We have an opening for a Postdoctoral Associate at the Duke University School of Medicine. We are seeking a motivated person to take on projects defining host factors that are able to control influenza virus replication, and then determining the mechanisms behind how those factors affect the virus. To address these questions, we will utilize high-throughput genomic screening approaches, primary cell culture systems, and animal models of influenza disease. Check out the link below for more information!
Congrats to Al on his recent publication (and collaboration with the Lim lab) describing how the protein GPER1 protects fetal development from the inflammation produced during a maternal influenza virus infection. Normally, maternal respiratory viral infections cause only minor developmental problems (such as low birth weight) for the developing fetus. However, at least in a mouse model, the loss of GPER1 during maternal viral infection causes severe developmental abnormalities and fetal demise. Check out the full story at the links below!
Also featured on Duke Today:
See the link below for a collaboration between our lab and Ashley Moseman’s lab.
https://www.sciencedirect.com/science/article/pii/S2211124720310925
In this work, we present data showing how some respiratory viruses may be kept out of the brain.
Al and Griffin’s paper describing a new influenza therapeutic was published recently in PLoS Pathogens!
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008098
And Heather’s work describing a negative regulator of type I interferon signaling is available on BioRxiv!
https://www.biorxiv.org/content/10.1101/851543v2
Update, Dec 2019.
We have open positions for a lab research analyst and a post-doctoral fellow who are interested in defining the mechanisms of how influenza viruses cause disease. Check out the position descriptions at the links below and feel free to contact us if you have any questions.
https://careers.duke.edu/job/Durham-POSTDOCTORAL-ASSOCIATE-NC-27710/611424800/
https://careers.duke.edu/job/Durham-RESEARCH-TECHNICIAN-II-NC-27710/611518600/?locale=en_US
Rebekah’s review on the development and use of influenza B viruses harboring reporter genes was recently published. Check it out for some background on how these viruses are made and how they can be used!
https://www.mdpi.com/1999-4915/11/8/736/htm
Our newest paper is now online! In this collaborative work with the Cherry lab, we show that DNA mismatch repair is critical for club cells in the lung to be able to survive direct influenza A virus infection. Check it out at this link!
And here’s some press about the paper:
https://today.duke.edu/2019/07/lung-cell-patches-its-own-dna-fly-survive-influenza
https://www.eurekalert.org/pub_releases/2019-07/du-lcp072919.php
https://www.sciencesetavenir.fr/sante/ces-cellules-qui-resistent-face-au-virus-de-la-grippe_136087
Griffin’s and Al’s co-first author work describing the development of 10-segmented influenza viruses is now available as a pre-print. Check it out to see how these modified viruses can be used as therapeutics to limit the severity of influenza disease.
The link to the article is here: https://www.biorxiv.org/content/10.1101/547059v1
