Journal Publications

  • Gu, J.J., Rouse, C., Xu, X., Wang, J., Onaitis, M.W., and Pendergast, A.M. (2016). Inactivation of ABL kinases suppresses non-small cell lung cancer metastasis. JCI Insight 1(21): e89647. Doi:10.1172/jci.insight.89647. (PMCID: in progress).
  • Wang, J., Rousse, C., Jasper, J.S., and Pendergast, A.M. (2016). ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling. Science Signaling 9 (issue 413): ra12. (Cover article of February 2, 2016 issue).  (PMID: 26838548; PMCID- in process). http://stke.sciencemag.org/content/9/413/ra12.long
  • Wang, J. and Pendergast, A.M. (2015). The emerging role of ABL kinases in solid tumors. Trends in Cancer (Cell Press) 1: 110-123 (PMCID: PMC4669955). http://www.cell.com/trends/cancer/fulltext/S2405-8033(15)00005-9
  • Khatri, A., Wang, J., and Pendergast, A.M. (2016). Multifunctional Abl kinases in health and disease. J. Cell Sci129: 9-16. (PMCID: PMC4732293). http://www.ncbi.nlm.nih.gov/pubmed/26729027
  • Greuber E.K., Smith-Pearson, P., Wang, J., and Pendergast, A.M. (2013). Role of ABL family kinases in cancer: from leukaemia to solid tumors. Nature ReviewsCancer13:559-571(PMCID:PMC3935732). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935732/
  • Chislock, E.M., Ring, C., and Pendergast, A.M. (2013). Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival. PNAS 110: 12432-12437 (PMCID: PMC3725093).
  • Greuber, E.K., and Pendergast, A.M. (2012). Abl Family Kinases Regulate FcgR-Mediated Phagocytosis in Murine Macrophages. J. Immunol189, 5382-5392. (PMCID: PMC3504141).
  • Gu, J.J., Lavau, C.P., Pugacheva, E., Soderblom, E.J., Moseley, M.A., and Pendergast, A.M.  (2012). Abl Family Kinases Modulate T Cell-Mediated Inflammation and Chemokine-Induced Migration through the Adaptor HEF1 and the GTPase Rap1. Science Signaling 5, ra51. [DOI: 10.1126/scisignal.2002632] (Cover article 17 July 2012 issue).
  • Li, R. and Pendergast, A.M. (2011). Arg Kinase Regulates Epithelial Cell Polarity by Targeting b1-Integrin and Small GTPase Pathways. Current Biology 21: 1534-1542. (PMCID: PMC3189484).
  • Ring, C., Ginsberg, M.H., Haling, J., and Pendergast, A.M. (2011). Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the a4 integrin. PNAS 108, 149-154. Epub Dec 20, 2010. (PMCID: PMC3017183). (Cover Article January 4, 2011 issue).
  • Smith-Pearson, P.S., Greuber, Greuber, E. K., Yogalingam, G., and Pendergast, A.M. (2010). Abl Kinases are required for invadopodia formation and chemokine-induced invasion. J. Biol. Chem285, 40201-40211. Epub Oct 11, 2010. (PMCID: PMC3001002).
  • Ryun Ryu, J., Echarri. A., Li, R., and Pendergast, A.M. (2009). Regulation of cell-cell adhesion by Abi/Diaphanous complexes. Mol. Cell. Biol. 29: 1735-1748. (PMCID: PMC2655615).
  • Gu, J.J., Ryun Ryu, J., and Pendergast, A.M. (2009).  Abl Tyrosine Kinases in T cell signaling. Immunol. Rev. 228: 170-183. (PMCID: PMC2678244).
  • Yogalingam, G., and Pendergast, A.M. (2008). ABL kinases regulate autophagy by promoting the trafficking and function of lysosomal components. J. Biol. Chem283: 35941-35953. (PMCID: PMC2602914).
  • Augustine, C.K., Yoshimoto, Y., Gupta, M., Zipfel, P.A., Selim, M.A., Febbo, P., Pendergast, A.M., Peters, W.P., and Tyler, D.S. (2008). Targeting N-Cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment. Cancer Research 68: 3777-3784.
  • Jung, J.-H., Pendergast, A.M., Zipfel, P.A., and Traugh, J.A. (2008). Phosphorylation of c-Abl by Protein Kinase Pak2 Regulates Differential Binding of ABI2 and CRK. Biochemistry 47: 1094-1104.
