K, Fedor JG, McGinnis A, Zhao Y, Chen O, Bang S, Fan P, Spasojevic I, Hong J*, Ji RR*, Lee SY*. Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief. Nature Communications, 2024, 15, 10738. (*co-corresponding authors)
  7. Ennis AF, Cochrane CS, Dome PA, Jeong P, Yu J, Lee H, Williams CS, Ha Y, Yang W, Pei Zhou*, Hong J*. Design and evaluation of pyridinyl sulfonyl piperazine LpxH inhibitors with potent antibiotic activity against Enterobacterales. JACS Au, 2024, doi: 10.1021/jacsau.4c00731. (*co-corresponding authors)
  8. Rivera A, Lim WY, Park E, Dome PA, Hoy MJ, Spasojevic I, Sun S, Averette AF, Pina-Oviedo S, Juvvadi PR, Steinbach WJ, Ciofani M, Hong J*, Heitman J*. Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22 modified FK520 analog against C. neoformans. mBio, 2023, doi: 10.1128/mbio.01810-23. (*co-corresponding authors)
  9. Kwak SH, Skyler Cochrane C, Cho J, Dome PA, Ennis AF, Kim JH, Zhou P*, Hong J*. Development of LpxH inhibitors chelating the active site dimanganese metal cluster of LpxH. ChemMedChem, 2023, doi: 10.1002/cmdc.202300023. (*co-corresponding authors)
  10. Byun JK, Lee SH, Moon EJ, Park MH, Jang H, Weitzel DH, Kim HH, Basnet N, Kwon DY, Lee CT, Stephenson TN, Jeong JH, Patel BA, Park SJ, Chi JT, Dewhirst MW, Hong J*, Lee YM*. Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity. Br J Cancer, 2023 doi: 10.1038/s41416-023-02148-7. (*co-corresponding authors)
  11. Anand J, Chiou L, Sciandra C, Zhang X, Hong J, Wu D, Zhou P, Vaziri C. Roles of translesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy. NAR Cancer, 2023, doi: 10.1093/narcan/zcad005.
  12. Dayanidhi DL, Somarelli JA, Mantyh JB, Rupprecht G, Roghani RS, Vincoff S, Shin I, Zhao Y, Kim SY, McCall S, Hong J*, Hsu DS*. Psymberin, a marine-derived natural product, induces cancer cell growth arrest and protein translation inhibition. Front Med, 2022, doi: 10.3389/fmed.2022.999004. (*co-corresponding authors)
  13. Wright, Nicholas J.; Fedor, Justin G.; Zhang Han; Jeong, Pyeonghwa; Suo, Yang; Yoo, Jiho; Hong, Jiyong; Im, Wonpil; Lee, Seok-Yong. Methotrexate recognition by the human reduced folate carrier SLC19A1. Nature, 2022, doi: 10.1038/s41586-022-05168-0.
  14. Hoy, Michael J.; Park, Eunchong; Lee, Hyunji; Lim, Won Young; Cole, D. Christopher; DeBouver, Nicholas D.; Bobay, Benjamin G.; Pierce, Phillip G.; Fox, David 3rd; Ciofani, Maria; Juvvadi, Praveen R.; Steinbach, William; Hong, Jiyong; Heitman, Joseph. Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus. mBio, 2022, 13, e0104922.
  15. Ikeh, Kanayo E.; Lamkin, Erica N.; Crompton, Andrew; Deutsch, Jamie; Fisher, Kira J.; Gray, Mark; Argyle, David J.; Lim, Won Y.; Korzhnev, Dmitry M.; Hadden, M Kyle; Hong, Jiyong; Zhou, Pei; Chatterjee, Nimrat. REV1 inhibition enhances radioresistance and autophagy. Cancers. 2021, 13, 5290.
  16. Webster, Caroline G.; Park, Hyeri; Ennis, Amanda F.; Hong, Jiyong. Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III. Tetrahedron Letters, 2021, doi: 10.1016/j.tetlet.2021.153055.
