Publications at Duke

27. “Development and Mechanistic Investigations of Enantioselective Pd-Catalyzed Intermolecular Hydroaminations of Internal Dienes

Sangjune Park and Steven J. Malcolmson

ACS Catal. 2018, ASAP


26. “Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines

Xinxin Shao, Kangnan Li, and Steven J. Malcolmson

J. Am. Chem. Soc. 2018, 140, 7083-7087.

Highlighted in Synfacts.


25. “Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles

Nathan J. Adamson, Katherine C. E. Wilbur, and Steven J. Malcolmson

J. Am Chem. Soc. 2018, 140, 2761-2764.


24. 2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones”

Kangnan Li*, Xinxin Shao*, Luke Tseng, and Steven J. Malcolmson

*These authors contributed equally to this work.

 J. Am. Chem. Soc. 2018140598–601.

Highlighted in Synform and in Synfacts.


23. “Diastereoselective and Enantiospecific Synthesis of 1,3-Diamines via 2-Azaallyl Anion Benzylic Ring-Opening of Aziridines

Kangnan Li*, Alexandria E. Weber*, Luke Tseng, and Steven J. Malcolmson

*These authors contributed equally to this work.

Org. Lett., 2017, 19, 4239–4242. 


22. Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization”

Kun Shen,* Angus W. J. Logan,* Johannes F. P. Colell,* Junu BaeGerardo X. Ortiz, Jr.Thomas Theis, Warren S. WarrenSteven J. Malcolmsonand Qiu Wang
*These authors contributed equally to this work.
This paper is featured on the journal cover here.


21. “Umpolung Synthesis of 1,3-Amino Alcohols: Stereoselective Addition of 2-Azaallyl Anions to Epoxides

Paige E. Daniel, Alexandria E. Weber, Steven J. Malcolmson

Org. Lett. 2017, 19, 3490−3493,



20. “Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange”

Johannes F. P. Colell, Meike Emondts, Angus W. J. Logan, Kun Shen, Junu Bae, Roman V. Shchepin, Gerardo X. OrtizJr., Peter Spannring, Qiu Wang, Steven J. Malcolmson, Eduard Y. Chekmenev, Martin C. Feiters, Floris P. J. T. Rutjes, Bernhard Blümich, Thomas Theis, and Warren S. Warren



19. “Enantioselective Intermolecular Addition of Aliphatic Amines to Acyclic Dienes with a Pd–PHOX Catalyst”

Nathan J. Adamson, Ethan Hull, Steven J. Malcolmson

J. Am. Chem. Soc. 2017, 139(21), 7180–7183.


18. “Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange”

J. Phys. Chem., 2017, 121, 6626–6634.


17. “Hyperpolarization of Nitrogen15 Schiff Bases by Reversible Exchange Catalysis with paraHydrogen

Angus W. J. Logan, Thomas TheisJohannes F. P. ColellWarren S. Warren,  Steven J. Malcolmson.

.v …TOC Figure


16. “Direct and Cost-Efficient Hyperpolarization of Long-lived Nuclear Spin States on Universal 15N2-Diazirine Molecular Tags
Thomas Theis, Gerardo X. Ortiz,  Angus W.J. Logan, Kevin E. Claytor, Yesu Feng, William P. Huhn, Volker Blum, Steven J. Malcolmson, Eduard Y. Chekmenev, Qiu Wang, Warren S. Warren.



15. “The Posttranslational Modification Cascade to the Thiopeptide Berninamycin Generates Linear Forms and Altered Macrocyclic Scaffolds” 

Steven J. Malcolmson, Travis S. Young, J. Graham Ruby, Peter Skewes-Cox, Christopher T. Walsh.

Proc. Natl. Acad. Sci., USA, 2013, 110, 8483–8488.


14.  “Three Ring Posttranslational Circuses: Insertion of Oxazoles, Thiazoles, and Pyridines into Protein-Derived Frameworks” 

Christopher T. Walsh, Steven J. Malcolmson, Travis S. Young.

ACS Chem. Bio., 2012, 7, 429–442.


13. “Dihydrophenylalanine: a Prephenate-Derived Photorhabdus luminescens Antibiotic and Intermediate in Dihydrostilbene Biosynthesis” 

Jason M. Crawford, Sarah A. Mahlstedt, Steven J. Malcolmson, Jon Clardy, Christopher T. Walsh.

Chem Biol, 2011, 18, 1102–1112.


12. “Nine Enzymes are Required for Assembly of the Pacidamycin Group of Peptidyl Nucleoside Antibiotics” 

Wenjun Zhang, Ioanna Ntai, Megan L. Bolla, Steven J. Malcolmson, Daniel Kahne, Neil L. Kelleher, Christopher T. Walsh.

