ONGOING CLINICAL STUDIES

Study Location:

Duke Medical Center, Durham, NC

Most of our studies involve females with fibromyalgia and healthy controls.

In the near future, we plan to also study painful temporomandibular disorders (TMD).

 

Opioid Phase in fibromyALgia (OPAL)

 

PI: Dr. Katherine Martucci, with collaborators Dr. Alison Adcock, and Dr. Thomas Buchheit, funded by Duke Institute for Brain Science and by the National Institutes of Health.

 

We use non-invasive and non-radioactive imaging to understand how opioid use changes the brain’s response to motivation.

 

NOW ENROLLING:

 

healthy controls

 

women with fibromyalgia who take opioids

 

women with fibromyalgia who do not take opioids

 

Pain Response Imaging in Smokers (PRISM)

A HAPNL collaboration w/ PI Dr. Maggie Sweitzer, funded by Duke Institute for Brain Science

We are using functional MRI imaging to understand how individuals who smoke feel pain.

 

By comparing conditions of smoking versus abstinence, we can see how the brain changes response to pain in the presence or absence of nicotine.

 

 

Pain Response & TracTographY (PRETTY)

PI Dr. Katherine Martucci, with collaborator Dr. Allen Song, funded by DREAM Innovation Grant

We are using imaging to determine how pain activates the spinal cord.

 

We are also studying how the axons of neurons in the spinal cord are different in individuals with chronic pain.

 

 

Brain & Spinal Cord Activity in Chronic Pain (“BrainSpine” Study)

PI :Dr. Katherine Martucci, funded by the National Institutes of Health

We are studying how activity in the brain and spinal cord change over time in individuals with chronic pain.

 

*We are currently enrolling the last few patients who take opioids for this study – this could be you!*

 

 

PUBLISHED STUDIES

 

Altered Spinal Cord Activity at Rest in Fibromyalgia & 

Altered Brain’s Response to Reward using fMRI

PI: Dr. Katherine Martucci, funded by the National Institutes of Health

Study Location:

Stanford University, CA, USA

 

We identified important changes in the brain and spinal cord in women with fibromyalgia.

 

Results were published in the journals PAIN, Arthritis & Rheumatology, Frontiers in Neurology, and Scientific Reports.