Full List of publications: PubMed – Sudarshan Rajagopal
Selected Publications
2023
Viswanathan G, Kirshner HF, Nazo N, Ali S, Ganapathi A, Cumming I, Zhuang Y, Choi I, Warman A, Almeida-Peters S, Haney J, Corcoran D, Yu YR, Rajagopal S. Single-Cell Analysis Reveals Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension. Am J Respir Crit Care Med. 2023 Feb 21. doi: 10.1164/rccm.202203-0441OC. (PMID: 36803741)
2022
Park S, Ma Z, Zarkada G, Papangeli I, Paluri S, Nazo N, Rivera-Molina F, Toomre D, Rajagopal S, Chun HJ. Endothelial β-arrestins regulate mechanotransduction by the type II bone morphogenetic protein receptor in primary cilia. Pulm Circ. 2022 Oct 1;12(4):e12167. doi: 10.1002/pul2.12167. eCollection 2022 Oct. (PMID: 36532314)
Eiger DS, Boldiszar N, Honeycutt CC, Gardner J, Kirchner S, Hicks C, Choi I, Pham U, Zheng K, Warman A, Smith JS, Zhang JY, Rajagopal S. Location bias contributes to functionally selective responses of biased CXCR3 agonists. Nat Commun. 2022 Oct 4;13(1):5846. doi: 10.1038/s41467-022-33569-2. (PMID: 36195635)
Zheng K, Smith JS, Eiger DS, Warman A, Choi I, Honeycutt CC, Boldizsar N, Gundry JN, Pack TF, Inoue A, Caron MG, Rajagopal S. Biased agonists of the chemokine receptor CXCR3 differentially signal through Gα i:β-arrestin complexes. Sci Signal. 2022 Mar 22;15(726):eabg5203. (Link here for full text)
Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov K, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, Shukla AK, Sommer ME, Gloriam DE. Community Guidelines for GPCR Ligand Bias: IUPHAR Review XX. Br J Pharmacol. 2022 Feb 1. doi: 10.1111/bph.15811.
2021
Ma Z, Viswanathan G, Sellig M, Jassal C, Choi I, Garikipati A, Xiong X, Nazo N, Rajagopal S. β-Arrestin–Mediated Angiotensin II Type 1 Receptor Activation Promotes Pulmonary Vascular Remodeling in Pulmonary Hypertension. J Am Coll Cardiol Basic Trans Science. 2021 Nov, 6 (11) 854–869 (PMID: 34809910)
Tsai CF, Smith JS, Eiger DS, Martin K, Liu T, Smith RD, Shi T, Rajagopal S, Jacobs JM. Mass Spectrometry-Based Proteomics for Analysis of Hydrophilic Phosphopeptides. Methods Mol Biol. 2021;2259:247-257. (PMID: 33687720)
Alba GA, Samokhin AO, Wang RS, Zhang YY, Wertheim BM, Arons E, Greenfield EA, Lundberg Slingsby MH, Ceglowski JR, Haley KJ, Bowman FP, Yu YR, Haney JC, Eng G, Mitchell RN, Sheets A, Vargas SO, Seo S, Channick RN, Leary PJ, Rajagopal S, Loscalzo J, Battinelli EM, Maron BA. NEDD9 is a Novel and Modifiable Mediator of Platelet-Endothelial Adhesion in the Pulmonary Circulation. Am J Respir Crit Care Med. 2021 Feb 1. (PMID: 33523764)
Smith JS, Pack TF, Inoue A, Lee C, Zheng K, Choi I, Eiger DS, Warman A, Xiong X, Ma Z, Viswanathan G, Levitan IM, Rochelle LK, Staus DP, Snyder JC, Kahsai AW, Caron MG, Rajagopal S. Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors. Science. 2021 Jan 21:eaay1833. (here)
2020
Yu YA, Malakhau Y, Yu CA, Phelan SJ, Cumming RI, Kan MJ, Mao L, Rajagopal S, Piantadosi CA, Gunn MD. Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension. J Immunol. 2020 Mar 15;204(6):1474-1485. (PMID: 31996456)
Narayanan S, Vasukuttan V, Rajagopal S, Maitra R, Runyon SP. Identification of Potent Pyrazole Based APELIN Receptor (APJ) Agonists. Bioorg Med Chem. 2020 Feb 15;28(4):115237. (PMID: 31948845)
