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Thursday, November 14th
12:00 pm Registration and arrival
12:25 pm Welcome and opening remarks: Stacy Horner and Kate Meyer, Duke University
Session I: RNA Regulation and Structure
12:30 pm Keynote Lecture: Mitch Guttman, Cal Tech: RNA promotes the formation of spatial compartments throughout the nucleus
1:10 pm Joseph Yesselman, University of Nebraska: High-throughput determination of RNA tertiary contact thermodynamics by quantitative DMS chemical mapping
1:40 pm Claire Fleurisson, UNC-Chapel Hill: Contributions of RNA Structure Near Splice Sites to the Splicing Regulatory Code
2:00 pm Zoe Wright, NIEHS: Structural and Biochemical Analyses Reveal that Spontaneous Base Flipping Helps Drive SARS-CoV-2 Protein Nsp15’s Preferences in dsRNA Substrates
2:20 pm – 2:45 pm Break
Session II: RNA:Protein Interactions and RNA Modifications
2:45 pm Siggy Nachtergaele, Yale University: Exploring the roles of RNA modifications in drug-resistant glioblastoma
3:15 pm Kotaro Nakanishi, Ohio State University: Gene silencing by cityRNAs
3:45 pm Kayla Mason, UNC-Chapel Hill: The sex differential requirement of DDX3X in cardiac development
4:05 pm Matt Tegowski, Duke University: Single-cell m6A profiling in the mouse cortex reveals cell type-specific methylation profiles as well as changes during aging and stress
4:30 pm – 6:00 pm Sponsored Poster Session, Hors d’oeuvres and bar service
6:00 pm Dinner
Friday, November 15th
10:00 am Breakfast and networking
Session I: RNA Targeting and Therapeutics
10:30 am Amanda Hargrove, University of Toronto: Strategies to modulate the conformation and function of RNA with small molecules
11:00 am Wilton Snead, Duke University: A multicomponent, out-of-equilibrium logic controls the assembly of nuclear paraspeckles
11:20 am Edgar Faison, UNC-Chapel Hill: Chemical visualization of nascent RNA folding with co-transcriptional TMO-MaP
11:40 am Diana Dou, Duke University: A Complex issue: When 2 X’s need to Xist
12:00 pm – 1:00 pm Lunch
Session III: RNA Processing and Localization
1:00 pm Keynote Lecture: Geraldine Seydoux, Johns Hopkins University: A structural role for mRNAs in germ granules?
1:40 pm Wayne Hemphill: A general mechanism for tunable RNA-mediated regulation of chromatin-binding proteins
2:00 pm Alicia Darnell, Duke University: Metabolic control of protein synthesis by ribosome fall-off
2:20 pm – 2:40 pm Break
2:40 pm Eric Wang, University of Florida: RNA supply chain issues in repeat expansion diseases
3:10 pm Ru-pin Chi, NIEHS: A death-promoting post-transcriptional mechanism in heat exposed cells
3:30 pm Taylor Niehoff, Duke University: An unbiased screen identifies the PAXT connection as a modifier of rare codon-dependent expression
3:50 pm Lela Lackey, Clemson University: The impact of inflammation on alternative polyadenylation and A1AT protein expression
4:10 pm Awards Presentation
4:30 pm – 6:00 pm Reception, Hors d’oeuvres and bar service
~ Meeting Adjourns~
