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Duke Heart Pulse – Updates from the week ending April 24th 2022

Sunil Rao, MD to take New Role Leading Interventional Cardiology at NYU Langone

It is bittersweet that we announce that Sunil Rao has accepted the position of Director of Interventional Cardiology for the NYU Langone Health System where he will work to facilitate coordination, program development, uniform quality standards, operational efficiency, financial goals and best practices across the NYULH System Cardiac Catheterization Laboratories.

We are extremely excited for Sunil and thrilled that he will be taking on this important leadership opportunity to continue to innovate the care of patients undergoing invasive procedures, and certain his impact and skill will be immediately felt across the NYU Langone cath labs.

He will be missed at Duke where he has been a friend, trusted colleague, mentor, teacher, and consummate interventionalist over the last 26 years.  Sunil came to Duke after completing medical school at The Ohio State University and did his medical residency and cardiology, and interventional fellowship at Duke.  Since coming on Faculty, he has been a north star for our invasive labs – studying, teaching, and ushering in radial procedures, best cath practices, and playing an instrumental role in how we think about and train the next generation of leaders in cardiology.  His impact can be seen based on the number of fellows, trainees, and colleagues that look to work with him. He has been the repeatedly been the recipient of fellowship mentorship and teaching awards. Academically, he is an internationally recognized clinical investigator involved in many of the seminal trials in interventional cardiology around management of patients undergoing invasive procedures, including devices, access site, and treatment strategies.

He is also the current Chief of Cardiology at the Durham VA where is has helped transform the cardiovascular care of our veterans while supporting the faculty. He is currently the editor of Circulation Cardiovascular Interventions and will be the President of the Society for Cardiovascular Angiography and Intervention (SCAI) in May 2022.  He is the true triple threat.

Personally, what I will miss most is the camaraderie, fun, and drive for excellence that Sunil brought to Duke every day.

Reflecting on his time at Duke, Sunil said, “Duke has been my home for 26 years and I consider the Cardiology division my family. The mentorship, collaborations, and friendships over the years have been integral to my personal and professional life. Although I will be leaving Duke, Duke will always be part of who I am. It’s really been a privilege to be part of Duke Heart.”

Congratulations Sunil – you will certainly be missed and we look forward to collaborating in the future.

Duncan Recognized for 36 Years of Service in Heart

Lisa Duncan will be retiring on May 2, 2022 after more than 36 years of service. Lisa has worked in the Heart Center since 1987 in varying roles including professional nursing assistant, nursing assistant, staff nurse, assistant head nurse and, since the 1990’s, as 7100 Nurse Manager of Operations. Throughout her time at Duke, she served on many task forces and committees.

She received the highly esteemed Mary Ann Peter Friends of Nursing Award for excellence.  Lisa is known for her approachability, fair and consistent practice, and patient/staff advocacy.

On behalf of the entire Duke Heart Center Leadership team, we thank Lisa for her loyalty and dedication to our patients, the faculty and staff of Duke Heart, as well as to Duke University Hospital.

Please join us in wishing her well in her retirement!

 

Heart Transplant Team Celebrates Donate Life Month

April is Donate Life Month and members of our heart transplant team were overjoyed to celebrate in person this year by attending the NC Gift of Life Gala which was held Thursday, April 21 at the Prestonwood Country Club in Cary. There, they enjoyed interacting as a team, bidding on artwork by local artists, hearing from organ recipients, and enjoying the delicious dinner and the silent auction.

The theme of the Gala this year was the HeART of the Matter, marking the use of the red heart on NC state drivers’ licenses for all those who promise to give the gift of life by becoming an organ donor. The team asks if you are not a registered organ donor, please consider becoming one!

Shown here are (L to R): Rotunda Kearney, Melissa Shreve, Tia Thompson, Emily Schneidewind, Sam Murari, Kris Barnes, Cathy Alligood and Sonia Leon.

Rotunda is a program specialist for the heart transplant team. Sonia and Sam are pre-heart transplant coordinators. Tia, Emily, Melissa, Kris and Cathy are post-heart transplant coordinators.

Special thanks to Chet Patel and Adam DeVore for giving their team the opportunity to attend and represent Duke Heart Transplant.

NC Organ Donation Fast Fact: In 2019, when North Carolina Governor Roy Cooper signed into law SB 210 Organ and Tissue Donation/Heart Heroes, it brought North Carolina into parity with the rest of the nation by including tissue for transplantation along with organs and eyes when one says “Yes” to donation at the DMV. Today, anyone who says “Yes” to donation at the NCDMV will be making a legal first-person authorization to become an organ, eye, and tissue donor upon death. Those who had the heart symbol placed on their drivers’ license or ID card before October 1, 2019 must take an extra step to add tissue donation to their registry status by visiting DonateLifeNC.org. Changes to your donor registration status can be made at any time by visiting the same site.

Shout-Out to Duke’s HF Guidelines Contributors

A big shout-out to Duke Heart team members who served as authors, reviewers or ACC/AHA/HFSA Joint Committee Members for the recently published 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. We are deeply grateful for the effort each of you have put into this effort – your work helps educate others and saves lives. Well done, Adrian Hernandez, Carmelo Milano, Sana Al-Khatib, Schuyler Jones and Dan Mark!

Kudos to Senman!

We are always pleased to hear about the great work our fellows are doing. This week, we heard about Balim Senman from Corey Fry, our APP Team Lead in the Cardiac Intensive Care Unit via a note to Anna Lisa Chamis:

“I’d like to take a moment to recognize Dr. Balim Senman for the exceptional work she’s doing in CICU. Dr. Senman has been a leader, communicator, and positive source of support in CICU through the changes we’ve faced as a team over the past year.

“The CICU runs smoothly when Dr. Senman is working …and APP’s feel supported and heard. Her solution-based focus has made her a valuable partner in addressing workflow processes with the APP group…  I appreciate her input and feedback. She’s an exceptional fellow with a bright future and I’m glad to have opportunity to work with her.”

Nicely done, Balim!!

 

Kudos to Lin!

Shu Lin was recently commended by Andrea Carpenter, president of the Thoracic Surgery Directors Association (TSDA) and Matthew Romano, the In-Training Exam Cardiac Subcommittee Chair of the TSDA, for his contributions to the TSDA’s 2022 In-Training Exam and for his work as a member of the ITE Cardiac Subcommittee. Great work Shu! Thank you for representing Duke Heart!

Cybersecurity Advisory Alert

A critical message was issued to all employees on Thursday by Jeff Ferranti, MD, chief digital officer and senior vice president for DUHS and Randy Arvay, PhD, chief information security officer for DUHS.

Due to the Russian invasion of Ukraine, the U.S. Department of Health & Human Services Health Sector Cybersecurity Coordination Center and Health-ISAC has issued a joint advisory for credible cybersecurity threats to U.S. critical infrastructure sectors.

Duke Health has been responsive and continues to expand our defense strategies. Initial actions prioritized leveraging our strong vendor partnerships and intelligence feeds to monitor for indicators of threats.  But, we still need all Duke Health employees to remain vigilant and assist in protecting our systems and resources.

How to Safeguard Against Cyber Threats

We have seen an increase in suspicious email, phone calls, and text messaging to Duke staff, including some that have spoofed/faked prominent Duke leader names.

At this time, we feel that it is important to remind all staff of key steps that you can take, including:

  • Staying vigilant around the potential for social engineering and phishing via email, phone (vishing), text (smishing) and social media. Do not click links or attachments or give out personal or sensitive information. Always independently verify that requests are coming from a known, trusted source.
  • Using strong, unique passwords and multi-factor authentication (MFA) on all accounts. Duke offers a free password manager to all staff (oit.duke.edu/what-we-do/services/1password) and encourages staff to set their MFA preference to “Always” (idms-mfa.oit.duke.edu).
  • Patching/Updating all software and running current Antivirus on personal devices.
  • Avoiding use of free or untrusted Wi-Fi.
  • Report all suspicious emails using ReportPhish in Outlook or other concerning activity or by contacting security@duke.edu.

Each of us, working together, can do our part to ensure the safety of our patients, their loved ones and each other.

Thank you for your continued vigilance!

NC Walk for Victory Raises $50K

Duke Heart was very proud to serve as the presenting sponsor of the NC Walk for Victory held yesterday at Laurel Hills Park in Raleigh. The NC Walk for Victory raises much needed funding to support patients with Marfan syndrome, Loeys-Dietz, VEDS and related conditions. We had a really great day – and the teams exceeded their $50K fundraising goal — a testament to their dedication to research, programming and services offered by the Marfan Foundation

Chad Hughes served as the medical director for the event. Hughes, Melissa Burkett and their team have done an incredible job of welcoming more patients and their families to Duke and providing access to treatment and support not readily available elsewhere. Great job!

Thanks to all who donated and walked to support our patients and their families!

 

Sports Cardiology & Sudden Death in Athletes CME

James Daubert

The Duke Sports Cardiology & Sudden Death in Athletes Symposium was held yesterday, April 23 with course directors Jim Daubert and Bill Kraus. The virtual event drew just over 160 registrants. Guest speakers included Duke faculty members Igor Klem, Howard Rockman, Jeff Bytomski, Hap Zarzour, Al Sun and Kenzie Johnston along with Aaron Baggish (Mass General) and Norbert Guettler (Central Military Hospital, Koblenz, Germany). Shout-out to Christy Darnell for terrific planning! The CME was free to attend; enduring material can be accessed for up to two years by registering and obtaining the link. To do so, please visit https://duke.is/gkffw.

 

Reves Lecture

Mark F. Newman, MD, Executive Vice President of Health Affairs at the University of Kentucky, former president of the Duke PDC and former chair of Duke Anesthesiology delivered Cardiology Grand Rounds on Tuesday evening and the Reves Lecture/Anesthesiology Grand Rounds on Wednesday morning. It was great to have Mark back on campus! (Pictured are Joe Mathew and Newman.) If you were unable to attend the Reves Lecture, it can be viewed here: https://dukemed.mediasite.com/Mediasite/Play/bd690445bc724c8488afab4226b6891a1d. Note, the main presentation begins approximately 17 minutes into the video.

 

COVID-19 Update

All the latest Clinical Operations updates related to COVID can be found at https://covid-19.dukehealth.org. Patient-facing resources on DukeHealth.org can be found here: https://www.dukehealth.org/covid-19-update/resources. Duke University maintains a resource page as well, which can be accessed here: https://coronavirus.duke.edu/updates/for-staff.

Upcoming Events & Opportunities

Cardiology Grand Rounds

April 26: Clinicopathologic Conference with Francis Ugowe. 5 p.m. via Webex.

May 3: Topic TBA with Navid Nafissi. Details forthcoming.

May 10: Topic TBA with Caitlin Dresher. Details forthcoming.

MDEpiNet Spring 2022 Virtual Mini-Think Tank

May 5: MDEpiNet Spring 2022 Virtual Mini-Think Tank. Noon – 5:30 p.m., ET

MDEpiNet Predictable And SuStainable Implementation Of National CardioVascular Registries (PASSION CVR) Registry-Supported Prospective Clinical Trials

Join and invite your colleagues to join for updates from, and dialogues across our Registry-supported Prospective Trials Working Groups:

  • Data Governance & Access
  • Operational Roles & Responsibilities
  • Global Regulatory Acceptance
  • Use Cases:
    • Aortic Intervention
    • Heart Valves
    • Mechanical Circulatory Support
    • Peripheral Arterial Intervention

Registration now open: https://duke.qualtrics.com/jfe/form/SV_2f6JBD6WfaF9jBc.

Evening with Heart Raleigh

An Evening with Heart Raleigh, which has been rescheduled from earlier this year, will benefit Marfan families as well as those with Loeys-Dietz (LDS), Vascular Ehlers-Danlos (VEDS), and related conditions.

May 5, 2022

The Maxwell

7-10 p.m.

Cocktail attire

Tickets for the event include open bar, taco bar, heavy appetizers, dessert, silent auction, DJ, and a fun photo booth. For those unable to attend in person but who would like to participate, the silent auction items can be bid on online from anywhere. Lots of cool items have been donated so far! For tickets, more information or silent auction viewing and bidding, please visit: https://marfan.ejoinme.org/raleigh22.

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

Duke Heart in the News:

April 15 — Richard Shannon

WNCN, CBS-17

Annual campaign aims to improve maternal health outcomes for Black women

https://duke.is/zwp56

April 15 — Jonathan Piccini

DotMed/HealthCareBusiness News

Patients with infected cardiac implants should have them removed

https://duke.is/nmm2j

April 16 — Robert Mentz

Healio/Cardiology Today

Editors of HF journal question use of the word ‘candidate’

https://duke.is/b67cp

April 21 — Kevin Oeffinger (Duke Cancer Institute)

Healio/Hematology-Oncology

Cardiovascular care of pediatric cancer survivors: Mitigating a lifelong risk

https://duke.is/whpd9

April 22 — Sean Pokorney

Cardiology Advisor

ACC: Infected CV Implantable Electronic Devices Often Not Removed

https://duke.is/jvyyc

 

Duke Heart Pulse week ending April 17th 2022

Chief’s message:

This weekend hopefully you all got some time to spend with family around Easter, Ramadan, Passover, or just to get time spend together.  The last few years have taught all of use to ensure we enjoy the moments with friends and family to recharge.  Personally, we want to thank the Duke Heart teams that have continued to pull together for our patients and each other in the ever changing world of health care.

Highlights of the week:

Shout-out to Duke Heart teams

A tremendous shout-out to Duke Heart team members throughout our clinical care areas, in particular to our interventional teams. As many of you know, the EP and Cath Labs were tremendously busy this past week!

According to Anna Mall, cases in the cath lab began to spike on Friday, April 8 with a record setting 38 cases completed. She added that on Monday alone, 44% of cases were PCI, including four STEMI. Tuesday, the trend continued with 32 cases and multiple STEMI activations. Volume hadn’t waned toward the end of the week — the teams continued to see busy outpatient and inpatient case volumes.

“Special thanks to the cath lab staff, fellows and faculty for the amazing teamwork handling incredibly busy days – all with a smile!!” — Anna Mall

The interventional teams really pulled together to establish unique work flows in order to manage this uptick in patient cases, according to Jill Engel, associate VP, Duke Heart.

We’d like to add a special shout-out to Andrew Wang, MD, who has been exceptional with morning bed flow call. Across the board, we thank all cardiologists and nursing teams for helping manage bed capacity and patient care. This has been a truly busy time for everyone and Duke Heart leadership appreciates the way everyone has pulled together to help.

THANK YOU! We appreciate all that you and your teams are doing to take great care of our patients and to keep everyone safe. Great job, everyone!!!

Wrobel Named Chief Cardiology Fellow

We are pleased to share the wonderful news that our Duke Cardiology fellows have selected Dr. Christopher Wrobel as their 2022-2023 Chief Cardiology Fellow. The announcement was made earlier this week by fellowship director Anna Lisa Chamis, MD.

Wrobel was born and raised in Valparaiso, IN. He obtained a BS in chemistry from Duke in 2009. After teaching high school chemistry in New Orleans for two years, he returned to Indiana for medical school. There he met his wife, Dr. Heather Wolfe. Wrobel completed his internal medicine residency at University of Texas Southwestern (UTSW) in 2018. He worked as a hospitalist for one year at UTSW before returning to Duke for cardiology fellowship.

He will complete his Advanced Heart Failure and Transplant Cardiology fellowship in June. Heather and Chris are expecting their first child later this month. In his spare time, Chris enjoys traveling, moonlighting as an amateur restaurant critic, exploring Old World wine, and irrationally supporting his favorite sports teams.

Wrobel will transition to his new role in June. (Photo shows Drs. Chris and Heather Wrobel.)

Please join us in congratulating Chris and welcoming him to his new role!

Thank-you to Coniglio!

Please join us in thanking Dr. Amanda Coniglio for serving as the Cardiology fellowship Chief Fellow this past year. She has worked tirelessly to advocate for the fellows. In a message to the team this week, Dr. Anna Lisa Chamis shared the following:

“Dr. Coniglio’s impact on our fellowship program has been substantial! In particular, she started a bi-monthly fellows’ Critical Care conference, sent weekly educational and informational summaries to all the fellows with references and championed the return to in-person gatherings – in addition to the routine Chief Fellow responsibilities.

Coniglio will be joining the advanced heart failure team at Rochester General Hospital after graduation.” Amanda is shown here with her husband, Dr. Andrew Coniglio.

When asked about her experience this year, Dr. Coniglio said, “I am incredibly grateful for the opportunity to have served as chief this past year and am hopeful that the initiation of CICU case conferences and weekly conference summaries have been an educational resource to all. Congratulations and best wishes to Dr. Wrobel on being elected as chief!”

Coniglio will transition the Chief Fellow role to Dr. Chris Wrobel during June.

Great job, Amanda!

 

 

 

Patel Receives SOM Faculty Award

Manesh Patel

Manesh Patel, MD, professor of medicine and chief of the Division of Cardiology, has been selected to receive the School of Medicine’s Career Mentoring Award in Clinical Research – Population Health.  Patel commented that  he was “Humbled for the opportunity to work with some of  the best colleagues, fellows, and faculty in cardiovascular medicine. Also appreciative of those that have supported, mentored and taught me including Bob Harrington, Rob Califf, Pam Douglas, Chris O’Connor and many others.”

 

Chen Inducted to ASA

Congratulations to Edward P. Chen, MD, chief of the Division of Cardiovascular and Thoracic Surgery! Chen was inducted into the American Surgical Association during their 142nd annual meeting held April 7-9 in Chicago at the Chicago Marriott Downtown Magnificent Mile.

Way to go!

Edward Chen

Shah to Lead ASPC Group

Congratulations to Nishant Shah! He has been selected to serve a 1-year term as Chair of the Fellow-in-Training and Early Career Working Group of the American Society for Preventive Cardiology.

 

Mark Newman to Deliver Reves Lecture

This week, Dr. Mark F. Newman, Executive Vice President of Health Affairs at the University of Kentucky, former president of the Duke PDC and former chair of Duke Anesthesiology, will deliver Cardiology Grand Rounds and the Reves Lecture. Both events promise to be excellent and both are listed in the event section below. Not to be missed!

 

COVID-19 Update

Second Booster Shot Available for Eligible Faculty, Staff and Students

Duke is now offering second booster shots of the COVID-19 vaccine for eligible faculty, staff and students over the age of 50, as well as anyone who is considered severely immunocompromised to increase their protection against severe disease.

Following approval by the U.S. Food and Drug Administration and the Centers for Disease Control and Prevention last week, Duke will offer the Pfizer vaccine as a second booster shot for those who have had their first booster shot at least four months ago. The second booster shot is not currently required for Duke students, faculty or staff, but it is offered as an option for those who are eligible.

Second booster shots are available by appointment or walk-in at the Duke Medical Pavilion in Conference Room 2w91, Duke Clinic 1J, Duke Regional Hospital and Duke Raleigh Hospital. For more information or to schedule an appointment, visit the Duke COVID Vaccine website. Eligible faculty, staff and students are also encouraged to consider vaccination options at local pharmacies or their healthcare provider.

All the latest Clinical Operations updates related to COVID can be found at https://covid-19.dukehealth.org. Patient-facing resources on DukeHealth.org can be found here: https://www.dukehealth.org/covid-19-update/resources. Duke University maintains a resource page as well, which can be accessed here: https://coronavirus.duke.edu/updates/for-staff.

Upcoming Events & Opportunities

Cardiology Grand Rounds

April 19: Treating the Epidemic after the Pandemic with Mark Newman, University of Kentucky. 5 p.m., DN 2002 or online via Webex.  

Reves Lecture/Anesthesiology Grand Rounds

April 20: Reves Lecture: Creating Alignment for a Healthier State with Mark Newman, University of Kentucky. 7 a.m., DN 2001 or online via Webex. (Link will not be available until 4/18)

Dr. Mark Newman currently serves as Executive Vice President of Health Affairs at the University of Kentucky. The Reves Visiting Professorship and Lecture is supported by the philanthropic efforts of our donors in honor of Jerry Reves, MD, former chair of Duke Anesthesiology.

Note: seating for the in-person lectures on April 19 & 20 will be limited to half the room capacity due to COVID protocols.

Duke Heart CME

April 23: Duke Sports Cardiology & Sudden Death in Athletes Symposium with course directors Jim Daubert and Bill Kraus. Virtual. For information or to register, please visit: https://duke.is/gkffw. If you have additional questions, please contact Christy Darnell christy.darnell@duke.edu or 919-880-8686.

MDEpiNet Spring 2022 Virtual Mini-Think Tank

May 5: MDEpiNet Spring 2022 Virtual Mini-Think Tank. Noon – 5:30 p.m., ET

MDEpiNet Predictable And SuStainable Implementation Of National CardioVascular Registries (PASSION CVR) Registry-Supported Prospective Clinical Trials

Join and invite your colleagues to join for updates from, and dialogues across our Registry-supported Prospective Trials Working Groups:

  • Data Governance & Access
  • Operational Roles & Responsibilities
  • Global Regulatory Acceptance
  • Use Cases:
    • Aortic Intervention
    • Heart Valves
    • Mechanical Circulatory Support
    • Peripheral Arterial Intervention

Registration now open: https://duke.qualtrics.com/jfe/form/SV_2f6JBD6WfaF9jBc.

 

Marfan NC Walk for Victory, April 23

The North Carolina Walk for Victory to support Marfan patients and their families will take place on Saturday, April 23, 2022 from Noon to 3 p.m. at Laurel Hills Park on Edwards Mill Road in Raleigh.

Duke Heart is proud to serve as the presenting sponsor and we are excited for Chad Hughes, MD to serve as medical chair for the walk.

Please help us support all Marfan families as well as those with Loeys-Dietz (LDS), Vascular Ehlers-Danlos (VEDS), and related conditions. Donate or come join us at the event! Parking is easy to access and free.

