Our laboratory is focused on searching for cures for brain tumors. We have three main branches to our research:
We are exploring clinicopathological correlates in oliogendroglioma, by delving into the mechanisms that underlie features observed on histological sections. By understanding the mechanisms, we can begin to target pathways specifically activated in oligodendrogliomas at the time of progression.
Glioblastoma tumor microenvironment
The tumor microenvironment comprises tumor cells, inflammation, and blood vessels. In glioblastoma, a large component of the inflammatory infiltrate is macrophages. Our research explores the role of these macrophages in the glioblastoma tumor microenvironment.
Tumors metastatic to the brain
Tumors from the lung, breast, kidney, colon, and skin frequently metastasize to the brain, where they cause significant morbidity and mortality. We aim to better understand the tumor microenvironment in these metastases, and how the microenvironment differs from that in primary gliomas, with the goal of identifying targets for activating the immune system against the metastatic tumors.