Our Work

2025

  1. Luo Y, Mangan RJ, Weaver S, Zhao SA, Mosti F, Thomas MC, Karra R, Silver DL, Kellis M, Lowe CB. Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans. bioRxiv [Preprint]. 2025 Oct 21:2025.10.20.683446. doi: 10.1101/2025.10.20.683446. PMID: 41279559.
  2. Anglen T, Kaplow IM, Choi B, Dewars E, Perelli RM, Hagy KT, Tran D, Ramaker ME, Shah SH, Jung I, Landstrom AP, Karra R, Diao Y, Gersbach CA. A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress. Genome Res. 2025 Nov 3;35(11):2418-2432. doi: 10.1101/gr.280825.125. PMID: 41125440.
  3. Desai AS, Karns AD, Badariene J, Aswad A, Neutel JM, Kazi F, Park W, Stiglitz D, Makarova N, Havasi A, Zappe DH, Saxena M; KARDIA-2 Study Group. Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial. JAMA. 2025 Jul 1;334(1):46-55. doi: 10.1001/jama.2025.6681. PMID: 40434761.
  4. Brezitski K, Flores Rosario K, Kim HW, Fajardo JR, Khouri MG, Borges-Neto S, Karra R. Atypical Presentation of an Increasingly Recognized Disease: Transthyretin Amyloidosis Presenting With 18F-Fluorodeoxyglucose Uptake on Cardiac Positron Emission Tomography and Focal Late Gadolinium Enhancement on Cardiac Magnetic Resonance. Circ Heart Fail. 2025 Jun;18(6):e012002. doi: 10.1161/CIRCHEARTFAILURE.124.012002. Epub 2025 Apr 2. PMID: 40171643.
  5. Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS, Zheng SL, Malarstig A, Gratton J, Bond I, Roselli C, Miller D, Chopade S, Schmidt AF, Abner E, Adams L, Andersson C, Aragam KG, Ärnlöv J, Asselin G, Raja AA, Backman JD, Bartz TM, Biddinger KJ, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunak S, Bruun MT, Buckbinder L, Bundgaard H, Carey DJ, Chasman DI, Chen X, Cook JP, Czuba T, de Denus S, Dehghan A, Delgado GE, Doney AS, Dörr M, Dowsett J, Dudley SC, Engström G, Erikstrup C, Esko T, Farber-Eger EH, Felix SB, Finer S, Ford I, Ghanbari M, Ghasemi S, Ghouse J, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Hägg S, Haggerty CM, Hedman ÅK, Helgadottir A, Hemingway H, Hillege H, Hyde CL, Aagaard Jensen B, Jukema JW, Kardys I, Karra R, Kavousi M, Kizer JR, Kleber ME, Køber L, Koekemoer A, Kuchenbaecker K, Lai YP, Lanfear D, Langenberg C, Lin H, Lind L, Lindgren CM, Liu PP, London B, Lowery BD, Luan J, Lubitz SA, Magnusson P, Margulies KB, Marston NA, Martin H, März W, Melander O, Mordi IR, Morley MP, Morris AP, Morrison AC, Morton L, Nagle MW, Nelson CP, Niessner A, Niiranen T, Noordam R, Nowak C, O’Donoghue ML, Ostrowski SR, Owens AT, Palmer CNA, Paré G, Pedersen OB, Perola M, Pigeyre M, Psaty BM, Rice KM, Ridker PM, Romaine SPR, Rotter JI, Ruff CT, Sabatine MS, Sallah N, Salomaa V, Sattar N, Shalaby AA, Shekhar A, Smelser DT, Smith NL, Sørensen E, Srinivasan S, Stefansson K, Sveinbjörnsson G, Svensson P, Tammesoo ML, Tardif JC, Teder-Laving M, Teumer A, Thorgeirsson G, Thorsteinsdottir U, Torp-Pedersen C, Tragante V, Trompet S, Uitterlinden AG, Ullum H, van der Harst P, van Heel D, van Setten J, van Vugt M, Veluchamy A, Verschuuren M, Verweij N, Vissing CR, Völker U, Voors AA, Wallentin L, Wang Y, Weeke PE, Wiggins KL, Williams LK, Yang Y, Yu B, Zannad F, Zheng C; Genes & Health Research Team; Estonian Biobank Research Team; DBDS Genomic Consortium; Asselbergs FW, Cappola TP, Dubé MP, Dunn ME, Lang CC, Samani NJ, Shah S, Vasan RS, Smith JG, Holm H, Shah S, Ellinor PT, Hingorani AD, Wells Q, Lumbers RT; HERMES Consortium. Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. Nat Genet. 2025 Apr;57(4):815-828. doi: 10.1038/s41588-024-02064-3. Epub 2025 Mar 4. PMID: 40038546.