Walk for Victory is The Marfan Foundation’s global walk program. The event is low-key, fun and family-oriented. To learn more or to register for this event, please visit: https://give.marfan.org/event/2022-north-carolina-walk-for-victory/e353032.

To learn more about The Marfan Foundation, please visit marfan.org.

 

Evening with Heart Raleigh

May 5, 2022

The Maxwell

7-10 p.m.

Cocktail attire

(This event was rescheduled from earlier in the year.) For those unable to attend in person but who would like to participate, the silent auction items can be bid on online from anywhere. Lots of cool items have been donated so far! Tickets for the event include open bar, taco bar, heavy appetizers, dessert, silent auction, DJ, and a fun photo booth. Proceeds benefit The Loeyz-Dietz and Marfan Foundation. For tickets, more information or silent auction viewing and bidding, please visit: https://marfan.ejoinme.org/raleigh22.

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

Duke Heart in the News:

April 8 — G. Michael Felker

tctMD

METEORIC-HF: Omecamtiv Mecarbil Doesn’t Boost Exercise Capacity in HFrEF

https://duke.is/v4q88

April 8 — Sean Pokorney

U.S. News & World Report

Few People Get Infected Heart Devices Removed, Despite Benefit

https://duke.is/z8zbz

*this story was carried by 10 additional news outlets including UPI, HealthDay and MSN News

April 10 — Mark Sendak and Cara O’Brien (DIHI)

The Wall St. Journal

How Hospitals Are Using AI to Save Lives

https://duke.is/mucf7

April 11 — Sean Pokorney

Cardiovascular Business

VIDEO: Lowering mortality rates from infected EP implantable cardiac devices

https://duke.is/jypq3

April 11 — Jonathan Piccini

Healio/Cardiology

Fitbit receives FDA clearance for algorithm to detect AF

https://duke.is/ywqnc

April 11 — Sean Pokorney

HealthDay

ACC: Infected CV Implantable Electronic Devices Often Not Removed

https://duke.is/rfc5n

April 12 — Christopher Granger

tctMD

Managing AF Patients Undergoing PCI—Some Lingering Questions

https://duke.is/zmez8

April 12 — Duke University (CIED ACC LBCT)

Becker’s Hospital Review

7 recent heart study findings

https://duke.is/6vcuk

Duke Heart Pulse week ending April 10th 2022

Highlights of the week:

ACC.22: Looking Back

There were so many excellent presentations across ACC – great job, everyone! Sana Al-Khatib submitted the following thoughts to us regarding the outstanding presentations by our cardiology fellows:

It was very uplifting to connect with friends and colleagues at ACC22 and learn about the latest scientific discoveries that will benefit our patients. To me, the main highlight of the meeting was our fellows’ strong presence and participation.

Vishal Rao gave a very informative and interesting presentation on intravascular blood volume analysis and hemodynamic measures of vascular compliance in patients hospitalized with heart failure. Kelly Arps did a great job presenting novel data on time to relapse after weaning immune suppressive therapy in cardiac sarcoidosis. Vanessa Blumer gave a very engaging and insightful presentation on whether a PA catheter is needed for the cardiogenic shock patient (to which my answer is always ‘yes ’; my view on this has not changed since my fellowship ). Josephine Harrington did an excellent job presenting powerful data on NOAC use in patients with atrial fibrillation and reduced renal function in the COMBINE-AF database (the largest analysis on this topic to date). Anthony Peters gave a very important and clinically relevant presentation on decongestion, quality of life and outcomes among patients hospitalized for HFrEF versus HFpEF. Michelle Kelsey masterfully facilitated a discussion on managing the patient with obesity, new onset diabetes, and a family history of CV disease. Both Josephine and Vanessa did a great job moderating poster sessions.

Seeing our fellows share their research findings and knowledge on a national stage was incredibly rewarding. Indeed, having the opportunity to work with superb trainees is one of the best aspects of our work at Duke. Kudos to our fellows and the faculty mentoring them!

We agree, Sana! Our trainees are superb and we are so proud of them!

Additionally, Schuyler Jones let us know that the VALOR HCM team presented positive trial results on Saturday at ACC. Duke was the 6th highest enrolling site and Kim Biever was one of the CRCs recognized on the enrollment ranking. Great job, Kim and to Duke’s VALOR HCM team!

We also learned that Midge Bowers led Cardio-OB simulations at ACC. Way to go!

Our late-breaker teams received quite a bit of news coverage this week. Check it out below in our news section.

Mentz Recognized with Master CardioNerd Award

Robert Mentz

We were thrilled to learn this week that Robert Mentz was selected for the Master CardioNerd Award by the CardioNerds team.

“It is with the utmost respect, gratitude, and privilege that we offer you the Master CardioNerd Award. This honor is awarded to a faculty who ‘supports the mission to democratize cardiovascular education.’

The CardioNerds Clinical Trials Network is a major credit to your mentorship, innovation, and vision. We are hopeful that the lessons from this program will be applicable to other subspecialties as we learn how best to enhance trial enrollment that is both efficient and equitable as well as nurture careers in clinical research.

We are also very excited to produce the Decipher the Guidelines Series for the 2022 HF Guidelines with yourself and Dr. Anu Lala as Series Mentors.

CardioNerds is just a 28-month old toddler. Your constant support, mentorship, and encouragement has helped us mature into the platform it is today.  We are eternally grateful and will continue benefiting from your inspiration as we look beyond our terrible twos.”

The message was signed by CardioNerds co-founders Amit Goyal, MD, cardiovascular fellow at the Cleveland Clinic and Daniel Ambinder, MD, interventional/structural cardiology fellow at Johns Hopkins.

The video is a must-see: https://twitter.com/i/status/1512374750114459654

Congratulations, Rob!!!

 

Rymer, Greene Receive AHA Career Development Awards

Jennifer Rymer

Congratulations to Jennifer Rymer, MD and Stephen Greene, MD! Both have

Stephen Greene

been notified that they’ll be receiving Career Development Awards from the American Heart Association.

Rymer’s project title is Implementation of a Medication Adherence Instrument Among Patients with Symptomatic Peripheral Artery Disease after PVI. Her mentors include: Tracy Wang, Schuyler Jones, Hayden Bosworth, Sharron Docherty, and Manesh Patel. Her funding is for three years, effective April 1.

Greene’s project title is Use and Effectiveness of Outpatient Intravenous Diuretic Therapy as Treatment of Worsening Heart Failure. He will study the clinical and economic implications of treating select patients with worsening heart failure using an outpatient IV diuretic strategy, as compared with a traditional strategy centered on hospitalization. His mentors include G. Michael Felker, Adrian Hernandez, Brad Hammill, Javed Butler of the University of Mississippi Medical Center, and Greg Fonarow at UCLA. Funding is for three years, effective April 1.

Such great news! Congratulations!

Kudos to Glower

We received the following note regarding Donald Glower, MD:

Donald Glower

“Good Afternoon, I had the opportunity to spend time this afternoon with a patient who was being discharged from 3300 after valve surgery by Dr. Glower. He was effusive in his praise for his team. He noted that Dr. Glower communicated well and rounded on him, personally, often 2 times/day. He felt lucky to have had the very best for his surgery. He noted that his nurses, especially all in the ICU (whose names he could not recall) and Connie on 3300 were outstanding. He also called out by name Valerie, who kindly took his food order and was so professional and caring. He feels like he has a new lease on life and is grateful for your care. Thank you all for the part you have played and please forward this to those whose last names I do not have. Very best wishes, Lisa”

Lisa Clark Pickett MD FACS

Assistant Professor of Surgery and Medicine, Duke University & Chief Medical Officer, Duke University Hospital

Great work, Don!

 

Harpole Named Geller Distinguished Professor

We are pleased to share with you that thoracic surgeon David H. Harpole, Jr., MD, professor of surgery in the Division of Cardiovascular and Thoracic Surgery, will be named the George Barth Geller Distinguished Professor for Research in Cancer effective July 1, 2022.

Wonderful news, David! Congratulations!!

 

Kudos to Carlisle

We received the following note regarding cardiology fellow Matt Carlisle:

“Dr. Matt Carlisle came to see a rapidly decompensating patient in the Emergency Department recently. He had just began his shift when he received a phone call from the ED Cardiology Consult provider about an unstable patient. He came immediately to bedside to assess the patient. Ultimately, he placed an urgent temporary pacemaker in the patient. Dr. Matt Carlisle is always attentive to patient needs, and is super kind and helpful to his coworkers.” — Jordan Hausladen, Advanced Practice Provider, Division of Cardiology

Way to go, Matt!

Duke Sonographers Attend NCUS

The North Carolina Ultrasound Society’s 42nd annual Spring Symposium was held last weekend in Wilmington, NC. Congratulations to the Duke Heart CDU and Duke Cardiac Ultrasound Program for representing Duke at the conference this year!

Cardiac Sonographer Jon Owensby gave the Saturday morning lecture on Aortic Stenosis Evaluation and cardiac sonographer Jayne Leypoldt gave the Sunday morning lecture on Mitral Regurgitation; student Courtney Snyder entered the Scientific Exhibit competition, winning 3rd place for a stellar exhibit on Pericardiocentesis!

We have an incredible and active sonography team within Duke Heart! Great job!

Duke Heart Network Visit to Frey Regional

Members of the Duke Heart Network and Duke Heart leadership team received a warm welcome at Frey Regional during a site visit held on March 21.

Shown L-R are: Jill Engel, Katie Troxler, Desiree Bonadonna, Lisa Kotyra, Trevor Krawchuk, Dr. Edward P. Chen, Dr. Brett Starr (CT surgeon at Frey) and Pam Peaks.

Palma Appointed Commissioner for CAAHEP

Richard Palma, program director of the Duke Cardiac Ultrasound Certificate Program, has been appointed as a commissioner for the Commission on Accreditation of Allied Health Education Programs (CAAHEP) representing Hospital/VA Based Educational Institutions.

His 3-year term began late last month. Congratulations, Richie!

 

Join the NC Walk for Victory, April 23 – Support Marfan!

We are looking forward to the upcoming NC Walk for Victory in support of the Marfan Foundation and the many families they help. The walk is coming up on Saturday, April 23. Event details are below, under “events”. We have 125 registered participants with seven new families joining the walking teams from 2021. Please consider joining us! To learn more, visit: https://duke.is/phzdy.

 

COVID-19 Updates

Second Booster Shot Available for Eligible Faculty, Staff and Students

Duke is now offering second booster shots of the COVID-19 vaccine for eligible faculty, staff and students over the age of 50, as well as anyone who is considered severely immunocompromised to increase their protection against severe disease.

Following approval by the U.S. Food and Drug Administration and the Centers for Disease Control and Prevention last week, Duke will offer the Pfizer vaccine as a second booster shot for those who have had their first booster shot at least four months ago. The second booster shot is not currently required for Duke students, faculty or staff, but it is offered as an option for those who are eligible.

Second booster shots are available by appointment or walk-in at the Duke Medical Pavilion in Conference Room 2w91, Duke Clinic 1J, Duke Regional Hospital and Duke Raleigh Hospital. For more information or to schedule an appointment, visit the Duke COVID Vaccine website. Eligible faculty, staff and students are also encouraged to consider vaccination options at local pharmacies or their healthcare provider.

All the latest Clinical Operations updates related to COVID can be found at https://covid-19.dukehealth.org. Patient-facing resources on DukeHealth.org can be found here: https://www.dukehealth.org/covid-19-update/resources. Duke University maintains a resource page as well, which can be accessed here: https://coronavirus.duke.edu/updates/for-staff.

Upcoming Events & Opportunities

Cardiology Grand Rounds

April 19:  Treating the Epidemic after the Pandemic with Mark Newman (University of Kentucky). 5 p.m. In-person, DN2002. Online link coming soon.

April 20:  Alignment for a Healthier State (Reves Lecture) with Mark Newman (University of Kentucky). 7 a.m. In-person, DN 2001. Online link coming soon.

Dr. Mark Newman currently serves as Executive Vice President of Health Affairs at the University of Kentucky. The Reves Visiting Professorship and Lecture is supported by the philanthropic efforts of our donors in honor of Jerry Reves, MD, former chair of Duke Anesthesiology and a co-founder of Duke Heart Center. Note: seating for the in-person lectures will be limited to half the room capacity due to COVID protocols.

 

Duke Heart CME

April 23: Duke Sports Cardiology & Sudden Death in Athletes Symposium with course directors Jim Daubert and Bill Kraus. Virtual. For information or to register, please visit: https://duke.is/gkffw. If you have additional questions, please contact Christy Darnell christy.darnell@duke.edu or 919-880-8686.

 

Marfan NC Walk for Victory, April 23

The North Carolina Walk for Victory to support Marfan patients and their families will take place on Saturday, April 23, 2022 from Noon to 3 p.m. at Laurel Hills Park on Edwards Mill Road in Raleigh.

Duke Heart is proud to serve as the presenting sponsor and we are excited for Chad Hughes, MD to serve as medical chair for the walk.

Please help us support all Marfan families as well as those with Loeys-Dietz (LDS), Vascular Ehlers-Danlos (VEDS), and related conditions. Donate or come join us at the event! Parking is easy to access and free.

Walk for Victory is The Marfan Foundation’s global walk program. The event is low-key, fun and family-oriented. To learn more or to register for this event, please visit: https://give.marfan.org/event/2022-north-carolina-walk-for-victory/e353032.

To learn more about The Marfan Foundation, please visit marfan.org.

 

MDEpiNet Spring 2022 Virtual Mini-Think Tank

May 5: MDEpiNet Spring 2022 Virtual Mini-Think Tank. Noon – 5:30 p.m., ET

MDEpiNet Predictable And SuStainable Implementation Of National CardioVascular Registries (PASSION CVR) Registry-Supported Prospective Clinical Trials

Join and invite your colleagues to join for updates from, and dialogues across our Registry-supported Prospective Trials Working Groups:

  • Data Governance & Access
  • Operational Roles & Responsibilities
  • Global Regulatory Acceptance
  • Use Cases:
    • Aortic Intervention
    • Heart Valves
    • Mechanical Circulatory Support
    • Peripheral Arterial Intervention

Registration now open: https://duke.qualtrics.com/jfe/form/SV_2f6JBD6WfaF9jBc.

 

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

 

Duke Heart in the News:

March 31 — Harold Koenig (psychiatry) and Rachel Tobin (internal medicine)

Medscape

Spiritual Interventions Improve QOL, Outcomes in HF

https://duke.is/mq7ba

April 3 — Sean Pokorney and Jonathan Piccini

Cardiac Rhythm News

ACC.22: Analysis shows low rate of device removal in case of CIED infection

https://duke.is/rttj3

April 4 — Robert Mentz

CBS News*

Spirituality and Heart Health

https://duke.is/b6cpq

*carried by 152 additional news outlets

April 4 — Manesh Patel and Jonathan Piccini

News-Medical.net

New type of anti-clotting drug reduces bleeding incidents among patients with atrial fibrillation

https://duke.is/c5puu

April 4 — Stephen Greene

Practical Cardiology

Q&A on SODIUM-HF and Impact of Salt Restriction, with Stephen Greene, MD

https://duke.is/5kpcc

April 4 — Sean Pokorney

News-Medical.net

Just 18% of patients have their infected heart devices removed, even though removal is recommended

https://duke.is/w7f3j

April 4 — Sean Pokorney and Jonathan Piccini

Cardiology Today

Most patients with implantable device infections do not receive extraction

https://duke.is/6jtwe

 

April 4 — Sean Pokorney

tctMD

Most Infected Cardiac Implanted Electronic Devices Not Removed Fast Enough

https://duke.is/p4p5m

April 4 — Sean Pokorney

Modern Healthcare

Doctors aren’t removing infected heart implants, resulting in patient deaths, study finds

https://duke.is/4szqk

April 4 — G. Michael Felker

News-Medical.net

Experimental heart failure drug has little impact on exercise tolerance

https://duke.is/jrq7t

April 4 — G. Michael Felker

Cardiovascular Business

Cholesterol medications, flu shots and heart failure: Day 2 at ACC.22

https://duke.is/ybzsn

April 4 — Manesh Patel

Endpoints News

Running behind Bristol Myers and J&J, Bayer inches forward in the next-gen blood thinner race

https://duke.is/9ecn2

April 5 — Sean Pokorney and Jonathan Piccini

Medtech Dive

Nearly 80% of patients with infection following cardiac implant not treated appropriately: study

https://duke.is/2ycax

April 5 — Stephen Greene

Practical Cardiology

Don’t Miss a Beat: ACC.22 Recap of DIAMOND, SODIUM-HF, and PROMPT-HF

https://duke.is/gwet6

April 5 — Sean Pokorney

ScienceBlog.com

Few Patients Have Infected Heart Devices Removed Despite Lifesaving Benefits

https://duke.is/v3qrf

April 6 — Manesh Patel

Medscape

Less Bleeding With Factor XI Inhibitor Anticoagulant? PACIFIC-AF

https://duke.is/7mz84

April 6 — G. Michael Felker

Medical Dialogues

Omecamtiv Mecarbil Has Little Impact on Exercise Tolerance in HF Patient: METEORIC-HF Trial

https://duke.is/mv7y6

April 6 — Sean Pokorney

MDEdge.com

Extraction of infected implanted cardiac devices rare, despite guidelines

https://duke.is/65qs2

April 7 — Sean Pokorney

Medscape

Extraction of Infected Implanted Cardiac Devices Rare, Despite Guidelines

https://duke.is/8pcgb

Division of Cardiology Publications Indexed in PubMed March 31 – April 6, 2022

Avezum Á, Oliveira GBF, Oliveira H, Lucchetta RC, Pereira VFA, Dabarian AL, D O Vieira R, Silva DV, Kormann APM, Tognon AP, De Gasperi R, Hernandes ME, Feitosa ADM, Piscopo A, Souza AS, Miguel CH, Nogueira VO, Minelli C, Magalhães CC, Morejon KML, Bicudo et al. Hydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE – Coalition V): A double-blind, multicentre, randomised, controlled trial. Lancet Reg Health Am 2022 Jul;11:100243. PM: 35378952.

Bishawi M, Lee FH, Abraham DM, Glass C, Blocker SJ, Cox DJ, Brown ZD, Rockman HA, Mao L, Slaba TC, Dewhirst MW, Truskey GA, Bowles DE. Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure. iScience 2022 Mar 16;25(4):104086. PM: 35378858.

Coylewright M, Dodge SE, Bachour K, Hossain S, Zeitler EP, Kearing S, Douglas PS, Holmes D, Reddy VY, Nair D. Women in procedural leadership roles in cardiology: The Women In Local Leadership (WILL) observational study. Heart Rhythm 2022 Apr;19(4):623-629. PM: 34923161.

Dong OM, Poonnen PJ, Winski D, Reed SD, Vashistha V, Bates J, Kelley MJ, Voora D. Cost-Effectiveness of Tumor Genomic Profiling to Guide First-Line Targeted Therapy Selection in Patients With Metastatic Lung Adenocarcinoma. Value Health 2022 Apr;25(4):582-594. PM: 35365302.

Dzau VJ, Ellaissi WF, Krishnan KRR, Balatbat CA. How Academic Health Systems Can Be Ready for the Next Pandemic. Acad Med 2022 Apr 1;97(4):479-483. PM: 34966030.

Khan MS, Segar MW, Usman MS, Singh S, Greene SJ, Fonarow GC, Anker SD, Felker GM, Januzzi JL, Butler J, Pandey A. Frailty, Guideline-Directed Medical Therapy, and Outcomes in HFrEF: From the GUIDE-IT Trial. JACC Heart Fail 2022 Apr;10(4):266-275. PM: 35361446.

Martin CK, Höchsmann C, Dorling JL, Bhapkar M, Pieper CF, Racette SB, Das SK, Redman LM, Kraus WE, Ravussin E. Challenges in defining successful adherence to calorie restriction goals in humans: Results from CALERIE™ 2. Exp Gerontol 2022 Jun 1;162:111757. PM: 35240264.

Morrill J, Qirko K, Kelly J, Ambrosy A, Toro B, Smith T, Wysham N, Fudim M, Swaminathan S. A Machine Learning Methodology for Identification and Triage of Heart Failure Exacerbations. J Cardiovasc Transl Res 2022 Feb;15(1):103-115. PM: 34453676.

Rao VN, Fudim M, Wang J. Beyond the Anatomy of Renal Nerves: Functional Diversity of Renal Nerves. J Cardiovasc Transl Res 2022 Feb;15(1):27-28. PM: 35212975.

Tobin RS, Cosiano MF, O’Connor CM, Fiuzat M, Granger BB, Rogers JG, Tulsky JA, Steinhauser KE, Mentz RJ. Spirituality in Patients With Heart Failure. JACC Heart Fail 2022 Apr;10(4):217-226. PM: 35361439.

Vinson AJ, Singh S, Chadban S, Cherney D, Gaber O, Gill JS, Helgeson E, Herzog CA, Jardine M, Jha V, Kasiske BL, Mannon RB, Michos ED, Mottl AK, Newby K, Roy-Chaudhury P, Sawinski D, Sharif A, Sridhar VS, Tuttle KR, Vock DM, Matas A. Premature Death in Kidney Transplant Recipients: The Time for Trials is Now. J Am Soc Nephrol 2022 Apr;33(4):665-673. PM: 35292438.

Xiong X, Nazo N, Revoori R, Rajagopal S, Sparks MA. G protein- and -arrestin Signaling Profiles of Endothelin Derivatives at the Type A Endothelin Receptor. Kidney360 2021 May 17;2(7):1124-1131. PM: 35368349.

Xu H, Granger BB, Drake CD, Peterson ED, Dupre ME. Effectiveness of Telemedicine Visits in Reducing 30-Day Readmissions Among Patients With Heart Failure During the COVID-19 Pandemic. J Am Heart Assoc 2022 Apr 5;11(7):e023935. PM: 35229656.

