In this paper, we report the discovery of cryptic phosphorylation essential for the biosynthesis of nikkomycin and polyoxin class of antifungal peptidyl nucleoside natural products. Nikkomycins and polyoxins are an important class of antifungals currently used as agricultural fungicides and are clinically investigated to treat invasive fungal infections in humans. However, their biosynthesis has long remained poorly characterized. Our discovery of the cryptic phosphorylation allowed the characterization of all the downstream steps in these pathways and revealed a divergent mechanism of structurally related antifungal nucleosides. Furthermore, our study suggests that the cryptic phosphorylation is conserved in many other nucleoside biosynthetic pathways. Congratulations, Matthew and Jib!
- Matthew and Jib’s work is published online in Nature Chemical Biology
- Our Comprehensive Natural Products reviews are published online
- Haoran and Edward’s work on MoaA is published online in JACS
- Abhi successfully defended his PhD dissertation
- Dr. Ogasawara visited Duke to give a seminar
- Abhi and Anna’s paper on glucan synthase was published in Biochemistry.
- Hai and Matthew won poster award!
- Abhi won a poster prize in the 2019 Enzymes Coenzymes and Pathway GRC
- Hai’s paper on mitomycin biosynthesis was published
- Ken was selected as the 2019 ACS Pfizer Award in Enzyme Chemistry