Publications

Complete List of Publications
  • Rafael Fernández-Muñoz, Juan Carabaña, Montserrat Caballero, Paloma B. Litón, Beatriz M. Duque, M. Dolores Garcia Villalón and Maria Luisa Celma. Molecular Epidemiology of Measles Virus. Rev. Esp. Salud Pública 73:605-608. (1999). PMID: 10650751
  • Marianne Manchester, Danelle S. Eto, Alexandra Valsamakis, Paloma B. Litón, Rafael Fernández-Muñoz, Paul A. Rota, William J. Bellini, Donald N. Forthal and Michael B. A. Oldstone Clinical Isolates of Measles Virus use CD46 as a Cellular Receptor. Journal of Virology 74(9):3967-3974. (2000). PMID: 10756008
  • Caballero M, Liton PB, Epstein DL, Gonzalez P. Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells. Biochem. Biophys Res. Commun. 308(2):346-52. (2003). PMID: 12901875
  • Gonzalez P, Caballero M, Liton PB,  Stamer WD, Epstein DL. Expression analysis of the matrix GLA protein (MGP) and VE-cadherin (VE-cad) gene promoters in the outflow pathway. Invest Ophthalmol Vis Sci. May;45(5):1389-95. (2004). PMID: 15111593
  • Caballero M, Liton PB, Challa P, Epstein DL, Gonzalez P. Effects of donor age on proteasome activity and senescence in trabecular meshwork cells. Biochem. Biophys Res. Commun. 323(3):1048-1054. (2004). PMID: 15381105
  • Liton PB, Liu X, Stamer WD, Challa P, Epstein DL, Gonzalez P. Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter. Invest Ophthalmol Vis Sci. 46(1):183-90. (2005). PMID: 15623772
  • Liton PB, Liu X, Challa P, Epstein DL, Gonzalez P. Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress. J Cell Physiol. 205(3):364-71. (2005)
  • Challa P, Luna C, Liton PB, Chamblin B, Wakefield J, Ramabhadran R, Epstein DL, Gonzalez P. Lentiviral-mediated gene delivery to the anterior chamber of rodent eyes. Mol Vis 11: 425-30. (2005). PMID: 15988411
  • Liton PB, Challa P, Stinnett S, Luna C, Epstein DL, Gonzalez P. Cellular senescence in the glaucomatous outflow pathway. Exp. Geront. 40 (8-9):745-48 (2005). PMID: 16051457
  • Liton PB, Luna C, Bodman M, Hong A, Epstein DL, Gonzalez P. (2005). Induction of IL-6 expression by mechanical stress in the trabecular meshwork. Biochem Biophys Res Commun. Dec 2;337(4):1229-36 (2005). PMID: 16229816
  • Gonzalez P, Epstein DL, Luna C, Liton PB. Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro. Exp. Eye. Res. 82 (6): 959-967 (2006). PMID: 16310191
  • Liton PB, Luna C, Challa P, Epstein DL, Gonzalez P. Genome-wide expression profile of human trabecular meshwork cultured cells, non-glaucomatous and POAG tissue. Mol. Vis. 12: 774-90 (2006). PMID: 16862071
  • Liu Y, Liu X, Zhang T, Luna C, Liton PB, Gonzalez P. Protective effects of proteasome b5 subunit overexpression in lens epithelial cells. Mol. Vis. 13: 31-38 (2007). PMID: 17262013
  • Chow J, Liton PB, Luna C, Wong F, Gonzalez P. Effect of Cellular Senescence on the P2Y-receptor Mediated Calcium Response in Trabecular Meshwork Cells. Mol.Vis. 13: 1926-33 (2007). PMID: 17982416