  17. Zhou, Pei; Hong, Jiyong. Structure- and ligand-dynamics-based design of novel antibiotics targeting lipid A enzymes LpxC and LpxH in gram-negative bacteria. Accounts of Chemical Research, 2021, 54, 1623–1634.
  18. Kwak, Seung-Hwa; Lim, Won Young; Hao, Aili; Mashalidis, Ellene H.; Kwon, Do-Yeon; Jeong, Pyeonghwa; Kim, Mi Jung; Lee, Seok-Yong; Hong, Jiyong. Synthesis and evaluation of cyclopentane-based muraymycin analogs targeting MraY. European Journal of Medicinal Chemistry, 2021, 215, doi: 10.1016/j.ejmech.2021.113272.
  19. Chatterjee, Nimrat; Whitman, Matthew A.; Harris, Cynthia A.; Min, Sophia M.; Jonas, Oliver; Lien, Evan C.; Luengo, Alba; Vander Heiden, Matthew G.; Hong, Jiyong; Zhou, Pei; Hemann, Michael T.; Walker, Graham C. REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. Proceedings of the National Academy of Science of the United States of America. 2020, 117, 28918–28921.
  20. Kwak, Seung-Hwa; Cochrane, C. Skyler; Ennis, Amanda F.; Lim, Won Young; Webster, Caroline G.; Cho, Jae; Fenton, Benjamin A.; Zhou, Pei; Hong, Jiyong. Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors. Bioorganic Chemistry, 2020, doi:10.1016/j.bioorg.2020.104055.
  21. Kwak, Seung-Hwa; Stephenson, Tesia N.; Lee, Sun Hee; Ge, Yun; Lee, Hyunji; Min, Sophia M; Kim, Jea Hyun; Kwon, Do-Yeon; Lee, You Mie; Hong, Jiyong. Evaluation of manassantin A tetrahydrofuran core region analogs and synergistic therapeutic effects with EGFR inhibition. Journal of Medicinal Chemistry, 2020, 63, 6821–6833.
  22. Neal, Samantha E.; Buehne, Kristen L.; Besley, Nicholas A.; Yang, Ping; Silinski, Peter; Hong, Jiyong; Ryde, Ian T.; Meyer, Joel N.; Jaffe, Glenn J. Resveratrol protects against hydroquinone-induced oxidative threat in retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 2020, doi:10.1167/iovs.61.4.32.
  23. Choi, Hosam; Hong, Jiyong; Lee; Kiyoun. A stereoselective synthesis of quinolizidine (–)-217A. European Journal of Organic Chemistry, 2020, 2020, 689–692.
  24. Cho, Jae; Lee, Minhee; Cochrane, C. Skyler; Webster, Caroline G.; Fenton, Benjamin A.; Zhao, Jinshi; Hong, Jiyong*; Zhou, Pei*. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proceedings of the National Academy of Science of the United States of America, 2020, doi: 10.1073/pnas.1912876117. (*co-corresponding authors)
  25. Chhetri, Abhishek; Loksztejn, Anna; Nguyen, Hai; Pianalto, Kaila M.; Kim, Mi Jung; Hong, Jiyong; Alspaugh, J. Andrew; Yokoyama, Kenichi. Length specificity and polymerization mechanism of (1,3)-β-D-glucan synthase in fungal cell wall biosynthesis. Biochemistry, 2020, 59, 682–693.
  26. Park, Hyeri, Christian, Laura S.; Lee, Mi Jung; Li, Qi-Jing; Hong, Jiyong. Synthesis and biological evaluation of subglutinol analogs for immunomodulatory agents. Journal of Medicinal Chemistry, 2020, 63, 283–294.