2024

  1. Gunn AH, Fajardo J, Dibernardo L, Glass C, Alenezi F, Karra R, McPhail ED, Chase CC, Khouri MG. Light-Chain Pericardial Amyloidosis Emerging Alongside Variant Transthyretin Cardiac Amyloidosis. JACC CardioOncol. 2024 May 28;6(4):612-616. doi: 10.1016/j.jaccao.2024.04.002. PMID: 39239343.
  2. Parker LE, Karra R. Cardioprotective effects of the angiocrine CRELD2 after ischemic injury. Nat Cardiovasc Res. 2024 Feb;3(2):104-105. doi: 10.1038/s44161-023-00415-7. PMID: 39196187.
  3. Karpurapu A, Williams HA, DeBenedittis P, Baker CE, Ren S, Thomas MC, Beard AJ, Devlin GW, Harrington J, Parker LE, Smith AK, Mainsah B, Pla MM, Asokan A, Bowles DE, Iversen E, Collins L, Karra R. Deep Learning Resolves Myovascular Dynamics in the Failing Human Heart. JACC Basic Transl Sci. 2024 May 27;9(5):674-686. doi: 10.1016/j.jacbts.2024.02.007. PMID: 38984052.

2023

  1. Harrington J, Nixon AB, Daubert MA, Yow E, Januzzi J, Fiuzat M, Whellan DJ, O’Connor CM, Ezekowitz J, Piña IL, Adams KF, Felker GM, Karra R. 2023. Circulating Angiokines are Associated with Reverse Remodeling and Outcomes in Chronic Heart Failure. J Cardiac Failure.  doi: 10.1016/j.cardfail.2022.12.01. PMID 36632934.
  2. Parker L and Karra R.  2023. The (pluri)potential of cell therapy for heat failure.  J Cardiac Failure. doi: 10.1016/j.cardfail.2023.01.008.PMID: 37059513 
  3. Rosario KF, Karra R, Amos K, Landstrom AP, Lakdawala NK, Brezitski K, Kim H, Devore AD. 2023. J Cardiac Fail.  doi: 10.1016/j.cardfail.2023.08.016. PMID: 37659618 
  4. Arps K, Doss J, Geiger K, Flores-Rosario K, DeVore AD, Karra R, Kim HW, Piccini JP, Pokorney SD, Sun AY.Am J Cardiol. 2023 Incidence and Predictors of Relapse After Weaning Immune Suppressive Therapy in Cardiac Sarcoidosis.. doi: 10.1016/j.amjcard.2023.07.088. PMID: 37556894
  5. Bakkers J, Bellin M, Hmeljak J, Karra R. 2023. From mechanisms of heart failure to clinical heart success. Dis Model Mech. doi: 10.1242/dmm.050282.PMID: 37272386 

