REPRESENTATIVE PUBLICATIONS

2021

Coughlan, J. M., M. Wilson Brown and J. H. Willis. 2021. The genetic architecture and evolution of life-history divergence among perennials in the Mimulus guttatus species complex. Proceedings of the Royal Society B, in press.

2020

Coughlan, J. M., M. Wilson Brown and J. H. Willis. 2020. Patterns of Hybrid Seed Inviability in the Mimulus guttatus sp. Complex Reveal a Potential Role of Parental Conflict in Reproductive Isolation. Current Biology 30: 83-93.

2019

Coughlan, J. M. and J. H. Willis. 2019. Dissecting the role of a large chromosomal inversion in life history divergence throughout the Mimulus guttatus species complex. Molecular Ecology 28: 1343-1357.

Selby, J., and J. H. Willis. 2019. Major QTL controls adaptation to serpentine soils in Mimulus guttatus. Molecular Ecology, in press.

2018

Toll, K., and J. H. Willis. 2019. Hybrid inviability and differential submergence tolerance drive habitat segregation between two congeneric monkeyflowers. Ecology 99: 2776-2786.

Troth, A., J. R. Puzey, R. S. Kim, J. H. Willis, and J. K. Kelly. 2018. Selective trade-offs maintain alleles underpinning complex trait variation in plants. Science 361: 475-478.

Ferris, K. G., and J, H. Willis. 2018. Differential adaptation to a harsh granite outcrop habitat between sympatric Mimulus species. Evolution 72: 1225-1241.

Barnett, L. L., A. Troth, and J. H. Willis. 2018. Plastic breeding system response to day length in the California wildflower Mimulus douglasii. American Journal of Botany 105: 779-787.

2017

Aeschbacher, S., J. P. Selby, J. H. Willis, and G. Coop. 2017. Population-genomic inference of the strength and timing of selection against gene flow. Proceedings of the National Academy of Sciences of the United States of America 114: 7061-7066.

Greenham, K., P. Lou, J. R. Puzey, G. Kumar, C. Arnevik, H. Farid, J. H. Willis, and C. Robertson McClung. 2017. Geographic Variation of Plant Circadian Clock Function in Natural and Agricultural Settings. Journal of Biological Rhythms 32: 26-34. Abstract

Puzey, J. R., J. H. Willis, J. K. Kelly. 2017. Population structure and local selection yield high genomic variation in Mimulus guttatus. Molecular Ecology 26: 519-535. Abstract

2016

Ferris K.G., L. L. Barnett, B. K. Blackman, and J.H. Willis. 2016. The genetic architecture of local adaptation and reproductive isolation in sympatry within the Mimulus guttatus species complex. Molecular Ecology 26: 208-224. Abstract

Lee, Y. W., L. Fishman, J. K. Kelly, and J. H. Willis. 2016. Fitness Variation Is Generated by a Segregating Inversion in Yellow Monkeyflower (Mimulus guttatus). Genetics. 202: 1473-1484. Abstract

Oneal, E., J. H. Willis, and R. G. Franks. 2016. Disruption of endosperm development is a major cause of hybrid seed inviability between Mimulus guttatus and Mimulus nudatus. New Phytologist. 210: 1107-1120. Abstract

2015

Ferris, K. G., T. Rushton, A. B. Greenlee, K. Toll, B. K. Blackman, and J. H. Willis. 2015. Leaf shape evolution has a similar genetic architecture in three edaphic specialists within the Mimulus guttatus species complex. Annals of Botany. 116 (2): 213-223. Abstract

Friedman, J., A.D. Twyford, J.H. Willis, and B. K. Blackman. 2015. The extent and genetic basis of phenotypic divergence in life history traits in Mimulus guttatus. Molecular Ecology. 24: 111–122. Abstract

2014

Ferris, K. G., J. P. Sexton, and J. H. Willis. 2014. Speciation on a local geographic scale: the evolution of a rare rock outcrop specialist in Mimulus. Philosophical Transactions of the Royal Society B. 369:20140001. Abstract

Oneal E., D. B. Lowry, K. M. Wright, Z. Zhu, and J. H. Willis. 2014. Divergent population structure and climate associations of a chromosomal inversion polymorphism across the Mimulus guttatus species complex. Molecular Ecology. 23:2844-2860. Abstract

Modliszewski, J. L., and J. H. Willis. 2014. Near-Absent Levels of Segregational Variation Suggest Limited Opportunities for the Introduction of Genetic Variation via Homeologous Chromosome Pairing in Synthetic Neoallotetraploid Mimulus. G3. g3.113.008441. Full Text

Fishman, L., J. H. Willis, C. A. Wu and Y. W. Lee. 2014. Comparative linkage maps suggest that fission, not polyploidy, underlies near-doubling of chromosome number within monkeyflowers (Mimulus; Phrymaceae). Heredity. 112:562–568 Abstract

