Journal Articles

Hatstat, A.K.; Pupi, M.D.; McCafferty D.G. Bioinformatic and computational analysis reveals the prevalence and nature of PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases. BioRxiv.

 

Hatstat, A. K.; Ahrendt, H. D.; Foster, M. W.; Mayne, L.; Moseley, M. A.; Englander, S. W.; McCafferty, D. G. Characterization of Small-Molecule-Induced Changes in Parkinson’s-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade. Cell Chemical Biology 2020. https://doi.org/10.1016/j.chembiol.2020.10.008.

Morgan, K.T., Zheng, J. and McCafferty, D.G. Discovery of Six Ramoplanin Family Gene Clusters and the Lipoglycodepsipeptide Chersinamycin . ChemBioChem 2020. https://doi.org/10.1002/cbic.202000555

Hatstat, AK, McCafferty, DG. Robust and facile purification of full-length, untagged human Nedd4 as a recombinant protein from Escherichia coli. Protein Expression and Purification 2020, 173, 105649.

Dudiak, BD, Maksimchuk, KR, Bednar, MM, Podracky, CJ, Burg, JM, Nguyen, TM, Nwogbo, FO, Valdivia, RH, McCafferty, DG. Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Chlamydia trachomatis Virulence-Associated Protease CPAF. Biochemistry 201958(33), 3527-3536.

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Biniossek, ML, Niemer, M, Maksimchuk, K, Mayer, B, Fuchs, J, Huesgen, PF, McCafferty, DG, Turk, B, Fritz, G, Mayer, J, Haecker, G, Mach, L, Schilling, O. Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics. Mol Cell Proteomics 201615(7), 2515-2524.

Burg, JM, Gonzalez, JJ, Maksimchuk, KR, McCafferty, DG. Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length HistonesBiochemistry201655(11), 1652–1662.
Burg, JM, Makhoul, AT, Pemble, CW, Link, JE, Heller, FJ, McCafferty, DG. A rationally‐designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activityFEBBS Letters2015589(18), 2340-2346.
Snavely, EA, Kokes, M, Dunn, JD, Saka, HA, Nguyen, BD, Bastidas, RJ, McCafferty, DG, Valdivia, RH. Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches.Pathogens and Disease 2014,71(3), 336–351.
Qi, Y, Amiram, M, Gao, W, McCafferty, DG, Chilkoti, A. Sortase‐Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a ProteinMacromolecular Rapid Communications201334(15), 1256-1260.
Folk, DS, Torosian, JC, Hwang, S, McCafferty, DG, Franz, KJ. Monitoring β‐Secretase Activity in Living Cells with a Membrane‐Anchored FRET ProbeAngew Chem Int Ed Engl201251(43), 10795-10799.
Weinberg, DRGagliardi, CJHull, JFMurphy, CFKent, CAWestlake, BCPaul, AEss, DHMcCafferty, DG, Meyer, TJ. Proton-Coupled Electron TransferChem. Rev. 2012112(7), 4016–4093.
Pollock, JA, Larrea, MD, Jasper, JS, McDonnell, DP, McCafferty, DG. Lysine-Specific Histone Demethylase 1 Inhibitors Control Breast Cancer Proliferation in ERα-Dependent and -Independent MannersACS Chem. Biol. 20127(7), 1221–1231.

Hoertz, AJ, Hamburger, JB, Gooden, DM, Bednar, MM, McCafferty, DG. Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2Bioorganic and Medicinal Chemistry201220(2), 859-865.