  27. Mashalidis, Ellene H.; Kaeser, Benjamin; Terasawa, Yuma; Katsuyama, Akira; Kwon, Do-Yeon; Lee, Kiyoun; Hong, Jiyong; Ichikawa, Satoshi; Lee, Seok-Yong. Chemical logic of MraY inhibition by antibacterial nucleoside natural products. Nature Communications, 2019, 10, 2917.
  28. Wojtaszek, Jessica L.; Chatterjee, Nimrat; Najeeb, Javaria; Ramos, Azucena; Lee, Minhee; Bian, Ke; Xue, Yaohua; Fenton, Benjamin A.; Park, Hyeri; Li, Deyui; Hemann, Michael T.*; Hong, Jiyong*; Walker. Graham C.*; Zhou, Pei*. Small molecule adjuvant disrupting Rev1-Pol z mediated mutagenic translesion synthesis improves chemotherapy. Cell, 2019, 178, 152–159. (*co-corresponding authors)
  29. Lee, Hyunji; Derbyshire, Sylvester, Kayla; Emily, R.; Hong, Jiyong. Synthesis and analysis of natural product-like macrocycles via tandem oxidation/oxa-conjugate addition reactions. Chemistry-A European Journal, 2019, 25, 6500–6504, PMID: 30912197.
  30. Lee, Minhee; Zhao, Jinshi; Kwak, Seung-Hwa; Cho, Jae; Lee, Myungju; Gillespie, Robert A.; Kwon, Do-Yeon; Lee, Hyunji; Park, Hyun-Ju; Wu, Qinglin; Zhou, Pei; Hong, Jiyong. Structure–activity relationship of sulfonyl piperazine LpxH inhibitors analyzed by an LpxE-coupled malachite green assay. ACS Infectious Diseases, 2019, 12, 641–651, PMID: 30721024.
  31. Eubanks, Amber L.; Perkins, Marisha M.; Sylvester, Kayla; Ganley, Jack G.; Posfai, Dora; Sanschargrin, Paul C.; Hong, Jiyong; Sliz, Piotr; Derbyshire, Emily R. In silico screening and evaluation of Plasmodium falciparum protein kinase 5 (PK5) inhibitors. ChemMedChem, 2018, 13, 2479–2483.
  32. Kwon, Do-Yeon, Lee, Kiyoun, Park, Hyeri, Kim, Mi Jung, Hong Jiyong. Synthetic efforts towards the stereoselective synthesis of NF00659B1. Bioorganic & Medicinal Chemistry Letters, 2018, 28, 2746–2750. PMID: 29503022
  33. Siska, Peter J.; Beckermann, Kathryn E.; Mason, Frank M.; Andrejeva, Gabriela; Greenplate, Allison R.; Sendor, Adam B.; Chiang, Yun-Chen J.; Corona, Armando L.; Gemta, Lelisa F.; Vincent, Benjamin G.; Wang, Richard C.; Kim, Bumki; Hong, Jiyong; Chen, Chiu-lan.; Bullock, Timothy N.; Irish, JM.; Rathmell, W. Kimryn; Rathmell, Jeffrey C. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. Journal of Clinical Investigation Insight, 2017, 2, e93411. PMID: 28614802
  34. Lanier, Megan L.; Park, Hyeri; Mukherjee, Paramita; Timmerman, Jacob C.; Ribeiro, Anthony A.; Widenhoefer, Ross A.; Hong, Jiyong. Formal synthesis of (+)-laurencin by gold(I)-catalyzed intramolecular dehydrative alkoxylation. Chemistry – A European Journal, 2017, 23, 7180–7184. PMID: 28393406
  35. Kim, Bumki; Ratnayake, Ranjala; Lee, Hyunji; Shi, Guqin; Zeller, Sabrina; Li, Chenglong; Luesch, Hendrik; Hong, Jiyong. Synthesis and biological evaluation of largazole zinc-binding group analogs. Bioorganic & Medicinal Chemistry, 2017, 25, 3077–3086. PMID: 28416100
  36. Lee, Kiyoun; Lanier, Megan, L.; Kwak, Jae-Hwan; Kim, Hyoungsu; Hong, Jiyong. Advances in the synthesis of glycosidic macrolides: Clavosolides A–D and cyanolide A. Natural Product Reports, 2016, 33, 1393–1424. PMID: 27714078
