Embryonic and Germ Cells

A mutation in an RNA-binding protein, DND1, leads to a high incidence of teratomas on some genetic backgrounds. Teratomas arise from germ cells only during the developmental window soon after they arrive in the gonad. At this stage, the germ cell genome has a differentiation potential similar to embryonic stem cells.

Under normal conditions, DND1 suppresses the tumorigenic potential of germ cells and regulates their stable transition to prospermatogonia. Identification of the targets of DND1, and the strain-specific signals that influence this transition, will reveal common intracellular and extracellular mechanisms of communication between stem cells and their niches.

L. Ryan Baugh, Ph.D.
Assistant Professor, Department of Biology
Office Location: 4314 FFSC
Lab Location: 4336 FFSC
Office Phone: (919) 613-8179
Mailing Address:
Box 90338
Duke University
Durham, NC 27708
Email: ryan.baugh@duke.edu
Website

Phillip Benfey, Ph.D.
Professor, Department of Cell Biology
Box 90338, 130 Science Drive
Duke University
Durham, NC 27708
Email: philip.benfey@duke.edu
Website

Blanche Capel, Ph.D.
Department of Cell Biology
Box 3709
Durham, NC 27710
Phone: 919-684-6390
Email: b.capel@cellbio.duke.edu
Website

Stefano DiTalia, Ph.D.
Department of Cell Biology
368B Nanaline Duke Building, Box 3709
Duke University Medical Center
Durham, NC 27710
Email: stefano.ditalia@duke.edu
Website

David Sherwood, Ph.D.
Department of Biology
Box 90338, Science Drive
Duke University
Durham, NC 27710
Phone: 919-613-9037
E-mail: david.sherwood@duke.edu
Website