Selected Publications


Smith JS, Alagesan P, Desai NK, Pack TF, Wu JH, Inoue A, Freedman NJ, Rajagopal S. C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways. Mol Pharmacol. 2017 Aug;92(2):136-150. (PMID: 28559424)

Onaran HO, Ambrosio C, Uğur Ö, Madaras Koncz E, Grò MC, Vezzi V, Rajagopal S, Costa T. Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach. Sci Rep. 2017 Mar 14;7:44247. (PMID: 28290478)

Gundry J, Glenn R, Alagesan P, Rajagopal S. A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors. Front Neurosci. 2017 Jan 24;11:17. (PMID: 28174517)

Rajagopal S, Shenoy SK. GPCR desensitization: Acute and prolonged phases. Cell Signal. 2017 Jan 28. pii: S0898-6568(17)30030-X. (PMID: 28137506)



Ma Z, Mao L, Rajagopal S. Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension. J Vis Exp. 2016 Apr 11;(110). (PMID: 271676769)

Smith JS, Rajagopal S. The β-arrestins: Multifunctional regulators of G protein-coupled receptors. J Biol Chem. 2016 Apr 22;291(17):8969-77. [Review] (PMID: 26984408)



Onaran O, Rajagopal S, Costa TP. (2014) What is Biased Efficacy? Defining the Relationship Between Intrinsic Efficacy and Allosteric Coupling. Trends Pharmacol Sci 35(12):639-47. (PMID: 25448316)

Kahsai AW, Rajagopal S, Sun J, Xiao K. (2014) Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry. Nature Protocols 9(6): 1301-19. (PMID: 24810039)


Rajagopal S, Bassoni DL, Campbell JJ, Gerard NP, Gerard CG, Wehrman TS. (2013) Biased Agonism as a Mechanism for Differential Signaling. J Biol Chem. 288(49): 35039-48. (PMID: 24145037)

Rajagopal S. (2013) Quantifying biased agonism: understanding the links between affinity and efficacy. Nat Rev Drug Discov 12: 483. (PMID: 23681006)

Full List of publications: PubMed – Sudarshan Rajagopal