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Both Mechanism of Injury and Underlying Synovitis Impact the Effect of IL-1RA on Chondrocyte Gene Expression


Megan Libke completed a 10-week virtual research experience in the Olson Lab at Duke University School of Medicine. She analyzed data gathered in the previous semester, performed pathway analysis, and drew preliminary conclusions from the findings. Through collaboration with other lab members, she began to make progress on this complicated joint-injury study.

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5 thoughts on “Both Mechanism of Injury and Underlying Synovitis Impact the Effect of IL-1RA on Chondrocyte Gene Expression”

  1. Megan, it is very interesting to read about the genetic interactions with the factors that you evaluated in joint injury. These preclinical studies are key to bridging our understanding. Nicely done explanation of a complicated model.

  2. Megan, you never cease to inspire me! Also, working with multiple two-way ANOVAs is no joke — props to y’all!!!

  3. Well thought-out and written, it was certainly informative to read. As Cayley commented, using several two-way ANOVAs is quite the feat. All your figures made it quite easy to understand your conclusions with careful wording helping to remove any ambiguities, noting the limitations in different inflammatory environments. . Most of all I loved the careful explanation of the Venn Diagrams which was so central to understanding all the conclusions you made from your results. Great work!

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