2022

  1. Henry A, Gordillo-Marañón M, Finan C, Schmidt AF, Ferreira JP, Karra R, Sundström J, Lind L, Ärnlöv J, Zannad F, Mälarstig A, Hingorani AD, Lumbers RT for the HERMES and SCALLOP Consortia. Therapeutic Targets in Heart Failure Using Proteomics and Mendelian Randomization. 2022. Circulation. doi: 10.1161/CIRCULATIONAHA.121.056663. PMID: 35300523
  2. Scherba JC, Karra R, Turek JW, Bursac N. 2022. Towards Improved Understanding of the Cardiac Development and Congenital Heart Disease: The Advent of Cardiac Organoids. Journal of Thoracic and Cardiovascular Surgery. doi: 10.1016/j.jtcvs.2022.02.028. PMID: 35307217.
  3. DeBenedittis P, Karpurapu A, Henry A, Thomas MC, McCord TJ, Brezitski K, Prasad A, Baker CE, Kobayashi Y, Shah SH, Kontos CD, Tata PR, Lumbers RT, Karra R.
    Coupled myovascular expansion directs cardiac growth and regeneration. Development. 2022. doi: 10.1242/dev.200654. PMID: 36134690.
  4.  Olsen C, Mandawat A, Sun J, Triana T, Chiswell K, Karra R. 2022. Recovery of left ventricular function is associated with improved outcomes in LVAD recipients. Journal of Heart and Lung Transplantation. doi: 10.1016/j.healun.2022.03.008. PMID: 35410822
  5. Flores-Rosario K, Brezitski K, Arps K, Milne M, Doss J, Karra R. Cardiac Sarcoidosis: Current Approached to Diagnosis and Management.  2022.  Current Allergy and Asthma. PMID 36308680.
  6. Yan R, Cigliola V, Oonk K, Petrover Z, DeLuca S, Wolfson D, Vekstein A, Mendiola M, Devlin G, Bishawi M, Gemberling M, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams A, Bowles D, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD. 2023. Enhancer-based vectors for targeted heart regeneration. Cell Stem Cell. doi: 10.1016/j.stem.2022.11.012. PMID: 36516837.
  7. Karra R, Nafissi NA. 2022. Expanding the Molecular Autopsy to Uncover Occult Cardiomyopathy: Concealed to Revealed.
    .J Am Coll Cardiol. doi: 10.1016/j.jacc.2022.09.030. PMID: 36423991 

2021

  1. Mainsah BO, Patel PA, Chen XJ, Olsen C, Collins LM, Karra R. A Novel Acoustic Biomarker of Quality of Life in Left Ventricular Assist Device Recipients. 2021. JAHA. doi: 10.1161/JAHA.120.018588. PMID 33660516.
  2. Brezitski KD, Goff AW, DeBenedittis P, Karra R. A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals. 2021. Current Cardiology Reports. 23(4):29. doi: 10.1007/s11886-021-01459-6. PMID: 33655359
  3. Chen XJ, LaPorte ET, Olsen C, Collins LM, Patel R, Karra R, Mainsah BO. 2021. Heart Sound Analysis in Individuals Supported with Left Ventricular Assist Devices. IEEE Transactions on Biomedical Engineering. doi: 1109/TBME.2021.3060718. PMID: 33606625
  4. Lang NN, Ahmad FA, Cleland JG, O’Connor CM, Teerlink JR, Voors AA, Taubel J, Hodes AR, Anwar M, Karra R, Sakata Y, Ishihara S, Senior R, Khemka A, Prasad NG, DeSouza MM, Seiffert D, Ye JY, Kessler PD, Borentain M, Solomon SD, Felker GM, McMurray JJV. 2021. Hemodynamic Effects of the Nitroxyl Donor Cimlanod (BMS-986231) in Chronic Heart Failure: A Randomized Trial. Eur J Heart Failure. doi: 10.1002/ejhf.2138. PMID: 33620131.
  5. Nafissi NA, DeBenedittis P, Thomas MC, Karra R. Differentiation of Human Induced Pluripotent Stem Cells into Epicardial-Like Cells. 2021. In: Poss K., Kühn B. (eds) Cardiac Regeneration. Methods in Molecular Biology, vol 2158. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0668-1_11, PMID 32857371.

2020

  1. Voors AA, Tamby JF, Cleland JG, Koren M, Forgosh LB, Gupta D, Lund LH, Camacho A, Karra R, Swart HP, Pellicori P, Wagner F, Hershberger RE, Prasad N, Anderson R, Anto A, Bell K, Edelberg JM, Fang L, Henze M, Kelly C, Kurio G, Li W, Wells K, Yang C, Teichman SL, Del Rio CL, Solomon SD. Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial.  Eur J Heart Fail. 2020. doi: 10.1002/ejhf.1933. PMID  32558989.
  2. Rehorn MR, Loungani RS, Black-Meier E, Coniglio A, Karra R, Pokorney SD, Khouri MG. Cardiac Implantable Electronic Devices: A Window into the Evolution of Conduction Disease in Cardiac Amyloidosis. 2020.  JACC EP. ep;6(9):1144-1154. doi: 10.1016/j.jacep.2020.04.020.PMID 32972550. 
  3. Bakovic M, Thakkar D, DeBenedittis P, Chong DC, Thomas MC, Iversen ES, Karra R. Clonal analysis of the neonatal mouse heart using nearest neighbor modeling. 2020. Vis. Exp.(162), e61656, doi:10.3791/61656. PMID 32894270

