Order Questions
Most of our musculoskeletal treatments fall within a ‘gray zone’ of effectiveness1. Nearly none of our treatments are strongly effective all of the time and few have no benefit all of the time. This is one of the reasons we see outcomes that are consistently similar across well-designed musculoskeletal studies. To enhance treatment benefits and advance precision medicine, pain researchers have begun to move beyond the first-order question of “Does the treatment work?2 and have begun studying second and third order questions such as “how does this treatment work” (second order) and “who does this treatment benefit” (third order).