The Center for Research in Implementation Science and Prevention (CRISP) at the University of Colorado has produced an eBook on pragmatic clinical trials. The eBook uses the Pragmatic-Explanatory Continuum Indicator Summary (PRECIS-2) framework to cover topics including pragmatic trial design, study populations and settings, and real-world use. Methods for stakeholder engagement are also reviewed. The content is offered as self-study modules for researchers. Each section has learning objectives, links to resources and references, and key takeaways.