  37. Siska, Peter J.; Kim, Bumki; Ji, Xiangming; Massion, Pierre P.; Wu, Jianli; Chi, Jen-Tsan; Hong, Jiyong; Rathmell, Jeffrey C. Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. Journal of Immunological Methods, 2016, 438, 51–58. PMID: 27594594
  38. Geer, M. Ariel; Kwon, Do-Yeon; Weitzel, Douglas H.; Lee, Chen-Ting; Stephenson, Tesia N.; Chi, Jen-Tsan; Mook, Robert A.; Dewhirst, Mark W.; Hong, Jiyong; Fitzgerald, Michael C. Discovery of manassantin A protein targets using large-scale protein folding and stability measurements. Journal of Proteome Research, 2016, 15, 2688–2696. PMID: 27322910
  39. Chung, Ben C.; Mashalidis, Ellene H.; Tanino, Tetsuya; Kim, Mijung; Matsuda, Akira; Hong, Jiyong; Ichikawa, Satoshi; Lee, Seok-Yong. Structural insights into inhibition of Lipid I production in bacterial cell wall synthesis. Nature 2016, 533, 557–560. PMID: 27088606
  40. Kwon, Do-Yeon; Lee, Hye Eun; Weitzel, Douglas; Park, Kyunghye; Lee, Sun Hee; Lee, Chen-Ting; Stephenson, Tesia; Park, Hyeri; Fitzgerald, Michael C.; Chi, Jen-Tsan; Mook, Robert; Dewhirst, Mark; Lee, You Mie; Hong, Jiyong. Synthesis and biological evaluation of manassantin analogues for HIF-1α inhibition. Journal of Medicinal Chemistry 2015, 58, 7659–7671. PMID: 26394152, PMCID: PMC4765894
  41. Lim, Wonchung; Park, Joonwoo; Lee, Yong Hee; Hong, Jiyong*; Lee, Youngjoo.* Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist. Biochemical Biophysical Research Communications 2015, 461, 507–512. PMID: 25896764 (*co-corresponding author)
  42. Baker, Joseph B.; Kim, Hyoungsu; Hong, Jiyong. Total synthesis of clavosolide A via tandem allylic oxidation/oxa-conjugate addition reaction. Tetrahedron Letters 2015, 56, 3120–3122. PMID: 26236051 (Symposium-in-print in memory of Harry Wasserman)
  43. Kim, Bumki; Hong, Jiyong. An overview of naturally occurring histone deacetylase inhibitors. Current Topics in Medicinal Chemistry 2014, 14, 2759–2782. PMID: 25487010
  44. Kim, Bumki; Park, Heekwang; Salvador, Lilibeth A.; Serrano, Patrick E.; Kwan, Jason C.; Zeller, Sabrina L.; Chen, Qi-Yin; Ryu, Soyoung; Liu, Yanxia; Byeon, Seongrim; Luesch, Hendrik; Hong, Jiyong. Evaluation of class I HDAC isoform selectivity of largazole analogues. Bioorganic Medicinal Chemistry Letters 2014, 24, 3728–3731. PMID: 25070421, PMCID: PMC4135083
  45. Salvador, Lilibeth A.; Park, Heekwang; Al-Awadhi, Fatma H.; Liu, Yanxia; Kim, Bumki; Zeller, Sabrina L.; Chen, Qi-Yin; Hong, Jiyong; Luesch, Hendrik. Modulation of activity profiles for largazole-based HDAC inhibitors through alteration of prodrug properties. ACS Medicinal Chemistry Letters 2014, 5, 905–910. PMID: 25147612
  46. Johnson, Zachary L.; Lee, Jun-Ho; Lee, Kiyoun; Lee, Minhee; Kwon, Do-Yeon; Hong, Jiyong; Lee, Seok-Yong. Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife 2014, 3, e03604/1-e03604/19. PMID: 25082345
  47. Hong, Jiyong. Natural product synthesis at the interface of chemistry and biology. Chemistry – A European Journal 2014, 20, 10204–10212. PMID: 25043880
