The Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments (UPDATe) Study is working to identify the most effective treatments for women with pain at the vaginal opening during intercourse or when using tampons. Women who have VBD often have pain in other areas and may have conditions like Chronic Fatigue, Fibromyalgia, Irritable Bowel Syndrome (IBS), and temporomandibular disorder (TMD).
Sadly, we don’t know what the best treatments are for VBD, especially for women who also have other pain conditions. Many treatments are used on a trial-and-error basis, leaving women in pain and discomfort, which can often lead to stress, anxiety, and depression.
So, we need to better understand how women with VBD experience pain so we can find out what treatments work best (called precision medicine) for different women.
Participation available at
The University of North Carolina at Chapel Hill
Sponsors, Funders, and Approvals
This study is funded by a grant from the National Institutes of Health, National Institute of Child Health and Development (R01 HD096331).
The study has been approved by:
] The Duke Health Institutional Review Board (Pro00100678)
] The UNC Institutional Review Board (IRB# 19-1066)
] The UCLA Institutional Review Board (IRB# 19-000899)