Representative papers below are listed in reverse chronological order:
Dobrikov MI, Dobrikova EY, Nardone-White DT, McKay ZP, Brown MC, Gromeier M. Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling. mBio. 2023 Nov 14:e0191523. doi: 10.1128/mbio.01915-23. Epub ahead of print. PMID: 37962360.
https://doi.org/10.1128/mbio.01915-23
Brown MC, Beasley GM, McKay ZP, Yang Y, Desjardins A, Randazzo DM, Landi D, Ashley DM, Bigner DD, Nair SK, Gromeier, M (2023). Intratumor childhood vaccine-specific CD4+ T-cell recall coordinates antitumor CD8+ T cells and eosinophils. J Immunother Cancer 11:e006463. PMID: 37072349
https://jitc.bmj.com/content/11/4/e006463.long
Thompson EM, Landi D, Brown MC, Friedman HS, McLendon R, Herndon JE 2nd, Buckley E, Bolognesi DP, Lipp E, Schroeder K, Becher OJ, Friedman AH, McKay Z, Walter A, Threatt S, Jaggers D, Desjardins A, Gromeier M, Bigner DD, Ashley DM (2023). Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial. Lancet Child Adolesc Health 30:S2352-4642(23)00031-7. PMID 37004712
https://www.sciencedirect.com/science/article/pii/S2352464223000317?via%3Dihub
Yang Y, Brown MC, Zhang G, Stevenson K, Mohme M, Kornahrens R, Bigner DD, Ashley DM, Lopez GY, Gromeier M (2023). Polio virotherapy targets the malignant glioma myeloid infiltrate with diffuse microglia activation engulfing the CNS. Neuro Oncol 2:noad052. PMID 36864784
Dobrikov MI, Dobrikova EY, McKay ZP, Kastan JP, Brown MC, Gromeier M (2022). PKR binds enterovirus IRESs, displaces host translation factors, and impairs viral translation to enable innate antiviral signaling. mBio 13:e0085422. PMCID: PMC9239082
https://journals.asm.org/doi/10.1128/mbio.00854-22
Beasley GM, Nair SK, Farrow NE, Landa K, Selim MA, Wiggs CA, Jung SH, Bigner DD, True Kelly A, Gromeier M, Salama AK (2021). Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma. J Immunother Cancer 9:e002203. PMCID: PMC8057552
https://jitc.bmj.com/content/9/4/e002203
Brown MC, Mosaheb MM, Mohme M, McKay ZP, Holl EK, Kastan JP, Yang Yuanfan, Beasley GM, Hwang ES, Ashley DM, Bigner DD, Nair SK, Gromeier M (2021). Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling. Nat Commun 12:e1858. PMCID: PMC7994570
https://www.nature.com/articles/s41467-021-22088-1
McKay ZP, Brown MC, Gromeier M (2021). Aryl hydrocarbon receptor signaling controls CD155 expression on myeloid cells and mediates tumor immunosuppression. J Immunol 206:1385-94. PMCID: PMC7946722
Gromeier M, Brown MC, Zhang G, Lin X, Chen Y, Wei Z, Beaubier N, Yan H, He Y, Desjardins A, Herndon JE, Varn FS, Verhaak RG, Zhao J, Bolognesi D, Friedman A, Friedman HS, McSherry F, Muscat AM, Lipp ES, Nair SK, Khasraw M, Peters KB, Randazzo D, Sampson JH, McLendon RE, Bigner DD, Ashley DM (2021). Very low tumor mutation burden identifies inflamed recurrent glioblastomas responsive to cancer immunotherapy. Nat Commun 12:e352. PMCID: PMC7806846
https://www.nature.com/articles/s41467-020-20469-6
Kastan JP, Dobrikova EY, Bryant JD, Gromeier M (2020) CReP mediates selective translation initiation at the endoplasmic reticulum. Sci Adv 6:eaba0745. PMCID: PMC7269655
https://www.science.org/doi/10.1126/sciadv.aba0745
Mosaheb M, Dobrikova EY, Brown MC, Yang Y, Cable J, Okada H, Nair SK, Bigner DD, Ashley DM, Gromeier M (2020). Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity. Nat Commun 11:e524. PMCID: PMC6985231
https://www.nature.com/articles/s41467-019-13939-z
Dobrikov MI, Dobrikova EY, Gromeier M (2018). Ribosomal RACK1:PKCa phosphorylates eIF4G1(S1093) to modulate cap-dependent and -independent translation initiation. Mol Cell Biol 38:e00304-18. PMCID: PMC6146833
https://www.tandfonline.com/doi/full/10.1128/MCB.00304-18
Desjardins A*, Gromeier M*, Herndon J, Beaubier N, Bolognesi D, Friedman A, Friedman H, McSherry F, Muscat A, Nair S, Peters K, Randazzo D, Sampson J, Vlahovic G, Ashley D, Bigner, D (2018) Recurrent glioblastoma treated with recombinant poliovirus. N Engl J Med 379:150-61. PMCID: PMC6065102.
