Therapeutic Resistance in Cancer

Kris C. Wood, PhD
Assistant Professor of Pharmacology and Cancer Biology
Assistant Professor of Biomedical Engineering

Therapeutic Resistance in Cancer

Our lab leverages insights from cell biology, pharmacology, signaling, and genomics to design new, durable anticancer therapeutic strategies.

Under this broad heading, our work involves three key areas of emphasis. First, we use custom functional genomics approaches to define the landscape of signaling pathways capable of driving resistance to therapy. Second, we utilize knowledge of resistance landscapes to identify new therapeutic strategies that block or select against resistance evolution. Finally, we use unbiased approaches to define new, targetable vulnerabilities in human cancers, particularly those cancers driven by genomic alterations that are not amenable to conventional therapeutic strategies.

Beyond purely translational applications, our studies should advance our basic understanding of the architectures of biological signaling networks, and the genomic tools we develop may be useful for systematically dissecting a wide range of additional biological processes.