Home » Uncategorized » Duke Heart Pulse — November 12, 2023

Duke Heart Pulse — November 12, 2023


Highlights of the week:

Trifecta Weekend: AHA, Alumni, & Veteran’s Day

It’s AHA Scientific Sessions weekend and we are thrilled to have the opportunity to gather together once again in Philadelphia! We will send scientific updates and Duke Presentations next week as the meeting goes on until Monday.

It’s also Duke Alumni Weekend — we hope all those who were on campus this weekend had a great time.

Just as importantly, it’s Veteran’s Day weekend. As we see rising discord across the world, we continue to be humbled by the dedication, sacrifice, and commitment of our military members and their families. Our Duke Heart team has long valued the health and well-being of veterans in our region, and we’ll continue to do so for as long as they need us.

Please share photos and highlights with us from throughout the weekend by emailing anything you’d like to share in next weekend’s Pulse. You can send items via email to either Tracey Koepke or Manesh Patel (or both!).


Clark Joins Duke Heart Team

Duke Heart is pleased to welcome Brian Clark, MD to our team! Clark, a congenital heart surgeon, is the newest faculty member to join the Division of Cardiovascular and Thoracic Surgery’s Section of Pediatric Cardiac Surgery. Clark joined the Duke School of Medicine on Nov. 1 as a professor of surgery and of pediatrics and will transition into the roles of Executive Co-Director of the Pediatric and Congenital Heart Center and Director of the Congenital Cardiac Surgery Fellowship program over the coming months.

Clark was born into a military family in eastern North Carolina — his father was a pilot in the Marine Corps, and his mother was a school teacher. Their family moved often, with several stops on the East Coast, plus stays in California and Japan. He returned to complete high school in eastern North Carolina, and his parents have since retired in the New Bern area. 

With the support of a full-tuition college scholarship from the Air Force, Clark obtained his undergraduate degree in mechanical engineering from the Massachusetts Institute of Technology. He then served on active duty as a civil engineering officer at Luke Air Force Base in Glendale, Arizona. Following his military service, he again returned to NC to attend medical school at the University of North Carolina at Chapel Hill. He stayed at UNC for the next step in training, completing a residency in general surgery as well as a two-year NIH-funded research fellowship.

He subsequently went on to complete fellowship training in cardiothoracic surgery at the University of Virginia in Charlottesville and then congenital cardiac surgery at Boston Children’s Hospital. In 2007, he joined the faculty at the Penn State College of Medicine in Hershey, Pennsylvania, where he ultimately became Professor of Pediatrics and Surgery and Chief of the Division of Pediatric Cardiac Surgery. During his 16-year tenure, the Penn State pediatric heart program was nationally recognized for superior patient outcomes. His research contributions focus on pediatric cardiopulmonary bypass, mechanical circulatory support, and neuroprotection. He has authored numerous publications in these areas and has served as a co-investigator on multiple long-term NIH grants for the development of pediatric and congenital heart assist devices. 

Brian and his wife Carol have two children, Jack and Kate. We are excited for them to be back home in NC! Please give them a warm welcome when you meet them.


AHA.23: Yibin Wang Receives AHA’s 2023 Basic Research Prize

Congratulations to Yibin Wang, PhD, FAHA, of Duke-NUS Medical School in Singapore and Duke University School of Medicine! The American Heart Association (AHA) presented its 2023 Basic Research Prize to Yang during the Presidential Session of the AHA’s Scientific Sessions.

Wang’s research focuses on the fundamental molecular and genetic mechanisms of cardiovascular physiology and cardiometabolic diseases. Under Wang’s leadership, his laboratory has developed innovative approaches to unlock the key molecules and pathways in which cells in mammals respond to pathological stress. His lab is credited with discovering new regulatory paradigms in molecular, epigenetic, and metabolic reprogramming during cardiac maturation and pathological remodeling. Wang’s work has directly contributed to many clinical studies and new trials for heart diseases.  During his career, his research has been funded by the American Heart Association, the National Institutes of Health, and the Department of Defense, as well as the Ministry of Education and the Ministry of Health in Singapore.

“Dr. Yibin Wang was selected for this prize because of his commitment to learning more about the genetic, molecular, and cellular mechanisms behind cardiovascular disease,” said Joseph C. Wu, MD, PhD, 2023-2024 volunteer President of the AHA. “Additionally, his research applies discoveries made about stress signaling networks to new methods of treatment for heart disease and the management of heart failure. Congratulations, Dr. Wang!”