 

 

Duke Heart week ending April 3rd 2022

Chief’s message:

Living in the Moment:

If anything, the last few years have taught us how fragile our usual way life is and how much things can change quickly.  This week’s Pulse is notable for the fact that the American College of Cardiology conference has been going on both virtually but also in-person this weekend.  The conference has had vaccination confirmation and masking, but still has quite a bit of great science and clinical sessions that our fellows and faculty have worked to present.  You will see some of it here and more over the upcoming months.  More importantly has been the ability to see people (not on zoom) and exchange ideas and just be back together has been important.  The weekend of course has also had the ups and downs (depending on your shades of blue) around the Final Four.  The outcome of the game, despite not being favorable for the Duke side of the world, has also underscored the refrain from the pandemic to Coach K of living in the moment.  The ability to appreciate your colleagues, friends, and most importantly family.  As we continue to go through the changes in our healthcare environment, the unknown around virus resurgences or getting back to life, we hope you all have time to spend with loved ones.  The conference this week has highlighted for Duke Cardiology the value of our colleagues, alumni, fellows, and friend near and far.  More than ever – it has also provided an opportunity to enjoy and live in the moment  for our group.

Highlights of the week:

ACC.22: Few Patients Have Infected Heart Devices Removed Despite Lifesaving Benefits

Medicare patients whose implantable heart devices became infected were less likely to die from the complication if they had the hardware removed compared to patients who only received antibiotics, according to the largest study on the topic, led by the Duke Clinical Research Institute.

The study showed that just 18 percent of patients with device infections underwent surgeries to have their pacemakers or defibrillators removed, even though removal is recommended by all leading medical society treatment guidelines. There is a 43-percent lower risk of death in these patients if guidelines are followed.

The findings, reported earlier today as a late-breaker presentation at the 2022 American College of Cardiology Scientific Sessions, highlight that cardiac device infection is a major public health issue, and there are large gaps in guideline adherence.

“This is an important message about a persistent gap in care: These devices should be removed when an

Sean Pokorney

infection occurs, and their removal saves lives,” said lead author Sean D. Pokorney, MD, an electrophysiologist and cardiologist in the Department of Medicine at Duke University School of Medicine. Pokorney is also a member of the Duke Clinical Research Institute.

Pokorney and colleagues launched the study in 2021, using Medicare data for nearly 1.1 million patients who received cardiac implantable electronic devices, or CIEDs, between 2006 and 2019.

Of those study patients, 11,619 (about 1 percent) developed infections a year or more after implantation. Only 13 percent of the patients had the device removed within six days of infection, and an additional 5 percent had them removed from day 7 to 30.

The vast majority — nearly 82 percent — were treated solely with antibiotics, despite numerous earlier studies showing antibiotics fail to wipe out infections involving CIEDs.

Those earlier studies led to a 2017 consensus of leading health organizations to recommend removal of CIEDs when a definitive infection is identified.

In the current study, the researchers found that removing the devices had a clear survival benefit. The death rate for those who did not have their devices removed was 32.4 percent in the year after an infection was diagnosed, compared with a rate of 18.5 percent among patients who underwent extraction within six days and 23.2 percent for patients who had extractions on days 7 to 30.

“Any extraction was associated with lower mortality when compared to no extraction, but the highest benefit was to those who had devices removed within six days of an infection,” Pokorney said. “This speaks to the importance of putting systems in place to identify these patients and get them quickly and appropriately treated, because delays in care result in higher mortality.”

The Duke Clinical Research Institute, with funding from Philips and leadership from Pokorney and Christopher B. Granger, MD, is acting on this data and launching a quality improvement demonstration project to address the gap in care for CIED infection patients within three health care systems in the US.

In addition to Pokorney, study authors include Lindsay Zepel, Melissa A. Greiner, Eric Black-Maier, Robert K. Lewis, Donald D. Hegland, Christopher B. Granger, Laurence M. Epstein, Roger G. Carrillo, Bruce L. Wilkoff, Chantelle Hardy and Jonathan P. Piccini.

The study received funding support from Philips, which markets devices used in CIED extraction procedures. The funder had no role in the design, implementation or publication of the study. Six study authors — Pokorney, Lewis, Epstein, Carillo, Wilkoff, and Piccini — reported ties to the company; a full disclosure is provided in the study manuscript.

ACC.22: Investigational Anti-Clotting Drug Reduces Bleeding Risk Among AF Patients

A new type of anti-clotting drug caused fewer bleeding incidents among patients with atrial fibrillation than the commonly prescribed apixaban, according to results from a head-to-head comparison of the two.

The study, led by cardiologists at Duke, was reported today as a late-breaking presentation at the 2022 American College of Cardiology Scientific Sessions being held in Washington, DC. The results were simultaneously published in the journal The Lancet.

Manesh Patel

“Anti-clotting therapy is a lifesaver for people who develop atrial fibrillation, which can increase the risk of stroke by five-fold,” said presenter and senior author Manesh Patel, MD, chief of the Division of Cardiology at Duke University School of Medicine and member of the Duke Clinical Research Institute. “But a serious complication associated with anti-clotting therapies is bleeding, leading many patients to reduce or stop taking their medications. As a result, there is great interest in alternatives that reduce this risk.”

Asundexian is a new class of anti-clotting drug that is under investigation. It works by inhibiting a blood protein called Factor XI, which contributes to the development of blood clots but is not involved in the process of healing blood vessels.

In the PACIFIC-AF trial — a phase 2 study funded by Bayer AG, which manufactures the investigative therapy — the researchers focused on bleeding outcomes arising from two different doses among patients with atrial fibrillation.

Both doses of asundexian taken once daily, 20 mg and 50 mg, were tested in comparison to similar dosages of apixaban, which is one of several commonly prescribed anti-clotting therapies that affect a different blood clotting protein.

The trial included 755 patients with an average age of about 74 years old. At both doses, patients who took asundexian had a 67-percent lower risk of bleeding compared to patients taking apixaban.

“Reducing bleeding risks for atrial fibrillation patients is encouraging,” said lead author Jonathan Piccini, MD, clinical cardiac electrophysiologist at Duke. “One in four people will develop atrial fibrillation — it’s the leading cause of heart arrhythmia and is a risk factor for stroke — so it’s important that we have safe and effective therapies. We’re eager to see the research move into phase 3 studies.”

In addition to Piccini and Patel, study authors include Valeria Caso, Stuart J. Connolly, Keith A.A. Fox, Jonas Oldgren, W. Schuyler Jones, Diana A. Gorog, Václav Durdil, Thomas Viethen, Christoph Neumann, Hardi Mundl, on behalf of the PACIFIC-AF Investigators.


ACC.22: Investigational Drug for Heart Failure has Little Impact on Exercise Tolerance

Heart failure patients taking the investigational drug omecamtiv mecarbil, which has been previously shown to improve long-term outcomes, see little impact on their ability to exercise compared to a placebo, according to a study supported by Duke Clinical Research Institute (DCRI).

The study was designed to test whether the new therapy — a selective cardiac myosin activator — could yield improvements in overall exercise capacity for patients with heart failure. Therapies that help heart failure patients better tolerate exercise remains an unmet need.

The findings were reported today as a late-breaking presentation at the 2022 American College of Cardiology Scientific Sessions. Circulation: Heart Failure published the study design in March 2022.

Gary Michael Felker

“We are fortunate to have a lot of medications in heart failure that can help patients live longer or stay out of the hospital — all very important goals,” said Duke cardiologist Michael Felker, MD, study co-chair and a member of DCRI.

“However, exercise tolerance is the main symptom patients with heart failure have,” Felker said. “They get tired or out of breath very easily. This is a major impediment for their quality of life. Unfortunately, many of the guideline-directed drugs that improve survival don’t improve exercise tolerance.”

The research study, called the Multicenter Exercise Tolerance Evaluation of Omecamtiv Mecarbil Related to Increased Contractility in Heart Failure (METEORIC-HF), recruited patients across 64 sites in nine countries. It included 276 adult heart failure patients with reduced ejection fraction; they were randomly assigned to receive the study medication or a placebo. The results were blinded to the investigators, the study sponsor, and the participants.

As its primary outcome, METEORIC-HF sought to examine the changes omecamtiv mecarbil had on peak oxygen uptake during cardiopulmonary exercise over a 20-week period. Secondary outcome measurements included assessing overall exercise capacity, ventilator efficiency, and daily activity.

“We found in the trial that even though omecamtiv mecarbil was safe and well-tolerated, it did not improve exercise tolerance over placebo,” Felker said. “I think what that tells us is finding interventions that can improve people’s exercise tolerance is still an unsolved/unmet need for our patients with heart failure. What our trial has done is helped better define what this medication does and doesn’t do.”

During the METEORIC-HF trial, study authors for the Global Approach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure (GALACTIC-HF) trial published their own results. That trial examined outcomes between omecamtiv mecarbil and a placebo in a broad population of over 8,000 symptomatic patients. GALACTIC-HF found that omecamtiv mecarbil decreased the rate of heart failure or death from cardiovascular causes.

Felker and Gregory Lewis, MD, at Massachusetts General Hospital, co-chaired the study.

In addition to Felker and Lewis, study authors include Kieran Docherty, Adriaan Voors, Alain Cohen-Solal, Marco Metra, David Whellan, Justin Ezekowitz, Piotr Ponikowski, Michael Böhm, John Teerlink, Stephen Heitner, Stuart Kupfer, Fady Malik, and Lisa Meng.

Impressive work by all! Please note: We will have additional coverage from ACC.22 next weekend. Stay tuned! Please consider submitting photos from your ACC experience as well as information related to your presentation for inclusion in Pulse; please email your submissions to Tracey Koepke by EOB Wednesday, 4/6. Thank you!

Rymer to Host Post-ACC.22 Twitter Space

Duke Heart is collaborating with Med-IQ to conduct a Twitter Space ‘live’ on Wednesday, April 6 at 6:30 p.m. Join interventional cardiologist Dr. Jennifer Rymer for a recap of highlights from the ACC! Rymer will lead a free-flowing discussion highlighting data presented during the 2022 ACC Scientific Sessions and provide expert insight on the trials. You can follow Jenn on Twitter @jennifer_rymer. You can also follow Med-IQ (@MedIQCME).

When: Wednesday, April 6 at 6:30 p.m. ET

Where: https://twitter.com/i/spaces/1vAxRkbplgqKl

If you’re not familiar with Twitter, all you’ll need to do is visit the Twitter Space at https://twitter.com/i/spaces/1vAxRkbplgqKl and drop in. You DO NOT need a Twitter account just to listen in (simply click the link to join). You only need a Twitter account if you’d like to request to “speak” during the Twitter Space event.

If you can’t join the live space, Med-IQ will have the recording on their Facebook page (https://www.facebook.com/MedIQCME) later next week.

We’re looking forward to this and hope you’ll join us!

Karra & Team Score Grant Funding to Explore Sarcoidosis

Congratulations to Ravi Karra, MD, MHS, and team — they were recently notified that their project, Epithelioid Mechanisms of Sarcoidosis, has been selected for award funding by the Ann Theodore Foundation Breakthrough Sarcoidosis Initiative, supported by the Ann Theodore Foundation.

Sarcoidosis is a systemic disease defined by the presence of granulomas provoked by an unknown trigger. Although central to sarcoidosis, granulomas also occur in other diseases where they serve to contain bacteria or foreign materials. In prior work on infectious granulomas, David Tobin, PhD, an associate professor of Molecular Genetics and Microbiology at Duke and his team have determined that epithelioid cells, found in the granuloma interior, are responsible for the barrier function of the granuloma. Interfering with macrophage epithelioid transformation can loosen the granuloma and allow for inflammatory cells to clear the infection. Karra – who is partnering with Tobin on this project — and team hypothesize that specific targeting of epithelioid cells in sarcoidosis might similarly improve treatment responses. However, before such treatments can be developed, the biology of epithelioid cells in sarcoidosis needs to be better understood.

The goal of the Epithelioid Mechanisms of Sarcoidosis project is to identify key pathways and events that lead to the emergence of epithelioid cells. Their first aim is to use spatial RNA sequencing to profile granuloma formation following the Kveim test, the only system available to induce and follow sarcoid granulomas over time in humans. Their experiments will illuminate where and when signaling pathways are activated in different cell types during granuloma formation and provide a better understanding of how epithelioid cells form in sarcoidosis. Their second aim is to profile changes in DNA and RNA of individual circulating cells. They believe their work will identify why patients with sarcoidosis develop epithelioid cells in response to a trigger, while individuals without sarcoidosis do not.

The team hopes their project can lead to new therapeutic targets for treating sarcoidosis and new diagnostic tests for identifying sarcoidosis.

Duke Heart launched a multidisciplinary sarcoid clinic about one year ago, which has seen regular growth over time. According to Karra, the team has treated 50 sarcoid patients in the past year and are now seeing 2-3 new patients for evaluation each week and that a number of our cardiology fellows have been involved in the work, including Kelly Arps, MD, who will be presenting on arrhythmia concerns related to sarcoid during our next Cardiology Grand Rounds on Tuesday, April 5 (Webex link included in events listing, below).

Congratulations to Ravi and our sarcoid team — this is excellent news!

Shout-out to Barnes, Dimsdale!

The North Carolina Nurses Association held its annual Nurse Practitioner Spring Symposium in Asheville, NC from March 20-23. Presenters from Duke Heart included Stephanie Barnes and Allison Dimsdale.

Way to go!!!

Allison Dimsdale

 

 

 

 

 

 

 

 

 

 

In Memoriam: Kelly Ann Machovec, MD, MPH, Peds Cardiac Anesthesiologist

Kelly Machovec

It is with deep sadness that we share the news of the passing of our colleague, Kelly Ann Machovec, MD, MPH, a pediatric cardiac anesthesiologist and team member with the Duke Pediatric and Congenital Heart Center. She passed away on March 30 at the age of 43.

She will be remembered as an exceptional academician and physician who dedicated her career to improving the lives of children undergoing cardiothoracic or vascular surgery, and for her special impact that was palpable to her colleagues and patients throughout the Duke Children’s Heart Center.

Originally from Baltimore, Maryland, Machovec received her Master of Public Health degree in 2005 and her Doctor of Medicine degree in 2006, both at the University of North Carolina. She went on to complete a residency in anesthesiology at Drexel University College of Medicine in Philadelphia and a fellowship in pediatric anesthesiology at Duke University School of Medicine. In 2013, Dr. Machovec joined Duke Anesthesiology faculty as an assistant professor of anesthesiology; she was appointed an associate professor of anesthesiology in 2019. She was an accomplished pediatric anesthesiologist whose research primarily focused on the hemostasis management of children following open heart surgery performed on cardiopulmonary bypass.

Earlier this year she received the Duke Pediatric and Congenital Heart Center Impact Award, recognizing her exceptional impact on the clinical practice around hemostasis, on both local and national levels. She was a fierce advocate for child-centered health care policies and always questioned the status quo. For example, she led the charge to discontinue preoperative blood testing in children to prevent them from having unnecessary painful blood draws in the preoperative clinic.

Dr. Machovec’s excellence and research led to her invitation to write the book chapter on “Anesthesia for Pediatric Cardiac Surgery” in Miller’s Anesthesia textbook. In 2015, she co-founded the Hemostasis Interest Group, a committee within the Congenital Cardiac Anesthesia Society which she served on for six years as committee chair, member and mentor; she also served as an at-large member on the Board of Directors of the Congenital Cardiac Anesthesia Society. Dr. Machovec was a passionate educator, serving as chair of the Clinical Competency Committee for Duke’s Pediatric Anesthesiology Fellowship and as a question writer and committee member for the American Board of Anesthesiology’s Pediatric Maintenance of Certification.

In addition to being an outstanding clinician and a dedicated educator, she was recognized with the high honor of the Leonard Tow Humanism in Medicine Award at the Duke University School of Medicine in March of this year. Recipients of this distinguished award are recognized as exemplars of humanism in the care of their patients, their compassionate delivery of care and respectfulness given to their patients and health care colleagues, as well as for their clinical excellence.

Beyond her career, Dr. Machovec advocated and raised funds for basic science research. From 2013-2017, she also advocated for pediatric health care on a global scale by taking part in medical missions in India, the Philippines and Haiti for Operation Smile, which helps children with cleft lip and cleft palate, and Gift of Life International, which provides lifesaving cardiac treatment to children in need from developing countries.

When introduced by Dr. Edmund Jooste prior to her delivery of Duke Anesthesiology Grand Rounds last year, Dr. Machovec was described as having “the determination of Ruth Bader Ginsberg, the curiosity of Marie Curie and fierceness of Wonder Woman” and these are the qualities that her work family loved and admired in her. She was also described as funny, strong-willed and energetic, and a dedicated team member who will be deeply missed by her pediatric anesthesiology colleagues and all of her interprofessional friends and colleagues within Duke Anesthesiology and the Pediatric Heart Center.

To preserve Dr. Machovec’s legacy at Duke, the Department of Anesthesiology has formally established the Kelly Machovec Humanism Award. The recipient of this annual departmental award will exemplify grace and compassion in their delivery of patient-centered care, reverence for patients, their loved ones and colleagues, ethical principles, and a continuous commitment to clinical excellence.

Most importantly, Dr. Machovec’s legacy will live on through her family. She was a dedicated and loving wife to her husband, Scott Matthews, and proud mother to her three young daughters, Vivienne, Eva and Caroline. Her loved ones will remember her as an engaged, talented and powerful woman with unwavering passion and optimism, who loved spending time with her family and friends, running, practicing yoga, reading, and baking.

A Celebration of Life will be held on Monday, April 11 from 5:00 – 8:00 p.m. at the Rigmor House, 5501 NC Highway 54, in Chapel Hill. All are welcome to attend. The family kindly requests that if you do plan to attend, please respond via this link for catering purposes.

We extend our deep condolences to Dr. Machovec’s family, friends and colleagues. Duke flags were lowered on Friday in honor of her life and legacy. They will remain lowered through Monday. At the request of her family, in lieu of flowers, memorial gifts may be made in her name to the Dana-Farber Cancer Institute.

 

COVID-19 Updates

All the latest Clinical Operations updates related to COVID can be found at https://covid-19.dukehealth.org.

Upcoming Events & Opportunities

Cardiology Grand Rounds

April 5: Cardiac Sarcoidosis: Updates and Contemporary Challenges with Kelly Arps. 5 p.m. via Webex.

Duke Heart CME

April 23: Duke Sports Cardiology & Sudden Death in Athletes Symposium with course directors Jim Daubert and Bill Kraus. Virtual. For information or to register, contact Christy Darnell christy.darnell@duke.edu or 919-880-8686.

 

Marfan NC Walk for Victory, April 23

The North Carolina Walk for Victory to support Marfan patients and their families will take place on Saturday, April 23, 2022 from Noon to 3 p.m. at Laurel Hills Park on Edwards Mill Road in Raleigh. Duke Heart is proud to serve as the presenting sponsor and we are excited for Chad Hughes, MD to serve as medical chair for the walk.

Please help us support all Marfan families as well as those with Loeys-Dietz (LDS), Vascular Ehlers-Danlos (VEDS), and related conditions. Donate or come join us!

Walk for Victory is The Marfan Foundation’s global walk program. The event is low-key, fun and family-oriented. To learn more or to register for this event, please visit: https://give.marfan.org/event/2022-north-carolina-walk-for-victory/e353032.

To learn more about The Marfan Foundation, please visit marfan.org.

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

 

Duke Heart in the News:

March 17 — Pamela Douglas

Medscape

ACC Looks to Build Inclusive, Bully-Free Cardiology Workplaces

https://duke.is/zrp29

 

March 19 — Adrian Hernandez

The Western Journal

After Concerted Effort to Bury Ivermectin, New Bill Would Put This Medicine in the Hands of the American People

https://duke.is/v2tjr

 

March 22 – Joseph Turek, Mary Louise Markert and Allan Kirk

Medical News Today

Novel heart-thymus transplant technique may spell end of lifelong drugs

https://duke.is/ydzhp

 

March 24 — Nishant Shah

Cardiology Advisor

Mean Monthly BP Increased Among US Adults During COVID-19

https://duke.is/j7q7j

 

March 27 — Renato Lopes

Healio/Cardiology Today

Alirocumab does not impact AF risk after ACS

https://duke.is/wffkg

 

March 29 — Duke University/Duke Health

Becker’s Hospital Review

Best medical schools for 2023: US News

https://duke.is/ckpuc

 

March 29 — Duke University/Duke Health

Becker’s Hospital Review

10 best nursing schools for master’s and DNPs, as ranked by US News

https://duke.is/bgcp8

 

March 30 — Joseph Turek

Nation (Kenya)

New procedure gives hope to transplant patients

https://duke.is/nb7bn

 

March 31 — Sunil Rao

Cardiovascular News

SCAI aims to minimise risks in medical proctoring of new techniques and technologies

https://duke.is/5jcmw

 

 

Division of Cardiology Publications Indexed in PubMed March 17-23, 2022

Blumer V, Parsons JB, Anderson DR, Bloomfield GS, Ward C. Hemophagocytic Lymphohistiocytosis Associated With Endocarditis: A Case Years in the Making. Circulation 2022 Mar 22;145(12):934-939. PM: 35312382.

Dangas G, Baber U, Sharma S, Giustino G, Sartori S, Nicolas J, Goel R, Mehta S, Cohen D, Angiolillo DJ, Zhang Z, Camaj A, Cao D, Briguori C, Dudek D, Escaned J, Huber K, Collier T, Kornowski R, Kunadian V, Moliterno DJ, Ohman EM, Weisz G, Gil R, Krucoff M. Safety and efficacy of ticagrelor monotherapy according to drug-eluting stent type: the TWILIGHT-STENT study. EuroIntervention 2022 Mar 18;17(16):1330-1339. PM: 34881696.