  • Zandy, N.L., and Pendergast, A.M. (2008). Abl Tyrosine Kinases Modulate Cadherin-dependent Adhesion Upstream and Downstream of Rho Family GTPases. Cell Cycle 74: 444-448.
  • Gu, J.J., Zhang, N., He, Y.-H., Koleske, A.J., and Pendergast, A.M. (2007). Defective T cell development and function in the absence of Abl kinases. The Journal of Immunology 179: 7334-7343.
  • Zandy, N.L., Playford, M., and Pendergast, A.M. (2007). Abl Tyrosine Kinases regulate cell-cell adhesion via Rho GTPases. PNAS 104: 17686-17691. (PMCID: PMC2077043).
  • Tanos, B.E., and Pendergast, A.M. (2007). Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis. Cellular Signaling 19, 1602-1609.
  • Tanos, B., and Pendergast, A.M. (2006). Abl Tyrosine Kinase regulates endocytosis of the Epidermal Growth Factor Receptor. J. Biol. Chem. 281, 32714-32723.
  • Zipfel, P.A., and Pendergast, A.M. (2006). Arg. AfCS-Nature Molecule Page (doi:10.1038/mp.a000324.01).
  • Zipfel, P.A., and Pendergast, A.M. (2006). Abl1. AfCS-Nature Molecule Page (doi:10.1038/mp.a000161.01).
  • Zipfel, P.A., Bunnell, S.C., Witherow, D.S., Gu, J.J., Chislock, E.M., Ring, C., and Pendergast, A.M. (2006). Role for the Abi/Wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. Current Biology 16, 35-46.
  • Burton, E.A., Pendergast, A.M., and Aballay, A.  (2006).The Caenorhabditis elegans ABL-1 Tyrosine Kinase is required for Shigella flexneri pathogenesis. Appl. Environ. Microbiol. 72, 5043-5051.
  • Burton, E.A., Oliver, T.N., and Pendergast, A.M. (2005). Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway. Mol. Cell. Biol25, 8834-8843.
  • Zipfel, P.A., and Pendergast, A.M. (2005). Abi1. AfCS-Nature Molecule Page (doi:10.1038/mp.a002545.01).
  • Zipfel, P.A., and Pendergast, A.M. (2005). Abi2. AfCS-Nature Molecule Page (doi:10.1038/mp.a002546.01).
  • Pendergast, A. M. (2005). Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis. Nat. Cell Biol7, 213-214.
  • Grove, M., Demyanenko, G., Echarri, A., Zipfel, P.A., Quiroz, M.E., Rodriguiz, R.M., Playford, M., Martensen, S.A., Robinson, M. R., Wetsel, W.C., Maness, P.F., and Pendergast, A.M. (2004). Abi2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis and deficits in learning and memory. Mol. Cell. Biol. 24, 10905-10922.
  • Zipfel, P.A., Zhang, W., Quiroz, M., and Pendergast, A.M. (2004). Requirement for Abl kinases in T cell receptor signaling. Current Biology 14, 1222-1231.
  • Plattner, R., Koleske, A.J., Kazlauskas, A., and Pendergast, A.M. (2004). Bidirectional signaling links the Abelson Kinases to the Platelet-Derived Growth Factor Receptor. Mol. Cell. Biol24, 2573-2583.
  • Echarri, A., Lai, M.J., Robinson, M.R., and Pendergast, A.M. (2004). Abl Interactor 1 (Abi-1) Wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and Wave-1 levels. Mol. Cell. Biol24, 4979-4993.
  • Advani, A.S., Dressman, H.K., Quiroz, M., Taylor, G.A., and Pendergast, A.M. (2004). Elevated expression of a subset of interferon-inducible genes in primary bone marrow cells expressing P185 Bcr-Abl versus P210 Bcr-Abl by DNA microarray analysis. Leukemia Research 28, 285-294.
  • Plattner, R., and Pendergast, A.M. (2003). Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling. Cell Cycle2: 4, 273-274.
  • Burton, E.A., Plattner, R.,and Pendergast, A.M. (2003). Abl tyrosine kinases are required for infection by Shigella flexneri. EMBO J22, 5471-5479.
  • Plattner, R., Irvin, B.J., Guo, S., Blackburn, K., Kazlauskas, A., Abraham, R.T., York, J.D., and Pendergast, A.M.(2003). A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-g1. Nature Cell Biology 5, 309-319.
  • Finn, A.J., Feng, G., and Pendergast, A.M. (2003). Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. Nature Neuroscience6, 717-723.
