Human Affect & Pain Neuroscience (HAPN) Laboratory
Clinical Studies

To participate in any of the below ongoing studies at Duke, please complete our secure online screening survey


If you are interested in or want to check on your eligibility for a specific study, contact our lab at:
ChronicPainResearch@duke.edu

ONGOING CLINICAL STUDIES AND COLLABORATIONS

Study Location: All Current Studies are On-site at Duke Medical Center, Durham, NC

Most of our ongoing studies involve females with fibromyalgia and healthy controls. We hope in a future study to include patients with painful temporomandibular disorders.


Opioid Phase in fibromyALgia (OPAL)

PI Dr. Katherine Martucci, with collaborators Dr. Alison Adcock, and Dr. Kathryn Dickerson, funded by Duke Institute for Brain Science

Through this study we use non-invasive and non-radioactive imaging to understand how opioid use changes brain responses to motivational cues and the ability to train the brain to respond to these cues.

 

 

Pain Response Imaging in Smokers (PRISM)

A HAPNL collaboration w/ PI Dr. Maggie Sweitzer, and Dr. Alison Adcock, and Dr. Joseph McClernon, funded by Duke Institute for Brain Science

In this study we are using non-invasive and non-radioactive imaging to help us understand how individuals who smoke respond to pain and how their brain activity reflects their experience of painful sensations.

 

 

Pain Response and TracTographY (PRETTY)

PI Dr. Katherine Martucci, with collaborator Dr. Allen Song, funded by DREAM Innovation Grant

Through this study we are using non-invasive and non-radioactive imaging to determine how spinal cord activity changes in response to different types of painful sensations, and how the axons of neurons in the spinal cord are different in individuals who experience ongoing chronic pain.

 

 

Brain Reward and Spinal Cord Neuroimaging in Chronic Pain (BrainSpine)

PI Dr. Katherine Martucci, with collaborators Dr. Allen Song, Dr. Kenneth Weber, Dr. Brian Knutson, and Dr. Kelly H. MacNiven, funded by the National Institutes of Health

In this study we use non-invasive and non-radioactive imaging to help us understand how activity in the brain and spinal cord change over time in individuals who are experiencing chronic pain.

*We are currently enrolling the last few patients who take opioids for this study – this could be you!*

 

 

COMPLETED STUDIES & PUBLISHED RESEARCH FINDINGS

Clinical Research in Spinal Cord fMRI and Brain Reward Systems (BrainAndSpine)

PI Dr. Katherine Martucci, with collaborators Dr. Sean Mackey, Dr. Kenneth Weber, Dr. Brian Knutson, and Dr. Kelly H. MacNiven,  funded by the National Institutes of Health

Study Location: Stanford University, Stanford, CA, USA

 

We enrolled females with fibromyalgia and healthy volunteers in a neuroimaging and sensory testing study. Results showing new findings of changes across both the brain and spinal cord in patients with fibromyalgia were published in the journals PAIN, Arthritis & Rheumatology, Frontiers in Neurology, and Scientific Reports.

Join our
Research Studies

Are you eager to help advance knowledge about chronic pain? Have you noticed that many individuals with chronic pain are not adequately relieved by their pain medications? One way that we can help medicine identify new treatments is through research that involves and compares individuals with chronic pain to individuals who do not have chronic pain. In this way, we can take a peek into the brain to better understand what is happening in individuals with chronic pain. This new scientific knowledge will then, in turn, provide the foundation for new neuro-based treatments and medications targeted to have effective pain-relieving impacts and improve the lives of millions who experience chronic pain on a daily basis throughout the world. 

Get In Touch

Complete an eligibility survey to join our registry database of research participants. Our research team will contact you by phone or email to then conduct additional screening to see if you are a good fit for a research study. Or email us to ask questions at: ChronicPainResearch@Duke.edu

Tailored research Experience at a Top University

We tailor each research participant’s experience to be as convenient as possible. Parking is provided across the street from the Duke Hospital main entrance. Our trained research coordinators meet you at the entrance and escort you to our research facilities within the hospital. Times of study visits are flexible to work with your schedule.

“I really enjoyed meeting and interacting with the clinical research staff in the […] study. Everyone made sure I was as comfortable as possible and that I understood all the procedures. It was a great experience.” – Research Participant

Make A Difference

Millions of people across the globe suffer from chronic pain on a daily basis. Despite the prevalence of chronic pain, much still remains unknown regarding how it occurs in the body and treatments are inadequate. View our survey to volunteer and help us advance knowledge and discover new treatments.


Together We Can Cure Chronic Pain

The only way that medicine will be able to provide better treatments for people with chronic pain is through research. Team up with us to help our mission today.

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