Welcome to the lab, Amesha! We are so happy to have you.
Alveolar macrophages show two opposing “flavors” in the same lung fungal infection. Great job Shengjie!
Two of our recent collaboration work contributed by PhD student Shengjie Xu in our lab have been published:
The article published from Tomo Souma’s group found that Yolk-sac-derived macrophages can expand with age and become a major contributor to the renal macrophage population in older mice.
Read more: https://elifesciences.org/articles/51756
The article from Prof. Hyun-Ah Kang of Chung-An University revealed the roles of N-glycan core structure in cryptococcal pathogenicity by inducing macrophage cell death.
Read more: https://mbio.asm.org/content/11/3/e00711-20
New study lead by MD-PhD student Elizabeth Deerhake on a CLR, dectin-1, in CNS autoimmuity is now available in BioRxiv. Unexpectedly, Dectin-1 “limits” EAE through a CARD9-independent pathway in myeloid cells secreting OSM, which is then detected by astrocytes.
Read the article "Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway" here: https://www.biorxiv.org/content/10.1101/2020.05.06.080481v1
Two of our lab undergrads just defended their honor theses by Zoom. Due to COVID, a poster session turned into a Zoom presentation and celebration. Congratulations to Nathan Luzum and Emre Cardakli for their wonderful honor's theses. Great job done by their direct supervising students Will Barclay and Elizabeth Deerhake!
Despite the Covid pandemic hitting the country in early March and the restriction of any group gathering on Duke campus, our student Shengjie successfully defended her thesis in Jones Room 143 on March 13th, 2020 in front of her committee while streaming the whole public presentation through WebEx. We celebrated her defense afterward with champagne and cake.
Her thesis topic "Sentinel Functions of Tissue Resident Macrophages During Early Fungal Infections" especially featured the characterization of two distinct states of alveolar macrophages during early fungal infection. The results of her study will be published later this year in Science Immunology.
Please check out our review article discussing various animal models of IRIS (Immune Reconstitution inflammatory Syndrome):
Protocols and outcomes of three mouse IRIS models:
Please check our recent collaborative work on the developmental origins of osteoclast by the 1st author Yasuhito Yahara: https://t.co/XAb8YoX3F8?amp=1
Elizabeth @MEDeerhake in our lab was selected to attend the Young Scientist Summit sponsored by the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS).
Please check out our review article discussing pattern recognition receptors (PRRs) in MS and EAE: