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Njomen Lab
# corresponding authors *co-first authors
  1. Njomen, E#., Hayward, R. E., DeMeester, K. E., Ogasawara, D., Dix, M. M., Nguyen, T., Ashby, P., Simon, G. M., Schreiber, S. L., Melillo, B#., & Cravatt, B. F#. (2024). Multi-tiered chemical proteomic maps of tryptoline acrylamide-protein interactions in cancer cells. Nature chemistry, 16(10), 1592–1604. Read
  2. Won, S. J., Zhang, Y., Reinhardt, C. J., Hargis, L. M., MacRae, N. S., DeMeester, K. E., Njomen, E., Remsberg, J. R., Melillo, B., Cravatt, B. F., & Erb, M. A. (2024). Redirecting the pioneering function of FOXA1 with covalent small molecules. Molecular cell, 84(21), 4125–4141.e10. Read
  3. Ogasawara, D., Konrad, D. B., Tan, Z. Y., Carey, K. L., Luo, J., Won, S. J., Li, H., Carter, T. R., DeMeester, K. E., Njomen, E., Schreiber, S. L., Xavier, R. J., Melillo, B., & Cravatt, B. F. (2024). Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes. Cell chemical biology, S2451-9456(24)00440-9. Read
  4. Liu, Z., Remsberg, J. R., Li, H., Njomen, E., DeMeester, K. E., Tao, Y., Xia, G., Hayward, R. E., Yoo, M., Nguyen, T., Simon, G. M., Schreiber, S. L., Melillo, B., & Cravatt, B. F. (2024). Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society, 146(15), 10393–10406. Read
  5. Stanton C, Sun J, Nutsch K, Rosarda JD, Nguyen T, Li-Ma C, Njomen E, Melillo B, Kutseikin S, Saez E, Cravatt BF, Teijaro JR, Wiseman RL, Bollong MJ. Covalent Targeting as a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS Chem Biol. 2024 Feb 16;19(2):254-265. Read
  6. Tao Y, Felber JG, Zou Z, Njomen E, Remsberg J, Ogasawara D, Ye C, Melillo B, Schreiber SL, He C, Remillard D, Cravatt B. Chemical proteomic discovery of isotype-selective covalent inhibitors of the RNA Methyltransferase NSUN2. Angew Chem Int Ed Engl. 2023 Nov 1:e202311924. Read
  7. Li H, Ma T, Remsberg JR, Won SJ, DeMeester KE, Njomen E, Ogasawara D, Zhao KT, Huang TP, Lu B, Simon GM, Melillo B, Schreiber SL, Lykke-Andersen J, Liu DR, Cravatt BF. Assigning functionality to cysteines by base editing of cancer dependency genes. Nat Chem Biol. 2023 Nov;19(11):1320-1330. Read
  8. Staerz SD, Lisabeth EM, Njomen E, Dexheimer TS, Neubig RR, Tepe JJ. Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators. ACS Omega. 2023 Apr 21;8(17):15650-15659. Read
  9. Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, Njomen E, Hogg SJ, Rahman J, Whitby LR, Won SJ, Schafroth MA, Ogasawara D, Yokoyama M, Lindsey GL, Li H, Germain J, Barbas S, Vaughan J, Hanigan TW, Vartabedian VF, Reinhardt CJ, Dix MM, Koo SJ, Heo I, Teijaro JR, Simon GM, Ghosh B, Abdel-Wahab O, Ahn K, Saghatelian A, Melillo B, Schreiber SL, Yeo GW, Cravatt BF. Proteomic discovery of chemical probes that perturb protein complexes in human cells. Mol Cell. 2023 May 18;83(10):1725-1742.e12. Read
  10. Feldman, H. C., Merlini, E., Guijas, C., DeMeester, K. E., Njomen, E., Kozina, E. M., Yokoyama, M., Vinogradova, E., Reardon, H. T., Melillo, B., Schreiber, S. L., Loreto, A., Blankman, J. L., & Cravatt, B. F. Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119(35), e2208457119. Read
  11. *Njomen, E.; *Vanecek, A.; Lansdell, T.A.; Yang, Y.-T.; Schall, P.Z.; Harris, C.M.; Bernard, M.P.; Isaac, D.; Alkharabsheh, O.; Al-Janadi, A.; Giletto, M.B.; Ellsworth, E.; Taylor, C.; Tang, T.; Lau, S.; Bailie, M.; Bernard, J.J.; Yuzbasiyan-Gurkan, V.; Tepe, J.J. Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma. Biomedicines 2022, 10, 938. Read
  12. Njomen, E. and Tepe, J. J. Regulation of Autophagic Flux by the 20S Proteasome. Cell Chemical Biology 2019, 26, 1-12. Read
  13. Njomen, E.; Tepe, J. J. Proteasome Activation as a New Therapeutic Approach to Target Proteotoxic Disorders. J. Med. Chem. 2019, 62 (14), 6469-6481. Read
  14. Njomen, E.; Osmulski, P. A.; Jones, C. L.; Gaczynska, M. E.; Tepe, J. J. Small Molecule Modulation of Proteasome Assembly. Biochemistry 2018, 57 (28), 4214-4224. Read
  15. *Jones, C. L.; *Njomen, E.; Sjögren, B.; Dexheimer, T. S.; Tepe, J. J. Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins. ACS Chem. Biol. 2017, 12 (9), 2240–2247. Read
  16. Njomen, E.; Evans, H.; Gedara, S.; Heyl, D. Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β. Protein Pept. Lett. 2015, 22 (10), 869–876. Read

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