Melvin, JA1, Murphy, CF, Dubois, LG, Thompson, JW, Moseley, MA, McCafferty, DG. Staphylococcus aureus Sortase A Contributes to the Trojan Horse Mechanism of Immune Defense Evasion with Its Intrinsic Resistance to Cys184 Oxidation. Biochemistry201150(35), 7591–7599.
Jorgensen, I, Bednar, MM, Amin, V, Davis, BK, Ting, JP, McCafferty, DG, Valdivia, RH. The Chlamydia Protease CPAF Regulates Host and Bacterial Proteins to Maintain Pathogen Vacuole Integrity and Promote VirulenceCell Host and Microbe 201110(1), 21-32.
Cropp, TA, McCafferty, DG. Found in translation: applications of protein and peptide molecular diversityCurr Opin Chem Biol 201115(3), 347-349.
Hwang, S, Schmitt, AA, Luteran, AE, Toone, EJ, McCafferty, DG. Thermodynamic Characterization of the Binding Interaction between the Histone Demethylase LSD1/KDM1 and CoRESTBiochemistry 201150(4), 546–557.
Schmidt, JW, Greenough, A, Burns, M, Luteran, AE, McCafferty, DG. Generation of ramoplanin-resistant Staphylococcus aureusFEMS Microbiology Letters2010310(2), 104-111.
Clancy, KW, Melvin, JA, McCafferty, DG. Sortase transpeptidases: Insights into mechanism, substrate specificity, and inhibitionPeptide Science 201094(4), 385-396.
Hamburger, JB, Hoertz, AJ, Lee, A, Senturia, RJ, McCafferty, DG, Loll, PJ. A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface
Gaweska, H, Henderson Pozzi, M, Schmidt, DM, McCafferty, DG, Fitzpatrick, PF. Use of pH and Kinetic Isotope Effects To Establish Chemistry as Rate-Limiting in Oxidation of a Peptide Substrate by LSD1Biochemistry200948(23), 5440–5445.
Kudryavtsev, KV, Bentley, ML, McCafferty, DG. Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoformBioorganic and Medicinal Chemistry200917(7), 2886-2893.
Deshmukh, HS, Hamburger, JB, Ahn, SH, McCafferty, DG, Yang, SR, Fowler, VG Jr. Critical Role of NOD2 in Regulating the Immune Response to Staphylococcus aureusInfect Immun 200977(4), 1376-1382.
Race, PR, Bentley, ML, Melvin, JA, Crow, A, Hughes, RK, Smith, WD, Sessions, RB, Kehoe, MA, McCafferty, DG, Banfield, MJ. Crystal structure of Streptococcus pyogenes sortase A: implications for sortasemechanismJ. Biol. Chem. 2009284(11), 6924-6933.
Bentley, ML1, Lamb, EC, McCafferty, DG. Mutagenesis Studies of Substrate Recognition and Catalysis in the Sortase A Transpeptidase from Staphylococcus aureus.J. Biol. Chem. 2008283(21), 14762-14771.
Gooden, DM, Schmidt, DM, Pollock, JA, Kabadi, AM, McCafferty, DG. Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. Bioorganic and Medicinal Chemistry Letters 200818(10), 3047-3051.
Frankel, BA, Tong, Y, Bentley, ML, Fitzgerald, MC, McCafferty, DG. Mutational Analysis of Active Site Residues in the Staphylococcus aureusTranspeptidase SrtA.  Biochemistry200746(24), 7269–7278.
Schmidt, DM, McCafferty, DG. trans-2-Phenylcyclopropylamine Is a Mechanism-Based Inactivator of the Histone Demethylase LSD1.Biochemistry200746(14), 4408–4416.
Lee, MG1, Wynder, C, Schmidt, DM, McCafferty, DG, Shiekhattar, R. Histone H3 Lysine 4 Demethylation Is a Target of Nonselective Antidepressive Medications. Chemistry & Biology 200613(6), 563-567.
Frankel, BA, Kruger, RG, Robinson, DE, Kelleher, NL, McCafferty, DG. Staphylococcus aureus Sortase Transpeptidase SrtA:  Insight into the Kinetic Mechanism and Evidence for a Reverse Protonation Catalytic Mechanism.Biochemistry200544(33), 1188–11200.
Kapustin, GV, Fejér, G, Gronlund, JL, McCafferty, DG, Seto, E, Etzkorn, FA. Phosphorus-Based SAHA Analogues as Histone Deacetylase Inhibitors. Org. Lett. 20035(17), 3053–3056.