  48. Lanier, Megan L.; Kasper, Amanda C.; Kim, Hyoungsu; Hong, Jiyong. Synthesis of α,α’-trans-oxepanes through an organocatalytic oxa-conjugate addition reaction. Organic Letters 2014, 16, 2406–2409. PMCID: PMC4018174
  49. Lin, Regina; Kim, Hyoungsu; Hong, Jiyong*; Li, Qi-Jing.* Biological evaluation of subglutinol A as a novel immunosuppressive agent for inflammation. ACS Medicinal Chemistry Letters 2014, 5, 485–490. PMID: 24900866 (*co-corresponding authors)
  50. Yu, Mingming; Salvador, Lilibeth A.; Sy, Sherwin K. B.; Tang, Yufei; Singh, Ravi; Chen, Qi-Yin; Liu, Yanxia; Hong, Jiyong; Derendorf, Hartmut; Luesch, Hendrik. Largazole pharmacokinetics in rats by LC-MS/MS. Marine Drugs 2014, 12, 1623–1640. PMID: 24658499
  51. Strickland, Erin C.; Geer, M. Ariel; Hong, Jiyong; Fitzgerald, Michael C. False positive rate of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform. Journal of the American Society for Mass Spectrometry 2014, 25, 132–140.
  52. Chung, Ben C.; Zhao, Jinshi; Gillespie, Robert A.; Kwon, Do-Yeon; Guan, Ziqiang; Hong, Jiyong; Zhou, Pei; Lee, Seok-Yong. Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis. Science 2013, 341, 1012–1016. PMID: 23990562
  53. Law, Mary E.; Corsino, Patrick E.; Jahn, Stephan C.; Davis, Bradley J.; Chen, Sixue; Patel, Bhavitaben; Pham, Kien; Lu, Jianrong; Sheppard, Barbara, J.; Norgaard, Peter; Hong, Jiyong; Higgins, Paul; Kim, Jae-Sung; Luesch, Hendrik; Law, Brian K. Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms. Oncogene 2013, 32, 1316–1329. PMID: 22543582, PMCID: PMC3773700
  54. Kaoud, Tamer S.; Park, Heekwang; Mitra, Shreya; Yan, Chunli; Tseng, Chun-Chia; Shi, Y.; Jose, Jiney; Taliaferro, Juliana M.; Lee, Kiyoun; Ren, Pengyu; Hong, Jiyong; Dalby, Kevin N. Manipulating JNK signaling with (–)-zuonin A. ACS Chemical Biology 2012, 7, 1873–1883. PMID: 22916726
  55. Kaoud, Tamer S.; Yan, Chunli; Mitra, Shreya; Tseng, Chun-Chia; Jose, Jiney; Taliaferro, Juliana M.; Tuohetahuntila, Maidina; Devkota, Ashwini; Sammons, Rachel; Park, Jihyun; Park, Heekwang.; Shi, Yue; Hong, Jiyong; Ren, Pengyu; Dalby, Kevin N. From in silico discovery to intra-cellular activity: Targeting JNK-protein interactions with small molecules. ACS Medicinal Chemistry Letters 2012, 3, 721–725. PMID: 23002419
  56. Lee, Kiyoun; Kim, Hyoungsu; Hong, Jiyong. N-Heterocyclic carbene-catalyzed oxidative macrolactonization: Total synthesis of (+)-dactylolide. Angewandte Chemie International Edition 2012, 51, 5735–5738. PMID: 22539442
  57. Hong, Jiyong*; Luesch, Hendrik.* Largazole: From discovery to broad-spectrum therapy. Natural Product Reports 2012, 29, 449–456. PMID: 22334030 (*co-corresponding authors)
  58. Lee, Kiyoun; Kim, Hyoungsu; Hong, Jiyong. Stereoselective synthesis of tetrahydropyrans via tandem and organocatalytic oxa-Michael reactions: Synthesis of the tetrahydropyran cores of ent-(+)-sorangicin A. European Journal of Organic Chemistry 2012, 1025–1032.
