Image of a cycling cardiomyocyte and a cycling endothelial cell in a failing human heart.

We study how the heart grows during maturation and after injury.  Our long-term goal is to “re-wire”  the failing heart towards growth that will recover function and regenerate lost cardiac tissue. 

P21 mouse hearts after cryoinjury at P1 and treatment with either AAV-GFP or AAV-Vegfa. Blue dye shows the coronary vasculature and the circle shows the site of cryoinjury. From DeBenedittis et al, 2022.

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