Flagel, L. E., J. H. Willis, and T. J. Vision. 2014. The standing pool of genomic structural variation in a natural population of Mimulus guttatus. Genome Biology and Evolution. (1):53-64. Full Text

2013

Hellsten, U., Wright, K. M., Jenkins, J., Shu, S., Yuan, Y., Wessler, S. R., Schmutz, J., Willis, J. H., and D. S. Rokhsar. 2013. Fine-scale variation in meiotic recombination in Mimulus inferred from population shotgun sequencing. Proceedings of the National Academy of Science, USA. 110:19478-19482. Full Text

Friedman, J., and J. H. Willis. 2013. Major QTLs for critical photoperiod and vernalization underlie extensive variation in flowering in the Mimulus guttatus species complex. New Phytologist. 199:571–583. Abstract

Wright, K. M., D. Lloyd, D. B. Lowry, M. R. Macnair, J. H. Willis. 2013. Indirect Evolution of Hybrid Lethality Due to Linkage with Selected Locus in Mimulus guttatus. PLoS Biology. 11(2):e1001497. Full Text

2012

Sweigart, A. L., and J. H. Willis. 2012. Molecular evolution and genetics of postzygotic reproductive isolation in plants. F1000 Biology Reports. 4:23. Full Text

Modliszewski, J. L., and J. H. Willis. 2012. Allotetraploid Mimulus sookensis are highly interfertile despite independent origins. Molecular Ecology. 21:5280-5298. Abstract

Mojica, J. P., Y. W. Lee, J. H. Willis, and J. K. Kelly. Spatially and temporally varying selection on intrapopulation quantitative trait loci for a life history trade-off in Mimulus guttatus. Molecular Ecology. 21:3718-3728. Abstract

Mower, J. P., A. L. Case, E. R. Floro, and J. H. Willis. 2012. Evidence against equimolarity of large repeat arrangements and a predominant master circle structure of the mitochondrial genome from a monkeyflower (Mimulus guttatus) lineage with cryptic CMS. Genome Biology and Evolution 4:670-686. Full Text

Benedict, B. G., J. L. Modliszewski, A. L. Sweigart, N. H. Martin, F. R. Ganders, and J. H. Willis. 2012. Mimulus sookensis (Phyrmaceae), a new allotetraploid species derived from Mimulus guttatus and Mimulus nasutus. Madrono. 59:29-43. Full Text

Lowry, D. B., C. C. Sheng, Z. Zhu, T. E. Juenger, B. Lahner, D. E. Salt, and J. H. Willis. 2012. Mapping of ionomic traits in Mimulus guttatus reveals Mo and Cd QTLs that colocalize with MOT1 homologues. PLoS ONE. 7:e30730. Full Text

Strasburg, J. L., N. A. Sherman, K. M. Wright, L. C. Moyle, J. H. Willis, and L. H. Rieseberg. 2012. What can patterns of differentiation across plant genomes tell us about adaptation and speciation? Philosophical Transactions of the Royal Society B. 367:364-373. Full Text

Moran, E. V., J. H. Willis, and J. S. Clark. 2012. Genetic evidence for hybridization in red oaks (Quercus sect. Lobatae, Fagaceae). American Journal of Botany. 99:92-100. Abstract

Lowry, D. B., C. C. Sheng, J. R. Lasky, and J. H. Willis. 2012. Five anthocyanin polymorphisms are associated with an R2R3-MYB cluster in Mimulus guttatus (Phrymaceae). American Journal of Botany. 99:82-91. Abstract

2011

Magwene, P. M., J. H. Willis, and J. K. Kelly. 2011. The statistics of bulk segregant analysis using next generation sequencing. PLoS Computational Biology. 7:e1002255. Full Text

Scoville, A. G., Y. W. Lee, J. H. Willis, and J. K. Kelly. 2011. Explaining the heritability of an ecologically significant trait in terms of individual quantitative trait loci. Biology Letters. 7:896-898. Abstract

Anderson, J. T., J. H. Willis, and T. Mitchell-Olds. 2011. Evolutionary genetics of plant adaptation. Trends in Genetics. 27:258-266. Abstract

Cooley, A. M., J. L. Modliszewski, M. L. Rommel, and J. H. Willis. 2011. Gene Duplication in Mimulus Underlies Parallel Floral Evolution via Independent trans-Regulatory Changes. Current Biology. 21: 700-704. Abstract

2010

Lowry, D. B., and J. H. Willis. 2010. A widespread chromosomal inversion polymorphism contributes to a major life-history transition, local adaptation, and reproductive isolation. PLoS Biology. 8: e1000500. Full Text