  59. Lee, Won-Gil; Kim, Woo-Seok; Park, Sung-Gyoo; Kim, Hyoungsu; Hong, Jiyong; Ko, Hyojin; Kim, Yong-Chul. Immunosuppressive effects of subglutinol derivatives. ChemMedChem 2012, 7, 218–222. PMID: 22114006
  60. Byeon, Seong Rim; Park. Heekwang; Kim, Hyoungsu; Hong, Jiyong. Stereoselective synthesis of 2,6-trans-tetrahydropyran via primary diamine-catalyzed oxa-conjugate addition reaction of a,b-unsaturated ketone: Total synthesis of psymberin. Organic Letters 2011, 13, 5816–5819. PMID: 21988493
  61. Park, Heekwang; Kim, Hyoungsu; Hong, Jiyong. A Formal synthesis of SCH 351448. Organic Letters 2011, 13, 3742–3745. PMID: 21692467
  62. Lee, Kiyoun; Kim, Hyoungsu; Hong, Jiyong. A Stereoselective formal synthesis of leucascandrolide A. Organic Letters 2011, 13, 2722–2725. PMID: 21528873
  63. Hong, Jiyong. Role of natural product diversity in chemical biology. Current Opinion in Chemical Biology 2011, 15, 350–354. PMID: 21489856, PMCID: PMC3110584
  64. Kim, Hyoungsu; Byeon, Seong Rim; Leed, Marina G. D.; Hong, Jiyong. Intramolecular Michael reactions of aliphatic aldehyde enolates generated by imidazolium carbenes. Tetrahedron Letters 2011, 52, 2468–2470.
  65. Harrington, James M.; Park, Heekwang; Ying, Yongcheng; Hong, Jiyong; Crumbliss, Alvin L. Characterization of iron(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: Implications for the iron transport mechanism in mycobacteria. Metallomics 2011, 3, 464–471. PMID: 21442123
  66. Ying, Yongcheng; Kim, Hyoungsu; Hong, Jiyong. Stereoselective synthesis of 2,6-cis– and 2,6-trans-piperidines through organocatalytic aza-Michael reactions: A facile Synthesis of (+)-myrtine and (–)-epimyrtine. Organic Letters 2011, 13, 796–799. PMID: 21250755
  67. Lee, Su-Ui; Kwak, Han Bok; Pi, Sung-Hee; You, Hyung-Keun; Byeon, Seong Rim; Ying, Yongcheng; Luesch, Hendrik; Hong, Jiyong*; Kim, Seong Hwan.* In vitro and in vivo osteogenic activity of largazole. ACS Medicinal Chemistry Letters 2011, 2, 248–251. PMID: 21666868 (*co-corresponding authors)
  68. Liu, Yanxia; Salvador, Lilibeth A.; Byeon, Seongrim; Ying, Yongcheng; Kwan, Jason C.; Law, Brian K.; Hong, Jiyong; Luesch, Hendrik. Anti-colon cancer activity of largazole, a marine-derived tunable histone deaceylase inhibitor. Journal of Pharmacology and Experimental Therapeutics 2010, 335, 351–361. PMID: 20739454
  69. Kim, Hyoungsu; Hong, Jiyong. Total synthesis of cyanolide A and confirmation of its absolute stereochemistry. Organic Letters. 2010, 12, 2880–2883. PMID: 20491466
  70. Kim, Hyoungsu; Baker, Joseph B.; Park, Yongho; Park, Hyung-Bae; DeArmond, Patrick D.; Kim, Seong Hwan; Fitzgerald, Michael C.; Lee, Dong-Sup.; Hong, Jiyong. Total synthesis, assignment of the absolute stereochemistry, and structure–activity relationship studies of subglutinols A and B. Chemistry – An Asian Journal 2010, 5, 1902–1910. PMID: 20564278
  71. Lee, Kiyoun; Kim, Hyoungsu; Hong, Jiyong. A facile and efficient synthesis of 4-hydroxy-2,6-cis-tetrahydropyrans via tandem cross-metathesis/thermal SN2´ reaction: Protecting-group-free synthesis of (±)-diospongin A. Organic Letters 2009, 11, 5202–5205. PMID: 19824665