El-Chami MF, Bockstedt L, Longacre C, Higuera L, Stromberg K, Crossley G, Kowal RC, Piccini JP. Leadless vs. transvenous single-chamber ventricular pacing in the Micra CED study: 2-year follow-up. Eur Heart J 2022 Mar 21;43(12):1207-1215. PM: 34788416.

Fagundes A, Berg DD, Bohula EA, Baird-Zars VM, Barnett CF, Carnicelli AP, Chaudhry SP, Guo J, Keeley EC, Kenigsberg BB, Menon V, Miller PE, Newby LK, van Diepen S, Morrow DA, Katz JN. End-of-life care in the cardiac intensive care unit: a contemporary view from the Critical Care Cardiology Trials Network (CCCTN) Registry. Eur Heart J Acute Cardiovasc Care 2022 Mar 16;11(3):190-197. PM: 34986236.

Friedman DJ, Qin L, Parzynski C, Heist EK, Russo AM, Ranasinghe I, Zeitler EP, Minges KE, Akar JG, Freeman JV, Curtis JP, Al-Khatib SM. Longitudinal Outcomes of Subcutaneous or Transvenous Implantable Cardioverter-Defibrillators in Older Patients. J Am Coll Cardiol 2022 Mar 22;79(11):1050-1059. PM: 35300816.

Gallagher EJ, Rockey DC, Kontos CD, Vyas JM, Brass LF, Hu PJ, Isales CM, Ajijola OA, Rathmell WK, Conlin PR, Baiocchi RA, Kazmierczak BI, Akabas MH, Williams CS. Pearls of wisdom for aspiring physician-scientist residency applicants and program directors. JCI Insight 2022 Mar 22;7(6):10.1172/jci.insight.158467. PM: 35315364.

Gulati M, Korn RM, Wood MJ, Sarma A, Douglas PS, Singh T, Merz NB, Lee J, Mehran R, Andrews OA, Williams JC. Childbearing Among Women Cardiologists: The Interface of Experience, Impact, and the Law. J Am Coll Cardiol 2022 Mar 22;79(11):1076-1087. PM: 35300820.

Haeusler KG, Eichner FA, Heuschmann PU, Fiebach JB, Engelhorn T, Blank B, Callans D, Elvan A, Grimaldi M, Hansen J, Hindricks G, Al-Khalidi HR, Mont L, Nielsen JC, Piccini JP, Schotten U, Themistoclakis S, Vijgen J, Di Biase L, Kirchhof P. MRI-Detected Brain Lesions and Cognitive Function in Patients With Atrial Fibrillation Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial. Circulation 2022 Mar 22;145(12):906-915. PM: 35135308.

Mansour M, Radaideh Q, Alaiwah MN, Alnimer Y, Devabhaktuni SR, Dhar G, Vallurupalli S, Michos ED, Newby DE, Williams MC, Fudim M, Al’Aref SJ. Major adverse cardiac events in symptomatic women with non-obstructive CAD on coronary CTA: pooled analysis from PROMISE and SCOT-HEART. Int J Cardiovasc Imaging 2022 Mar;38(3):683-693. PM: 34628593.

Parker DC, Wan M, Lohman K, Hou L, Nguyen AT, Ding J, Bertoni A, Shea S, Burke GL, Jacobs DR, Post W, Corcoran D, Hoeschele I, Parks JS, Liu Y. Monocyte miRNAs Are Associated With Type 2 Diabetes. Diabetes 2022 Apr 1;71(4):853-861. PM: 35073575.

Pinsker BL, Serfas JD, Krasuski RA. Burden and Impact of Arrhythmias in Repaired Tetralogy of Fallot. Curr Cardiol Rep 2022 Mar;24(3):225-234. PM: 35138576.

Salah HM, Minhas AMK, Khan MS, Khan SU, Ambrosy AP, Blumer V, Vaduganathan M, Greene SJ, Pandey A, Fudim M. Trends and characteristics of hospitalizations for heart failure in the United States from 2004 to 2018. ESC Heart Fail 2022 Apr;9(2):947-952. PM: 35098700.

Usman MS, Khan MS, Fonarow GC, Greene SJ, Friede T, Vaduganathan M, Filippatos G, Coats AJS, Anker SD, Butler J. Robustness of outcomes in trials evaluating sodium-glucose co-transporter 2 inhibitors for heart failure. ESC Heart Fail 2022 Apr;9(2):885-893. PM: 35029056.

Voors AA, Angermann CE, Teerlink JR, Collins SP, Kosiborod M, Biegus J, Ferreira JP, Nassif ME, Psotka MA, Tromp J, Borleffs CJW, Ma C, Comin-Colet J, Fu M, Janssens SP, Kiss RG, Mentz RJ, Sakata Y, Schirmer H, Schou M, Schulze PC, Spinarova L, Volterrani. The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial.                                                       Nat Med 2022 Mar;28(3):568-574. PM: 35228754.

Zheng K, Smith JS, Eiger DS, Warman A, Choi I, Honeycutt CC, Boldizsar N, Gundry JN, Pack TF, Inoue A, Caron MG, Rajagopal S. Biased agonists of the chemokine receptor CXCR3 differentially signal through Gα:β-arrestin complexes. Sci Signal 2022 Mar 22;15(726):eabg5203. PM: 35316095.

Division of Cardiology Publications Indexed in PubMed March24-30, 2022

Alexander JH. Equipoise in Clinical Trials: Enough Uncertainty in Whose Opinion? Circulation 2022 Mar 29;145(13):943-945. PM: 35344405.

Elgendy IY, Wegermann ZK, Li S, Mahtta D, Grau-Sepulveda M, Smilowitz NR, Gulati M, Garratt KN, Wang TY, Jneid H. Sex Differences in Management and Outcomes of Acute Myocardial Infarction Patients Presenting With Cardiogenic Shock. JACC Cardiovasc Interv 2022 Mar 28;15(6):642-652. PM: 35331456.

Komisarow JM, Toro C, Curley J, Mills B, Cho C, Simo GM, Vavilala MS, Laskowitz DT, James ML, Mathew JP, Hernandez A, Sampson J, Ohnuma T, Krishnamoorthy V. Utilization of Brain Tissue Oxygenation Monitoring and Association with Mortality Following Severe Traumatic Brain Injury. Neurocrit Care 2022 Apr;36(2):350-356. PM: 34845596.

Rao SV. RESPONSE: Navigating the Transition From Fellowship to Early Career: “Sink or Swim” to “Lifting All Boats”. J Am Coll Cardiol 2022 Mar 29;79(12):1218-1219. PM: 35331418.

Xian Y, Xu H, Smith EE, Saver JL, Reeves MJ, Bhatt DL, Hernandez AF, Peterson ED, Schwamm LH, Fonarow GC. Achieving More Rapid Door-to-Needle Times and Improved Outcomes in Acute Ischemic Stroke in a Nationwide Quality Improvement Intervention. Stroke 2022 Apr;53(4):1328-1338. PM: 34802250.

 

Duke Heart Week ending March 27th 2022

Highlights of the week:

Milano, Ward to Receive Distinguished Palumbo Award

We are thrilled to share that two Duke Heart faculty members have been selected to receive the 2022 Leonard Palumbo Jr., MD Faculty Achievement Award.

Carmelo Milano

Cardiovascular and thoracic surgeon Carmelo Milano, MD, and cardiologist Cary Ward, MD, were selected by a committee of Duke faculty members.

According to a message from Ann Brown, MD, MHS, vice dean for faculty, Duke University School of Medicine, “The committee found this year’s nominees exceptionally impressive, making it extremely difficult to select one recipient for this award.”

The Palumbo award honors a faculty member who displays both a dedication to compassionate patient care and excellence in the teaching and mentoring of young physicians.

The award is named for Dr. Leonard Palumbo Jr., who completed his undergraduate and medical degrees, as well as his clinical training, here at Duke. Dr. Palumbo was a compassionate and empathetic clinician and a dedicated and talented educator. His commitment to both patients and students inspired the establishment of this award in 1999 by his brother, also a Duke alumnus, Art Palumbo.

Milano and Ward will be presented the awards at the upcoming annual School of Medicine Spring Faculty Celebration currently planned as an in-person event on Tuesday, May 10, at 5 p.m. at the Sarah Duke Gardens.

We will share more information as it becomes available. We are so pleased for Cary and Carmelo! Congratulations!

Please Join Us at ACC.22 – We will be watching the Final Four Game at the Reception….

Saturday April 2nd 5:30-8:30 PM RedBud Room Renaissance Hotel Washington DC

 

Scientific Presence at American College of Cardiology 2022.  Cardiology Faculty and Fellows will have several presentations at the upcoming meeting and we will update those in the upcoming week.

Celebrating Heart Units 7100 and 6E – CLABSI Free Day Milestones!

Duke University Hospital Unit 7100 has gone more than 700 days since having a Central Line-Associated Bloodstream Infection (CLABSI) attributed to one of their patients. Pictured here are the 7100 Hospital Acquired Infection (HAI) Champion, Amanda Burke with her co-worker Ann Keiper and (second photo) Lisa Duncan, 7100 Nurse Manager, with unit team members.

Similarly, Duke Medical Pavilion 6 East has gone more than 800 days since having a CLABSI attributed to one of their patients. Pictured here are the 6 East HAI Champions, Jose Kaminski and Mutya Valente and (second photo) the 6 East Nurse Manager, Ciarra Ashley and unit team members.

Way to go, Duke Heart units! Keep up the great work!

 

Duke Heart Grows by One

Congratulations to Fran Cosgrove Reda, one of our amazing cardiology NPs, and Jonathan Reda on the birth of their daughter, Kay Lennon Reda, born March 12. Mom and baby are doing well. We are thrilled for Fran and her family – welcome to the Duke Heart family, Kay. We are excited to meet you!

 

COVID-19 Updates

All the latest Clinical Operations updates related to COVID can be found at https://covid-19.dukehealth.org.

Upcoming Events & Opportunities

 

Marfan NC Walk for Victory, April 23

The North Carolina Walk for Victory to support Marfan patients and their families will take place on Saturday, April 23, 2022 from Noon to 3 p.m. at Laurel Hills Park on Edwards Mill Road in Raleigh. Duke Heart is proud to serve as the presenting sponsor and we are excited for Chad Hughes, MD to serve as medical chair for the walk.

Please help us support all Marfan families as well as those with Loeys-Dietz (LDS), Vascular Ehlers-Danlos (VEDS), and related conditions. Donate or come join us!

Walk for Victory is The Marfan Foundation’s global walk program. The event is low-key, fun and family-oriented. To learn more or to register for this event, please visit: https://give.marfan.org/event/2022-north-carolina-walk-for-victory/e353032.

To learn more about The Marfan Foundation, please visit marfan.org.

Duke Heart CME

April 23: Duke Sports Cardiology & Sudden Death in Athletes Symposium with course directors Jim Daubert and Bill Kraus. Virtual. For information or to register, contact Christy Darnell christy.darnell@duke.edu or 919-880-8686.

 

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

 

Duke Heart in the News will resume coverage next weekend

Duke Heart Week ending March 20th 2022

Highlights of the week:

Swaminathan Elected to SCAI’s Board of Trustees

Congratulations to Raj Swaminathan! We learned this week that Swaminathan has been elected to the Board of Trustees for the Society for Cardiovascular Angiography and Interventions (SCAI), the international professional society for interventional cardiology. The SCAI Board of Trustees is responsible for furthering SCAI’s mission and for setting its long-term priorities and goals. The Board establishes and oversees the strategic plan and all related activities.

Well-deserved, Raj!

Cardiology is the Family Business for Kelsey Mother-Daughter Duo

The weekly Kelsey family meal—lunch at Duke Cardiology Arringdon Clinic—is a time to catch up for Duke cardiology fellow Michelle Kelsey, MD, and her cardiologist Mom, Anita Kelsey, MD, MBA, professor of medicine.

Michelle likes to bring the meal each Thursday when she’s working at the Morrisville, NC, clinic as part of her research fellowship at the Duke Clinical Research Institute where she is working toward a master’s degree in health science. It’s just one of the ways she makes it a point to show support and appreciation for Mom.

“She knows how much I love taking care of patients and she has respected all of the things that I was doing that take away from family time so, to her credit, Michelle made my life a lot easier,” Anita says. “A doctor cannot be successful if their family is not supportive.”

Growing up as the child of a physician, Michelle understands that traditional family time often has to take a back seat to duty. It’s just one of the lessons she learned from Mom.

The Family Business

“When I started medical school, I wanted to do something different but I realized that cardiology was the most fun, and I saw how much enjoyment my mom had and how satisfying it was for her,” Michelle says. “That was part of what moved me into the profession.”

But the really cool thing, she adds, is they are the only mother-daughter legacy in cardiology to have gone through the same training program. “There are other mother-daughter academic cardiologists but they trained in separate places, and there are father-son legacies, but no mother-daughter that we know of,” says Anita.

Cardiology, the Kelseys are fond of saying, is the family business,

Having a cardiologist mother as a role model helped shape Michelle’s perceptions about women in the workplace, she explains. So, being a female cardiologist was nothing really out of the ordinary because Anita made it look easy.

But while women are no longer a minority in medicine, they still very much need the support of others, Anita and Michelle note.

“Women need someone to set the norms for what women can do,” says Anita. “Even in leadership positions women aren’t heard as well as men. We need to support each other when we’re in these settings because we haven’t broken through the glass ceiling, despite what everybody says. We still have a long way to go, I think.”

Footsteps to Follow

Following in the footsteps of her engineer father and brothers, Anita Kelsey majored in biomedical engineering at Duke as an undergraduate.  She earned her medical degree at the University of Connecticut and did her residency there before returning to Duke as a cardiology fellow from 1995 to 1998.

Anita went back to Connecticut, where her clinical career focused on echocardiography, education, heart disease in women, and leadership. She served as associate chief of cardiology at Saint Francis Hospital in Hartford, where she began a women’s heart program that has reached 11,000 women with special focus on the highest-risk, underserved, inner-city women.

Anita again returned to Duke in 2019 as vice chief of noninvasive cardiac imaging and earned a master’s degree in business administration through Duke’s executive weekend program. She attributes her drive for excellence, in large part, to her own mother who returned to higher education later in life to earn an accounting degree and run the family engineering business.

“I certainly had a great role model,” Anita says. “Duke engineering was very sparse with women in the 80s, when I was an undergrad but it never bothered me. My mom always told me that whatever my brothers could do I could do better. I believed her, so that’s where I started.”

Like mother, like daughter, Michelle also attended Duke as an undergraduate. She majored in philosophy, then followed Anita to medical school at the University of Connecticut and did her residency at Beth Israel Deaconess Medical Center in Boston, Mass.

“My journey, watching my mom, reminds me that it’s so important to have women in this field that other women can look up to,” Michelle says. “Role models are so helpful for women in medicine.”

As for Anita, she has found a new source of enjoyment from her profession—watching Michelle’s professional growth. “I enjoy taking care of patients but I’ve enormously enjoyed watching my daughter enter the field of cardiology and seeing what she can do as a woman,” she says. “If I were somebody else, I would be impressed by her integrity, her work ethic, and how well she practices in medicine, but being her mother I’m enormously proud.”

–this article was published March 15 by the Duke Department of Medicine.

ICYMI: Bahnson Circulation Article & Podcast

The lead research article in Circulation for Monday, March 15, “Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results from the CABANA Trial is by Tristram Bahnson et al.

Bahnson was interviewed for an accompanying Circulation on the Run podcast (produced by AHA & Circulation) regarding the paper. Check it out here: https://circulation.libsyn.com/circulation-march-15-2022-issue

Nicely done!

 

Kudos to Flores-Rosario

Drs. Jennifer Rymer and Anna Lisa Chamis want to give a special shout-out to cardiology fellow Karen Flores Rosario, MD, who planned and organized the special Women’s Heart Health Grand Rounds held on Tuesday, March 15. Dr. Rymer notes that Dr. Flores Rosario, “literally planned the whole GR today. She picked the speakers of Drs. Rymer, Patterson, and Daubert, spoke with each of us regarding what she wanted to be discussed, followed up multiple times, and made sure it all came together. She has been really active in keeping the Women in Cardiology group going!”

Great job, Karen! CGR was terrific!

 

Kudos to Loriaux

Dr. Anna Lisa Chamis shared a note with us this week about cardiology fellow, Daniel Loriaux, MD.

“Hi Anna Lisa, I just wanted to say what a delight having Dan in clinic has been. He comes to literally every clinic with notes prepped, he knows the basics of my whole panel for that day, and he has questions jotted down. We end up having extra time to look up films and talk over patients, and it makes the clinic honestly so much fun for me. Patients remark how kind and respectful he is. I hope he knows how wonderful he is!” – Jenn Rymer

Way to go, Dan!

 

Finding Your Why

If you haven’t yet had an opportunity to do so, please check out this beautifully written piece by cardiology fellow, Vanessa Blumer, MD. It was published this week in the Journal of Cardiac Failure. Michele — This is my why, now let’s find the way…”

Thank you for sharing your story, Vanessa. You’re an inspiring and gifted clinician!

 

Pitching In to Fight Hunger in Durham

Several members of our Cardiology APP team volunteered at The Food Bank of Central and Eastern NC this past week.

Shown L-to-R are Shelley Thompson, Michelle Martwick, Jade Clausen (holding a sweet potato that strongly resembled an anatomical heart), Faith Williams, and Jesslyn Doody.

Thank you so much for taking time to contribute to supporting a great cause. Way to represent Duke Heart!

 

Alumni News: Vora Selected for SCAI Leadership Program

Amit Vora, MD, one of our former interventional fellows, has been selected for the Society for Cardiovascular Angiography and Interventions (SCAI) Emerging Leader Mentorship (ELM) program, a competitive two-year leadership development opportunity offered in partnership with the American College of Cardiology (ACC) and the Cardiovascular Research Foundation (CRF). ELM is designed to provide career and professional development, mentoring, and group training for early-career interventionalists. Through access to experienced SCAI, ACC, and CRF leaders, collaboration with industry supporters, and professional coaching, the ELM program will provide participants with:

  • Financial and logistical support to attend SCAI, ACC, and TCT Scientific Sessions over a two-year period
  • Speaking opportunities at SCAI, ACC, and TCT Scientific Sessions during the two-year program
  • Focused one-on-one mentoring
  • Enhance media, communication, and podium skills
  • Committee involvement with the partner organizations based on individual interests
  • A network of colleagues who serve as a resource of support throughout career
  • Broad exposure to SCAI, CRF, and ACC
  • Individualized professional development towards a clinical, research, or educational niche

This is terrific, Amit – congratulations!

 

Last Call! Voting for USNWR ‘Best Hospitals’ Open in Doximity

The survey period for U.S. News & World Report’s ‘Best Hospitals’ is open in Doximity through the end of the week: Friday, March 25. We encourage all those who are eligible to vote in the survey of “Best Hospitals for Cardiology and Heart Surgery” to consider casting a vote for Duke.

Reminder: paper surveys have been discontinued. The only way to vote in the survey is online via Doximity.

If you have not yet claimed your profile on this platform, you can do so at any time during the voting period.

  • Go to com
  • Enter your first and last name on the home screen
  • Click on the ‘Find My Profile’ button

A survey will display in your profile until you vote or the survey closes on March 25, 2022.

 

COVID-19 Updates

All the latest Clinical Operations updates related to COVID can be found at https://covid-19.dukehealth.org.

 

Upcoming Events & Opportunities

 

Genomic & Precision Medicine Forum

March 24: “Molecular Signatures of the Response to Antiplatelet Therapy” with Deepak Voora, part of the Genomic & Precision Medicine Forum Series sponsored by the Center for Applied Genomics & Precision Medicine. Virtual event, Noon. Registration is required.

 

Marfan NC Walk for Victory

April 23: The North Carolina Walk for Victory to support Marfan patients and their families will take place on Saturday, April 23, 2022 from Noon to 3 p.m. at Laurel Hills Park on Edwards Mill Road in Raleigh. Duke Heart is proud to serve as the presenting sponsor and we are excited for Chad Hughes, MD to serve as medical chair for the walk.

Please help us support all Marfan families as well as those with Loeys-Dietz (LDS), Vascular Ehlers-Danlos (VEDS), and related conditions. Donate or come join us!

Walk for Victory is The Marfan Foundation’s global walk program. The event is low-key, fun and family-oriented. To learn more or to register for this event, please visit: https://give.marfan.org/event/2022-north-carolina-walk-for-victory/e353032.

To learn more about The Marfan Foundation, please visit marfan.org.

Duke Heart CME

April 23: Duke Sports Cardiology & Sudden Death in Athletes Symposium with course directors Jim Daubert and Bill Kraus. Virtual. For information or to register, contact Christy Darnell christy.darnell@duke.edu or 919-880-8686.

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

Duke Heart in the News:

March 11 — Muhammad Shahzeb Khan

tctMD

Guideline-Directed Therapies Underused in Frail HF Patients

https://duke.is/mk8nh

March 11 – Joe Turek

WLDS/WEAI (West central Illinois)

Petersburg Native On Cusp of Solving Organ Transplant Rejection

https://duke.is/8fk6k

March 11 — Manesh Patel and Christopher Granger

HCPLive

Peripheral Artery Disease (PAD) Pathophysiology and Coronary Artery Disease

https://duke.is/cg6ze

March 11 – Joe Turek

Good Morning America

Baby gets first-of-its kind heart transplant to help fight rejection

https://duke.is/j2d8d

March 13 — Salim Idriss

Healio

Pediatric cardiac screening data warehouse created

https://duke.is/6p92q

March 14 — Joe Turek

Southern Living

Baby Receives World’s First Combined Heart and Thymus Transplant at Duke

https://duke.is/gaww8

March 15 — Daniel Friedman

tctMD

Subcutaneous ICD Has Favorable Outcomes in Older Patients

https://duke.is/pw64r

March 15 — Daniel Friedman

Healio/Cardiology Today

For older adults, similar outcomes for subcutaneous vs. transvenous ICDs

https://duke.is/43vdj

March 16 — Duke Health

WUNC 91.5 FM/NC Public Radio

VA considering closure, replacement of Durham medical center

https://duke.is/9quap

Division of Cardiology Publications Indexed in PubMed March 10-16, 2022

Bagiella E, Puskas JD, Moskowitz AJ, Gelijns AC, Alexander JH, Narula J, Smith PK, Hutcheson K, Chang HL, Gammie JS, Iribarne A, Marks ME, Vengrenyuk Y, Yasumura K, Raymond S, Taylor BS, Yarden O, Orion E, Dagenais F, Ailawadi G, Chu MWA, Gupta L, Levitan B. Rationale and design of a randomized trial evaluating an external support device for saphenous vein coronary grafts. Am Heart J 2022;246:12-20. PM: 34936861.

