This report is the first and largest cross-sectional analysis using primary care data to assess risk factors for testing positive for SARS-CoV-2. The findings concluded increasing age, male sex, increasing socioeconomic deprivation, urban location, and black ethnicity were associated with increased odds of a positive SARS-CoV-2 test. Surprisingly, there was no association between increased household size and risk of SARS-CoV-2 positivity, despite a previously reported higher risk of transmission among household contacts. Importantly, chronic kidney disease and increased BMI were the only clinical factors independently associated with a positive test. Surprisingly, this study reported that smoking is associated with decreased odds of COVID-19 infections, the plausible reasons are explained in Figure. (infographic of smoking and odds of COVID-19 infections)