Wang is a professor and director of the Cardiovascular and Metabolic Disorders Signature Research Program of Cardiovascular and Metabolic Disorders at Duke-NUS and a professor in medicine at Duke University School of Medicine. He is the scientific founder of a biotech start-up Ramino Bio and the principal investigator leading a 12-person research team that is developing new therapies based on what they have learned about cellular stress responses related to heart and metabolic diseases. He has written more than 270 peer-reviewed scientific articles, and two of his patents were licensed for evaluating and treating cardiometabolic disorders including heart failure, diabetes, and obesity.

“I’m truly humbled by this award from the Association, an organization that I am very fortunate to call home since the very beginning of my academic career,” said Wang. “However, this recognition is not for me alone but for all the team members and our collaborators over the years, who have devoted their talents and hard work in order to uncover new knowledge that can one day lead to new therapies for people with heart disease. I am very grateful to each of them and will use this award as a constant reminder that heart disease is still the number one killer and a challenge we must overcome with more research and better knowledge.”

Wang studied biochemistry at Fudan University during his undergraduate education. He earned a bachelor’s degree in biological sciences from the State University of New York and a doctoral degree in cell biology and molecular genetics from Baylor College of Medicine. He completed a research fellowship in neurobiology at Scripps Research Institute and a second research fellowship in molecular cardiology at the University of California San Diego. Wang was previously recognized by the AHA with the Established Investigator Award in 2005 and the Thomas Smith Memorial Lectureship in 2016. He has served on several AHA leadership committees at the national level including as a member of the Basic Cardiovascular Sciences Council.

Congratulations, Yibin!


Patel Delivers 2023 Stead Lecture:

Manesh Patel, MD, Richard Sean Stack, M.D. Distinguished Professor, delivered the Annual Eugene A. Stead Jr. Memorial Lecture as part of Medicine Grand Rounds on Friday morning, Nov. 10 in the Great Hall of the Trent Semans Center for Health Education at Duke. In case you missed his terrific lecture, Antithrombotic Therapy and Vascular Disease Management: Moving towards Precision CV care and the Duke Databank 3.0, you can watch a recording here.  

The lecture was very well attended and included FDA Commissioner Robert Califf, MD.


LEADS: Caring for Hospitalized Patients at the End-of-Life

Please join the Department of Medicine for their next LEADS: Caring for Hospitalized Patients at the End-of-Life, on November 14, 2023, from 12:15-1:00 p.m. in Duke North 2002 or via Zoom

Presenters for this session will be Neha Kayastha, MD, and Roberta Turner, MD, both assistant professors of medicine in Duke’s Division of General Internal Medicine.

Learning Objectives:

  • Use the physical exam to provide a prognosis in a dying patient.
  • Identify helpful ways to provide anticipatory guidance about difficult changes at the end-of-life.
  • Develop a treatment approach to the common physical symptoms that arise at the end-of-life.
  • Describe the hospice benefit and Duke-specific resources.

To learn more about the LEADS program and to see their current schedule, please visit: https://duke.is/y/vvrk.


Duke’s Annual Quality & Safety Conference Announced

Save the date for Duke’s Annual Quality and Safety Conference scheduled for April 11 in the Trent Semans Center. Click here to view Abstract Guidelines. Abstracts are due by 5 p.m. on Dec. 31, 2023. Late submissions will not be accepted. Contact cynthia.gordon@duke.edu or kyle.rehder@duke.edu with any questions.


Upcoming Events & Opportunities

  • November is Native American Heritage Month; Men’s Health month, and Lung Cancer Awareness month.
  • This week is National Nurse Practitioner Week (Nov. 12-18). Thank an NP for all they do!
  • Masking is strongly recommended throughout all clinical areas during respiratory virus season, from now through early March.


Cardiology Grand Rounds

Nov. 14: Cardiogenic shock treatment: Between clinical practice and current evidence with Holger Thiele of the Heart Center Leipzig at University of Leipzig, Germany. 5 p.m., DN 2002 or via Zoom.

All 2023 Duke Cardiology Grand Rounds recordings are uploaded to Warpwire. Recordings can be accessed via this link: https://duke.is/DukeCGR; NET ID and password required. Our newest recording is of Dr. Sandra Ofori of McMaster University who presented to us Nov. 8 on Perioperative Smoking Cessation.

CD Fellows Core Curriculum Conference

Conference information was not provided for the coming week ahead of publications. We’ll add dates/times as they are received. Sorry for any inconvenience.

2023 Barbara Hertzberg Women’s Health Lectureship

Nov. 16: Coronary Artery Disease in Women: Where are we in 2023? with Leslee J. Shaw, PhD, of the Icahn School of Medicine at Mt. Sinai. 7:30 a.m., DN 2002 or via Zoom.