Bahnson TD, Giczewska A, Mark DB, Russo AM, Monahan KH, Al-Khalidi HR, Silverstein AP, Poole JE, Lee KL, Packer DL. Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results From the CABANA Trial. Circulation 2022;145(11):796-804. PM: 34933570.

Camm AJ, Blomström-Lundqvist C, Boriani G, Goette A, Kowey PR, Merino JL, Piccini JP, Saksena S, Reiffel JA. AIM-AF: A Physician Survey in the United States and Europe. J Am Heart Assoc 2022;11(6):e023838. PM: 35243874.

Chew DS, Cowper PA, Al-Khalidi H, Anstrom KJ, Daniels MR, Davidson-Ray L, Li Y, Michler RE, Panza JA, Piña IL, Rouleau JL, Velazquez EJ, Mark DB. Cost-Effectiveness of Coronary Artery Bypass Surgery Versus Medicine in Ischemic Cardiomyopathy: The STICH Randomized Clinical Trial. Circulation 2022;145(11):819-828. PM: 35044802.

Coniglio AC, Patel CB, Kittleson M, Schlendorf K, Schroder JN, DeVore AD. Innovations in Heart Transplantation: A Review. J Card Fail 2022;28(3):467-476. PM: 34752907.

Cooper LB, Bruce S, Psotka M, Mentz R, Bell R, Seliger SL, O’Connor C, deFilippi C. Proteomic differences among patients with heart failure taking furosemide or torsemide. Clin Cardiol 2022;45(3):265-272. PM: 35014074.

El-Chami MF, Piccini JP, Bockstedt L. Leadless Pacing-Uncertainties Remain About Safety and Efficacy-Reply. JAMA Cardiol 2022;7(3):361-362. PM: 35080586.

Fendrick AM, Djatche L, Pulungan Z, Teigland C, Yang M, Lautsch D, Hilkert R, Mentz R. Out-of-pocket payments for part d covered medications by medicare fee-for-service beneficiaries with heart failure with reduced ejection fraction. Am Heart J 2022;246:74-81. PM: 34774543.

Fudim M, Khan MS, Paracha AA, Sunagawa K, Burkhoff D. Targeting Preload in Heart Failure: Splanchnic Nerve Blockade and Beyond. Circ Heart Fail 2022;15(3):e009340. PM: 35290092.

Greene SJ, Butler J, Hellkamp AS, Spertus JA, Vaduganathan M, Devore AD, Albert NM, Patterson JH, Thomas L, Williams FB, Hernandez AF, Fonarow GC. Comparative Effectiveness of Dosing of Medical Therapy for Heart Failure: From the CHAMP-HF Registry. J Card Fail 2022;28(3):370-384. PM: 34793971.

Han JK, Al-Khatib SM, Albert CM. Changes in the digital health landscape in cardiac electrophysiology: A pre-and peri-pandemic COVID-19 era survey. Cardiovasc Digit Health J 2020;2(1):55-62. PM: 35265890.

Ijaz SH, Jamal S, Minhas AMK, Sheikh AB, Nazir S, Khan MS, Minhas AS, Hays AG, Warraich HJ, Greene SJ, Fudim M, Honigberg MC, Khan SS, Paul TK, Michos ED. Trends in Characteristics and Outcomes of Peripartum Cardiomyopathy Hospitalizations in the United States Between 2004 and 2018. Am J Cardiol 2022;168:142-150. PM: 35074213.

Kandzari DE, Mahfoud F, Weber MA, Townsend R, Parati G, Fisher NDL, Lobo MD, Bloch M, Böhm M, Sharp ASP, Schmieder RE, Azizi M, Schlaich MP, Papademetriou V, Kirtane AJ, Daemen J, Pathak A, Ukena C, Lurz P, Grassi G, Myers M, Finn AV, Morice MC, Mehran R. Clinical Trial Design Principles and Outcomes Definitions for Device-Based Therapies for Hypertension: A Consensus Document From the Hypertension Academic Research Consortium. Circulation 2022;145(11):847-863. PM: 35286164.

Kaneko T, Vemulapalli S, Kohsaka S, Shimamura K, Stebbins A, Kumamaru H, Nelson AJ, Kosinski A, Maeda K, Bavaria JE, Saito S, Reardon MJ, Kuratani T, Popma JJ, Inohara T, Thourani VH, Carroll JD, Shimizu H, Takayama M, Leon MB, Mack MJ, Sawa Y. Practice Patterns and Outcomes of Transcatheter Aortic Valve Replacement in the United States and Japan: A Report From Joint Data Harmonization Initiative of STS/ACC TVT and J-TVT. J Am Heart Assoc 2022;11(6):e023848. PM: 35243902.

Kelsey MD, Newby LK. In CV disease, GLP-1 RAs and SGLT2 inhibitors reduce CV mortality. Ann Intern Med 2022;175(3):JC26. PM: 35226528.

Lala A, Mentz RJ. #ConstructivelyDisruptive – Breaking Molds at JCF. J Card Fail 2022;28(3):351-352. PM: 35279266.

Lala A, Tayal U, Hamo CE, Youmans Q, Al-Khatib SM, Bozkurt B, Davis MB, Januzzi J, Mentz R, Sauer A, Walsh MN, Yancy C, Gulati M. Sex Differences in Heart Failure. J Card Fail 2022;28(3):477-498. PM: 34774749.

Lusk JB, Xu H, Thomas LE, Cohen LW, Hernandez AF, Forrest CB, Michtalik HJ, Turner KB, O’Brien EC, Barrett NJ. Racial/Ethnic Disparities in Healthcare Worker Experiences During the COVID-19 Pandemic: An Analysis of the HERO Registry. EClinicalMedicine 2022;45:101314. PM: 35265822.

Marston NA, Giugliano RP, Melloni GEM, Park JG, Morrill V, Blazing MA, Ference B, Stein E, Stroes ES, Braunwald E, Ellinor PT, Lubitz SA, Ruff CT, Sabatine MS. Association of Apolipoprotein B-Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis: Distinguishing Between Particle Concentration, Type, and Content. JAMA Cardiol 2022;7(3):250-256. PM: 34773460.

Oliveira Junior HA, Ferri CP, Boszczowski I, Oliveira GBF, Cavalcanti AB, Rosa RG, Lopes RD, Azevedo LCP, Veiga VC, Berwanger O, Avezum Á. Rationale and Design of the COVID-19 Outpatient Prevention Evaluation (COPE – Coalition V) Randomized Clinical Trial: Hydroxychloroquine vs. Placebo in Non-Hospitalized Patients. Arq Bras Cardiol 2022;118(2):378-387. PM: 35262569.

Patel KV, Keshvani N, Pandey A, Vaduganathan M, Holmes DN, Matsouaka RA, DeVore AD, Allen LA, Yancy CW, Fonarow GC. Association of readmission penalty amount with subsequent 30-day risk standardized readmission and mortality rates among patients hospitalized with heart failure: An analysis of get with the guidelines – heart failure participating centers. Am Heart J 2022;246:1-11. PM: 34973189.

Peterson BE, Harrington RA, Stone GW, Steg PG, Gibson CM, Hamm CW, Price MJ, Lopes RD, Leonardi S, Prats J, Deliargyris EN, Mahaffey KW, White HD, Bhatt DL. Effect of Platelet Inhibition by Cangrelor Among Obese Patients Undergoing Coronary Stenting: Insights From CHAMPION. Circ Cardiovasc Interv 2022;15(3):e011069. PM: 35196863.

Roifman I, Han L, Fang J, Chu A, Austin P, Ko DT, Douglas P, Wijeysundera H. Patient, physician and geographic predictors of cardiac stress testing strategy in Ontario, Canada: a population-based study. BMJ Open 2022;12(3):e059199. PM: 35273065.

Sharma A, Mahaffey KW, Gibson CM, Hicks KA, Alexander KP, Ali M, Chaitman BR, Held C, Hlatky M, Jones WS, Mehran R, Menon V, Rockhold FW, Seltzer J, Spitzer E, Wilson M, Lopes RD. Clinical events classification (CEC) in clinical trials: Report on the current landscape and future directions – proceedings from the CEC Summit 2018. Am Heart J 2022;246:93-104. PM: 34973948.

Varma N, Cygankiewicz I, Turakhia MP, Heidbuchel H, Hu Y, Chen LY, Couderc JP, Cronin EM, Estep JD, Grieten L, Lane DA, Mehra R, Page A, Passman R, Piccini JP, Piotrowicz E, Piotrowicz R, Platonov PG, Ribeiro AL, Rich RE, Russo AM, Slotwiner D, Steinberg. 2021 ISHNE/HRS/EHRA/APHRS Collaborative Statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals: From the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm. Cardiovasc Digit Health J 2021;2(1):4-54. PM: 35265889.

Wan EY, Ghanbari H, Akoum N, Itzhak Attia Z, Asirvatham SJ, Chung EH, Dagher L, Al-Khatib SM, Stuart Mendenhall G, McManus DD, Pathak RK, Passman RS, Peters NS, Schwartzman DS, Svennberg E, Tarakji KG, Turakhia MP, Trela A, Yarmohammadi H, Marrouche NF. HRS White Paper on Clinical Utilization of Digital Health Technology. Cardiovasc Digit Health J 2021;2(4):196-211. PM: 35265910.

Wei S, Le N, Zhu JW, Breathett K, Greene SJ, Mamas MA, Zannad F, Van Spall HGC. Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. Circ Heart Fail 2022;15(3):e008685. PM: 34911363.

Windle JR, Windle TA, Shamavu KY, Nelson QM, Clarke MA, Fruhling AL, Tcheng JE. Roadmap to a more useful and usable electronic health record. Cardiovasc Digit Health J 2021;2(6):301-311. PM: 35265926.

Zhang L, Olalere D, Mayrhofer T, Bittner DO, Emami H, Meyersohn NM, Puchner SB, Abidov A, Moloo J, Dolor RJ, Mark DB, Ferencik M, Hoffmann U, Douglas PS, Lu MT. Differences in Cardiovascular Risk, Coronary Artery Disease, and Cardiac Events Between Black and White Individuals Enrolled in the PROMISE Trial. JAMA Cardiol 2022;7(3):259-267. PM: 34935857.

Duke Heart Week ending March 13th 2022

Highlights of the week:

Baby Receives World’s First Combination Heart Transplant/Thymus Procedure

Using processed thymus tissue from the heart donor could lower the risk of organ rejection

A baby believed to be the first person to receive a combination heart transplant and allogeneic processed thymus tissue implantation appears to be gaining the immune cells necessary to reduce or eliminate the need for prolonged use of toxic anti-rejection drugs.

The two procedures — performed at Duke University Hospital last summer under an expanded access application that was cleared by the FDA — represent a milestone in heart transplantation.

“This has the potential to change the face of solid organ transplantation in the future,” said Joseph W. Turek, MD, PhD, associate professor in the division of cardiovascular and thoracic surgery, section chief of pediatric cardiac surgery and a member of the surgical team that performed the landmark procedure.

“If this approach proves successful – and further validation is contemplated – it would mean transplant recipients would not reject the donated organ and they would also not need to undergo treatment with long-term immune-suppression medications, which can be highly toxic, particularly to the kidneys,” Turek said. “This concept of tolerance has always been the Holy Grail in transplantation, and we are now on the doorstep.”

Currently, transplanted hearts have an average lifespan of about 10 to 15 years. With durability limited by the toxicity of immune-suppression drugs, other options have long been sought.

The idea of using donated and processed thymus tissue during heart transplantation has been under study at Duke and other sites for several years. Because the thymus gland stimulates the development of T-cells, which fight foreign substances in the body, implanting the processed tissue is hoped to establish the donor’s immune system as the recipient’s, so the donated heart is recognized as “self.”

The approach has shown promise in animal experiments, including in Turek’s lab at Duke, but it had previously not been tried in a living organ recipient.

Duke researchers received permission from the FDA for the investigational procedures after two important factors lined up serendipitously – the youngster, Easton Sinnamon, needed both a heart transplant and processed thymus tissue implantation independent of one another, and he was a patient at Duke, where the processed thymus tissue implantation is solely available.

The processed thymus tissue implantation method, pioneered at Duke by Louise Markert, MD, uses a proprietary technique to culture and administer processed thymus tissue; the process has been licensed to Enzyvant Therapeutics GmbH. The company received FDA approval last fall for allogeneic processed thymus tissue-agdc, indicated for immune reconstitution in pediatric patients with congenital athymia, a rare condition in which children are born without a thymus. Enzyvant provided financial support for processing of the thymus tissue that was used in this research.

“We see tremendous promise in this technology for patients and we are working with urgency to advance research and development for all children in need of cardiac transplants,” said Rachelle Jacques, chief executive officer of Enzyvant.

For Easton, the first-in-human combination of procedures appears to be working.

Tests taken 172 days post-transplant/implantation indicate the processed thymus tissue is functioning, building the critical T-cells that are integral to a well-functioning immune system. Easton’s care team at Duke continues to monitor progress; another milestone is possible in several months when he could be tapered off anti-rejection drugs.

“Cases like this underscore how important new insights emerge when surgery and science are expertly practiced together,” said Allan D. Kirk, MD, PhD, chair of the Department of Surgery at Duke University School of Medicine. “This case has implications for more than just heart transplantation – it could change the way that many solid organ transplants are done in the future.

“The team performed the transplant and implant in a patient who lacked significant thymus function, providing an excellent opportunity to examine how allogeneic processed thymus tissue can shape a person’s immune system to be more receptive to a donor organ,” Kirk said. “If this can be extrapolated to patients who already have a functioning thymus, it could potentially allow them to restructure their immune systems to accept transplanted organs with substantially less dependence on anti-rejection medication. The processing method used for the thymus tissue seems to be critical and is of great interest.”

Born with severe heart defects as well as thymic deficiency from an unknown cause, which severely impaired his immune system, Easton received his transplant on Aug. 6, 2021, when he was 6 months old, followed two weeks later with the implantation of the cultured thymus tissue from his heart donor.

Easton recently celebrated his first birthday and continues to do well.

“It was one of those things where it could help him, and if it works, it not only helps him, but it could help thousands of other people as well with their children who need transplants,” said Easton’s mom, Kaitlyn Sinnamon. “When we talked about it, it was like ‘Why would we not do it when we can make a difference for all these other people?’”

During a media briefing held Monday, March 7, the Sinnamon’s were asked what message they hope their son grows up embracing. Kaitlyn responded, “I think my biggest thing is, especially with all the scars that he has, is that I hope he will just be proud of those and know that we did everything for what was the best decision for that moment.

“That he should be proud of those because it’s something that shows he was fighting for his life and he should be honored to let people know that that’s one thing that he did, and that he got to make a difference.”

We look forward to seeing Easton continue to do well, especially now that he can be home with his family. Congratulations to Joe and team – we are very excited about the work you’re doing, as well as the potential this treatment holds.

 

2022 Triangle Heart Ball Held

The American Heart Association’s Triangle Heart Ball was held Friday evening, March 11 at the Raleigh Convention Center. The event included a silent auction, live auction, dinner and fellowship with other area sponsors. Duke Heart is pleased to support the work of the AHA. We thank all who were able to join us.

 

Frazier to Serve as Nurse Manager DUH 7100, Effective March 28th

Duke Heart is pleased to announce that Ashley Frazier, BSN, RN, CCRN will become nurse manager for Duke University Hospital’s Cardiology Stepdown Unit 7100 effective Monday, March 28th.  Ashley earned a Bachelor of Science in Nursing from Duke University School of Nursing in 2013. She was hired as a new graduate nurse in the Duke Pediatric Cardiac Intensive Care Unit in July, 2013 and has served as a nightshift Clinical Lead since August, 2017.

As a Clinical Lead, Ashley has been heavily involved with Duke Children’s safety and quality initiatives including pressure injury prevention, cardiac arrest prevention, and breast milk handling process improvement. At the Health System Level, Ashley participates in numerous Maestro Care work groups focusing on nursing documentation improvements. Additionally, Ashley is a Well-Being Ambassador, holds a Patient Safety Leadership certification, and has contributed to burnout reduction initiatives.  She currently serves on the Nursing Informatics Council, DUHS Cardiac Monitoring Subcommittee, and DUHS Nursing Quality Council.

Please join us in congratulating and welcoming Ashley to her new role.

 

Nesmith Receives High Five

Georgina Nesmith, RN, nursing program manager for the Duke Heart Center Communications team received a DUHS “High Five” on Tuesday, March 8. She was nominated by Carroll Enterkin, who wrote:

“In addition to teaching me how to make new patient appointments, Gina has advised me in ways to do my job to make it easier, all in such a calming voice. I have been so blessed to work in Heart Communications Center this past year. I feel the Lord blessed me so much with this job.”

Well-deserved, Georgina! Thank you for all you do. Carroll, we are pleased to have you on the Duke Heart team. We’re glad you’re here!

 

Voting for USNWR ‘Best Hospitals’ Open in Doximity

The survey period for U.S. News & World Report’s ‘Best Hospitals’ is open in Doximity through March 25. We encourage all those who are eligible to vote in the survey of “Best Hospitals for Cardiology and Heart Surgery” to consider casting a vote for Duke.

Reminder: paper surveys have been discontinued. The only way to vote in the survey is online via Doximity.

If you have not yet claimed your profile on this platform, you can do so at any time during the voting period.

  • Go to com
  • Enter your first and last name on the home screen
  • Click on the ‘Find My Profile’ button

A survey will display in your profile until you vote or the survey closes on March 25, 2022.

 

COVID-19 Updates

All the latest Clinical Operations updates related to COVID can be found at https://covid-19.dukehealth.org.

 

Upcoming Events & Opportunities

Cardiology Grand Rounds

March 15: Coronary Artery Disease in Women with Jennifer Rymer; Hypertensive Disorders of Pregnancy with Melissa Daubert; and Cardio-Oncology in Women with Brandy Patterson. 5 p.m. via Webex.

 

Upcoming Duke Heart CME

April 23: Duke Sports Cardiology & Sudden Death in Athletes Symposium with course directors Jim Daubert and Bill Kraus. Virtual. For information or to register, contact Christy Darnell christy.darnell@duke.edu or 919-880-8686.

 

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

 

Duke Heart in the News:

March 4 — Neha Pagidipati

HCPLive

Neha Pagidipati, MD: New Approaches in Obesity Management

https://duke.is/jg96f

March 4 – Christopher Granger

HCPLive

Christopher Granger, MD: Integration, Value of SGLT2 Inhibitors in Practice

https://duke.is/rqvh6

March 7 – Joe Turek

Associated Press

Baby gets heart transplant with a twist to fight rejection

https://duke.is/c2vt9

*also carried by 421 additional outlets including ABC News, China Global Television Network, San Francisco Gate, Washington Post

*AP local outlets in Atlanta, Chicago, Dallas, Gainesville, Houston, Los Angeles, New York, Philadelphia, Phoenix, San Francisco

March 8 – Joe Turek

BBC News

‘World-first’ heart-thymus transplant success for Easton

https://duke.is/w4uxe

March 9 — Robert Mentz

Medpage Today

Exercise Intervention May Slow HF Progression Before Disease Takes Hold

https://duke.is/znusb

March 9 — Muhammed Shahzeb Khan

Healio/Cardiology

In HFrEF, therapy in patients with frailty often not optimized despite high risk

https://duke.is/m79vp

March 9 — Duke University (ADAPTABLE)

Clinical Research Forum

Clinical Research Forum Announces the 2022 Top Ten Clinical Research Achievement Awards

https://duke.is/8d68h

March 7-11 — Heart-Thymus News Coverage

As of March 11, news coverage for this story had been included in at least 675 individual outlets including national coverage by the Associated Press (AP), ABC, CBS, NBC and FOX affiliates, McClatchy papers, MSN & Yahoo News and international coverage by the BBC and WION (India). The majority of coverage was by AP affiliates.

Division of Cardiology Publications Indexed in PubMed March 3-9, 2022

Abraham WT, Piccini JP, Dufton C, Carroll IA, Healey JS, O’Connor CM, Marshall D, Aleong R, van Veldhuisen DJ, Rienstra M, Wilton SB, White M, Sauer WH, Anand IS, Huebler SP, Connolly SJ, Bristow MR. Dose-limiting, adverse event-associated bradycardia with β-blocker treatment of atrial fibrillation in the GENETIC-AF trial. Heart Rhythm O2. 2021;3(1):40-49. PM: 35243434.

Arnold SV, Manandhar P, Vemulapalli S, Vekstein AM, Kosinski AS, Spertus JA, Cohen DJ. Patient-reported vs. physician-estimated symptoms before and after transcatheter aortic valve replacement. Eur Heart J Qual Care Clin Outcomes. 2022;8(2):161-168. PM: 34718485.

Beck TP, Tsipis N, Kisslo JA, Rivera JD, Armour AC, Moon RE. Immersion-Induced Mitral Regurgitation: A Novel Risk Factor for Swimming-Induced Pulmonary Edema. Chest. 2022;161(3):e137-e143. PM: 35256086.

