Hai’s paper on the discovery of radical SAM oxygenase is published in JACS

In this work, Hai found that DarE radical SAM enzyme uses O2 to form the ether crosslink in the darobactin A biosynthesis. This is the first radical SAM enzyme that uses O2 as a co-substrate. In general, radical SAM enzymes are known to be inactivated by O2. Thus, this finding significantly extends the scope of radical SAM catalysis.