THIS WEEK! 15th Annual Pulmonary Hypertension Symposium

The 15th annual NC Research Triangle Pulmonary Hypertension Symposium will be held this week on Friday, November 17th at the Durham Convention Center. Faculty directors will be H. James Ford, MD, director of the PH program at UNC, and Terry Fortin, MD, co-director of the Pulmonary Vascular Disease Center at Duke. Registration is now open: https://duke.is/9/7rs5. Please join us!

A&H Winterfest 2023

The dates for Winterfest Marketplace 2023, the annual holiday art show and sale hosted by Arts & Health at Duke, will take place across six Thursdays in November and December, local North Carolina-based artisans will display and sell their work to Duke Health employees, visitors and patients in the main concourse of Duke Hospital

The event begins on November 2 and runs until December 14. During Winterfest, art will be available for purchase on Thursdays from 11 a.m. to 2 p.m. Featured artisans will include Beth Ann Taylor, Chapel Hill Woodturners, Bonnie Toney, and Justin Leitner.

A portion of the proceeds from Winterfest will go back to Arts & Health at Duke, which provides support to patients through music, visual art activities, and journaling. This is a great opportunity to support local artists, and the Arts & Health programming at Duke Health, and to score some beautiful holiday gifts for loved ones!


5th Annual Invented at Duke Celebration

Duke’s Office for Translation & Commercialization (OTC) invites you to the 2023 ‘Invented at Duke’ celebration, their annual showcase of Duke inventors and inventions. This year, the event will take place on Tuesday, November 28, 2023, from 4:30 to 7 p.m. at Duke’s beautiful Penn Pavilion.

Remarks are expected from Vincent Price, president of Duke University; Robin Rasor, head of OTC; and Jungsang Kim, the Schiciano Family Distinguished Professor of Electrical and Computer Engineering, co-founder of IonQ and a strong supporter of the translation and commercialization community on campus.

The remainder of the event will feature booths hosted by Duke inventors, drinks and hors d’oeuvres, gifts for Duke inventors who register and attend, and more. The celebration will showcase innovations and companies that have not only been started by Duke faculty and students but have also been supported through funding and mentoring by a variety of Duke translational funds, incubators, and more.

Whether you’re already part of the Duke entrepreneurial and innovation ecosystem or you’re just starting to explore how to bring your research out to the public – or perhaps you’re a member of the wider Triangle technology commercialization ecosystem – there will be something to learn and celebrate.

Attire: business casual.

Parking: at the Bryan Center Parking Garage – follow event signs and tell the attendant at the entrance and exit that you’re there for Invented at Duke and you will receive free parking.

The event is free, but registration is required. You’ll receive an e-ticket to present at the door.


Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, on Wednesdays, will be considered for weekend inclusion.

Duke Heart in the News:

November 4 — Renato Lopes


Lower rates of access thrombosis for patients with CKD who receive daprodustat vs. EPO

November 4 — Robert Lefkowitz

Spectrum News Charlotte  **(*clip begins @ 04:31:34)

Researcher marks 50 years of science (updates 10/30 story)

November 5 — Joseph Turek

CBS-17 (Raleigh-Durham)

NC baby gets new heart, donates valves to another in state’s 1st domino partial heart transplant at Duke

Fox-8/WGHP (Greensboro/High Point/Winston-Salem)

North Carolina baby gets new heart, donates valves to another in state’s 1st domino partial heart transplant at Duke


NC baby gets new heart in state’s 1st domino partial heart transplant at Duke

November 6 — Duke Raleigh Hospital

WUNC, 91.5/NC Public Radio

Cursed at. Shoved. Punched. Bitten. Violence against doctors and nurses is rising. A new N.C. law aims to help protect them.

November 6 — DUH & Duke Raleigh

Becker’s Clinical Leadership

56 US hospitals honored for surgical patient care

November 7 — Duke Health

Triangle Business Journal*

Duke Health, WakeMed shine as NC stays among top states for hospital safety

*subscription required; for a PDF, contact Tracey

November 7 — Yuichiro Yano (Family Medicine/Community Health)

Cardiovascular Business

ChatGPT tackles hypertension: Popular AI model a helpful resource for patients with high blood pressure

November 9 — Nishant Shah

NBC News

What to know about Zepbound, Eli Lilly’s new weight loss drug

*also carried by NBC News affiliates, Yahoo, MSN & AOL.com News, and Chiang Rai News (China)

November 10 — Nishant Shah

NBC Today Show

Weight loss drug Zepbound approved by FDA: Woman who lost 123 pounds shares story

November 10 — Zubin Eapen

DotMed Healthcare Business News

One company’s approach to advancing wearable defibrillators

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