2019
Tsai C-F, Smith JS, Krajewski K, Zhao R, Moghieb AM, Nicora CD, Xiong X, Moore RJ, Liu T, Smith RD, Jacobs JM, Rajagopal S, Shi T. Tandem Mass Tag Labeling Facilitates Reversed-Phase Liquid Chromatography-Mass Spectrometry Analysis of Hydrophilic Phosphopeptides. Anal Chem. 2019 Sep 17;91(18):11606-11613. (PMID: 31418558)
Viswanathan G, Mamazhakypov A, Schermuly RT, Rajagopal S. The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension. Front Cardiovasc Med. 2018 Dec 17;5:179. (PMID: 30619886)
Ma Z, Yu YR, Badea CT, Kovacs JJ, Xiong X, Comhair S, Piantadosi CA, Rajagopal S. Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1. Circulation. 2019 Mar 26;139(13):1629-1642. (PMID: 30586762)
Rajarathnam K, Schnoor M, Richardson RM, Rajagopal S. How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways. Cell Signal. 2019 Feb;54:69-80. (PMID: 30465827)
2018
Smith JS, Nicholson LT, Suwanpradid J, Glenn RA, Knape NM, Alagesan P, Gundry JN, Wehrman TS, Atwater AR, Gunn MD, MacLeod AS, Rajagopal S. Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation. Sci Signal. 2018 Nov 6;11(555). (PMID: 30401786)
Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ. Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Sci Signal. 2018 Sep 25;11(549). pii: eaat7650 (PMID: 30254056)
Smith JS, Lefkowitz RJ, Rajagopal S. Biased signalling: from simple switches to allosteric microprocessors. Nat Rev Drug Discov. 2018 Apr;17(4):243-260. (PMID: 29302067)
2017
Smith JS, Alagesan P, Desai NK, Pack TF, Wu JH, Inoue A, Freedman NJ, Rajagopal S. C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways. Mol Pharmacol. 2017 Aug;92(2):136-150. (PMID: 28559424)
Onaran HO, Ambrosio C, Uğur Ö, Madaras Koncz E, Grò MC, Vezzi V, Rajagopal S, Costa T. Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach. Sci Rep. 2017 Mar 14;7:44247. (PMID: 28290478)
Gundry J, Glenn R, Alagesan P, Rajagopal S. A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors. Front Neurosci. 2017 Jan 24;11:17. (PMID: 28174517)
Rajagopal S, Shenoy SK. GPCR desensitization: Acute and prolonged phases. Cell Signal. 2017 Jan 28. pii: S0898-6568(17)30030-X. (PMID: 28137506)
2016
Ma Z, Mao L, Rajagopal S. Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension. J Vis Exp. 2016 Apr 11;(110). (PMID: 271676769)
Smith JS, Rajagopal S. The β-arrestins: Multifunctional regulators of G protein-coupled receptors. J Biol Chem. 2016 Apr 22;291(17):8969-77. [Review] (PMID: 26984408)
2014
Onaran O, Rajagopal S, Costa TP. (2014) What is Biased Efficacy? Defining the Relationship Between Intrinsic Efficacy and Allosteric Coupling. Trends Pharmacol Sci 35(12):639-47. (PMID: 25448316)
Kahsai AW, Rajagopal S, Sun J, Xiao K. (2014) Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry. Nature Protocols 9(6): 1301-19. (PMID: 24810039)
2013
Rajagopal S, Bassoni DL, Campbell JJ, Gerard NP, Gerard CG, Wehrman TS. (2013) Biased Agonism as a Mechanism for Differential Signaling. J Biol Chem. 288(49): 35039-48. (PMID: 24145037)
Rajagopal S. (2013) Quantifying biased agonism: understanding the links between affinity and efficacy. Nat Rev Drug Discov 12: 483. (PMID: 23681006)
