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The McCafferty Lab

PUBLICATIONS

Publications

Preprints

Hatstat, A.K.; Quan, B.; Bailey, M.A.; Fitzgerald, M.C.; Reinhart, M.C.; McCafferty, D.G. Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzdiimadazole ligand's rescue of Parkinson's associated cell toxicity. BioRxiv. https://doi.org/10.1101/2021.05.05.442776

Hatstat, A.K.;Pupi, M.D.; McCafferty D.G. Bioinformatic and computational analysis reveals the prevalence and nature of PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases. BioRxiv.https://doi.org/10.1101/2020.11.12.380584

Peer-Reviewed Publications

Stariha, L.M.; McCafferty, D.G. Discovery of the Class I Antimicrobial Lasso Peptide Arcumycin. ChemBioChem 2021. Selected as Very Important Paper. https://doi.org/10.1002/cbic.202100132

 

Hatstat, A. K.; Ahrendt, H. D.; Foster, M. W.; Mayne, L.; Moseley, M. A.; Englander, S. W.; McCafferty, D. G. Characterization of Small-Molecule-Induced Changes in Parkinson’s-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade. Cell Chemical Biology 2021, 28, 14-25. https://doi.org/10.1016/j.chembiol.2020.10.008.

Morgan, K.T., Zheng, J, McCafferty, D.G.. Discovery of Six Ramoplanin Family Gene Clusters and the Lipoglycodepsipeptide Chersinamycin. ChemBioChem 2021, 22, 176. https://doi.org/10.1002/cbic.202000555  Selected as Very Important Paper and featured on the issue cover!

Hatstat, AK, McCafferty, DG. Robust and facile purification of full-length, untagged human Nedd4 as a recombinant protein from Escherichia coli. Protein Expression and Purification 2020, 173, 105649.

Dudiak, BD, Maksimchuk, KR, Bednar, MM, Podracky, CJ, Burg, JM, Nguyen, TM, Nwogbo, FO, Valdivia, RH, McCafferty, DG. Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Chlamydia trachomatis Virulence-Associated Protease CPAF. Biochemistry 2019, 58(33), 3527-3536.

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Biniossek, ML, Niemer, M, Maksimchuk, K, Mayer, B, Fuchs, J, Huesgen, PF, McCafferty, DG, Turk, B, Fritz, G, Mayer, J, Haecker, G, Mach, L, Schilling, O. Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics. Mol Cell Proteomics 2016, 15(7), 2515-2524.

Maksimchuk, KR, Alser, KA, Mou, R, Valdivia, RH, McCafferty, DG. The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins. PLoS ONE 2016, 11(2), e0147233.
Burg, JM, Gonzalez, JJ, Maksimchuk, KR, McCafferty, DG. Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones. Biochemistry2016, 55(11), 1652–1662.
Burg, JM, Makhoul, AT, Pemble, CW, Link, JE, Heller, FJ, McCafferty, DG. A rationally‐designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activityFEBBS Letters2015, 589(18), 2340-2346.
Snavely, EA, Kokes, M, Dunn, JD, Saka, HA, Nguyen, BD, Bastidas, RJ, McCafferty, DG, Valdivia, RH. Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches.Pathogens and Disease 2014,71(3), 336–351.
Qi, Y, Amiram, M, Gao, W, McCafferty, DG, Chilkoti, A. Sortase‐Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a Protein. Macromolecular Rapid Communications2013, 34(15), 1256-1260.
Folk, DS, Torosian, JC, Hwang, S, McCafferty, DG, Franz, KJ. Monitoring β‐Secretase Activity in Living Cells with a Membrane‐Anchored FRET Probe. Angew Chem Int Ed Engl2012, 51(43), 10795-10799.
Weinberg, DR, Gagliardi, CJ, Hull, JF, Murphy, CF, Kent, CA, Westlake, BC, Paul, A, Ess, DH, McCafferty, DG, Meyer, TJ. Proton-Coupled Electron Transfer. Chem. Rev. 2012, 112(7), 4016–4093.
Pollock, JA, Larrea, MD, Jasper, JS, McDonnell, DP, McCafferty, DG. Lysine-Specific Histone Demethylase 1 Inhibitors Control Breast Cancer Proliferation in ERα-Dependent and -Independent Manners. ACS Chem. Biol. 2012, 7(7), 1221–1231.

Hoertz, AJ, Hamburger, JB, Gooden, DM, Bednar, MM, McCafferty, DG. Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2. Bioorganic and Medicinal Chemistry2012, 20(2), 859-865.

