3R01CA281320-01A1S1  •  PI: Gromeier, M; Nardone-White, D  •   04/01/2024 – 03/27/2027

Research Supplement to Promote Diversity in Health-Related Research
Glycolytic Metabolism in Myeloid Cells Accentuates RLR-mediated Virotherapy 

 

In this project, we will investigate means to enhance immune stimulatory signaling in myeloid cells by modulating glucose metabolism with metabolic modifiers.

 

R01 CA281320  •  PI: Gromeier, M  •   08/01/2023 – 07/31/2028

Resolving Spatiotemporal Dynamics of Recombinant Poliovirus Immunotherapy

This project will unravel how virus-induced endogenous type-I interferon release in specific myeloid subsets in tumors and in the lymphatic system generates tumor immune surveillance.

 

R01 NS108773  •  PI: Gromeier, M  •   06/01/2018 – 08/31/2028

Innate Antiviral Signals for Cancer Immunotherapy

Our research aims to decipher mechanisms of innate immune stimulation of tissue-resident myeloid compartments in the CNS for generating tumor antigen-specific antitumor immunity in the brain.