Selected Publications

Su, A.; Ling, F.; Vaganay, C.; Sodaro, G.; Benaksas, C.; Del Bello, R.; Forget, A.; Benajiba, L.; Pardieu, B.; Lin, K.H.; Rutter, J.C.; Bassil, C.F.; Fortin, G.; Pasanisi, J.; Antony-Debre, I.; Alexe, G.; Benoist, J.-F.; Pruvost, A.; Pikman, Y.; Qi, J.; Schlageter, M.H.; Micol, J.B.; Roti, G.; Cluzeau, T.; Dombret, H.; Preudhomme, C.; Fenouille, N.; Golan, H.M.; Stegmaier, K.; Lobry, C.*; Wood, K.C.*; Itzykson, R.*; Puissant, A.* (2020). The folate cycle enzyme MTHFR is a critical regulator of cell response to MYC-targeting therapies, Cancer Discovery 10, 1894-1911. (Co-first authors; *Co-senior authors) [Pubmed][PDF]

Lin, K.H.; Rutter, J.C.; Xie, A.; Pardieu, B.; Winn. E.T.; Dal Bello, R.; Forget, A.; Itzykson, R.; Ahn, Y.-R.; Dai, Z.; Sobhan, R.T.; Anderson, G.R.; Singleton, K.R.; Decker, A.E.; Winter, P.S.; Locasale, J.W.; Crawford, L.; Puissant, A.*; Wood, K.C.* (2020). Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer, Nature Genetics 52, 408-417. (co-first authors; *co-corresponding authors) [PDF][Pubmed]

Manzari, M.T.; Anderson, G.R.; Lin, K.H.; Soderquist, R.S.; Cakir, M.; Zhang, M.; Moore, C.E.; Skelton, R.N.; Fevre, M.; Li, X.; Bellucci, J.J.; Wardell, S.E.; Costa, S.A.; Wood, K.C.*; Chilkoti, A.* (2019). Genomically informed small molecule drugs overcome resistance to a sustained release formulation of an engineered death receptor agonist in patient-derived tumor models, Science Advances 5, eaaw9162. (*Co-corresponding authors) [PDF][Pubmed]

Lin, K.H.; Xie, A.; Rutter, J.C.; Ahn, Y.; Lloyd-Cowden, J.M.; Nichols, A.G.; Soderquist, R.S.; Koves, T.R.; Muoio, D.; MacIver, N.J.; Lamba, J.; Pardee, T.S.; McCall, C.M.; Rizzieri, D.A.; Wood, K.C. (2019). Systematic dissection of the metabolic-apoptotic interface in AML reveals heme biosynthesis to be a regulator of drug sensitivity, Cell Metabolism 29, 1217. (Co-first authors) [PDF][Pubmed]

Ding, Y.; Huang, D.; Chen, R.; Gong, C.; Sui, P.; Lin, K.H.; Yuan, L.; Xiang, H.; Chen, J.; Yin, T.; Wang, Q.F.; Alexander, P.D.; Song, E.W.; Li, Q.-J.; Wood, K.C.*; Wang, X.F.* (2018). Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers, Nature Communications 9, 4274. (*Co-corresponding authors) [PDF][Pubmed]

Soderquist, R.S.; Crawford, L.; Liu, E.; Lu, M.; Agarwal, A.; Anderson, G.R.; Lin, K.H.; Winter, P.S.; Cakir, M.; Wood, K.C. (2018). Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity, Nature Communications 9, 3513. [PDF][Pubmed]

Anderson, G.R.; Wardell, S.E.; Cakir, M.; Yip, C.; Ahn, Y.; Ali, M.; Yllanes, A.P.; Chao, C.A.; McDonnell, D.P.; Wood, K.C. (2018). Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors, Nature Communications 9, 1677. [PDF][Pubmed]

Singleton, K.R.; Crawford, L.; Tsui, E.; Manchester, H.E.; Maertens, O.; Liu, X.; Liberti, M.V.; Magpusao, A.N.; Stein, E.M.; Tingley, J.P.; Frederick, D.T.; Boland, G.M.; Flaherty, K.T.; McCall, S.J.; Krepler, C.; Sproesser, K.; Herlyn, M.; Adams, D.J.; Locasale, J.W.; Cichowski, K.; Mukherjee, S.; Wood, K.C. (2017). Melanoma therapeutic strategies that select against resistance by exploiting MYC-driven evolutionary convergence, Cell Reports 21, 2796-2812. (Co-first authors) [PDF][Pubmed]

Anderson, G.R.¶; Winter, P.S.¶; Lin, K.H.; Nussbaum, D.P.; Cakir, M.; Stein, E.M.; Soderquist, R.; Crawford, L.; Leeds, J.C.; Newcomb, R.; Stepp, P.; Yip, C.; Wardell, S.E.; Tingley, J.P.; Ali, M.; Xu, M.; Ryan, M.; McCall, S.J.; McRee, A.; Counter, C.M.; Der, C.J.; Wood, K.C. (2017). A landscape of therapeutic cooperativity in KRAS mutant cancers reveals principles for controlling tumor evolution, Cell Reports 20, 999-1015. (¶Co-first authors) [PDF][Pubmed]

Ali, M.¶; Kaltenbrun, E.¶; Anderson, G.R.¥; Stephens, S.J.¥; Arena, S.; Bardelli, A.; Counter, C.M.*; Wood, K.C.* (2017). Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance, Nature Communications 8, 15617. (¶Co-first authors, ¥Co-second authors, *Co-corresponding authors) [PDF] [PubMed]

Anderson, G.R.; Wardell, S.E.; Cakir, M.; Crawford, L.; Leeds, J.C.; Nussbaum, D.N.; Shankar, P.S.; Soderquist, R.S.; Stein, E.M.; Tingley, J.P.; Winter, P.S.; Zeiser-Misenheimer, E.K.; Alley, H.M.; Yllanes, A.; Haney, V.; Blackwell, K.L.; McCall, S.J.; McDonnell, D.P.; Wood, K.C. (2016). PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation, Science Translational Medicine 8, 369ra175. [PDF][Pubmed]

Martz, C.A.¶; Ottina, K.A.¶; Singleton, K.S.¶; Jasper, J.S.; Wardell, S.E.; Peraza-Penton, A.; Anderson, G.R.; Winter, P.S.; Wang, T.; Alley, H.M.; Kwong, L.N.; Cooper, Z.A.; Tetzlaff, M.; Chen, P.-L.; Rathmell, J.C.; Flaherty, K.T.; Wargo, J.A.; McDonnell, D.M.; Sabatini, D. M.*; Wood, K.C.* (2014). Systematic identification of signaling pathways with potential to confer anticancer drug resistance, Science Signaling 7, ra121. (¶Co-first authors, *Co-corresponding authors) [PDF] [Pubmed]

Winter, P.S.; Sarosiek, K.A.; Lin, K.H.; Meggendorfer, M.; Schnittger, S.; Letai, A.; Wood, K.C. (2014). RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis, Science Signaling 7, ra122. [PDF] [Pubmed]