  • Li G, Luna C, Liton PB, Navarro I, Epstein DL, Gonzalez P. Sustained stress response after oxidative stress in trabecular meshwork cells. Mol. Vis. 13: 2282-8 (2007). PMID: 18199969
  • Liton PB and Gonzalez P. Stress Response of the Trabecular Meshwork. Journal of Glaucoma 17: 378-85 (2008). PMID: 18703948
  • Liton PB (*), Lin Y, Luna C, Li G, Gonzalez P, Epstein DL. Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress. IOVS 49: 3961-9 (2008). PMID: 18469195
  • Liton PB, Gonzalez P, Epstein DL. The role of proteolytic cellular systems in trabecular meshwork homeostasis.  Exp Eye Res 88:724-8 (2008). PMID: 19046967
  • Liton PB (*), Lin Y, Gonzalez P, Epstein DL. Potential lysosomal dysfunction in the pathogenesis of POAG. Autophagy 5(1):122-4 (2009). PMID: 19001861
  • Luna C, Li G, Liton PB, Epstein DL, Challa PL, Gonzalez P. Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells.  Food Chem Toxicol 47(1):198-204 (2009).  PMID: 19027816
  • Liton PB (*), Li G, Luna C, Gonzalez P, Epstein DL. Cross-talk between TGF-beta 1 and IL-6 in human trabecular meshwork cells.  Mol Vis 15:326-34 (2009). PMID: 19209241
  • Luna C, Li G, Liton PB, Epstein DL, Gonzalez P. Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells.  Mol Vis 15:534-44 (2009). PMID: 19279691
  • Lin Y, Epstein DL, Liton PB (*). Intralysosomal iron induces lysosomal permeabilization and cathepsin D-mediated cell death in trabecular meshworks cells exposed to oxidative stress. IOVS 51(12): 6483-95 (2010). PMID: 20574010
  • Porter KM, Epstein DL, Liton PB (*). Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells. PLoS One 7 (4):e34792 (2012). PMID: 22529935
  • Klionsky DJ, […], Liton PB, et al. (**). Guidelines for the use and interpretation of assays for monitoring autophagy (2nd Edition). Autophagy 8(4): 445-544 (2012). PMID: 22966490
  • Porter K, Nallathambi J, Lin Y, Liton PB (*). Lysosomal basification and decreased autophagic flux in oxidatively stress trabecular meshwork cells: implications for glaucoma pathogenesis. Autophagy 9(4):581-594 (2013). PMID: 23360789
  • Gagen D, Filla MS, Clark RW, Liton PB, Peters DM. Activated αvβ3 Integrin Regulates αvβ5 Integrin-Mediated Phagocytosis in Trabecular Meshwork Cells. IOVS 54:5000-11 (2013). PMID: 23821196.
  • Porter K, Lin Y, Liton PB (*). Cathepsin B is Up-regulated and Mediates Extracellular Matrix Degradation in Trabecular Meshwork Cells Following Phagocytic Challenge. PLoS One 8 (7):e68668 (2013). PMID: 23844232
  • Xu P, Lin Y, Porter K, Liton PB (*). Ascorbic Acid Modulation of Iron Homeostasis and Lysosomal Function in Trabecular Meshwork Cells. Journal of Ocular Pharmacology and Therapeutics 30:246-53 (2014). PMID: 24552277
  • Porter K, Nallathambi J, Liton PB (*). mTOR-Independent Induction of Autophagy in Trabecular Meshwork Cells Subjected to Biaxial Stretch. BBA Molecular Cell Research 184:1054-62 (2014). PMID: 24583119
  • Porter K, Hirt J, Stamer WD, Liton PB (*). Autophagic Dysregulation in Glaucomatous Trabecular Meshwork Cells. BBA Molecular Basis of Disease 1852: 379-85 (2015). PMID: 25483712.