J. Am. Chem. Soc. 2011, 133, 5240–5243.



11. “Catalyst-Controlled Stereoselective Olefin Metathesis”

Amir H. Hoveyda, R. Kashif M. Khan, Sebastian Torker, Steven J. Malcolmson.

(Handbook of Olefin Metathesis, Vol. 2, Second Edition, Grubbs, Wenzel, O’Leary, Khosravi, Eds.; 503–562); Wiley-VCH: Weinheim, 2015.


10. “Bipyridine Adducts of Molybdenum Imido Alkylidene and Imido Alkylidyne Complexes”

Alejandro G. Lichtscheidl, Victor W. L. Ng, Peter Müller, Michael K. Takase, Richard R. Schrock, Steven J. Malcolmson, Simon J. Meek, Bo Li, Elizabeth T. Kiesewetter, Amir H. Hoveyda.

Organometallics, 2012, 31, 4558–4564.


9.    “Catalytic Enantioselective Olefin Metathesis and Natural Product Synthesis” 

Amir H. Hoveyda, Steven J. Malcolmson, Simon J. Meek, Adil R. Zhugralin.

(Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts; Cossy, Arseniyadis, Meyer, Eds.; 343–348); Wiley-VCH: Weinheim, 2010.


8. “Catalytic Enantioselective Olefin Metathesis Reactions” 

Amir H. Hoveyda, Steven J. Malcolmson, Simon J. Meek, Adil R. Zhugralin.

(Catalytic Asymmetric Synthesis, Third Edition; Ojima, Ed.; 739–770); Wiley-VCH: Weinheim, 2010.


7. “Catalytic Enantioselective Olefin Metathesis in Natural Product Synthesis.  Chiral Metal-Based Complexes that Deliver High Enantioselectivity and More” 

Amir H. Hoveyda, Steven J. Malcolmson, Simon J. Meek, Adil R. Zhugralin.

Angew. Chem., Int. Ed. 2010, 49, 34–44.


6. “Molybdenum,[(S)-3,3′-bis(1,1-dimethylethyl)-5,5′,6,6′-tetramethyl[1,1′-biphenyl]-2,2′-diolato(2-)-kO,kO’]-2-methyl-2-phenylpropylidene)-[tricyclo[,7]decan-1-aminato(2-)]”

Steven J. Malcolmson, Amir H. Hoveyda, Richard R. Schrock.

(Encyclopedia of Reagents for Organic Synthesis, Second Edition; Paquette, Crich, Fuchs, Molander, Eds.; 1765–1768); Wiley-VCH: Weinheim, 2009.


5. “The Significance of Degenerate Processes to Enantioselective Olefin Metathesis Reactions Promoted by Stereogenic-at-Mo Complexes”

Simon J. Meek, Steven J. Malcolmson, Bo Li, Richard R. Schrock, Amir H. Hoveyda.

J. Am. Chem. Soc. 2009, 131, 16407–16409.


4. “Design and Stereoselective Preparation of a New Class of Chiral Olefin Metathesis Catalysts and Application to Enantioselective Synthesis of Quebrachamine. Catalyst Development Inspired by Natural Product Synthesis” 

Elizabeth S. Sattely, Simon J. Meek, Steven J. Malcolmson, Richard R. Schrock, Amir H. Hoveyda.

J. Am. Chem. Soc. 2009, 131, 943–953.


3.    “Enantioselective Synthesis of P-Stereogenic Phosphinates and Phosphine Oxides by Mo-Catalyzed Asymmetric Ring-Closing Metathesis” 

James Stephen Harvey, Steven J. Malcolmson, Katherine S. Dunne, Simon J. Meek, Amber L. Thompson, Richard R. Schrock, Amir H. Hoveyda, Véronique Gouverneur.

Angew. Chem., Int. Ed. 2009, 48, 762–766.


2. “Highly Efficient Molybdenum-Based Catalysts for Enantioselective Alkene Metathesis”

Steven J. Malcolmson*, Simon J. Meek*, Elizabeth S. Sattely, Richard R. Schrock, Amir H. Hoveyda.  *these authors contributed equally

Nature, 2008, 456, 933–937.


1. “Enantioselective Synthesis of Cyclic Enol Ethers and All-Carbon Quaternary Stereogenic Centers Through Catalytic Asymmetric Ring-Closing Metathesis” 

Ai-Lan Lee, Steven J. Malcolmson, Alessandra Puglisi, Richard R. Schrock, Amir H. Hoveyda.

J. Am. Chem. Soc. 2006, 128, 5153–5157.