Bicong L, Allen JC, Arps K, Al-Khatib SM, Bahnson TD, Daubert JP, Frazier-Mills C, Hegland DD, Jackson KP, Jackson LR, Lewis RK, Pokorney SD, Sun AY, Thomas KL, Piccini JP. Leadless pacemaker implantation after lead extraction for cardiac implanted electronic device infection. J Cardiovasc Electrophysiol. 2022;33(3):464-470. PM: 35029307.

Brancato SC, Wang M, Spinelli KJ, Gandhavadi M, Worrall NK, Lehr EJ, DeBoard ZM, Fitton TP, Leiataua A, Piccini JP, Gluckman TJ. Temporal trends and predictors of surgical ablation for atrial fibrillation across a multistate healthcare system. Heart Rhythm O2. 2021;3(1):32-39. PM: 35243433.

Carvalho GD, Armaganijan LV, Lopes RD, Olandoski M, Galvão BMDA, Pessoa CC, Erbano BO, Luz RSBD, Demarchi AV, Medeiros BG, Moreira DAR. Relationship between ventricular repolarization parameters and the inducibility of ventricular arrhythmias during electrophysiological study in patients with coronary artery disease. Rev Assoc Med Bras (1992). 2022;68(1):61-66. PM: 35239939.

Chew DS, Jones KA, Loring Z, Black-Maier E, Noseworthy PA, Exner DV, Packer DL, Grant J, Mark DB, Piccini JP. Diagnosis-to-ablation time predicts recurrent atrial fibrillation and rehospitalization following catheter ablation. Heart Rhythm O2. 2021;3(1):23-31. PM: 35243432.

Dhruva SS, Shah ND, Vemulapalli S, Deshmukh A, Beatty AL, Gamble GM, Freeman JV, Hummel JP, Piccini JP, Akar JG, Ervin K, Arges KL, Emanuel L, Noseworthy PA, Hu T, Bartlett V, Ross JS. Heart Watch Study: protocol for a pragmatic randomised controlled trial. BMJ Open. 2021;11(12):e054550. PM: 35234659.

Fox KAA, Virdone S, Pieper KS, Bassand JP, Camm AJ, Fitzmaurice DA, Goldhaber SZ, Goto S, Haas S, Kayani G, Oto A, Misselwitz F, Piccini JP, Dalgaard F, Turpie AGG, Verheugt FWA, Kakkar AK. GARFIELD-AF risk score for mortality, stroke, and bleeding within 2 years in patients with atrial fibrillation. Eur Heart J Qual Care Clin Outcomes. 2022;8(2):214-227. PM: 33892489.

Gaffey AE, Cavanagh CE, Rosman L, Wang K, Deng Y, Sims M, O’Brien EC, Chamberlain AM, Mentz RJ, Glover LM, Burg MM. Depressive Symptoms and Incident Heart Failure in the Jackson Heart Study: Differential Risk Among Black Men and Women. J Am Heart Assoc 2022;11(5):e022514. PM: 35191315.

Girotra S, Chan ML, Starks MA, Churpek M, Chan PS. Association of COVID-19 Infection With Survival After In-Hospital Cardiac Arrest Among US Adults.   JAMA Netw Open. 2022;5(3):e220752. PM: 35234884.

Ijioma NN, Don C, Arora V, Edgar L, Hawkins B, Monteleone P, Tcheng JE, Helmy T. ACGME Interventional Cardiology Milestones 2.0-an overview: Endorsed by the Accreditation Council for Graduate Medical Education. Catheter Cardiovasc Interv. 2022;99(3):777-785. PM: 34708916.

Januzzi JL, Ohman EM. Underdiagnosis of Ischemic Heart Disease in New-Onset Heart Failure: A Call to Action. J Am Coll Cardiol. 2022;79(9):861-863. PM: 35241219.

Kalayci A, Gibson CM, Hernandez AF, Hull RD, Cohen AT, Fitzgerald C, Hussain SD, Chi G, Alkhalfan F, Harrington RA, Goldhaber SZ. Inverse relationship between body mass index and risk of venous thromboembolism among medically ill hospitalized patients: Observations from the APEX trial. Thromb Res. 2022;211:63-69. PM: 35091313.

Khan MS, Solomon N, DeVore AD, Sharma A, Felker GM, Hernandez AF, Heidenreich PA, Matsouaka RA, Green JB, Butler J, Yancy CW, Peterson PN, Fonarow GC, Greene SJ. Clinical Outcomes With Metformin and Sulfonylurea Therapies Among Patients With Heart Failure and Diabetes. JACC Heart Fail. 2022;10(3):198-210. PM: 34895861.

Nanni AN, Harris M, Watson M, Yang Z, Lee HJ, DeVore AD, Henderson JB. Association of tacrolimus time-to-therapeutic range on renal dysfunction and acute cellular rejection after orthotopic heart transplantation in a high use basiliximab population. Clin Transplant. 2022;36(3):e14542. PM: 34797576.

Paluch AE, Bajpai S, Bassett DR, Carnethon MR, Ekelund U, Evenson KR, Galuska DA, Jefferis BJ, Kraus WE, Lee IM, Matthews CE, Omura JD, Patel AV, Pieper CF, Rees-Punia E, Dallmeier D, Klenk J, Whincup PH, Dooley EE, Pettee Gabriel K, Palta P, Pompeii LA. Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts. Lancet Public Health. 2022;7(3):e219-e228. PM: 35247352.

Regan JA, Abdulrahim JW, Bihlmeyer NA, Haynes C, Kwee LC, Patel MR, Shah SH. Phenome-Wide Association Study of Severe COVID-19 Genetic Risk Variants. J Am Heart Assoc. 2022;11(5):e024004. PM: 35179038.

Sampognaro JR, Lewis RK, Black-Maier E, Pokorney SD, Hegland DD, Piccini JP. Cases of Azygous Coil Extraction. Heart Rhythm O2. 2021;3(1):65-69. PM: 35243437.

Samsky MD, Rao SV. Review of Cardiogenic Shock After Acute Myocardial Infarction-Reply. JAMA 2022;327(9):879. PM: 35230396.

Selvaraj S, Hu R, Vidula MK, Dugyala S, Tierney A, Ky B, Margulies KB, Shah SH, Kelly DP, Bravo PE. Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants. J Am Soc Echocardiogr 2022;35(3):305-311. PM: 34798244.

Senman B, Rao SV. Heart Team Without Borders: Taking the Heart Team Beyond the Institution. J Am Heart Assoc 2022;11(5):e025080. PM: 35225005.

Solomon SD, Vaduganathan M, Claggett BL, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Belohlavek J, Chiang CE, Willem Borleffs CJ, Comin-Colet J, Dobreanu D, Drozdz J, Fang JC, Alcocer Gamba MA, Al Habeeb W. Baseline Characteristics of Patients With HF With Mildly Reduced and Preserved Ejection Fraction: DELIVER Trial. JACC Heart Fail 2022;10(3):184-197. PM: 35241246.

Thakkar A, Valente T, Andesia J, Njuguna B, Miheso J, Mercer T, Mugo R, Mwangi A, Mwangi E, Pastakia SD, Pathak S, Pillsbury MKM, Kamano J, Naanyu V, Williams M, Vedanthan R, Akwanalo C, Bloomfield GS. Network characteristics of a referral system for patients with hypertension in Western Kenya: results from the Strengthening Referral Networks for Management of Hypertension Across the Health System (STRENGTHS) study. BMC Health Serv Res. 2022;22(1):315. PM: 35255913.

Zeitler EP, Austin AM, Leggett CG, Gilstrap LG, Friedman DJ, Skinner JS, Al-Khatib SM. Complications and Mortality Following CRT-D Versus ICD Implants in Older Medicare Beneficiaries With Heart Failure. JACC Heart Fail 2022;10(3):147-157. PM: 35241242.

Zeitler EP, Felker GM. Natriuretic Peptides and Stratification for ICD Therapy in Nonischemic Heart Failure: A Definite Maybe? JACC Heart Fail 2022;10(3):172-174. PM: 35241244.

 

 

 

Duke Heart Pulse – Week ending March 6th 2022

Highlights of the Week

Fall 2021 GTSD Star Ratings Announced

We are pleased to share our General Thoracic Surgery Database (GTSD) Star Ratings for the Fall 2021 Harvest. Duke University Hospital received a three-star rating for lobectomy and a two-star rating for esophagectomy. The Star Ratings are a quality indicator based on reporting in the GTSD, which is managed by the Society of Thoracic Surgeons.

The GTSD star ratings provide composite quality ratings for two types of surgeries: lobectomies for primary lung cancer and esophagectomies for primary esophageal cancer. They will soon add a composite quality rating for the broader category of pulmonary resections for lung cancer, according to Melissa Williams, registry team clinical manager of cardiovascular informatics & quality improvement for the Duke Heart Center of Excellence.

Betty Tong

Duke University Hospital had taken a pause in submitting data to the GTSD to completely revise the data abstraction and submission processes. Working closely with Dr. Betty Tong, the Duke Heart Center of Excellence resumed data submission in the fall of 2020. These new results with the 3-star rating for lobectomies for lung cancer reflect the three-year cohort of surgeries with dates 7/1/2018 – 6/30/2021. The rating reflects better than expected risk-adjusted results.

According to the previous Harvest Composite Quality Ratings Summary for Spring 2021, there were a total of 222 participating centers entering data into the GTSD for that time period (the total number for Fall 2021 Harvest has not yet been shared). Participants must have at least 30 eligible procedures for each individual composite, meeting inclusion criteria for the 3-year harvest period in order to receive a star rating.

Congratulations to our Thoracic Surgery team – great work!

 

CRT22 Held in DC

The annual Cardiovascular Research Technologies meeting was held in Washington, DC from Feb. 26-March 1, 2022. CRT22 not only marked the 25th anniversary of CRT, it afforded many opportunities to reconnect with others — in person! — including this reunion of current and former Duke Heart Faculty and Cath lab  team members: Tracy Wang, Schuyler Jones, Mike Nanna and Angela Lowenstern. Other Duke faculty members in attendance at CRT22 included Jenn Rymer, Dave Kong, Mitch Krucoff and Magnus Ohman as well as former Duke fellows Amit Voora and Matt Sherwood.

 

Kudos to Lin & Duke Regional Team

We received a wonderful note this week from Duke Regional Hospital president Katie Galbraith. She shared with us a letter she received about care provided to a patient (and their family) by Shu Lin and team.

“I received the letter below from one of our team members, whose loved one was recently a patient in our care. What a beautiful tribute to you and her entire care team! I continue to be amazed and inspired by the wonderfully caring people here at Duke Regional, and this letter reinforces what a special place this is … all because of team members like you and those highlighted in this letter.

Lisa, Sandy and Tom, could you send me the full names of your team members named in the letter, so I can reach out and personally thank them?”

With much appreciation, Katie Galbraith, President, Duke Regional Hospital

The letter states:

“I wanted to send an email to you on the really great care my Mom #2 (mother-in-law) received here recently.

My mother-in-law had been having some health issues over last 6 months and was diagnosed with a large benign tumor (myxoma). She had a cardiac catheterization done here on Friday 2/11 with Dr. Kamada. He, Dr. Lin and his team had excellent bedside manner with my Dad #2 (who is 82 and a little hard of hearing) and Mom. I was also present to hear the information he was giving them about follow up. They were all kind and answered all their questions not seeming rushed or like they had to be elsewhere and my father-in-law noticed that and appreciated as he knew “they are all very busy”.

Surgery was rapidly scheduled for Wednesday 2/16/22 as Dr. Lin explained it needed to happen sooner vs later. Dad was a little concerned at first as he felt her surgery due to the complexity should possibly have been done at Duke Medical Center (Duke University Hospital). Dr. Lin and his team and I reassured him that Duke Regional has all the same benefits and excellent providers that (DUH) has and she would be well taken care of here. She was pre-admitted on 2/15/22 to 5-2. There were many nurses/NAs she met and they were all great on 5-2. I personally remembered Julia, Sade, and a male student nurse that were especially kind. Her surgery took over 5 hours where she then went to the CCU. The nurses/OR team kept my father in law and his daughter updated throughout and commented on how kind everyone had been to them during this process as of course it was very hard for them waiting in the lobby for news. They allowed us to see her in the CCU that evening briefly and Jill whom we met first was amazing and very kind explaining what was going to happen that evening.

Barbara and Tyler from the CCU were also great and mentioned by my family as being great with Mom and Dad.

She was able to return to 5-2 the next day and Julia, Jordyn and David were all great working with her as she had some issues with her heart rate which was scary for my sister and father in law but they explained things clearly as well as Dr. Lin. Sade remembered her from her pre-admit and even came by to speak to her wishing her well and saying she was happy she was back on her floor.

She had PT and OT (of course) and Kellie and Loy did a wonderful job with her and she mentioned how kind they were (even though they made her walk further than she wanted).

Mom was able to return home that Sunday 2/20/22 and is happy to be home.

I have worked here at DRH for over 22 years. I know the challenges the hospital has with staff shortages and high work stress levels from COVID and general work duties.

I want you to know that I saw NONE of that with the people that were working with Mom (and her family) and they have nothing but good things to say about the care they received here. I will try to reach the staff members individually and their supervisors to thank them personally for their care but wanted leadership to know that although we have MANY daily challenges, we have wonderful and caring people working here and wouldn’t have wanted my family being treated anywhere else.”grateful family member, name withheld for privacy

Superb job by all! This is well-deserved recognition and great representation of Duke’s core values!

Shout-out to Chen, Sullivan & CTS team

Edward Chen

We received a note this week from a Press Ganey survey regarding members of the Duke Cardiovascular & Thoracic Surgery team:

“Dr. (Edward) Chen and his staff are just superior to any other heart specialists we have ever consulted.  Because of my long term HH, when I was given a preliminary diagnosis of Ascending Aortic Aneurysm and Hypertrophic Cardiomyopathy by [a hospital in Virginia] we decided to seek an immediate second opinion from the very best Thoracic Surgeon we could on the east coast. We are very blessed that Duke is in our own back yard and that Dr. Chen is here now and not in Texas or California. We called Dr. Chen’s office directly on Valentine’s Day and was given an immediate appointment for Thursday 2/17/22. Annette Sullivan was very kind and sent a FedEx label for us to overnight both the Echocardiogram and the CT results from (the Virginia) hospital to Dr. Chen’s office directly. His assessment was firm and amazing. My heart is fine. The Echocardiogram was misleading and the CT proved that there was nothing at all wrong with my heart. We had been in limbo since the second of February when the Echo was conducted. The CT was never read to us nor were any lab results posted on the patient portal by (the hospital in VA). Frankly their system leaves much to be desired. It was Dr. Chen who told us that we were fine. It was his expertise, his positive affirmation of good heart health. You have no idea as to the devastation my wife felt at the thought of the possible outcomes. She has true dilated cardiomyopathy. Her father had an AAA with EVAR. My father died suddenly of heart attack at age 67 and we both know what can happen with a C282Y gene mutation. We watch my heart, liver, pancreas and endocrine systems constantly. I have regular phlebotomies. I have had PVNS (giant cell tumors), treated by Dr. Briggman, Duke Orthopedic Oncology, with a great outcome BTW from another of your most excellent physicians. Needless to say, we are very relieved that Duke is in-network for us and that Dr. Edward Chen chooses to practice at Duke. To top off our experience with Dr. Chen and his staff, he promised to review our previous results from the (Virginia-based) system and call us when he had finished his assessment. This morning he called us and reassured us once again that my heart is doing fine. He is a very busy man, but he made the time for us, folks he does not even know. But he truly cares. This is what makes him an exceptional physician and a truly great man. Thank you Dr. Chen. God Speed.” – grateful patient, name withheld for privacy.

Wonderful feedback, Dr. Chen, Annette and team!

 

Bowers Involved AANP Heart Health Campaign

Midge Bowers lent her voice to a national campaign sponsored by the American Association of Nurse Practitioners last month. “Caring for your Heart and Your Heart Health” was aimed at patients and their caregivers. Bowers authored a blog post and narrated a two-minute video  for the campaign.

Great work, Midge! Way to represent Duke Heart!

Margaret “Midge” Bowers
School of Nursing faculty
studio headshot

 

Robert H. Jones Celebration of Life Held

The service of life in memory of Robert H. Jones, MD, professor emeritus of surgery (cardiovascular and thoracic) and a founder of Duke Heart Center was held yesterday, Saturday, March 5, at the Cole Mill Road Church of Christ in Durham, NC. The event was a touching tribute to Dr. Jones by members of his family and his church community. He was remembered for his adventurous spirit, humility, vision & perseverance, his concern for others, a deep and abiding faith, and his love for family. The in-person service was shared live via Zoom. We thank all who were able to attend and who have shown their support to the Jones family.

Shown here, flags lowered across the Duke campus in his memory on Monday, Jan. 31, 2022.

 

ICYMI: Two CPT Pieces Highlight Duke Heart Programs

We wanted to be sure to highlight two recently published articles from Duke Health’s Clinical Practice Today. Many thanks to the Heart Transplant and Cardio-Oncology teams for taking time to give interviews. Clinical Practice Today (CPT) is distributed to referring physicians throughout the region and is an important vehicle for sharing and promoting the services we provide to patients as well as our latest research findings.

 

ICYMI: Newsweek Rankings of Best Specialty Hospitals

Newsweek, in its rankings of the Best Specialty Hospitals in the World, has ranked Duke University Hospital at #13 for Cardiology care and #18 for Cardiac Surgery care. See the full rankings for all specialties in the article below in News. Congratulations to all!

Voting for USNWR ‘Best Hospitals’ Open in Doximity

The survey period for U.S. News & World Report’s ‘Best Hospitals’ is open in Doximity through March 25. We encourage all those who are eligible to vote in the survey of “Best Hospitals for Cardiology and Heart Surgery” to consider casting a vote for Duke.

Reminder: paper surveys have been discontinued. The only way to vote in the survey is online via Doximity.

If you have not yet claimed your profile on this platform, you can do so at any time during the voting period.

  • Go to com
  • Enter your first and last name on the home screen
  • Click on the ‘Find My Profile’ button

A survey will display in your profile until you vote or the survey closes on March 25, 2022.

 

COVID-19 Updates

The COVID-19 Employee Hotline hours are changing to reflect recent utilization trends. Beginning March 1, the hotline will be available during these times:

  • Monday — Friday: 8 a.m. to 5 p.m.
  • Saturday — Sunday: 8 a.m. to 12 p.m.

The phone number for the hotline is 919-385-0429 (option 1).

 

All the latest Clinical Operations updates related to COVID can be found at https://covid-19.dukehealth.org.

 

Upcoming Events & Opportunities

Cardiology Grand Rounds

March 8: Lipoprotein (a): Unveiling the Mysterious Biomarker with Nishant Shah. 5 p.m. via Webex.

Upcoming Duke Heart CME

April 23: Duke Sports Cardiology & Sudden Death in Athletes Symposium with course directors Jim Daubert and Bill Kraus. Virtual. For information or to register, contact Christy Darnell christy.darnell@duke.edu or 919-880-8686.

 

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

Duke Heart in the News:

February 27 — Anthony Peters

cardionerds.com

Case Summary – Dyspnea with an LVAD: A Tale of Hypoxia and Hemodynamics

https://duke.is/za4wg

February 28 — E. Magnus Ohman

Medpage Today

Heart Failure Patients Still Undertested for CAD

https://duke.is/vhhgc

March 2 — Adrian Hernandez

RT magazine

Study to Test Higher Dose of Ivermectin for Mild-to-Moderate COVID-19

https://duke.is/gcyf8

March 2 — Jonathan Piccini

WQAD ABC-8 (Davenport, IA)

YOUR HEALTH: Checking your rhythm all of the time

https://duke.is/584z2

March 2 — Brandi Bottiger (CT Anesthesiology)

The National Tribune

Mode of intraoperative support impacts primary graft dysfunction after lung transplant

https://duke.is/n5hua

March 4 — Adrian Hernandez

ABC News

Group of physicians combats misinformation as unproven COVID-19 treatments continue to be prescribed

https://duke.is/5uxjs

March 2022 — Duke University Hospital

Newsweek

The World’s Best Specialized Hospitals 2022

https://duke.is/6jrgr

Division of Cardiology Publications Indexed in PubMed February 24- March 2, 2022

Emmens JE, Ter Maaten JM, Matsue Y, Figarska SM, Sama IE, Cotter G, Cleland JGF, Davison BA, Felker GM, Givertz MM, Greenberg B, Pang PS, Severin T, Gimpelewicz C, Metra M, Voors AA, Teerlink JR. Worsening renal function in acute heart failure in the context of diuretic response. Eur J Heart Fail 2022;24(2):365-374. PM: 34786794.

Gajewski P, Fudim M, Kittipibul V, Engelman ZJ, Biegus J, Zymliński R, Ponikowski P. Early Hemodynamic Changes following Surgical Ablation of the Right Greater Splanchnic Nerve for the Treatment of Heart Failure with Preserved Ejection Fraction. J Clin Med 2022;11(4):1063. PM: 35207336.

Garg K, Patel TR, Kanwal A, Villines TC, Aggarwal NR, Nasir K, Blumenthal RS, Blaha MJ, Douglas PS, Shaw LJ, Sharma G. The evolving role of coronary computed tomography in understanding sex differences in coronary atherosclerosis. J Cardiovasc Comput Tomogr 2022;16(2):138-149. PM: 34654676.

Nikolakopoulos I, Vemmou E, Xenogiannis I, Karacsonyi J, Rao SV, Romagnoli E, Tsigkas G, Milkas A, Velagapudi P, Alaswad K, Rangan BV, Garcia S, Burke MN, Brilakis ES. Radial versus femoral access in patients with coronary artery bypass surgery: Frequentist and Bayesian meta-analysis. Catheter Cardiovasc Interv 2022;99(2):462-471. PM: 34779096.

