Seayoung Lee is a senior at Duke University, majoring in Biology and minoring in Chemistry and Korean. She continued her research in the Devi Lab this summer on dysregulated apoptotic signaling in inflammatory breast cancer (IBC) with the Dean’s Summer Research Fellowship and enrichment funding as a BN Duke Scholar. She plans to extend this project for her honors thesis project to focus on adaptive stress response signaling and therapeutic resistance in IBC 3D models this year.
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This is an amazing research project that you’ve done Seayoung! I was wondering what the future direction of your research will be considering that you exposed XIAP’s independent association with chemotherapy resistance. Are you going to investigate the molecular processes underlying this correlation or are you going to investigate some other form of dysregulated apoptotic signaling? Could a better understanding of its molecular mechanism lead to some form of treatment to decrease its resistance and lead to better outcomes?
Great job Seayoung! I find this work to be quite fascinating especially given recent developments in breast cancer drug therapies, although I am not sure if they are XIAP related or not. The thorough statistical analysis of the results and the Kaplan-Meier DFS curve, which clearly showed XIAP’s overall relevance in the treatment of breast cancer were quite helpful to me as a reader. I share the views of the previous commenter in wondering where this project will head next. I would certainly be interested in what the molecular mechanisms of XIAP are and how its pathways, even for just a singular pathway could potentially be hijacked to complete apoptosis. Although I am unaware of their meaning, the HR+/HER2- and PAM50 seem particularly strong in finding links to move forward and the research seems to have a promising outlook.
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