Representative papers below are listed in reverse chronological order:
1. Brown MC#, Mckay ZP, Yang Y, Beasley GM, Ashley DM, Bigner DD, Nair SK, Gromeier M. “Intratumoral Recall of Childhood Vaccine-Specific CD4+ T cells Coordinates Type I and II Antitumor Immunity.” Journal of Immunotherapy of Cancer. 2023 Apr;11 (4). PMID: 37072349, (#corresponding author)
2. Thompson EM, Landi D, Brown M, Friedman H, McLendon R, Herndon J, Buckley E, Bolognesi D, Lipp E, Schroeder K, Becher O, Friedman A, McKay Z, Walter A, Threatt S, Jaggers D, Desjardins A, Gromeier M, Bigner D, Ashley D. “Phase Ib Trial of Recombinant Polio:rhionvirus Immunotherapy for Recurrent Pediatric High Grade Glioma.” The Lancet Child and Adolescent Health. 2023 Mar 30 (23). Epub ahead of print. PMID 37004712.
3. Yang Y, Brown MC, Zhang G, Stevenson K, Mohme M, Kornahrens R, Bigner DD, Ashley DM, Lopez GY, Gromeier M. “Polio virotherapy of malignant glioma engages the tumor myeloid infiltrate and induces diffuse microglia activation”. Neuro-Oncology. 2023 Mar 2. Epub ahead of print. PMID 36864784.
4. Li S, McLendon R, Sankey E, Kornahrens R, Lyne AM, Cavalli FMG, McKay Z, Herndon JE, Remke M, Picard D, Gromeier M, Brown M, Thompson EM. “CD155 is a putative therapeutic target in medulloblastoma.” Clinical and Translational Oncology. 2023 Mar; 25(3):695-705.
5. Beasley GM*, Brown MC*, Farrow NE, Landa K, Al-Rohil R, Selim MA, Therien AD, Jung SH, Gao J, Boczkowski D, Holl EK, Salama AKS, Bigner DD, Gromeier M, Nair SK. “Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma.” Journal of ImmunoTherapy of Cancer. Sept 2022; 10(9). PMID 36175036. (*Co-first author).
6. Dobrikov MI, Dobrikova EY, McKay ZP, Kastan JK, Brown MC, Gromeier M. “PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling.” mBio June 2022; 854-22. PMID 35652592.
7. Low JT, Chandramohan V, Bowie, ML, Brown MC, Waitkus MS, Briley A, Stevenson K, Fuller R, Reitman ZJ, Muscat AM, Hariharan S, Hostettler J, Danehower S, Baker A, Khasraw M, Wong NC, Gregory S, Nair SK, Heimberger A, Gromeier M, Bigner DD, Ashley DM. “STING is silenced in GBM by promoter methylation that is established by tissue of origin.” Cancer Cell. May 2022; 439-440. PMID 35487217.
8. Sarver M, Brown MC, Rhodin KE, Salama AKS, Beasley GM. “Predictive factors of neoadjuvant immune checkpoint blockade in melanoma.” Human Vaccines & Immunotherapy. Jul 2021; 1-9 (Review). PMID: 34254900
9. Kastan JP, Tremblay MW, Brown MC, Trimarco JD, Dobrikova EY, Dobrikov M, Gromeier M. “Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.” mBio. 2021 Apr 13;12(2). PMID: 33849973
10. Brown MC, Mosaheb MM, Mohme M, McKay ZP, Holl EK, Kastan JP, Yang Y, Beasley GM, Hwang ES, Ashley DM, Bigner DD, Nair SK, Gromeier M. “Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.” Nature Communications. 2021 Mar 25;12(1858). PMID: 33767151
11. McKay ZP, Brown MC#, Gromeier M#. “Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression.” Journal of Immunology. 2021 Mar 15;206(6). (#co-corresponding author). PMID: 33504618
12. Gromeier M*, Brown MC*, Zhang G, Lin X, Chen Y, Wei Z, Beaubier N, Yan H, He Y, Desjardins A, Herndon JE, Varn FS, Verhaak RG, Zhao J, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Lipp ES, Nair SK, Khasraw M, Peters KB, Randazzo D, Sampson JH, McLendon RE, Bigner DD, Ashley DM. “Very low tumor mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.” Nature Communications 2021 Jan 12(1) 1-7. (*Co-first authors.) PMID: 33441554
13. Mosaheb MM, Brown MC, Dobrikova EY, Dobrikov M, Gromeier M. “Harnessing virus tropism for dendritic cells for vaccine design.” Current Opinion in Virology. Oct 2020; 44, 73-80. (Review). PMID: 32771959
14. Mosaheb MM, Dobrikova EY, Brown MC, Yang Y, Cable J, Okada H, Nair SK, Bigner DD, Ashley DM, Gromeier M. “Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity.” Nature Communications. 2020 Jan 27;11(1): 524. PMID: 31988324
15. Puza C, Bressler ES, Terando AM, Howard JH, Brown MC, Hanks BA, Salama AK, Beasley GM. “The Emerging Role of Surgery for Patients with Advanced Melanoma Treated with Immunotherapy.” Journal of Surgical Research. 2019 Apr 1; 236:209-215. PMID 30694757
