The UPDATe Study

The Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments (UPDATe) Study is working to identify the most effective treatments for women with pain at the vaginal opening during intercourse or when using tampons. Women who have VBD often have pain in other areas and may have conditions like Chronic Fatigue, Fibromyalgia, Irritable Bowel Syndrome (IBS), and temporomandibular disorder (TMD).

Sadly, we don’t know what the best treatments are for VBD, especially for women who also have other pain conditions. Many treatments are used on a trial-and-error basis, leaving women in pain and discomfort, which can often lead to stress, anxiety, and depression.

So, we need to better understand how women with VBD experience pain so we can find out what treatments work best (called precision medicine) for different women.

Participation possible at


The University of California, Los Angeles




The University of North Carolina at Chapel Hill

Sponsors, Funders, and Approvals

This study is funded by a grant from the National Institutes of Health, National Institute of Child Health and Development (R01 HD096331).

The study has been approved by:

] The Duke Health Institutional Review Board (Pro00100678)

] The UNC Institutional Review Board (IRB# 19-1066)

] The UCLA Institutional Review Board (IRB# 19-000899)

Additional Resources

Federal guidelines require all NIH approved clinical trials made accessible for reference on; our study identifier is NCT03844412.


Many individuals suffer from more than one chronic illness, and knowing who to turn to can be overwhelming. The Chronic Pain Research Alliance strives to put an end to the neglect, dismissal and discrimination faced by these individuals in the hopes of improving their quality of life and medical care.