This review summarizes the functions and mechanisms of the emerging group of radical SAM enzymes that catalyze C-C bond formations during natural products and cofactor biosynthesis. The review focuses on the roles of these enzymes in the biosynthetic pathways, and the key mechanistic questions relevant to many of these enzymes. Numbers of C-C bond forming radical SAM enzymes are increasing, but their mechanistic characterizations are still in its infancy.
-
Search It!
-
Recent Entries
- Matthew and Jib’s work is published online in Nature Chemical Biology
- Our Comprehensive Natural Products reviews are published online
- Haoran and Edward’s work on MoaA is published online in JACS
- Abhi successfully defended his PhD dissertation
- Dr. Ogasawara visited Duke to give a seminar
- Abhi and Anna’s paper on glucan synthase was published in Biochemistry.
- Hai and Matthew won poster award!
- Abhi won a poster prize in the 2019 Enzymes Coenzymes and Pathway GRC
- Hai’s paper on mitomycin biosynthesis was published
- Ken was selected as the 2019 ACS Pfizer Award in Enzyme Chemistry
-
Links