16. Thompson EM, Brown, M, Dobrikova E, Ramaswamy V, Taylor MD, McLendon R, Sanks J, Chondramohan V, Bigner D, Gromeier M. “Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastroctoma”. Journal of Neuropathology and Experimental Neurology. 2018 Aug 1;77(8):696-702. PMID: 29878245
17. Walton RW, Brown MC, Sacco MT, Gromeier M. “Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells.” Journal of Virology. 2018 Sep 12; 92(19). PMID: 29997212
18. Bryant JD, Brown MC, Dobrikov MI, Dobrikova EY, Gemberling SL, Zhang Q, Gromeier M. “Regulation of Hypoxia Inducible-Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2.” Molecular and Cellular Biology. 2018 May 15;38(11). PMID: 29530922
19. Evans MK*, Brown MC*, Geradts J, Bao X, Robinson TJ, Jolly MK, Vermeulen PB, Palmer GM, Gromeier M, Levine H, Morse MA, Van Laere SJ, Devi GR. “XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype. Cancer Research. 2018 Apr 1;78(7): 1726-1738. (*Co-first author) PMID: 29351901
20. Brown MC*, Holl EK*, Boczkowski D, Chandramohan V, Bigner DD, Gromeier M, Nair SK. “Cancer Immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.” Science Translational Medicine. 2017 Sep 20;9(408). (*Co-first authors) PMID: 28931654
21. Brown MC#, Gromeier M. “MNK inversely regulates TELO2 vs. DEPTOR to control mTORC1 signaling.” Molecular & Cellular Oncology. 2017 Mar 17; 4(3):e1306010. (# corresponding author). (Review) PMID: 28616583
22. Brown, MC# and Gromeier M. “MNK Controls mTORC1:Substrate Association Through Regulation of TELO2 Binding with mTORC1.” Cell Reports. 2017 Feb 7;18(6):1444-57. (# corresponding author). PMID: 28178522
23. Holl, EK, Brown MC, Boczkowski D, McNamara MA, George DJ, Bigner DD, Gromeier M, Nair SK. “Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.” Oncotarget. 2016 Nov 29;7(48):79828-41. PMID: 27806313
24. Brown MC and Gromeier M. “Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus.” Current Opinion in Virology 2015 Jun 12.13:81-85. (Review). PMID: 26083317
25. Brown MC and Gromeier M. “Oncolytic Immunotherapy Through Tumor-specific Translation and Cytotoxicity of Poliovirus.” Discovery Medicine. 2015 May;19(106):359-65. (Review). PMID: 26105699
26. Reynolds J, Preston GA, Pressler BM, Hewins P, Brown M, Roth A, Alderman E, Bunch D, Jennette JC, Cook HT, Falk RJ, Pusey CD. “Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by ‘autoantigen complementarity’.” Journal of Autoimmunity. 2015 May;59 8-18. PMID: 25841937
27. Brown MC, Dobrikov MI, Gromeier M. “MAPK-interacting kinase regulates mTOR/AKT signaling and controls SRPK-responsive type 1 IRES-mediated translation and viral oncolysis.” Journal of Virology 2014 Nov 15;88(22): 13149-60. PMID: 24187540
28. Brown MC, Bryant JD, Dobrikova EY, Shveygert M, Bradrick SS, Chandramohan V, Bigner DD, Gormeier M. “Induction of Viral m7G cap-independent translation and oncolysis by MAPK interacting Kinase (MNK)-mediated effects on the Ser-Arg rich protein kinase, SRPK.” Journal of Virology. 2014 Nov 15;88(22):13135-48. PMID: 25187541
29. Brown MC, Dobrikova EY, Dobrikov MI, Walton RW, Gemberling SL, Nair SK, Desjardins A, Sampson JH, Fridman HS, Friedman AH, Tyler DS, Bigner DD, Gromeier M. “Oncolytic polio virotherapy of cancer.” Cancer. 2014 Nov 1;120(21): 3277-86. (Review). PMID: 33441554
30. Inoue M, Arikawa T, Chen YH, Moriwaki Y, Price M, Brown M, Perfect JR, Shinohara ML. “T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation.” Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5295-300. PMID: 24706909
31. Dobrikov MI, Shveygert M, Brown MC, Gromeier M. “Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.” Mol Cell Biol. 2014 Feb;34(3):439-51. PMID: 24248602
32. Roth AJ*, Brown MC*, Smith RN, Badhwar AK, Parente O, Chung HC, Bunch DO, McGregor JG, Hogan SL, Hu Y, Yang JJ, Berg EA, Niles J, Jennette JC, Preston GA, Falk RJ. “Anti-LAMP-2 antibodies are not prevalent in patients with antineutrophil cytoplasmic autoantibody glomerulonephritis.” J Am Soc Nephrol. 2012 Mar;23(3):545-55. (*co-first author) PMID: 22021709
