Hai’s work on the characterization of MitE and MitB enzymes in mitomycin biosynthesis was published in ACS Biochemistry. In this paper, we provide experimental evidence that the early steps of mitomycin biosynthesis proceeds with the biosynthetic intermediates linked to an acyl carrier protein (ACP). This is one of the first examples of ACP-dependent non-PKS/NRPS pathways, and the first step towards understanding the complex mechanism of mitomycin biosynthesis.
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Recent Entries
- Bach received TriCEM fellowship to study the natural evolution of antibiotics
- Hai’s paper on the discovery of radical SAM oxygenase is published in JACS
- Elisha and Rachel presented posters at SURF
- Chitin synthase structure paper was published in Nature Structural & Molecular Biology
- Haoran successfully defended his Ph.D. dissertation
- Our latest manuscript about malayamycin biosynthesis was published in ACS Chemical Biology
- Haoran received 2021-2022 Chancellor’s Award for Research Excellence (CARE)
- Our perspective on MoaA and MoaC is published in ACS Bio Med Chem Au
- Haoran’s paper is highlighted in JACS Spotlight
- Haoran’s paper is published in JACS.
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