Martin, N. H., and J. H. Willis. 2010. Geographical variation in postzygotic isolation and its genetic basis within and between two Mimulus species. Philosophical Transactions of the Royal Society B. 365:3469-2478. Full Text

Hall, M. C., D. B. Lowry, and J. H. Willis. 2010. Is local adaptation in Mimulus guttatus caused by trade-offs at individual loci? Molecular Ecology. 19:2739-2753. Abstract

Wu, C. A., D. B. Lowry, L. I. Nutter, and J. H. Willis. 2010. Natural variation for drought response traits in the Mimulus guttatus species complex. Oecologia. 162:23-33. Abstract

2009

Charlesworth, D., and J. H. Willis. 2009. The genetics of inbreeding depression. Nature Reviews Genetics. 10:783-796. Abstract

Cooley, A. M., and J. H. Willis. 2009. Genetic divergence causes parallel evolution of flower color in Chilean Mimulus. New Phytologist. 183: 729-739. Abstract

Lowry, D. B., M. C. Hall, D. E. Salt, J. H. Willis. 2009. Genetic and physiological basis of adaptive salt tolerance divergence between coastal and inland Mimulus guttatus. New Phytologist. 183: 776-788. Abstract

Scoville, A., Y. W. Lee, J. H. Willis, and J. K. Kelly. 2009. Contribution of chromosomal polymorphisms to the G-matrix of Mimulus guttatus. New Phytologist. 183: 803-815. Abstract

2008

Lowry, D. B., R. C. Rockwood, and J. H. Willis. 2008. Ecological reproductive isolation of coast and inland races of Mimulus guttatus. Evolution. 62:2196-2214. Abstract

Lowry, D. B., J. L. Modliszewski, K. M. Wright, C. A. Wu, and J. H. Willis. 2008. The strength and genetic basis of reproductive isolating barriers in flowering plants. Philosophical Transactions of the Royal Society B. 363:3009-3021. Full Text

McDaniel, S.F., J. H. Willis, and A. J. Shaw. 2008. The genetic basis of developmental abnormalities in interpopulation hybrids of the moss Ceratodon purpureus. Genetics. 179:1425-1435. Full Text

Case, A. L., and J. H. Willis. 2008. Hybrid male sterility in Mimulus (Phrymaceae) is associated with a geographically restricted mitochondrial rearrangement. Evolution. 62: 1026-1039. Abstract

Sweigart, A. L., N. H. Martin, and J. H. Willis. 2008. Patterns of nucleotide variation and reproductive isolation between a Mimulus allotetraploid and its progenitor species. Molecular Ecology. 17:2089-2100. Abstract

Cooley, A. M., G. Carvallo, and J.H. Willis. 2008. Is Floral Diversification Associated with Pollinator Divergence? Flower Shape, Flower Colour and Pollinator Preference in Chilean Mimulus. Annals of Botany. 101: 641-650. Abstract

Fishman, L., and J. H. Willis. 2008. Pollen limitation and natural selection on floral characters in the yellow monkeyflower Mimulus guttatus. New Phytologist. 177:802-810. Full Text

Wu, C. A., D. B. Lowry, A. M. Cooley, K. M. Wright, Y.W. Lee, and J. H. Willis. 2008. Mimulus is an emerging model system for the integration of ecological and genomic studies. Heredity. 100:220-230. PDF

2007

Mitchell-Olds, T., J. H. Willis, and D. Goldstein. 2007. What evolutionary processes influence natural genetic variation for phenotypic traits? Nature Reviews Genetics. 8:845-856. Abstract

McDaniel, S.F., J. H. Willis, and A. J. Shaw. 2007. A linkage map reveals a complex basis for segregation distortion in an interpopulation cross in the moss Ceratodon purpureus. Genetics. 176:2489-2500. Abstract

Rieseberg, L. H., and J. H. Willis. 2007. Plant speciation. Science. 317:910-914. Abstract

Martin, N. H., and J. H. Willis. 2007. Ecological divergence associated with mating system causes nearly complete reproductive isolation between sympatric Mimulus species. Evolution. 61:68-82. Abstract

Sweigart, A. L., A. Mason, J. H. Willis. 2007. Natural variation for a hybrid incompatibility between two species of Mimulus. Evolution. 61:141-151. Abstract

2006

Hall, M. C., and J. H. Willis. 2006. Divergent selection on flowering time contributes to local adaptation in Mimulus guttatus populations. Evolution. 60:2466-2477.

Aagaard, J. E., J. H. Willis, and P. C. Phillips. 2006. Relaxed selection among duplicate floral regulatory genes in Lamiales. Journal of Molecular Evolution. 63:493-503.

Fishman, L. and J. H. Willis. 2006. A cytonuclear incompatibility causes anther sterility in Mimulus hybrids. Evolution. 60:1372-1381.