  72. Kim, Hyoungsu; Park, Yongho; Hong, Jiyong. Stereoselective synthesis of 2,6-cis-tetrahydropyrans through a tandem allylic oxidation/oxa-Michael reaction promoted by the gem-disubstituent effect: Synthesis of (+)-neopeltolide macrolactone. Angewandte Chemie International Edition 2009, 48, 7577–7581. PMID: 19739173
  73. Yuan, Langtian; Seo, Jin-Soo; Kang, Nam Sook; Keinan, Shahar; Steele, Sarah. E.; Michelotti, George A.; Wetsel, William C.; Beratan, David N.; Gong, Young-Dae; Lee, Tong H.; Hong, Jiyong. Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-z inhibitors and potential therapeutics for psychostimulant abuse. Molecular BioSystems 2009, 5, 927–930. PMID: 19668856 (Emerging investigators issue)
  74. Kasper, Amanda C.; Moon, Eui Jung; Hu, Xiangqian; Park, Yongho; Wooten, Ceshea M.; Kim, Hyoungsu; Yang, Weitao; Dewhirst, Mark W.; Hong, Jiyong. Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. Bioorganic and Medicinal Chemistry Letters 2009, 19, 3783–3786.PMID: 19423348, PMCID: PMC2709708 (Symposium-in-print honoring C. F. Barbas, 2009 Tetrahedron Young Investigator Award)
  75. Kasper, Amanda C.; Baker, Joseph B.; Kim, Hyoungsu; Hong, Jiyong. The end game of chemical genetics: Target identification. Future Medicinal Chemistry 2009, 1, 727–736. PMID: 21426035
  76. Kim, Hyoungsu; Baker, Joseph B.; Lee, Su-Ui; Park, Yongho; Bolduc, Kyle L.; Park, Hyung-Bae; Dickens, Marina G.; Lee, Dong-Sup; Kim, Yong-Chul; Kim, Seong Hwan; Hong, Jiyong. Stereoselective synthesis and osteogenic activity of subglutinols A and B. Journal of the American Chemical Society 2009, 131, 3192–3194. PMID: 19216570
  77. Kim, Hyoungsu; Kasper, Amanda C.; Wooten, Ceshea M.; Park, Yongho; Moon, Eui Jung; Dewhirst, Mark W.; Hong, Jiyong. Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: Stereoselective synthesis of manassantins A and B. Organic Letters 2009, 11, 89–92. PMID: 19111058, PMCID: PMC2656112
  78. Ying, Yongcheng; Liu, Y.; Byeon, Seong Rim; Kim, Hyoungsu; Luesch, Hendrik; Hong, Jiyong. Synthesis and activity of largazole analogues with linker and macrocycle modification. Organic Letters 2008, 10, 4021–4024. PMID: 18707106
  79. Ying, Yongcheng; Taori, Kanchan; Kim, Hyoungsu; Hong, Jiyong*; Luesch, Hendrik.* Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. Journal of the American Chemical Society 2008, 130, 8455–8459. PMID: 18507379 (*co-corresponding authors)
  80. Lee, Hyunjoo; Kim, Kwan Woo; Park, Janghyun; Kim, Hyoungsu; Kim, Sanghee; Kim, Deukjoon; Hu, Xiangqian; Yang, Weitao; Hong, Jiyong. A general strategy for construction of both 2,6-cis– and 2,6-trans-disubstituted tetrahydropyrans: Substrate-controlled asymmetric total synthesis of (+)-scanlonenyne. Angewandte Chemie International Edition 2008, 47, 4200–4203. PMID: 18435525
  81. Ying, Yongcheng; Hong, Jiyong. Synthesis of brasilibactin A and confirmation of absolute configuration of of b-hydroxy acid fragment. Tetrahedron Letters 2007, 48, 8104–8107.