*Indicates joint first authorship
https://www.nejm.org/doi/10.1056/NEJMoa1716435
Bryant J, Brown MC, Dobrikova MI, Dobrikova EY, Gemberling SL, Zhang Q, Gromeier M (2018) Regulation of HIF-1a during hypoxia by DAP5-induced translation of PHD2. Mol Cell Biol 38:e00647-17. PMCID: PMC5954183
https://www.tandfonline.com/doi/abs/10.1128/MCB.00647-17?journalCode=tmcb20
Brown MC, Holl EK, Boczkowski D, Dobrikova EY, Mubeen M, Chandramohan V, Bigner DD, Gromeier M*, Nair SK* (2017). Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs. Sci Transl Med 9:408. PMCID: PMC6034685.
*Indicates joint senior authorship
https://www.science.org/doi/10.1126/scitranslmed.aan4220
Brown MC, Gromeier M (2017) MNK Controls mTORC1:substrate association through regulation of TELO2 binding with mTORC1. Cell Rep 18:1444-57. PMCID: PMC5321627
https://www.sciencedirect.com/science/article/pii/S2211124717300608?via%3Dihub
Dobrikov MI, Shveygert M, Brown MC, Gromeier M (2014) Mitotic phosphorylation of eukaryotic initiation factor 4G1 at Ser1232 by Cdk1:Cyclin B stimulates its association with helicase eIF4A. Mol Cell Biol 34:439-51. PMCID: PMC3911517
https://www.tandfonline.com/doi/abs/10.1128/MCB.01046-13?journalCode=tmcb20
Brown M, Dobrikova EY, Dobrikov MI, Walton RW, Gemberling SL, Nair SK, Desjardins A, Sampson JH, Friedman HS, Friedman AH, Tyler DS, Bigner DD, Gromeier M (2014). Oncolytic polio virotherapy of cancer. Cancer 120:3277-86. PMCID: PMC4205207
https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.28862
Dobrikov MI, Dobrikova EY, Gromeier M (2013) Dynamic regulation of the translation initiation helicase complex by mitogenic signal transduction to eukaryotic translation initiation factor 4G. Mol Cell Biol 33:937-46. PMCID: PMC3623071
https://www.tandfonline.com/doi/abs/10.1128/MCB.01441-12?journalCode=tmcb20
Dobrikova EY, Goetz C, Walters RW, Lawson SK, Peggins JO, Muszynski K, Ruppel S, Poole K, Giardina SL, Vela EM, Estep JE, Gromeier M (2012) Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in M. Fascicularis. J Virol 86:2750-9. PMCID: PMC3302279
https://journals.asm.org/doi/10.1128/JVI.06427-11
Dobrikov M, Dobrikova E, Shveygert M, Gromeier M (2011) Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C-a regulates eIF4G1 binding to Mnk1. Mol Cell Biol 31:2947-59. PMCID: PMC3133411
https://www.tandfonline.com/doi/abs/10.1128/MCB.05589-11?journalCode=tmcb20
Shveygert M, Kaiser C, Bradrick SS, Gromeier M (2010) Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction. Mol Cell Biol 30:5160-7. PMCID: PMC2953056
https://www.tandfonline.com/doi/abs/10.1128/MCB.00448-10?journalCode=tmcb20
Walters RW, Bradrick SS, Gromeier M (2010) Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression. RNA 16:239-50. PMCID: PMC2802033
https://rnajournal.cshlp.org/content/16/1/239
Merrill MK, Dobrikova E, Gromeier M (2006) Cell type specific repression of internal ribosomal entry site activity by dsRNA binding protein 76. J Virol 80:3147-56. PMCID: PMC1489066
https://journals.asm.org/doi/10.1128/JVI.80.7.3147-3156.2006
Dufresne A, Gromeier M (2004) A non-polio enterovirus with respiratory tropism cause poliomyelitis in intercellular adhesion molecule-1 transgenic mice. Proc Natl Acad Sci USA 101:13636-41. PMCID: PMC518806
https://www.pnas.org/doi/full/10.1073/pnas.0403998101
Dobrikova E, Florez P, Gromeier M (2003) Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3’ non-translated region. Proc Natl Acad Sci USA 100:15125-30. PMCID: PMC299919
https://www.pnas.org/doi/full/10.1073/pnas.2436464100
Gromeier M, Lachmann S, Rosenfeld M, Gutin PH, Wimmer E (2000) Intergeneric poliovirus recombinants for the treatment of glioma. Proc Natl Acad Sci USA 97:6803-8. PMCID: PMC18745
https://www.pnas.org/doi/full/10.1073/pnas.97.12.6803
Gromeier M, Bossert B, Arita M, Nomoto A, Wimmer E (1999) Dual stem loops within the internal ribosomal entry site of poliovirus control neurovirulence. J Virol 73:958-64. PMCID: PMC103915
https://journals.asm.org/doi/10.1128/JVI.73.2.958-964.1999
Gromeier M, Alexander L, Wimmer E (1996) Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants. Proc Natl Acad Sci USA 93:2370-5. PMCID: PMC39803
