The Acharya Lab leverages a broad range of advanced technologies to support our structural and biophysical research. Our core capabilities include X-ray crystallography, cryo-electron microscopy (cryo-EM), and molecular binding assays focused on biophysics, enabling us to investigate viral protein structure, dynamics, and interactions with high precision.
Our dedicated protein production team supports scalable expression and purification workflows across diverse expression systems, ensuring a steady pipeline of high-quality proteins for structural and functional studies.
Our lab fosters a culture of innovation and is always exploring new technologies and instrumentation. We regularly evaluate cutting-edge tools through demo partnerships with industry leaders and continuously integrate new methods that enhance our research capabilities.
We actively collaborate with academic and industry partners, both within Duke and beyond, and welcome opportunities to work together to advance shared scientific goals.
Protein Production
Our protein production team specializes in the expression and purification of high-quality recombinant proteins to support structural and biophysical studies. Expression Systems We utilize a variety of expression platforms to produce proteins across multiple scales [...]
Biophysics
Our dedicated biophysics lab specializes in characterizing the interactions between viral envelope and spike proteins with antibodies and host cell receptors. These binding studies are essential to understanding viral entry mechanisms and immune recognition. We employ [...]
Protein Crystallography
We employ the Oryx4 Protein Crystallization Robot to enable high-throughput screening using both sitting-drop and microbatch methods. This system allows for precise and reproducible setup of crystallization trials, significantly accelerating the screening process [...]
Cryo-EM
Our lab is equipped with advanced instrumentation to support high-quality cryo-electron microscopy (cryo-EM) research and data analysis: Sample Preparation: We utilize Leica Microsystems plunge freezers for consistent and reliable vitrification of cryo-EM grids [...]