  • Advani, A.S., and Pendergast, A.M. (2002). Bcr-Abl variants: biological and clinical aspects. Leukemia Research 26, 713-720.
  • Pendergast, A.M. (2002). The Abl family kinases: mechanisms of regulation and signaling. Advances in Cancer Research 85, 51-100.
  • Echarri, A., and Pendergast, A.M. (2001). Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway.  Current Biology  11, 1759-1765.
  • Stradal, T., Courtney, K.D., Rottner, K., Hahne, P., Small, J.V., and Pendergast, A.M. (2001).  The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.  Current Biology 11, 891-895.
  • Roig, J., Tuazon, P.T., Zipfel, P.A., Pendergast, A. M., and Traugh, J.A. (2000).  Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK.  Proc. Natl. Acad. Sci. USA 97, 14346-14351.
  • Zipfel, P.A., Grove, M., Blackburn, K., Fujimoto, M., Tedder, T.F., and Pendergast, A.M.  (2000).The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. J. Immunol. 165, 6872-6879.
  • Quackenbush, R.C., Reuther, G.W., Miller, J.P., Courtney, K.D., Pear, W.S. and Pendergast, A.M. (2000).  Analysis of the biological properties of P230 Bcr-Abl reveals unique and overlapping properties with the oncogenic P185 and P210 Bcr-Abl tyrosine kinases.  Blood 95, 2913-2921.
  • Courtney, K.D., Grove, M., Vandongen, H., Vandongen, A., LaMantia, A.-S., and Pendergast, A.M. (2000).  Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system. Mol. Cell. Neuroscience 16, 244-257.
  • Plattner, R., Kadlec, L., DeMali, K.A., Kazluskas, A. and Pendergast, A.M. (1999).  C-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF.  Genes & Dev. 13, 2400-2411.
  • Dai, Z., Quackenbush, R. C., Courtney, K. D., Grove, M., Cortez, D., Reuther, G. W. and Pendergast, A. M. (1998).  Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway.  Genes & Dev. 12, 1415-1424.
  • Pear, W. S., Miller, J. P., Xu, L., Pui, J. C., Soffer, B., Quackenbush, R. C., Pendergast, A. M., Bronson, R., Aster, J. C., Scott, M. L. and Baltimore, D. (1998).  Efficient and rapid induction of a CML-like myeloproliferative disease in mice receiving P210 bcr/abl- transduced bone marrow. Blood 92, 3780-3792.
  • Reuther, J. Y., Reuther, G. W., Cortez, D., Pendergast, A. M. and Baldwin, Jr., A. S. (1998).  A requirement for NF-kB activation in Bcr-Abl-mediated transformation.  Genes & Dev12, 968-981.
  • LaMontagne, Jr., K. R., Flint, A. J., Franza, Jr., B. R., Pendergast, A. M. and Tonks, N. K. (1998).  Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.  Mol. Cell. Biol. 18, 2965-2975.
  • Cortez, D., Reuther, G. and Pendergast, A. M. (1997).  The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells.  Oncogene 15, 2333-2342.
  • Kadlec, L. and Pendergast, A. M. (1997).  The amphiphysin-like protein 1 (ALP1) interacts functionally with the c-ABL tyrosine kinase and may play a role in cytoskeletal regulation.  Proc. Natl. Acad. Sci. USA 94, 12390-12395.
  • Cortez, D., Stoica, G., Pierce, J. H. and Pendergast, A. M. (1996).  The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway.  Oncogene13, 2589-2594.
  • Reuther, G. W. and Pendergast, A. M. (1996).  The roles of 14-3-3 proteins in signal transduction.  Vitamins and Hormonesvol. 52, pp 149-175. Academic Press.
  • Pendergast, A. M. (1996). Nuclear tyrosine kinases: from Abl to WEE1.  Curr. Opin. Cell Biol. 8, 174-181.
  • Gishizky, M.L., Cortez, D. and Pendergast, A.M. (1995).  Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation.  Proc. Natl. Acad. Sci. USA 92, 10889-10893.
  • Dai, Z. and Pendergast, A. M. (1995).  Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes & Dev. 9, 2569-2582.
  • Xie, Y., Pendergast, A. M. and Hung, M.-C. (1995). Dominant- negative mutants of Grb2 induce reversal of the transformed phenotypes caused by the point-mutation activated Rat HER2/NeuJ. Biol. Chem. 270, 30717-30724.
