MODEL-AD: Model Organism Development & Evaluation for Late-Onset AD

The MODEL-AD consortium consisting of a Center at Indiana University School of Medicine, The Jackson Laboratory, Sage Bionetworks and the University of Pittsburgh School of Medicine, and a Center at the University of California Irvine has been established by the National Institute on Aging to:

• Develop the next generation of in vivo AD models based on human data
• Institute a standardized and rigorous process for characterization of animal models
• Align the pathophysiological features of AD models with corresponding stages of clinical disease using translatable biomarkers
• Establish guidelines for rigorous preclinical testing in animal models
• Ensure rapid availability of animal models, protocols and validation data to all researchers for preclinical drug development