Our work on developing a platform to study nutrient transport in cells is published in Nature Cell Biology
In this work, we developed a CRISPR interference/activation-based system to manipulate the expression level of single transporter genes. Using pooled screening, we can then systematically interrogate the contribution of all transporters to nutrient import/export in environments ranging from standard culture media to tumors. We applied this platform to identify the transporters of amino acids in leukemia cells and found that … Read More
