This study investigates the impact of exercise on cardiac function across different APOE genotypes in mice using low-dose cardiac photon-counting micro-CT and deep learning-based segmentation. Results show significant, genotype-dependent improvements in cardiac performance, with the largest effects observed in APOE3 and APOE4 mice.
Allphin AJ, Nadkarni R, Han ZY, Clark DP, Ghaghada KB, Badea A, Badea CT. Assessing the cardioprotective effects of exercise in APOE mouse models using deep learning and photon-counting micro-CT. PLOS ONE. 2025 Apr 10; https://doi.org/10.1371/journal.pone.0320892.
