Bach’s study on the mechanism of radical SAM enzyme DynA is published in JACS!

In this work, Bach uncovered a novel mechanism used by radical SAM enzyme DynA to catalyze the cross-linking in dynobactin biosynthesis. Specifically, DynA utlizes a radical-mediated nucleophilic mechanism for the unprecedented C-N cross-link through a p-quinone methide intermediate. This quinone methide-dependent mechanism of RiPPs cross-linking is distinct from the previously reported RiPPs cross-linking mechanisms and represents a novel mechanism in RiPPs biosynthesis. Congrats, Bach!

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