Schubert R, Geoffroy E, Gregga I, Mulford AJ, Aguet F, Ardlie K, Gerszten R, Clish C, Van Den Berg D, Taylor KD, Durda P, Johnson WC, Cornell E, Guo X, Liu Y, Tracy R, Conomos M, Blackwell T, Papanicolaou G, Lappalainen T, Mikhaylova AV, Thornton TA, Cho. Protein prediction for trait mapping in diverse populations. PLoS One 2022 ;17(2):e0264341. PM: 35202437.

Shahid I, Khan MS, Sohail A, Khan SU, Greene SJ, Fudim M, Michos ED. Evaluation of Representation of Women as Authors in Pivotal Trials Supporting US Food and Drug Administration Approval of Novel Cardiovascular Drugs. JAMA Netw Open 2022;5(2):e220035. PM: 35212753.

Duke Heart Pulse for week ending Feb 27th 2022

Highlights of the week:

Thank you, Residents & Fellows

On behalf of the Duke Heart Leadership team and faculty across the Divisions of Cardiology and Cardiovascular and Thoracic Surgery, we thank each and every one of our trainees – our surgery residents and all fellows — we hope you know how much we value and appreciate the work you do, your dedication to patient care, and the fact that you chose to spend your training years here with us in Durham, NC.

These are not easy years for anyone who chooses to embark on a career in surgery or medicine – but we hope you find your time here fulfilling, enriching, fun and inspiring. This week happens to be GME Appreciation Week, but your work matters today and every day, and it will matter for years to come. Thank you for the many ways in which you inspire each of us and for being part of the Duke Heart family!

Voting for USNWR ‘Best Hospitals’ Now Open in Doximity

The survey period for U.S. News & World Report’s ‘Best Hospitals’ is now open in Doximity. We encourage all those who are eligible to vote in the survey of “Best Hospitals for Cardiology and Heart Surgery” to consider casting a vote for Duke’s hospitals – this is a great way to support our efforts in leading the country in patient care, innovation, research and the education of future specialists.

Reminder: paper surveys have been discontinued. The only way to vote in the survey is online via Doximity.

If you have not yet claimed your profile on this platform, you can do so at any time during the voting period.

  • Go to Doximity.com
  • Enter your first and last name on the home screen
  • Click on the ‘Find My Profile’ button

A survey will display in your profile until you vote or the survey closes on March 25, 2022.

 

Circulate! 2022 Recognizes Duke Efforts

Members of the Duke Heart team were recently celebrated by our Vascular Cures partners at Circulate!, their annual gala held to celebrate the work done throughout the year by patient advocates, industry members and researchers, all of whom are dedicated to improving the care of patients with vascular disease.

According to Megan Patterson, chief executive officer of Vascular Cures, all proceeds from the gala support national education and awareness initiatives that help at-risk populations, patients, and their caregivers. This year’s gala was held virtually on Feb. 3.

Some of the work done through Duke in support of Vascular Cures and honored this year include the following:

Chronic Limb-Threatening Ischemia (CLTI) Research

Manesh Patel, MD and E. Hope Weissler, MD, a resident in our Vascular Surgery Integrated Residency Program, are members of the Vascular Cures Chronic Limb-Threatening Ischemia (CLTI) Working Group for Patient Engagement, an initiative to promote and facilitate CLTI patient engagement in research. Patel and Weissler comprise half the team responsible for organizing this working group. This initiative is designed to build capacity to engage CLTI patients in research as advisors and participants, so that study results align with the needs of patients. It also works to prioritize the kinds of research that are most important to patients. Ultimately, the goal of this work is to create new knowledge and treatments that more closely align with CLTI patient needs and improve health outcomes in this population.

Kevin Southerland, MD, assistant professor of vascular surgery, is the 2021 Wylie Scholar Award recipient for his project Transcriptional Dynamics and Heterogeneity of Macrophages in Chronic Limb Threatening Ischemia. The award is given annually by the Vascular Cures Foundation and the Society for Vascular Surgery Foundation. Chronic limb-threatening ischemia (CLTI) is the most severe manifestation of peripheral arterial disease. Patients with CLTI are at high risk for limb loss and death. A significant number of CLTI patients suffer limb loss despite successful restoration of arterial flow. Novel approaches to treat CLTI remain an unmet clinical need. The goal of Dr. Southerland’s work is to understand the communication signals between the various cell types in the ischemic limb. He is particularly interested in how macrophages interact with muscle stem cells. He believes that understanding these mechanisms will be the groundwork for the development of new therapies for CLTI patients.

Patient Reported Outcome Measures in Peripheral Artery Disease (PAD)

Patel and Jennifer Rymer, MD have been instrumental in facilitating the Vascular Cures Working Group on

Jennifer Rymer

Patient-Reported Outcome Measures in PAD, which resulted in the recently published (23 Dec 2021) review article in Circulation: Cardiovascular Interventions, “Patient-Reported Outcome Measures in Symptomatic, Non-Limb Threatening Peripheral Artery Disease: A State-of-the-Art Review”.

 

The Circulate! gala includes the announcement of the recipient of the Ron Stoney Vascular Hero Award which is given annually to an outstanding care provider and/or researcher who goes above and beyond to advocate for patients. Stoney, a surgeon and professor emeritus at UCSF, co-founded Vascular Cures in 1982 to “save and improve the lives of those living with vascular diseases outside the heart.”

This year’s honoree was Manesh Patel, MD.

Manesh Patel

“Dr. Patel received this award not just because of the incredible support he has provided Vascular Cures as an advisor, but his persistent and passionate commitment to improving vascular health for patients through research and other national initiatives with organizations like the American Heart Association,” says Patterson. “He is a visionary and is always inspiring us to do more and do it better so that more people can have happy healthy lives.”

Congratulations to Hope, Jenn, Kevin and Manesh – well deserved recognition for the work you are doing!

 

Kelsey Appointed to CAAHEP’s JRC on Education in CV Technology

Anita Kelsey

Congratulations to Anita M. Kelsey, MD, MBA! Kelsey has been appointed as Commissioner for the Joint Review Committee on Education in Cardiovascular Technology (JRC) by the Commission on Accreditation of Allied Health Education Programs (CAAHEP). CAAHEP is the largest programmatic accreditor of the health sciences professions.

Originally established in 1976 by the American Medical Association as the Committee on Allied Health Education and Accreditation (CAHEA) with our own Joseph Kisslo, MD and Kitty B. (Filly) Kisslo (who was then at Stanford) as founding JRC members who led the way in defining the standards of cardiac sonography.

CAAHEP reviews and accredits more than 2100 individual education programs across 32 health science occupations. CAAHEP-accredited programs are assessed on an ongoing basis to ensure they meet the standards and guidelines of each profession.

Duke’s Cardiac Ultrasound Certificate Program received CAAHEP accreditation in 2021. We are proud to be accredited by this organization that upholds the highest standards of quality, outcomes-based education. We are equally as proud of Dr. Kelsey for her new role.

Congratulations Dr. Kelsey, for your work to ensure quality allied health education here at Duke and, now, across the U.S. as part of CAAHEP. Way to go!

 

Newest HF Collaboratory Members Include Three from Duke Heart

Congratulations to cardiology fellows Vanessa Blumer and Shahzeb Khan, and to former cardiology fellow Jordan Pomeroy! Blumer, Khan and Pomeroy were each asked to join the Heart Failure Collaboratory (HFC), and all were welcomed as new members last week during a quarterly meeting of the HFC’s Drugs and Devices Working Group.

Excellent additions to the Collaboratory!

 

Paul Farmer, MD & Dzau Distinguished Lecture in Global Health

We were shocked and deeply saddened this week by the passing of Duke alumnus and trustee emeritus Dr. Paul Farmer, who — along with Dr. Agnes Binagwaho, vice chancellor of the University of Global Health Equity in Rwanda — delivered the annual Victor J. Dzau Distinguished Lecture in Global Health on Jan. 26, 2022.

For those who were unable to attend that event (held via Zoom), we share the following article by our colleagues at Duke Global Health Institute. The article includes a link to the lecture: https://globalhealth.duke.edu/news/never-try-save-people-without-them-participating.

Reaction to his passing was swift and widespread. A compilation of moving tributes, including several from members of our Duke Heart team, can be found here:  https://globalhealth.duke.edu/news/dghi-reacts-death-dr-paul-farmer

Duke Today’s memorial piece about Farmer is available here: https://duke.is/jmxq6.

ICYMI: Genomic & Precision Medicine Forum

Duke Heart’s Bill Kraus was guest speaker at the Genomic & Precision Medicine Forum sponsored by the Duke Center for Applied Genomics & Precision Medicine on Thursday, Feb. 24. His lecture, “Components of Personalized Lifestyle Medicine with a Focus on Physical Activity” can be viewed here.

Great job, Bill!

Participants in Duke’s PROMOTE Study Hope to Improve Care for Type 2 Diabetes

Joining Duke’s diabetes study in Kannapolis at the N.C. Research Campus was part of Susan Wagner’s commitment to improving the health of her community.

“I have diabetes, and it’s somewhat under control. But I wanted to provide Duke with statistical data that they will need to build a model to address the issues of diabetes in Cabarrus County,” said Wagner, of Concord.

Retired from manufacturing, Wagner, 68, participates in several Duke Clinical and Translational Science Institute (CTSI) studies in Kannapolis, including the PROMOTE study. PROMOTE will assess whether a test product can improve insulin sensitivity in people with Type 2 diabetes.

The study seeks more people like Wagner, who are between the ages of 18 and 70 and are under the care of a healthcare professional for management of their disease.

“This study fit into the bigger picture for me,” she said. “I don’t know if I am getting the placebo or the product, but diabetics in Cabarrus County need data to improve their health.”

Study participation lasts about 15 weeks with six appointments in either Kannapolis or Durham. Participants are randomly assigned to receive either the test product or placebo.

The PROMOTE team in Kannapolis, led by Duke cardiologist Dr. Kristin Newby, recently expanded the study to a new Duke research facility in Durham. Launched in October 2020, Duke Research at Pickett Road encourages community participation and diversity in clinical research by providing a convenient and comfortable site for study participants and researchers.

“We are grateful to our study participants for their contributions to answering important healthcare questions,” Newby said. “Diabetes mellitus is such a challenging disease that affects almost every system in the body and can lead to a number of major long-term health consequences. Research into ways to improve management of diabetes is critical to reduce the burden of illness resulting from diabetes mellitus. To this end, we are excited to work with the community to conduct studies like PROMOTE.”

Wagner, who has had Type 2 diabetes since 1995, began focusing on diet and exercise when she took a class at Cabarrus Health Alliance and began reading labels, counting steps, and keeping a daily food log.

As her focus on health grew, Wagner began volunteering at Green Leaf Farms in the garden. She now eats mostly food that she has helped grow, and she’s enjoying relatively good health.

“This is not something that happened overnight,” Wagner said. “Part of this evolution was to join the PROMOTE study, as well as doing things like getting enough sleep and eating correct portions. It’s about expanding your toolbox.”

Like Wagner, Rosa Dorantes has Type 2 diabetes and participates in several Duke studies in Kannapolis. She joined PROMOTE after returning home to Granite Quarry from Mexico, where she had cared for a loved one who eventually passed away from complications due to diabetes.

Her family history of diabetes, and witnessing the devastating effects of the disease if untreated, motivated Dorantes to begin participating in clinical research seven years ago.

“I never thought that I would be a research participant, but it is important to me to help other people by helping researchers find new medicines,” said Dorantes, 56. “People are suffering.”

Dorantes, who works for her daughter’s diaper service in Charlotte, said she has improved her health by eating well and staying active. When her PROMOTE appointments are complete, she plans to keep enrolling in new studies.

“We are regular people,” she said. “For me to be able to do something like this, to perhaps save a life or help find a new medicine to help people, I can say I did something good during my journey.”

People who want to learn whether they qualify for PROMOTE can call 704-273-5456, email mailto:TransPop@duke.edu or visit duketranspop.org/promote. Compensation is provided for completed study activities.

To learn more about the Duke CTSI clinical research facility in Kannapolis, visit https://ctsi.duke.edu/research-support/duke-kannapolis. To learn more about Duke CTSI, visit ctsi.duke.edu.

 

COVID-19 Updates

The COVID-19 Employee Hotline hours are changing to reflect recent utilization trends. Beginning March 1, the hotline will be available during these times:

  • Monday — Friday: 8 a.m. to 5 p.m.
  • Saturday — Sunday: 8 a.m. to 12 p.m.

The phone number for the hotline is 919-385-0429 (option 1).

 

All the latest Clinical Operations updates related to COVID can be found at https://covid-19.dukehealth.org.

 

Upcoming Events & Opportunities

Cardiology Grand Rounds

March 1: Toward Allograft Longevity: Leveraging Multiomic Approaches to Understand Biomarkers and Biology of Heart Transplant Outcomes with Lauren Truby. 5 p.m. via Webex.

 

Duke Research & Innovation Virtual Conference

March 3 & March 4: The Evolving Role of Universities in the American Innovation System

Duke Research & Innovation is proud to co-sponsor The Evolving Role of Universities in the American Innovation System, a two-day virtual conference discussing the role of university research in the U.S. innovation ecosystem.

Hosted by the Center for Innovation Policy at Duke Law, this conference aims to outline a new framework for America’s universities in the context of the country’s long-term competitive future and features five presidents from five major universities, including Duke’s very own President Price.

The conference kicks off next Thursday, March 3rd and is open to everyone. Registration is required.

Upcoming Duke Heart CME

April 23: Duke Sports Cardiology & Sudden Death in Athletes Symposium with course directors Jim Daubert and Bill Kraus. Virtual. For information or to register, contact Christy Darnell christy.darnell@duke.edu or 919-880-8686.

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

Duke Heart in the News:

February 17 — Christopher Granger

HCPLive

Multifaceted Therapy Interventions Suggested for Patients with Diabetes, ASCVD

https://duke.is/nerg3

February 17 — Kristin Newby

WBTV.com (Charlotte, NC)

Participants in Duke’s PROMOTE study in Kannapolis hope to improve care for Type 2 diabetes

https://duke.is/bxx9c

February 19 — Kristin Newby

Independent Tribune

Participants in Duke’s PROMOTE study hope to improve care for Type 2 diabetes

https://duke.is/2cnjj

February 19 — Christopher Granger

Medscape

Full-press Therapy Rare in Diabetes With ASCVD

https://duke.is/48mqn

February 22 — Duke Health

Advisory Board

Update: The ‘Best Employers’ in health care, according to Forbes

https://duke.is/95myg

February 24 — Duke University

Forbes.com

Johns Hopkins Tops List Of Leading Universities For NIH Funding In 2021

https://duke.is/4ggpc

February 28 — Allan Kirk

The New Yorker

The Medical Miracle of a Pig’s Heart in a Human Body

https://duke.is/9phm8

Division of Cardiology Publications Indexed in PubMed February 17-23, 2022

Bodkin N, Ross M, McClain MT, Ko ER, Woods CW, Ginsburg GS, Henao R, Tsalik EL. Systematic comparison of published host gene expression signatures for bacterial/viral discrimination. Genome Med 2022;14(1):18. PM: 35184750.

Fanaroff AC, Lopes RD. The role of triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention. Prog Cardiovasc Dis 2021;69:11-17. PM: 34883097.

Fanaroff AC, Vora AN, Lopes RD. Non-vitamin K antagonist oral anticoagulants in patients with valvular heart disease. Eur Heart J Suppl 2022;24(Suppl A):A19-A31. PM: 35185406.

Kam W, Holmes DN, Hernandez AF, Saver JL, Fonarow GC, Smith EE, Bhatt DL, Schwamm LH, Reeves MJ, Matsouaka RA, Khan YM, Unverdorben M, Birmingham MC, Lyden PD, Asimos AW, Altschul D, Schoonover TL, Jumaa MA, Nomura JT, Suri MFK, Moore SA, Lafranchise EF. Association of Recent Use of Non-Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase. JAMA 2022;327(8):760-771. PM: 35143601.

Lam CSP, Ramasundarahettige C, Branch KRH, Sattar N, Rosenstock J, Pratley R, Del Prato S, Lopes RD, Niemoeller E, Khurmi NS, Baek S, Gerstein HC. Efpeglenatide and Clinical Outcomes With and Without Concomitant Sodium-Glucose Cotransporter-2 Inhibition Use in Type 2 Diabetes: Exploratory Analysis of the AMPLITUDE-O Trial. Circulation 2022;145(8):565-574. PM: 34775781.

Lau ES, Binek A, Parker SJ, Shah SH, Zanni MV, Van Eyk JE, Ho JE. Sexual Dimorphism in Cardiovascular Biomarkers: Clinical and Research Implications. Circ Res 2022;130(4):578-592. PM: 35175850.

Nelson AJ, O’Brien EC, Kaltenbach LA, Green JB, Lopes RD, Morse CG, Al-Khalidi HR, Aroda VR, Cavender MA, Gaynor T, Kirk JK, Lingvay I, Magwire ML, McGuire DK, Pak J, Pop-Busui R, Richardson CR, Senyucel C, Kelsey MD, Pagidipati NJ, Granger CB. Use of Lipid-, Blood Pressure-, and Glucose-Lowering Pharmacotherapy in Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease. JAMA Netw Open 2022;5(2):e2148030. PM: 35175345.

Pasquali SK, Thibault D, Hall M, Chiswell K, Romano JC, Gaynor JW, Shahian DM, Jacobs ML, Gaies MG, O’Brien SM, Norton EC, Hill KD, Cowper PA, Shah SS, Mayer JE, Jacobs JP. Evolving Cost-Quality Relationship in Pediatric Heart Surgery. Ann Thorac Surg 2022;113(3):866-873. PM: 34116004.

Peters AE, Mentz RJ, DeWald TA, Greene SJ. An evaluation of torsemide in patients with heart failure and renal disease. Expert Rev Cardiovasc Ther 2022;20(1):5-11. PM: 34936522.

Russo JJ, Yan AT, Pocock SJ, Brieger D, Owen R, Sundell KA, Bagai A, Granger CB, Cohen MG, Yasuda S, Nicolau JC, Brandrup-Wognsen G, Westermann D, Simon T, Goodman SG. Determinants of long-term dual antiplatelet therapy use in post myocardial infarction patients: Insights from the TIGRIS registry. J Cardiol 2022;79(4):522-529. PM: 34857432.

Utz PJ, Jain MK, Cheung VG, Kobilka BK, Lefkowitz R, Yamada T, Dzau VJ. Translating science to medicine: The case for physician-scientists. Sci Transl Med 2022;14(632):eabg7852. PM: 35171650.

Welsh RC, Dehghani P, Lopes R, Wojdyla DM, Aronson R, Granger CB, Windecker S, Vora AN, Vinereanu D, Halvorsen S, Parkhomenko A, Mehran R, Alexander JH, Goodman S. Impact of prior oral anticoagulant use and outcomes on patients from secondary analysis in the AUGUSTUS trial. Open Heart 2022;9(1):e001892. PM: 35172988.

Wilson RJ, Lyons SP, Koves TR, Bryson VG, Zhang H, Li T, Crown SB, Ding JD, Grimsrud PA, Rosenberg PB, Muoio DM. Disruption of STIM1-mediated Ca sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass. Mol Metab 2022;57:101429. PM: 34979330.

Wu JH, Zhang L, Nepliouev I, Brian L, Huang T, Snow KP, Schickling BM, Hauser ER, Miller FJ, Freedman NJ, Stiber JA. Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation. Cardiovasc Res 2022;118(3):772-784. PM: 33914863.

Zeitler EP, Poole JE, Albert CM, Al-Khatib SM, Ali-Ahmed F, Birgersdotter-Green U, Cha YM, Chung MK, Curtis AB, Hurwitz JL, Lampert R, Sandhu RK, Shaik F, Sullivan E, Tamirisa KP, Santos Volgman A, Wright JM, Russo AM. Arrhythmias in Female Patients: Incidence, Presentation and Management. Circ Res 2022;130(4):474-495. PM: 35175839

Duke Heart Pulse Week ending February 20th 2022

Highlights of the week:

Califf Confirmed as Commissioner for the FDA

Robert M. Califf, MD, Duke University adjunct professor of medicine (cardiology) and former director of the Duke Clinical Research Institute (DCRI), has been confirmed as commissioner for the U.S. Food and Drug Administration following a vote by the Senate on Tuesday, Feb. 15.  Califf’s appointment to the position will mark his second time heading the agency, which he also led during the final year of former President Barack Obama’s administration.

Califf was nominated to the post by President Joe Biden in November of 2021. His confirmation was hailed by his colleagues in the world of clinical research and academic medicine.

“Dr. Califf is the ideal choice to lead the FDA at this critical time,” said Mary E. Klotman, MD, dean of the Duke University School of Medicine. “He brings extraordinary experience and wisdom. I’m so appreciative of his willingness to serve our country again.”

“There’s no question that Rob Califf is the perfect fit for this job at this moment,” said Duke cardiologist and current executive director of the DCRI Adrian Hernandez, MD, a longtime colleague of Califf’s. “He has the background, the skills, the knowledge, and the personal integrity to lead the FDA at a critically important time.”

The nomination also garnered swift support from six former FDA Commissioners, who in a joint letter to the Senate confirmation committee praised Califf’s “lifelong commitment to leadership in promoting public health and advancing clinical science” and noted that his previous experience as commissioner would allow him to be uniquely well prepared to be “effective from day one.”

Califf’s new tenure at the FDA is likely to be marked by what many of his supporters consider one of his key strengths: a combination of enthusiasm and expertise applied to the task of developing scientific evidence that can be used to create better therapies and guide more informed decision-making by clinicians and patients.

That enthusiasm has long been a hallmark of Califf’s work at Duke, where he established a global reputation as an innovative and highly knowledgeable expert in clinical trials, particularly large, complex, and logistically challenging international studies.

“Rob has been a major force in establishing Duke as a leader in clinical and translational research on the world stage,” said A. Eugene Washington, MD, chancellor for health affairs at Duke University and president and CEO of Duke University Health System. “His exceptional leadership and unwavering commitment to evidence-based medicine and to the health and welfare of patients have driven us to higher levels of excellence and impact. His contributions have no doubt improved the lives of millions here and around the world, making Rob uniquely qualified to take on this pivotal role during these unprecedented times.”

