Welcome to the Living Textbook

Welcome to the NIH Collaboratory’s Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials! The Living Textbook is designed to provide information on how to understand, design, conduct, analyze & disseminate pragmatic clinical trials (PCTs).

Rethinking Clinical Trials - Page for all topic chapter links


Topic Chapters provide detailed, textbook-like information on various aspects of pragmatic clinical trials, complete with citations and links to resources.

Introduction Conflict of Interest Informed Consent Patient-Reported Outcomes Regulatory Issues Learning Healthcare Systems EHR Phenotyping

Rethinking Clinical Trials - Page for all links for Tools for Research


Tools for Research encompasses practical guidance and “toolkits” for conducting different aspects of pragmatic clinical research.

Electronic Phenotyping Biostatistical Guidances Data QualityComputer-Adaptive Testing Patient-Reported Outcomes White Papers Writing for Clinical Research Intro to Pragmatic Clinical Trials

Link for front page of Living Textbook blog


The Living Textbook Blog offers news and updates related to pragmatic clinical research, as well as bulletins about new content available on Rethinking Clinical Trials and the NIH Collaboratory Knowledge Repository.

Blog Front Page RSS Feed Knowledge Repository Collaboratory Grand Rounds

Originally published on January 3, 2014.
Updated April 13, 2015.

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