Brad’s JACS 2015 paper about the peptide rescue of GG-motif mutations was selected for the JACS young investigator virtual issue. In this paper, we reported that some of the mutations in MoaA that cause human Moco deficiency disease could be rescued by a synthetic peptide, suggesting potentials for the future development of a novel therapeutics. Interestingly, this study also revealed that the C-terminal tail of MoaA is involved in the radical initiation during the MoaA catalysis.
