Meeting Agenda

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Thursday, November 14th

12:00 pm         Registration and arrival

12:25 pm         Welcome and opening remarks: Stacy Horner and Kate Meyer, Duke University

          Session I: RNA Regulation and Structure

12:30 pm         Keynote Lecture: Mitch Guttman, Cal Tech: RNA promotes the formation of spatial compartments throughout the nucleus

1:10 pm           Joseph Yesselman, University of Nebraska: High-throughput determination of RNA tertiary contact thermodynamics by quantitative DMS chemical mapping

1:40 pm           Claire Fleurisson, UNC-Chapel Hill: Contributions of RNA Structure Near Splice Sites to the Splicing Regulatory Code

2:00 pm           Zoe Wright, NIEHS: Structural and Biochemical Analyses Reveal that Spontaneous Base Flipping Helps Drive SARS-CoV-2 Protein Nsp15’s Preferences in dsRNA Substrates

2:20 pm – 2:45 pm      Break

          Session II: RNA:Protein Interactions and RNA Modifications

2:45 pm           Siggy Nachtergaele, Yale University: Exploring the roles of RNA modifications in drug-resistant glioblastoma

3:15 pm           Kotaro Nakanishi, Ohio State University: Gene silencing by cityRNAs

3:45 pm           Kayla Mason, UNC-Chapel Hill: The sex differential requirement of DDX3X in cardiac development

4:05 pm           Matt Tegowski, Duke University: Single-cell m6A profiling in the mouse cortex reveals cell type-specific methylation profiles as well as changes during aging and stress

4:30 pm – 6:00 pm            Sponsored Poster Session, Hors d’oeuvres and bar service

6:00 pm           Dinner

Friday, November 15th

10:00 am         Breakfast and networking

          Session I: RNA Targeting and Therapeutics

10:30 am         Amanda Hargrove, University of Toronto: Strategies to modulate the conformation and function of RNA with small molecules

11:00 am         Wilton Snead, Duke University: A multicomponent, out-of-equilibrium logic controls the assembly of nuclear paraspeckles

11:20 am         Edgar Faison, UNC-Chapel Hill: Chemical visualization of nascent RNA folding with co-transcriptional TMO-MaP

11:40 am         Diana Dou, Duke University: A Complex issue: When 2 X’s need to Xist

12:00 pm – 1:00 pm    Lunch

          Session III: RNA Processing and Localization

1:00 pm           Keynote Lecture: Geraldine Seydoux, Johns Hopkins University: A structural role for mRNAs in germ granules?

1:40 pm           Wayne Hemphill: A general mechanism for tunable RNA-mediated regulation of chromatin-binding proteins

2:00 pm          Alicia Darnell, Duke University: Metabolic control of protein synthesis by ribosome fall-off

2:20 pm – 2:40 pm      Break

2:40 pm           Eric Wang, University of Florida: RNA supply chain issues in repeat expansion diseases

3:10 pm           Ru-pin Chi, NIEHS: A death-promoting post-transcriptional mechanism in heat exposed cells

3:30 pm           Taylor Niehoff, Duke University: An unbiased screen identifies the PAXT connection as a modifier of rare codon-dependent expression

3:50 pm           Lela Lackey, Clemson University: The impact of inflammation on alternative polyadenylation and A1AT protein expression

4:10 pm           Awards Presentation

4:30 pm – 6:00 pm Reception, Hors d’oeuvres and bar service

~ Meeting Adjourns~