Recent collaborative work got published!

Two of our recent collaboration work contributed by PhD student Shengjie Xu in our lab have been published:

The article published from Tomo Souma’s group found that Yolk-sac-derived macrophages can expand with age and become a major contributor to the renal macrophage population in older mice.
Read more: https://elifesciences.org/articles/51756

The article from Prof. Hyun-Ah Kang of Chung-An University revealed the roles of N-glycan core structure in cryptococcal pathogenicity by inducing macrophage cell death.
Read more: https://mbio.asm.org/content/11/3/e00711-20

Study about CLR functions in CNS autoimmunity has been published!

New study lead by MD-PhD student Elizabeth Deerhake on a CLR, dectin-1, in CNS autoimmuity is now available in BioRxiv. Unexpectedly, Dectin-1 “limits” EAE through a CARD9-independent pathway in myeloid cells secreting OSM, which is then detected by astrocytes.

Read the article "Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway" here: https://www.biorxiv.org/content/10.1101/2020.05.06.080481v1

- Dectin-1 is a protective C-type lectin receptor (CLR) in experimental autoimmune encephalomyelitis (EAE) - Dectin-1 promotes expression of Osm, a neuroprotective IL-6 family cytokine, in myeloid cells - OsmR signaling in astrocytes limits EAE progression and promotes remission - Non-canonical Card9-independent signaling drives a distinct Dectin-1-mediated transcriptional program to induce expression of Osm and other factors with protective or anti-inflammatory functions

Two undergrad students defended their honor theses

Two of our lab undergrads just defended their honor theses by Zoom. Due to COVID, a poster session turned into a Zoom presentation and celebration. Congratulations to Nathan Luzum and Emre Cardakli for their wonderful honor's theses. Great job done by their direct supervising students Will Barclay and Elizabeth Deerhake!

Congratulations to our first PhD student Shengjie for defending her thesis virtually!

Despite the Covid pandemic hitting the country in early March and the restriction of any group gathering on Duke campus, our student Shengjie successfully defended her thesis in Jones Room 143 on March 13th, 2020 in front of her committee while streaming the whole public presentation through WebEx. We celebrated her defense afterward with champagne and cake.

Her thesis topic "Sentinel Functions of Tissue Resident Macrophages During Early Fungal Infections" especially featured the characterization of two distinct states of alveolar macrophages during early fungal infection. The results of her study will be published later this year in Science Immunology.