Califf’s history at Duke stretches back to his undergraduate years in the early 1970s, when he majored in psychology. He went on to earn his medical degree from Duke, and aside from three years of residency in internal medicine at the University of California, San Francisco, Califf spent his entire career as cardiologist, researcher and senior leader at Duke until leaving in 2015 to assume the posts of deputy commissioner and later commissioner at the FDA.

During his medical training at Duke, Califf was mentored by Dr. Eugene Stead, Jr., a cardiologist and chair of Duke’s Department of Medicine. An early pioneer in the use of computer technology, Stead influenced Califf’s focus on gathering and analyzing data on patient outcomes. Stead’s mentorship would ignite Califf’s lifelong interest in the potential for combining computer technology with clinical data to answer important questions about medicine and patient care. That passion would ultimately lead to the creation of the Duke Clinical Research Institute, one of the world’s leading academic clinical research organizations. As the founding director of the DCRI, Califf oversaw and in many cases personally led numerous pivotal trials in cardiology and other medical specialties.

Despite the demands of his career in clinical research, throughout his decades at Duke, Califf continued to see patients as a working cardiologist. He distinguished himself as a teacher and mentor, helping to shape a new generation of physicians and clinical researchers.

After stepping down from his leadership post at the DCRI in 2006, Califf served as vice chancellor for clinical and translational research at Duke before moving to the FDA. Shortly afterward, Obama nominated him as commissioner and the Senate confirmed him in early 2016. Califf’s time at the helm of FDA was marked by efforts to update the agency’s approach to evaluating scientific evidence about the safety and effectiveness of medical products. In particular, this included developing a framework for incorporating new sources of data, including information gathered from sources such as electronic health records and administrative databases.

After leaving the FDA in early 2017, Califf returned briefly to Duke to create and lead Duke Forge, a university center for health data science, before transitioning in 2019 to a leadership role as senior adviser at Verily Life Sciences, a Google-affiliated company focused on health data. He will step down from that role to assume his new position as FDA chief.

“It’s hard for me to think of anyone who would be better prepared to lead the FDA, given the scope of Rob’s experience in patient care, research, and policy,” said Amy Abernethy, MD, PhD, president of Verily’s clinical research business and a former Duke professor of medicine who served as principal deputy commissioner and acting chief information officer at the FDA from February 2019 to April 2021. “And the fact that he’s led the FDA effectively before means that he’ll be able to get to work immediately on the most pressing issues on the agency’s to-do list. There’s no question that Rob will be prepared to hit the ground running.”

 

ADAPTABLE Team Selected for CR Forum Achievement Award

The Clinical Research (CR) Forum, a nonprofit organization dedicated to promoting understanding and support for clinical research and its impact on health and health care, has selected the ADAPTABLE study as a Top 10 Clinical Research Achievement Awardee for 2022. The awards recognize outstanding achievements in clinical research from across the U.S., identifying major advances in the biomedical field resulting from the nation’s investment in health and welfare.

The CR Forum will honor the ADAPTABLE research team on April 19 at a ceremony to be held at the Hyatt Regency McCormick Place in Chicago. The team will then present at Translational Science 2022 and meet with members of the U.S. Congress to promote the importance of funding for clinical research.

The CR Forum will present this award to Duke interventional cardiologist Schuyler Jones, MD, ADAPTABLE’s

Schuyler Jones

principal investigator, member of the Duke Clinical Research Institute and the lead author of the results paper, which was simultaneously published in the New England Journal of Medicine and presented at the 70th annual American College of Cardiology Scientific Session & Expo.

A pragmatic, open-label, patient-centered, randomized clinical trial, ADAPTABLE sought to determine the safest and most effective dose of aspirin for patients with existing cardiovascular disease. Despite aspirin being used as a secondary prevention method for nearly three decades, this question had not been studied previously.

Beginning in 2016, ADAPTABLE randomized 15,076 people with existing cardiovascular disease to receive either baby aspirin (81 mg) or regular strength aspirin (325 mg). Ultimately, investigators found no significant difference in either protective effects or bleeding risk between the two doses. However, the patients in the group taking the lower dose were less likely to switch doses mid-study; furthermore, that group’s patients were slightly less likely to discontinue aspirin completely.

Congratulations, Schuyler and team!

 

Early Exercise Interventions Used from Duke Trial to Decrease Cardiovascular Disease

With 2022 underway and the pandemic continuing, health and prevention of disease continues to be of the upmost importance. Physical activity has been shown to not only improve health, but help prevent the onset of many disorders – including cardiovascular disease.

Duke cardiologist William Kraus, MD, the Richard and Pat Johnson University Distinguished Professor at Duke University School of Medicine, a researcher and affiliated faculty for the Duke Center for Applied Genomics & Precision Medicine (CAGPM), is studying exercise effects in individuals ranging from healthy to those at-risk of disease and those with disease, such as coronary heart disease.

For the last 35 years, the Kraus laboratory particularly focuses on increased physical activity as the means by which to prevent premature cardiovascular death. Kraus’ well-known randomized exercise trials – STRRIDE (Studies of a Targeted Risk Reduction Intervention through Defined Exercise) are being used to investigate genetic predictors associated with individuals dropping out from or adherence to an exercise intervention. Postdoc Katherine Collins, PhD, is a research assistant in the Kraus Lab part of this endeavor, through the CAGPM T32 fellowship.

Specifically, Kraus Lab is currently working on a project using data from the STRRIDE trial to undertake the project, “Molecular Predictors of Dropout from and Adherence to Lifestyle Interventions.” The team has identified multiple variants within an array of genes associated with an individual’s ability to adhere to — or lack of ability to adhere to (i.e. dropout) — the STRRIDE exercise interventions. During her fellowship, Dr. Collins’ goal is to validate findings Kraus and his team have made to identify genetic variants associated with dropout and adherence to the randomized exercise trials. The team has investigated potential mediators of the genetic association with intervention dropout. During Collins’ time as a T32 fellow, she has been a valuable contributor to the project, bringing biospecimens from a 12-month behavioral weight loss randomized trial and utilizing data from the 2-year caloric restriction dietary intervention – CALERIE™ (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy) trial to further investigate Dr. Kraus’ initial findings.

“The CAGPM T32 fellowship has provided me hands-on experience, under the mentorship of Dr. Kraus, in human clinical trials, bio-banking, developing human samples into bio-molecular data, and human translational research as a whole,” said Collins. “This fellowship has helped me establish a foundation for my future research endeavors around precision medicine approaches in exercise and lifestyle interventions.”

These findings will help guide future interventions and help identify those individuals who may be most at-risk or prone to dropout or have poor adherence to exercise. The overarching goal of this investigation is to develop a personalized medicine approach for exercise, giving interventionists the ability to target at-risk individuals early in the invention process, pushing them past the key dropout phase—the initial 2 months—of the exercise intervention.

“We know physical activity is good and anything is better than none and more is better than less,” said Kraus. “However, the responses to physical activity and exercise are individually different, partly mediated by genetic factors. The tendency to engage in and maintain regular physical activity patterns are mediated by a combination of personality and genetic factors.”

Lack of physical activity is an ongoing public health concern. This is contributing to heart disease, even for people that have no risk factors, while also increasing the rates of obesity, diabetes, high blood pressure, and more.

“Outside of communicable diseases, cardiovascular disease remains the number one cause of premature death in the US and the World,” said Kraus. “The spectrum of cardiometabolic risk factors—hypertension, abnormal blood lipids and diabetes—are, separately and combined, the major non-lifestyle risk factor contributors to cardiovascular risk. Smoking, the lack of physical activity, and poor diets are the major lifestyle-related risk factors which also contribute to worsening hypertension, lipids and diabetes.”

Studies like these ultimately aim to help individuals maintain active lifestyles long-term.

Many of these issues will be addressed during the Genomic & Precision Medicine Forum being held February 24, where Kraus will be presenting on “Components of Personalized Lifestyle Medicine with a Focus on Physical Activity.” Learn more and register to attend the virtual talk on Zoom.

 

Kudos to Spates!

Cardiology fellow Toi Spates presented an excellent grand rounds this past week on the management of pregnancy and heart disease. Further, she did an interview on a related topic with CBS-17 (WNCN), see link below under “news”.

Nicely done!

 

COVID-19 Updates

All the latest Clinical Operations updates related to COVID can be found at https://covid-19.dukehealth.org.

Upcoming Events & Opportunities

Cardiology Grand Rounds

March 1: Lipoprotein (a): Unveiling the Mysterious Biomarker. Presenter will be Nishant Shah. 5 p.m. via Webex. Link will be sent via email.

Duke Genomic & Precision Medicine Forum Series

February 24: Guest will be William E. Kraus, MD speaking on Components of Personalized Lifestyle Medicine with a Focus on Physical Activity. Noon – 1 p.m. via Zoom. Sponsored by Duke Center for Applied Genomics & Precision Medicine. Registration is required; event is free. To learn more and to register, please visit:  https://bit.ly/3ouqDiK.

 

Upcoming Duke Heart CME

April 23: Duke Sports Cardiology & Sudden Death in Athletes Symposium with course directors Jim Daubert and Bill Kraus. Virtual. For information or to register, contact Christy Darnell christy.darnell@duke.edu or 919-880-8686.

 

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

Duke Heart in the News:

February 11 — Tracy Wang

The Science Times

Gestational Diabetes Linked to Chronic Cardiovascular Outcome Later in Life

https://duke.is/cwaa8

February 11 — Duke University Health System

Becker’s Hospital Review

48 hospitals on Forbes’ list of best employers

https://duke.is/wz8ez

February 13 — Stuart Russell

WPTF AM-640/Podcast

Aging Matters: Heart Failure 101

https://duke.is/4w5w4

February 15 — Toi Spates

WNCN CBS-17

Most women giving birth in the US have poor heart health before pregnancy

https://duke.is/9zj9w

February 17 — Adrian Hernandez

WNCN CBS-17

Duke doctors testing whether more ivermectin for twice as long will work against COVID-19

https://duke.is/wxmgt

Division of Cardiology Publications Indexed in PubMed February 10-16, 2022

Bhasin S, Lincoff AM, Basaria S, Bauer DC, Boden WE, Cunningham GR, Davey D, Dubcenco E, Fukumoto S, Garcia M, Granger CB, Kalahasti V, Khera M, Miller MG, Mitchell LM, O’Leary MP, Pencina KM, Snyder PJ, Thompson IM, Travison TG, Wolski K, Nissen SE. Effects of long-term testosterone treatment on cardiovascular outcomes in men with hypogonadism: Rationale and design of the TRAVERSE study. Am Heart J 2022;245:41-50. PM: 34871580.

Bhatt DL, Lopes RD, Harrington RA. Diagnosis and Treatment of Acute Coronary Syndromes: A Review. JAMA 2022;327(7):662-675. PM: 35166796.

Bloomfield GS, Weir IR, Ribaudo HJ, Fitch KV, Fichtenbaum CJ, Moran LE, Bedimo R, de Filippi C, Morse CG, Piccini J, Zanni MV, Lu MT, Hoffmann U, Grinspoon SK, Douglas PS. Prevalence and Correlates of Electrocardiographic Abnormalities in Adults With HIV: Insights From the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE). J Acquir Immune Defic Syndr 2022;89(3):349-359. PM: 35147583.

Bozkurt B, Hill JA, Al-Khatib SM. Sixth Annual Go Red for Women Issue. Circulation 2022;145(7):489-490. PM: 35157526.

Cardoso R, Ternes CMP, Justino GB, Fernandes A, Rocha AV, Knijnik L, d’Avila A, Lopes RD. Non-Vitamin K Antagonists Versus Warfarin in Patients with Atrial Fibrillation and Bioprosthetic Valves: A Systematic Review and Meta-Analysis. Am J Med 2022;135(2):228-234. PM: 34634252.

Carnicelli AP, Blumer V, Genovese L, Gage A, Agarwal R, Lakdawala NK, Bohula E, Katz JN. The Road Not Yet Traveled: Distinction in Critical Care Cardiology through the Advanced Heart Failure and Transplant Cardiology Training Pathway. J Card Fail 2022;28(2):339-342. PM: 35148880.

Carnicelli AP, Clare RM, Hofmann P, Chiswell K, DeVore AD, Vemulapalli S, Felker GM, Kelsey AM, DeWald TA, Sarocco P, Mentz RJ. Clinical trajectory of patients with a worsening heart failure event and reduced ventricular ejection fraction. Am Heart J 2022;245:110-116. PM: 34932997.

Chan PS, Spertus JA, Kennedy K, Nallamothu BK, Starks MA, Girotra S. In-Hospital Cardiac Arrest Survival in the United States During and After the Initial Novel Coronavirus Disease 2019 Pandemic Surge. Circ Cardiovasc Qual Outcomes 2022;15(2):e008420. PM: 35098727.

Chew DS, Li Y, Zeitouni M, Whellan DJ, Kitzman D, Mentz RJ, Duncan P, Pastva AM, Reeves GR, Nelson MB, Chen H, Reed SD. Economic Outcomes of Rehabilitation Therapy in Older Patients With Acute Heart Failure in the REHAB-HF Trial: A Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol 2022;7(2):140-148. PM: 34817542.

Chew DS, Li Z, Steinberg BA, O’Brien EC, Pritchard J, Bunch TJ, Mark DB, Patel MR, Nabutovsky Y, Greiner MA, Piccini JP. Arrhythmic Burden and the Risk of Cardiovascular Outcomes in Patients With Paroxysmal Atrial Fibrillation and Cardiac Implanted Electronic Devices. Circ Arrhythm Electrophysiol 2022;15(2):e010304. PM: 35089799.

Chiarito M, Baber U, Cao D, Sharma SK, Dangas G, Angiolillo DJ, Briguori C, Cohen DJ, Dudek D, Džavík V, Escaned J, Gil R, Hamm CW, Henry T, Huber K, Kastrati A, Kaul U, Kornowski R, Krucoff M, Kunadian V, Mehta SR, Moliterno D, Ohman EM, Oldroyd K, Sarde. Ticagrelor Monotherapy After PCI in High-Risk Patients With Prior MI: A Prespecified TWILIGHT Substudy. JACC Cardiovasc Interv 2022;15(3):282-293. PM: 35033468.

Echouffo-Tcheugui JB, Mwasongwe SE, Musani SK, Hall ME, Correa A, Hernandez AF, Golden SH, Mentz RJ, Bertoni AG. Dysglycemia and incident heart failure among blacks: The jackson heart study. Am Heart J 2022;245:1-9. PM: 34808103.

Ekerstad N, Javadzadeh D, Alexander KP, Bergström O, Eurenius L, Fredrikson M, Gudnadottir G, Held C, Ängerud KH, Jahjah R, Jernberg T, Mattsson E, Melander K, Mellbin L, Ohlsson M, Ravn-Fischer A, Svennberg L, Yndigegn T, Alfredsson J. Clinical Frailty Scale classes are independently associated with 6-month mortality for patients after acute myocardial infarction. Eur Heart J Acute Cardiovasc Care 2022;11(2):89-98. PM: 34905049.

Fordyce CB, Giugliano RP, Cannon CP, Roe MT, Sharma A, Page C, White JA, Lokhnygina Y, Braunwald E, Blazing MA. Cardiovascular Events and Long-Term Risk of Sudden Death Among Stabilized Patients After Acute Coronary Syndrome: Insights From IMPROVE-IT. J Am Heart Assoc 2022;11(4):e022733. PM: 35112882.

Fulda ES, Fitch KV, Overton ET, Zanni MV, Aberg JA, Currier JS, Lu MT, Malvestutto C, Fichtenbaum CJ, Martinez E, Umbleja T, Douglas PS, Ribaudo HJ, Grinspoon SK. COVID-19 Vaccination Rates in a Global HIV Cohort. J Infect Dis 2022;225(4):603-607. PM: 34794178.

Gibson CM, Mack MJ, Lee VT, Schneider DJ, Sellke FW, Ohman EM, Thourani VH, Doros G, Kroger H, Cutlip DE, Deliargyris EN. Rationale and design of the safe and timely antithrombotic removal – ticagrelor (STAR-T) trial: A prospective, multi-center, double-blind, randomized controlled trial evaluating reductions in postoperative bleeding with intraoperative removal of ticagrelor. Am Heart J 2022;245:19-28. PM: 34736855.

Granger BB, Tulsky JA, Kaufman BG, Clare RM, Anstrom K, Mark DB, Johnson KA, Patel CB, Fiuzat M, Steinhauser K, O’Connor C, Rogers JG, Mentz RJ. Polypharmacy in Palliative Care for Advanced Heart Failure: The PAL-HF Experience. J Card Fail 2022;28(2):334-338. PM: 34628013.

Gutierrez JA, Christian RT, Aday AW, Gu L, Schulteis RD, Shihai L, Petrini M, Sun AY, Swaminathan RV, Katzenberger DR, Banerjee S, Rao SV. Electronic alerts to initiate anticoagulation dialogue in patients with atrial fibrillation. Am Heart J 2022;245:29-40. PM: 34808105.

Harrington J, Felker GM. Leveraging Multiple Biomarkers to Assess Risk of Acute Heart Failure: Is More Better? J Card Fail 2022;28(2):234-236. PM: 34952784.

Harrington J, Gouda P, Ezekowitz J, Mentz RJ. Exploring the pragmatic-explanatory spectrum across cardiovascular clinical trials. Contemp Clin Trials 2022;113:106646. PM: 34863929.

Hirji SA, Sabatino ME, Minhas AMK, Okoh AK, Fudim M, Vaduganathan M, Khan MS. Contemporary Nationwide Heart Transplantation and Left Ventricular Assist Device Outcomes in Patients with Histories of Bariatric Surgery. J Card Fail 2022;28(2):330-333. PM: 34509598.

Lala A, Mentz RJ. Heart Month – A Historical Look and Simple “Walk” of Acknowledgement in the Present. J Card Fail 2022;28(2):169-170. PM: 35148879.

Mac Grory B, Ohman EM, Feng W, Xian Y, Yaghi S, Kamel H, Reznik ME. Advances in the management of cardioembolic stroke associated with patent foramen ovale. BMJ 2022;376:e063161. PM: 35140114.

Megaly M, Buda K, Alaswad K, Brilakis ES, Dupont A, Naidu S, Ohman M, Napp LC, O’Neill W, Basir MB. Comparative Analysis of Patient Characteristics in Cardiogenic Shock Studies: Differences Between Trials and Registries. JACC Cardiovasc Interv 2022;15(3):297-304. PM: 35144785.

Nanna MG, Vemulapalli S, Fordyce CB, Mark DB, Patel MR, Al-Khalidi HR, Kelsey M, Martinez B, Yow E, Mullen S, Stone GW, Ben-Yehuda O, Udelson JE, Rogers C, Douglas PS. The prospective randomized trial of the optimal evaluation of cardiac symptoms and revascularization: Rationale and design of the PRECISE trial. Am Heart J 2022;245:136-148. PM: 34953768.

Nathan AS, Yang L, Yang N, Eberly LA, Khatana SAM, Dayoub EJ, Vemulapalli S, Julien H, Cohen DJ, Nallamothu BK, Baron SJ, Desai ND, Szeto WY, Herrmann HC, Groeneveld PW, Giri J, Fanaroff AC. Racial, Ethnic, and Socioeconomic Disparities in Access to Transcatheter Aortic Valve Replacement Within Major Metropolitan Areas. JAMA Cardiol 2022;7(2):150-157. PM: 34787635.

Piccini JP, Ahlsson A, Dorian P, Gillinov MA, Kowey PR, Mack MJ, Milano CA, Perrault LP, Steinberg JS, Waldron NH, Adams LM, Bharucha DB, Brin MF, Ferguson WG, Benussi S. Design and Rationale of a Phase 2 Study of NeurOtoxin (Botulinum Toxin Type A) for the PreVention of Post-Operative Atrial Fibrillation – The NOVA Study. Am Heart J 2022;245:51-59. PM: 34687654.

Rao VN, Kelsey MD, Blazing MA, Pagidipati NJ, Fortin TA, Fudim M. Unexplained Dyspnea on Exertion: The Difference the Right Test Can Make. Circ Heart Fail 2022;15(2):e008982. PM: 35038884.

Sheehy S, Fonarow GC, Holmes DN, Lewis WR, Matsouaka RA, Piccini JP, Zhi L, Bhatt DL. Seasonal Variation of Atrial Fibrillation Admission and Quality of Care in the United States. J Am Heart Assoc 2022;11(4):e023110. PM: 35156386.

Ullal AJ, Holmes DN, Lytle BL, Matsouaka RA, Sheng S, Desai NR, Curtis AB, Fang MC, McCabe PJ, Fonarow GC, Russo AM, Lewis WR, Heidenreich PA, Piccini JP, Turakhia MP, Perino AC. Achievement and quality measure attainment in patients hospitalized with atrial fibrillation: Results from The Get With The Guidelines – Atrial Fibrillation (GWTG-AFIB) registry. Am Heart J 2022;245:90-99. PM: 34932998.

Vaduganathan M, Fonarow GC, Greene SJ, Devore AD, Albert NM, Duffy CI, Hill CL, Patterson JH, Spertus JA, Thomas LE, Williams FB, Hernandez AF, Butler J. Treatment Persistence of Renin-Angiotensin-Aldosterone-System Inhibitors Over Time in Heart Failure with Reduced Ejection Fraction. J Card Fail 202;28(2):191-201. PM: 34428591.

Vemulapalli S, Kerr MSD, Roberts GJ, Prillinger JB, Meduri CU, McCarthy P. Tricuspid valve disease prevalence and the impact of tricuspid valve surgery on cardiovascular events and hospital resource use in medicare beneficiaries. Am Heart J 2022;245:100-109. PM: 34932999.

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