The Living Textbook Has Moved!

Visit the new Living Textbook at

If you’re looking for the NIH Health Care Systems Research Collaboratory’s Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials, you can now find us at:

We hope you’ll come explore our redesigned site, which features new content and features designed to provide answers to your questions about the design, conduct, and dissemination of pragmatic clinical trials, including:

  • 12 detailed chapters with expert insight on pragmatic trials
  • Real-world examples from the NIH Collaboratory
  • Up-to-date information on best practices for designing and conducting pragmatic trials
  • Strategies for disseminating and implementing evidence from pragmatic trials
  • Descriptions of unique challenges posed by pragmatic trials and solutions to these
  • Information on the importance of pragmatic trials and their impact on healthcare
  • Trusted resources and academic references that can help guide pragmatic trials
  • Comprehensive information about the NIH Collaboratory program, including its Demonstration Projects, Core Working Groups, News, Events, and more