Duke Sub–PI
Douglas Marchuk, PhD
James B. Duke Professor, Department of Molecular Genetics and Microbiology, Duke University

Visit Dr. Marchuk’s faculty page

Research Interests
My laboratory studies the genetics of cardiovascular and cerebrovascular disease using both the human and the mouse as a model system

Research Plan
Through the use of a surgically-induced mouse model of focal cerebral ischemia we have shown large, reproducible differences in infarct volume among different inbred mouse strains. A genome-wide linkage scan in various cross of inbred mouse strains identified a small number of loci that account for the majority of the phenotypic variance in infarct volume. In vitro and in vivo studies are currently underway to investigate the role of these genes in modulating tissue damage after ischemia. This research may provide new targets for therapeutic intervention for stroke.