  82. Kim, Hyoungsu; Wooten, Ceshea M.; Park, Yongho; Hong, Jiyong. Stereoselective synthesis of tetrahydrofuran lignans via BF3·OEt2-promoted reductive deoxygenation/epimerization of cyclic hemiketal: Synthesis of (–)-odoratisol C, (–)-futokadsurin A, (–)-veraguensin, (+)-fragransin A2, (+)-galbelgin, and (+)-talaumidin. Organic Letters 2007, 9, 3965–3968. PMID: 17764190
  83. Lee, Jongkook; Hong, Jiyong; Nam, Tae-Gyu; Peters, Eric C.; Orth, Anthony P.; Geierstanger, Bernhard H.; Goldfinger, Lawrence E.; Ginsberg, Mark H.; Cho, Charles Y.; Schultz, Peter G. A small molecule inhibitor of a4 integrin-dependent cell migration. Bioorganic and Medicinal Chemistry 2009, 17, 977–980. PMID: 18329275
  84. Lee, Jongkook; Wu, Xu; di Magliano, Marina P.; Peters, Eric C.; Wang, Yan; Hong, Jiyong; Hebrok, Metthias; Ding, Sheng; Cho, Charles Y.; Schultz, Peter G. A small molecule antagonist of the hedgehog signaling pathway. ChemBioChem 2007, 8, 1916–1919. PMID: 17886323
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  86. Collins, Cynthia*; Hong, Jiyong*; Sapinoso, Lisa; Zhou, Yingyao; Liu, Zheng; Micklash, Kenneth; Schultz, Peter G.; Hampton, Garret M. A genetic siRNA screen for modulators of tumor cell motility identifies MAP4K4 as a pro-migratory kinase. Proceedings of the National Academy of Sciences of the United States of America 2006, 103, 3775–3780. PMID: 16537454 (*equal contribution)
  87. Lee, Jongkook; Hong, Jiyong. First synthesis and structural elucidation of (–)-presphaerene. Journal of Organic Chemistry 2004, 69, 6433–6440. PMID: 15357605
  88. Boger, Dale L.; Hong, Jiyong. Asymmetric total synthesis of ent-(–)-roseophilin: Assignment of absolute configuration. Journal of the American Chemical Society 2001, 123, 8515–8519.
  89. Boger, Dale L.; Hong, Jiyong; Hikota, Masataka; Ishida, Michio. Total synthesis of phomazarin. Journal of the American Chemical Society 1999, 121, 2471–2477.
  90. Boger, Dale L.; Hong, Jiyong. Total synthesis of nothapodytine B and (–)-mappicine. Journal of the American Chemical Society 1998, 120, 1218–1222.
  91. Kim, Deukjoon; Choi, Won Jun; Hong, Jiyong; Park, Il Yeong; Kim, Yang Bae. An asymmetric synthesis of (+)-isonitramine by ‘triple allylic strain-controlled’ intramolecular SN2´ alkylation. Tetrahedron Letters 1996, 37, 1433–1434.