Edward’s review was published online in Natural Product Reports

This review summarizes the functions and mechanisms of the emerging group of radical SAM enzymes that catalyze C-C bond formations during natural products and cofactor biosynthesis. The review focuses on the roles of these enzymes in the biosynthetic pathways, and the key mechanistic questions relevant to many of these enzymes. Numbers of C-C bond forming radical SAM enzymes are increasing, but their mechanistic characterizations are still in its infancy.

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