  • Liton PB (*). The Autophagic Lysosomal System in Outflow Pathway Physiology and Pathophysiology. Exp Eye Res. 144:29-37 (2016). PMID: 26226231
  • Klionsky DJ, […], Liton PB, et al. (**) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd Edition). Autophagy 12(1): 1-222 (2016). PMID: 26799652
  • Williams AM, Perkumas KM, Perry I, Wen JC, Keeling J, Tramber M, Liton PB, Stamer WD. Successful Implementation of a Program for Increasing Donor Eyes for Research: The Duke-Miracles In Sight Program. J. Ocul. Pharmacol. Ther. 32: 1459-9 (2016). PMID: 26982653
  • Mao M, Wang L, Chang C, Rothenberg K, Huang J, Wang Y, Hoffman B, Liton P, and Fan Yuan. “Involvement of a Rac1-dependent macropinocytosis pathway in plasmid DNA delivery by electrotransfection”. Molecular Therapy. 25 (3):803-815 (2017). PMID: 28129959
  • Hirt J and Liton PB (*). Autophagy and Mechanotransduction in Outflow Pathway Cells. Exp Eye Res 158:146-153 (2017). PMID: 27373974
  • Muñoz-Alía MA, Casasnovas JM, Celma ML, Carabaña J, Liton PB, Fernandez-Muñoz R. “Measles Virus Hemagglutinin epitopes immunogenic in natural infection and vaccination are targeted by broad or genotype-specific neutralizing monoclonal antibodies”. Virus Research 236:30-43 (2017). PMID: 28465158.
  • Benischke AS, Vasanth S, Miyai T, Reddy K, Chen Y, Halilovic A, Price M, Price F, Liton PB, Jurkunas U. “Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy”. Scientific Reports 7(1):6656 (2017). PMID: 28751712.
  • Keller KE, […], Liton P, et al. “Consensus recommendations for trabecular meshwork cell isolation, characterization and culture”. Exp. Eye Res. 171:164-173 (2018). PMID: 29526795.
  • Hirt J, Porter K, Dixon A, McKinnon SJ, Liton PB. “Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model”. Cell Death & Discov. 4:75 (2018). PMID: 30210817.
  • Nettesheim A, Shim MS, Hirt J, Liton PB. “Transcriptome analysis reveals autophagy as a regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells”. Sci. Rep. 9:16092 (2019). PMID: 31695131.
  • Shim MS, Nettesheim A, Hirt J, Liton PB. “The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress”. Autophagy 16:1248-1261 (2020). PMID: 31476975.
  • Mao M, Chang CC, Pickar-Oliver A, Cervia L, Wang L, Ji J, Liton PB, Gersback C, Yuan F. “Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo”. Advance Biosystems. July (2020). https://doi.org/10.1002/adbi.202000059
  • Nettesheim A, Dixon A, Shim MS, Coyne A, Walsh M, Liton PB. “Autophagy in the aging and experimental ocular hypertensive mouse model”. IOVS Aug 3; 61:31(2020). PMID: 32797200.
  • Nettesheim A, Shim MS, Dixon A, Raychaudhuri U, Gong H, Liton PB. “Cathepsin B localizes in the caveolae and participates in the proteolytic cascade in trabecular meshwork cell. Potential new drug target for the treatment of glaucoma. J. Clin. Med 10 (1): E78 (2020). PMID: 33379277.
  • Klionsky DJ, […], Liton PB, et al. (**) Guidelines for the use and interpretation of assays for monitoring autophagy (4th Edition). Autophagy Feb8: 1-382 (2021). PMID: 33634751.
  • Shim MS, Nettesheim A, Dixon A, Liton PB. “Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells”. PNAS 118(13) (2021). PMID: 33753495.
  • Shyam R, Ogando D, Choi M, Liton PB, Bonanno JA. “Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy”. IOVS 62(12):15 (2021). PMID: 34533563.
  • Mc Dowell C, […], Liton PB, et al. (**) “Consensus recommendation for mouse models of ocular hypertension to study aqueous humor outflow and its mechanisms”. IOVS 63(2), doi: 10.1167/iovs.63.2.12. doi: PMID: 35129590.
  • Shim MS, Liton PB. “The physiological and pathophysiological roles of the autophagy lysosomal system in the outflow pathway: more than cellular clean up”. Prog Retin Eye Res (2022). PMID: 35370083.
  • Kaarniranta K, Blasiak J, Liton P, Boulton M, Klionsky D, Sinha D. “Autophagy faces inflammation in age-related macular degeneration”. Autophagy. In Press.