Sweigart, A. L., L. Fishman, and J. H. Willis. 2006. A simple genetic incompatibility causes hybrid male sterility in Mimulus. Genetics. 172:2465-2479.

Hall, M. C., C. Basten, and J. H. Willis. 2006. Pleiotropic quantitative trait loci contribute to population divergence in traits associated with life-history variation in Mimulus guttatus. Genetics. 172:1829-1844.

2005

Aagaard, J. E., R. G. Olmstead, J. H. Willis, and P. C. Phillips. 2005. Duplication of floral regulatory genes in the Lamiales. American Journal of Botany. 92:1284-1293.

Hall, M. C. and J. H. Willis. 2005. Transmission ratio distortion in intraspecific hybrids of Mimulus guttatus: Implications for genomic divergence. Genetics. 170:375-386.

Fishman, L. and J. H. Willis. 2005. A novel meiotic drive locus almost completely distorts segregation in Mimulus (monkeyflower) hybrids. Genetics. 169:347-353.

2000-2004

Sweigart, A. L. and J. H. Willis. 2003. Patterns of nucleotide diversity are affected by mating system and asymmetric introgression in two species of Mimulus. Evolution, 57:2490-2506.

Fishman, L. A. J. Kelly, J. H. Willis. 2002. Minor quantitative trait loci underlie floral traits associated with mating system divergence in Mimulus. Evolution. 56 (11): 2138-2155.

Kelly, JK; Willis, JH. 2002. A manipulative experiment to estimate biparental inbreeding in monkeyflowers. International Journal of Plant Sciences. 163:575-579.

Fishman, L., A. J. Kelly, E. Morgan, and J. H. Willis. 2001. A genetic map in the Mimulus guttatus species complex reveals transmission ratio distortion due to heterospecific interactions. Genetics.159:1701-1716.

Fishman, L. and J. H. Willis. 2001. Evidence for Dobzhansky-Muller incompatibilites contributing to the sterility of hybrids between Mimulus guttatus and M. nasutus. Evolution. 55:1932-1942.

Kelly, J. K., and J. H. Willis. 2001. Deleterious mutations and genetic variation for flower size in Mimulus guttatus. Evolution. 55:937-942.

Earlier Papers

Willis, J. H. 1999. Inbreeding load, average dominance, and the mutation rate for mildly deleterious alleles in Mimulus guttatus. Genetics. 153:1885-1898.

Willis, J. H. 1999. The role of genes of large effect on inbreeding depression in Mimulus guttatus. Evolution. 53:1678-1691.

Willis, J. H. 1999. The contribution of male sterility mutations to inbreeding depression in Mimulus guttatus. Heredity. 83:337-346.

Sweigart, A., K. Karoly, A. Jones, and J. H. Willis. 1999. The distribution of individual inbreeding coefficients and pairwise relatedness in a population of Mimulus guttatus. Heredity. 83:625-632.

Schultz, S. T., M. Lynch, and J. H. Willis. 1999. The genomic mutation rate for fitness in Arabidopsis thaliana. Proceedings of the National Academy of Science, USA. 96:11393-11398.

Lynch, M., J. Blanchard, D. Houle, T. Kibota, S. Schultz, L. Vassilieva, and J. H. Willis. 1999. Spontaneous deleterious mutation. Evolution, 53:645-663.

Kelly, A. J. and J. H. Willis. 1998. Polymorphic microsatellite loci in Mimulus guttatus and related species. Molecular Ecology. 7:769-774.

Willis, J. H. 1996. Measures of phenotypic selection are biased by partial inbreeding. Evolution. 50:1501-1511.

Schultz, S. T. and J. H. Willis. 1995. Individual variation in inbreeding depression: the roles of inbreeding history and mutation. Genetics. 141:1209-1223.

Gimelfarb, A. and J. H. Willis. 1994. Linearity vs. nonlinearity of offspring-parent regression: experimental study. Genetics. 138:343-352.

Willis, J. H. and H. A. Orr. 1993. Increased heritable variation following population bottlenecks: The role of dominance. Evolution. 47:949-957.

Willis, J. H. 1993. Effects of different levels of inbreeding on fitness components in Mimulus guttatus. Evolution. 47:864-876.

Willis, J. H. 1993. Partial self-fertilization and inbreeding depression in two populations of Mimulus guttatus. Heredity. 71:145-154.

Willis, J. H. 1992. Genetic analysis of inbreeding depression caused by chlorophyll-deficient lethals in Mimulus guttatus. Heredity. 69: 562-572.

Willis, J. H., J. A. Coyne, and M. Kirkpatrick. 1991. Can one predict the evolution of quantitative traits without genetics? Evolution. 45:441-444.