  • Cortez, D., Kadlec, L. and Pendergast, A. M. (1995). Structural and signaling requirements for BCR-ABL mediated transformation and inhibition of apoptosis. Mol. Cell. Biol. 15, 5531-5541.
  • Reuther, G.W., Fu, H., Cripe, L.D., Collier, R.J. and Pendergast, A.M. (1994).  Association of c-BCR and BCR-ABL with 14-3-3 family proteins.  Science 266, 129-133.
  • Pendergast, A.M., Quilliam, L.A., Cripe, L.D., Bassing, C.H., Dai, Z., Li, N., Batzer, A., Rabun, K.M., Der, C.J., Schlessinger, J. and Gishizky, M.L. (1993).  BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.  Cell  75, 175-185.
  • Pendergast, A.M., Gishizky, M.L., Havlik, M.H. and Witte, O.N. (1993).  SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor-independence. Mol. Cell. Biol. 13, 1728-1736.
  • Goga, A., McLaughlin, J., Pendergast, A.M., Parmar, K., Muller, A., Rosenberg, N. and Witte, O.N. (1993).  Oncogenic activation of cABL by mutation within its last exon.  Mol. Cell. Biol. 13, 4967-4975.
  • Muller, A.J., Pendergast, A.M., Parmar, K., Havlik, M.H., Rosenberg, N. and Witte, O.N. (1993).  En bloc substitution of the SH2 domain activates the transforming potential of the c-ABL protein tyrosine kinase.  Proc. Natl. Acad. Sci. USA.  90, 3457-3461.
  • Muller, A.J., Pendergast, A.M., Havlik, M.H., Puil, L., Pawson, T. and Witte, O.N. (1992) A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. Mol. Cell. Biol. 12, 5087-5093.
  • Pendergast, A.M., Muller, A.J., Havlik, M.H., Clark, R., McCormick, F. and Witte, O.N. (1991) Evidence for regulation of the c-ABL tyrosine kinase by a cellular inhibitor. Proc. Natl. Acad. Sci. USA 88, 5927-5931.
  • Pendergast, A.M., Muller, A.J., Havlik, M.H., Maru, Y. and Witte, O.N. (1991) BCR sequences essential for transformation by the BCR/ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell 66, 161-171.
  • Gishizky, M.L., McLaughlin, J., Pendergast, A.M. and Witte, O.N. (1991) The 5’ non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells. Oncogene 6, 1299-1306.
  • Muller, A.J., Young, J.C., Pendergast, A.M., Pondel, M., Landau, N.R., Littman, D.R. and Witte, O.N. (1991) BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Mol. Cell. Biol. 11, 1785-1792.
  • Lugo, T.G., Pendergast, A.M., Muller, A.J. and Witte, O.N. (1990) Tyrosine kinase activity and transformation potency of BCR/ABL oncogene products. Science 247, 1079-1082.
  • Pendergast, A.M., Clark, R., Kawasaki, E.S., McCormick, F.P., and Witte, O.N. (1989) Baculovirus expression of functional p210 BCR/ABL oncogene product. Oncogene 4, 759-766.
  • Ponzetto, C., Wadewitz, A., Pendergast, A.M., Witte, O.N. and Wolgemuth, D.J. (1989) P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells. Oncogene 4, 685-690.
  • Clark, S.S., McLaughlin, J., Timmons, M., Pendergast, A.M., Ben-Neriah, Y., Dow, L.W., Crist, W., Rovera, G., Smith, S.D. and Witte, O.N. (1988) Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL). Science 239, 775-777.
  • Pendergast, A.M., Traugh, J.A. and Witte, O.N. (1987) Normal cellular and transformation-associated ABL proteins share common sites for protein kinase C phosphorylation. Mol. Cell. Biol. 7, 4280-4289.
  • Pendergast, A.M., Venema, R.C. and Traugh, J.A. (1987) Regulation of phosphorylation of aminoacyl-tRNA synthetases in the high molecular weight core complex in reticulocytes. J. Biol. Chem. 262, 5939-5942.
  • Pendergast, A.M. and Traugh, J.A. (1986) Identification of three protein kinases which phosphorylate threonyl-tRNA synthetase from rat liver. FEBS 206, 335-338.
  • Pendergast, A.M. and Traugh, J.A. (1985) Alteration of aminoacyl-tRNA synthetase activities by phosphorylation with casein kinase I. J. Biol. Chem. 260, 11769-11774.