Melvin, JA1, Murphy, CF, Dubois, LG, Thompson, JW, Moseley, MA, McCafferty, DG. Staphylococcus aureus Sortase A Contributes to the Trojan Horse Mechanism of Immune Defense Evasion with Its Intrinsic Resistance to Cys184 Oxidation. Biochemistry2011, 50(35), 7591–7599.
Jorgensen, I, Bednar, MM, Amin, V, Davis, BK, Ting, JP, McCafferty, DG, Valdivia, RH. The Chlamydia Protease CPAF Regulates Host and Bacterial Proteins to Maintain Pathogen Vacuole Integrity and Promote Virulence. Cell Host and Microbe 2011, 10(1), 21-32.
Cropp, TA, McCafferty, DG. Found in translation: applications of protein and peptide molecular diversity. Curr Opin Chem Biol 2011, 15(3), 347-349.
Hwang, S, Schmitt, AA, Luteran, AE, Toone, EJ, McCafferty, DG. Thermodynamic Characterization of the Binding Interaction between the Histone Demethylase LSD1/KDM1 and CoREST. Biochemistry 2011, 50(4), 546–557.
Schmidt, JW, Greenough, A, Burns, M, Luteran, AE, McCafferty, DG. Generation of ramoplanin-resistant Staphylococcus aureus. FEMS Microbiology Letters2010, 310(2), 104-111.
Clancy, KW, Melvin, JA, McCafferty, DG. Sortase transpeptidases: Insights into mechanism, substrate specificity, and inhibition. Peptide Science 2010, 94(4), 385-396.
Hamburger, JB, Hoertz, AJ, Lee, A, Senturia, RJ, McCafferty, DG, Loll, PJ. A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface. PNAS 2009, 106(33), 13759-13764.
Gaweska, H, Henderson Pozzi, M, Schmidt, DM, McCafferty, DG, Fitzpatrick, PF. Use of pH and Kinetic Isotope Effects To Establish Chemistry as Rate-Limiting in Oxidation of a Peptide Substrate by LSD1. Biochemistry2009, 48(23), 5440–5445.
Kudryavtsev, KV, Bentley, ML, McCafferty, DG. Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform. Bioorganic and Medicinal Chemistry2009, 17(7), 2886-2893.
Deshmukh, HS, Hamburger, JB, Ahn, SH, McCafferty, DG, Yang, SR, Fowler, VG Jr. Critical Role of NOD2 in Regulating the Immune Response to Staphylococcus aureus. Infect Immun 2009, 77(4), 1376-1382.
Race, PR, Bentley, ML, Melvin, JA, Crow, A, Hughes, RK, Smith, WD, Sessions, RB, Kehoe, MA, McCafferty, DG, Banfield, MJ. Crystal structure of Streptococcus pyogenes sortase A: implications for sortasemechanism. J. Biol. Chem. 2009, 284(11), 6924-6933.
Bentley, ML1, Lamb, EC, McCafferty, DG. Mutagenesis Studies of Substrate Recognition and Catalysis in the Sortase A Transpeptidase from Staphylococcus aureus.J. Biol. Chem. 2008, 283(21), 14762-14771.
Gooden, DM, Schmidt, DM, Pollock, JA, Kabadi, AM, McCafferty, DG. Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. Bioorganic and Medicinal Chemistry Letters 2008, 18(10), 3047-3051.
Frankel, BA, Tong, Y, Bentley, ML, Fitzgerald, MC, McCafferty, DG. Mutational Analysis of Active Site Residues in the Staphylococcus aureusTranspeptidase SrtA.  Biochemistry2007, 46(24), 7269–7278.
Schmidt, DM, McCafferty, DG. trans-2-Phenylcyclopropylamine Is a Mechanism-Based Inactivator of the Histone Demethylase LSD1.Biochemistry2007, 46(14), 4408–4416.
Bentley, ML, Gaweska, H, Kielec, JM, McCafferty, DG. Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA.J. Biol. Chem. 2007, 289(9), 6571-6581
Lee, MG1, Wynder, C, Schmidt, DM, McCafferty, DG, Shiekhattar, R. Histone H3 Lysine 4 Demethylation Is a Target of Nonselective Antidepressive Medications. Chemistry & Biology 2006, 13(6), 563-567.
Frankel, BA, Kruger, RG, Robinson, DE, Kelleher, NL, McCafferty, DG. Staphylococcus aureus Sortase Transpeptidase SrtA:  Insight into the Kinetic Mechanism and Evidence for a Reverse Protonation Catalytic Mechanism.Biochemistry2005, 44(33), 1188–11200.
Kapustin, GV, Fejér, G, Gronlund, JL, McCafferty, DG, Seto, E, Etzkorn, FA. Phosphorus-Based SAHA Analogues as Histone Deacetylase Inhibitors. Org. Lett. 2003, 5(17), 3053–3056.

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