Full List of publications: PubMed – Sudarshan Rajagopal

Selected Publications


Narayanan S, Vasukuttan V, Rajagopal S, Maitra R, Runyon SP. Identification of Potent Pyrazole Based APELIN Receptor (APJ) Agonists. Bioorg Med Chem. 2020 Feb 15;28(4):115237. (PMID: 31948845)


Tsai C-F, Smith JS, Krajewski K, Zhao R, Moghieb AM, Nicora CD, Xiong X, Moore RJ, Liu T, Smith RD, Jacobs JM, Rajagopal S, Shi T. Tandem Mass Tag Labeling Facilitates Reversed-Phase Liquid Chromatography-Mass Spectrometry Analysis of Hydrophilic Phosphopeptides. Anal Chem. 2019 Sep 17;91(18):11606-11613. (PMID: 31418558)

Viswanathan G, Mamazhakypov A, Schermuly RT, Rajagopal S. The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension. Front Cardiovasc Med. 2018 Dec 17;5:179. (PMID: 30619886)

Ma Z, Yu YR, Badea CT, Kovacs JJ, Xiong X, Comhair S, Piantadosi CA, Rajagopal S. Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1. Circulation. 2019 Mar 26;139(13):1629-1642. (PMID: 30586762)

Rajarathnam K, Schnoor M, Richardson RM, Rajagopal S. How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways. Cell Signal. 2019 Feb;54:69-80. (PMID: 30465827)



Smith JS, Nicholson LT, Suwanpradid J, Glenn RA, Knape NM, Alagesan P, Gundry JN, Wehrman TS, Atwater AR, Gunn MD, MacLeod AS, Rajagopal S. Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation. Sci Signal. 2018 Nov 6;11(555). (PMID: 30401786)

Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ. Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Sci Signal. 2018 Sep 25;11(549). pii: eaat7650 (PMID: 30254056)

Smith JS, Lefkowitz RJ, Rajagopal S. Biased signalling: from simple switches to allosteric microprocessors. Nat Rev Drug Discov. 2018 Apr;17(4):243-260. (PMID: 29302067)



Smith JS, Alagesan P, Desai NK, Pack TF, Wu JH, Inoue A, Freedman NJ, Rajagopal S. C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways. Mol Pharmacol. 2017 Aug;92(2):136-150. (PMID: 28559424)

Onaran HO, Ambrosio C, Uğur Ö, Madaras Koncz E, Grò MC, Vezzi V, Rajagopal S, Costa T. Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach. Sci Rep. 2017 Mar 14;7:44247. (PMID: 28290478)

Gundry J, Glenn R, Alagesan P, Rajagopal S. A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors. Front Neurosci. 2017 Jan 24;11:17. (PMID: 28174517)

Rajagopal S, Shenoy SK. GPCR desensitization: Acute and prolonged phases. Cell Signal. 2017 Jan 28. pii: S0898-6568(17)30030-X. (PMID: 28137506)



Ma Z, Mao L, Rajagopal S. Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension. J Vis Exp. 2016 Apr 11;(110). (PMID: 271676769)

Smith JS, Rajagopal S. The β-arrestins: Multifunctional regulators of G protein-coupled receptors. J Biol Chem. 2016 Apr 22;291(17):8969-77. [Review] (PMID: 26984408)



Onaran O, Rajagopal S, Costa TP. (2014) What is Biased Efficacy? Defining the Relationship Between Intrinsic Efficacy and Allosteric Coupling. Trends Pharmacol Sci 35(12):639-47. (PMID: 25448316)

Kahsai AW, Rajagopal S, Sun J, Xiao K. (2014) Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry. Nature Protocols 9(6): 1301-19. (PMID: 24810039)



Rajagopal S, Bassoni DL, Campbell JJ, Gerard NP, Gerard CG, Wehrman TS. (2013) Biased Agonism as a Mechanism for Differential Signaling. J Biol Chem. 288(49): 35039-48. (PMID: 24145037)

Rajagopal S. (2013) Quantifying biased agonism: understanding the links between affinity and efficacy. Nat Rev Drug Discov 12: 483. (PMID: 23681006)