2019

  1. Gancz D, Raftrey BC, Perlmoter G, Marín-Juez R, Semo J, Matsuoka RL,Karra R, Raviv H, Moshe N, Addadi Y, Golani O, Poss KD, Red-Horse K, Stainier DY, Yaniv K. 2019. Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. Elife. 8. pii: e44153. doi: 10.7554/eLife.44153. PMID 31702554.
  2. Van Kirk J, Fudim M, Green CL, Karra R. Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction. J Cardiovasc Transl Res. 2019. doi: 10.1007/s12265-019-09919-9. PMID 31721131.
  3. Abdulrahim JW, Kwee LC, Grass E, Siegler IC, Williams R, Karra R, Kraus WE, Gregory SG, Shah SH. 2019. Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1). J Am Heart Assoc.8(21):e013228. doi: 10.1161/JAHA.119.013228.  PMID 31642367.
  4. Patel P, Mainsah B, Milano C, Nowacek D, Collins D, Karra R.   Acoustic signatures of left ventricular assist device thrombosis. 2019. ASME J of Medical Diagnostics. 2(2):024501-024501-4. doi:10.1115/1.4041529. PMID 35832210.

2018

  1. Karra R, Foglia MJ, Choi WY, Belliveau C, DeBenedittis P, Poss KD. 2018. vegfaa instructs cardiac muscle hyperplasia in adult zebrafish.  Proc Natl Acad Sci. 115(35):8805-8810. doi: 10.1073/pnas.1722594115. PMID 30104362.
  2. Fernandez, CE, Bakovic M, Karra R. 2018. Endothelial contributions to zebrafish heart regeneration.  Cardiovasc. Dev. Dis.5(4): 56. doi:10.3390/jcdd5040056. PMID 30544906.

2017

  1. Karra R and Poss KD.  Redirecting cardiac growth mechanisms for therapeutic regeneration.  2017. J Clin Invest. 127(2):427-436. PMID 28145902.
  2. Goldman JA, Kuzu G, Lee N, Karasik J, Gemberling M, Foglia MJ, Karra R, Dickson AL, Sun F, Tolstorukov MY, et al. Resolving Heart Regeneration by Replacement Histone Profiling. 2017. Dev Cell. 40(4):392-404. PMID.  28245924

2016

  1. Cao J, Navis A, Cox B, Dickson AL, Gemberling M, Karra R, Bagnat M, and Poss KD.  2016. Single epicardial cell transcriptome sequencing identified Caveolin-1 as an essential factor in zebrafish heart regeneration.  Development.  143(2):232-43. PMID 26657776.
  2.  Kang J, Hu J,Karra R, Dickson AL, Tornini V, Nachtrab G, Gemberling M, Goldman JA, Black BL, and Poss KD. Modulation of tissue repair by regeneration enhancer elements. 2016. Nature. 532(7598):2016. PMID 27049946.

2015

  1. Gemberling M, Karra R, Dickson AL, Poss KD. 2015. Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. Elife. Apr 1;4. PMID 25830562.
  2. Karra R, Knecht A, Kikuchi K, Poss KD. 2015. Myocardial NF-κB activation is essential for zebrafish heart regeneration. Proc Natl Acad Sci. 112(43): 13255-60. PMID 26472034.

2013

  1. Gupta V, Gemberling M, Karra R, Rosenfeld GE, Evans T, Poss KD. 2013. An injury-responsive gata4 program shapes the zebrafish cardiac ventricle. Curr Biol. 23(13):1221-7. PMID 23791730.
  2. Fang Y, Gupta V, Karra R, Holdway JE, Kikuchi K, Poss KD. 2013. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. PNAS. 110(33):13416-21. PMID 23901114.
  3. Wang J, Karra R, Dickson AL, Poss KD. 2013. Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration.  Dev Biol. 382(2):427-35. PMID 23988577.

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